Compulsive redosing

Compulsive redosing can be described as the experience of a powerful and difficult to resist urge to continuously redose a psychoactive substance in an effort to increase or maintain the subjective effects which it induces. [1] [2] [3] effect is considerably more likely to manifest itself when the user has a large supply of the given substance within their possession. It can be partially avoided by pre-weighing dosages, not keeping the remaining material within sight, exerting self-control, and giving the compound to a trusted individual to keep until they deem it safe to return. Compulsive redosing is often accompanied by other coinciding effects such as cognitive euphoria, physical euphoria, or anxiety suppression alongside of other effects which inhibit the clarity of one's decision-making processes such as disinhibition, motivation enhancement, and ego inflation. It is most commonly induced under the influence of moderate dosages of a wide variety of compounds, such as opioids, entactogens, stimulants, [4] [5] and GABAergics. However, it can also occur to a lesser extent under the influence of dissociatives and cannabinoids.

References

  1. Everitt, B. J., & Robbins, T. W. (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nature neuroscience, 8(11), 1481. | https://doi.org/10.1038/nn1579
  2. Volkow, N. D., & Fowler, J. S. (2000). Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cerebral cortex, 10(3), 318-325. | https://doi.org/10.1093/cercor/10.3.318
  3. Hyman, S. E., & Malenka, R. C. (2001). Addiction and the brain: the neurobiology of compulsion and its persistence. Nature reviews neuroscience, 2(10), 695. | https://doi.org/10.1038/35094560
  4. Soussan, C., & Kjellgren, A. (2015). “Chasing the High”–Experiences of Ethylphenidate as Described on International Internet Forums. Substance abuse: research and treatment, 9, SART-S22495. | https://doi.org/10.4137/SART.S22495
  5. Stanciu, C. N., Penders, T. M., Gnanasegaram, S. A., Pirapakaran, E., Padda, J. S., & Padda, J. S. (2017). The Behavioral Profile of methylenedioxypyrovalerone (MDPV) and α-pyrrolidinopentiophenone (PVP)-A Systematic Review. Curr Drug Abuse Rev. | https://doi.org/10.2174/1874473710666170321122226

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