Skip to main content
dose.wiki is still in beta. Entries may contain inaccuracies and/or lack citations. See our docs for more info.

A-PVP

A-PVP molecule structureA-PVP molecule structure
alpha-pyrrolidinovalerophenone
Flakka, Gravel, O-2387
Psychoactive Class
Chemical Class

α-PVP is a synthetic stimulant of the cathinone and pyrrolidinophenone classes, chemically related to prolintane and pyrovalerone. Originally patented by Boehringer Ingelheim in the 1960s but never marketed, it emerged as a recreational substance in the early 2010s. Known colloquially as flakka1, α-PVP acts as a norepinephrine-dopamine reuptake inhibitor2, producing powerful but short-lived effects comparable to methamphetamine and cocaine. It has been linked to numerous hospitalizations and deaths, with very limited toxicity data availablecitation needed.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~3 mg
Light3-10 mg
Moderate10-20 mg
Strong20-30 mg
Heavy30+ mg

Duration

Onset2-20 minutes
Come Up15-60 minutes
Peak1-2 hours
Offset1-4 hours
After Effects4-12 hours
Total2-6 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

Tactile enhancementIncreased heart rateIncreased perspirationAppetite suppressionVisual acuity suppressionFocus enhancement

Cognitive

The cognitive effects of α-PVP can be broken down into several components which progressively intensify proportional to dosage. The general head space of α-PVP is described by many as one of extreme mental stimulation and powerful euphoria. It contains a large number of typical stimulant cognitive effects.

Forked from Subjective Effect Documentation byJosie Kins September 2015.

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Mecke(ME)
white → yellow1
Mandelin(MD)
yellow2 → orange2 → red2 → brown2 → yellow2
Liebermann(LB)
white → yellow1
Hofmann(HM)
white → yellow1
Powered by PROtestkit.eu

Pharmacology

Pharmacodynamics

α-PVP acts as a potent and selective norepinephrine-dopamine reuptake inhibitor (NDRI).3 It inhibits dopamine reuptake with IC50 values of 13 to 80 nM and norepinephrine reuptake with IC50 values of 14 to 70 nM, as measured in rat brain synaptosomes and HEK293 cells expressing the monoamine transporters. Notably, α-PVP does not function as a transporter substrate and therefore does not induce neurotransmitter release.citation needed It has negligible activity at the serotonin transporter.3 In vitro, α-PVP is considerably more potent than amphetamine as an NDRI, showing 46-fold greater potency for dopamine reuptake inhibition and 7-fold greater potency for norepinephrine reuptake inhibition in HEK293 cells, making it one of the most potent dopamine reuptake inhibitors known in vitro.

Pharmacokinetics

Human pharmacokinetic evidence remains limited. In a naturalistic observational study of eight healthy volunteers who self-administered a single 10 mg or 20 mg intranasal dose, mean oral-fluid peak concentration occurred at 60 minutes after 10 mg and 47 minutes after 20 mg. Parent α-PVP and metabolites were recovered mainly in urine collected 2–5 hours after administration. The most abundant identified urinary product was an N-butanoic-acid metabolite formed by oxidative opening of the pyrrolidine ring, including a glucuronide; β-hydroxy-α-PVP was a minor metabolite. Because the study measured oral fluid and urine rather than serial plasma, it does not establish a human plasma half-life or absolute intranasal bioavailability. In non-vaccinated male rats given 0.56–3 mg/kg subcutaneously, serum kinetics were approximately linear and the terminal half-life ranged from 1.82 to 2.54 hours. Apparent distribution volumes of 14.1–17.9 L/kg and measured brain, heart, and kidney concentrations indicated extensive tissue distribution in this animal model. These subcutaneous rat values must not be presented as human or route-independent kinetics; absolute bioavailability was not measured because the study had no intravenous reference dose.

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

5-HTPAlcoholDXMDissociativesMAOIsMDMAMXENBOMe compoundsSNRIsSSRIsSerotonin releasersStimulantsTramadol
Powered by TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Tolerance to many of the effects of α-PVP develops with prolonged and repeated use, resulting in users needing to administer increasingly large doses to achieve the same effects.
Baseline Reset
1-2 weeks
Half Tolerance
3-7 days
Cross Tolerance

Dopaminergic stimulants

Harm Potential

Addiction & Dependence

Psychological

High

Chronic use is considered highly addictive with a high potential for abuse and is capable of causing psychological dependence. Compulsive use patterns are commonly associated with this substance, and when addiction has developed, cravings and withdrawal effects may occur if usage is suddenly stopped.

Toxicity

Cardiovascular

Due to the potency of its rush, α-PVP can cause various uncomfortable or painful sensations in the heart, especially when abused or used for extended periods; sudden spikes in blood pressure may occur particularly when vaporized or injected.

Psychosis Risk

This compound is known to readily induce psychosis if abused for prolonged periods. Symptoms can easily escalate into frightening delusions, paranoid psychosis, extreme agitation, and other altered mental states.1 In emergency settings, psychosis-like states, agitation, aggression, and hallucinations are commonly observed. Approximately 5-15% of users who develop stimulant psychosis fail to recover completely.

Seizure Risk

α-PVP may lower the seizure threshold in some individuals, especially when abused.

History & Culture

α-PVP (alpha-pyrrolidinovalerophenone) was first described in scientific literature in 1963 and subsequently patented by the pharmaceutical company Boehringer Ingelheim during the 1960s, though it was never developed for medical use or brought to market.

Legality

International

UN Convention on Psychotropic Substances 1971: scheduled

By Country

Illegal36
United States flagUnited StatesIllegal
Australia flagAustraliaIllegal
Austria flagAustriaIllegal
Belgium flagBelgiumIllegal
Brazil flagBrazilIllegal
Chile flagChileIllegal
China flagChinaIllegal
Cyprus flagCyprusIllegal (analog/blanket ban)
Czech Republic flagCzech RepublicIllegal
Estonia flagEstoniaIllegal
Finland flagFinlandIllegal
France flagFranceIllegal
Greece flagGreeceIllegal
Hungary flagHungaryIllegal
India flagIndiaIllegal
Ireland flagIrelandIllegal
Italy flagItalyIllegal
Japan flagJapanIllegal
Latvia flagLatviaIllegal
Lithuania flagLithuaniaIllegal
Netherlands flagNetherlandsIllegal
New Zealand flagNew ZealandIllegal
Norway flagNorwayIllegal
Philippines flagPhilippinesIllegal
Poland flagPolandIllegal
Portugal flagPortugalIllegal
Romania flagRomaniaIllegal
Singapore flagSingaporeIllegal
Slovakia flagSlovakiaIllegal
Slovenia flagSloveniaIllegal
South Korea flagSouth KoreaIllegal
Sweden flagSwedenIllegal
Switzerland flagSwitzerlandIllegal
Turkey flagTurkeyIllegal
United Arab Emirates flagUnited Arab EmiratesIllegal
United Kingdom flagUnited KingdomIllegal (analog/blanket ban)
Controlled / restricted4
Colombia flagColombiaRestricted
Germany flagGermanyAnlage II BtMG
Mexico flagMexicoRestricted
Spain flagSpainRestricted

References

Citations

  1. Jiri Patocka, Baoming Zhao, Wei Wu, Blanka Klimova, Martin Valis, Eugenie Nepovimova, & Kamil Kuca. (2020-10-31). Flakka: New Dangerous Synthetic Cathinone on the Drug Scene. International Journal of Molecular Sciences, 21(21), Article 8185. https://doi.org/10.3390/ijms21218185123
  2. G De la Rosa, E Papaseit, O Hladun, L Poyatos, DA Caicedo, MC Argote, S Martín, M Ventura, N La Maida, A Di Trana, S Graziano, S Pichini, M Farré, & C Pérez-Mañá. (2025-07-02). Acute pharmacological effects of α-PVP in humans: a naturalistic observational study. Frontiers in Pharmacology, 16, Article 1626692. https://doi.org/10.3389/fphar.2025.16266921
  3. John A. Marusich, Kenneth R. Antonazzo, Jenny L. Wiley, Bruce E. Blough, John S. Partilla, & Michael H. Baumann. (2014). Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV). Neuropharmacology, 87, 206–213. https://doi.org/10.1016/j.neuropharm.2014.02.016123
  4. Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/asmade/2026-05-28/text/original/epub/OEBPS/document_1/document_1.html1
  5. Suchtgiftverordnung (SV). ris.bka.gv.at (n.d.). https://ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Anlage=4&Artikel=&Gesetzesnummer=10011053&Paragraf=&Uebergangsrecht=1
  6. Législation - Substances, AFMPS. afmps.be (n.d.). https://www.afmps.be/fr/humain/produits_particuliers/subst_specialement_reglementees/stupefiants_et_psychotropes/substances1
  7. AFMPS Annex II non-official consolidated version. afmps.be (n.d.). https://www.afmps.be/sites/default/files/content/INSP/NARC/annex%20II_non%20official%20consolidated%20version.pdf1
  8. AFMPS Annex IV non-official consolidated version. afmps.be (n.d.). https://www.afmps.be/sites/default/files/content/INSP/NARC/annex%20IV_non%20official%20consolidated%20version.pdf1
  9. Council Implementing Decision (EU) 2016/1070, EUR-Lex. eur-lex.europa.eu (n.d.). https://eur-lex.europa.eu/legal-content/EN/ALL/?uri=CELEX%3A32016D10701
  10. Arrêté royal du 14 décembre 2006 relatif aux médicaments à usage humain et vétérinaire, AFMPS-hosted official publication PDF. afmps.be (n.d.). https://www.afmps.be/sites/default/files/downloads/AR-KB-2006-12-14_fr.pdf1

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Lyrea avatar
    Step 2 · First-pass review

    A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes8 human edits · latest

Times are UTCNewest first

12 August 2026

  1. Lyrea · Updated the article

  2. Lyrea · Updated the article

  3. Lyrea · Updated the article

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

All changes to this article · Site-wide recent changes

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the A-PVP article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.