Skip to main content
dose.wiki is still in beta. Entries may contain inaccuracies and/or lack citations. See our docs for more info.

4-FA

4-FA molecule structure4-FA molecule structure
4-Fluoroamphetamine
4-FMP, PAL-303, Flux, para-Fluoroamphetamine, PFA

4-FA is a synthetic substituted amphetamine that produces a distinctive combination of stimulant and entactogenic effects. It became commercially available as a research chemical in the early 2000s and gained particular popularity in the Netherlands. Users commonly describe its effects as intermediate between amphetamine and MDMAcitation needed, with a moderate entactogenic onset that gradually transitions into traditional amphetamine-type stimulation. Very little data exists regarding its pharmacological properties, metabolism, and toxicity.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~40 mg
Light40-100 mg
Moderate100-130 mg
Strong130-150 mg
Heavy150+ mg

Lower doses within the common range are described as producing milder, more functional stimulation, while higher doses are associated with stronger recreational and entactogenic effects.

Duration

Onset20-40 minutes
Come Up30-75 minutes
Peak2.5-3.5 hours
Offset2-3 hours
After Effects6-12 hours
Total5-8 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

In comparison to other substituted amphetamines, 4-FA is particularly free of side effects such as nausea, high blood pressure, anxiety and an uncomfortable offset. In low doses, it is considered to be an extremely functional and effective nootropic for performing tasks or general productivity of any sort. At higher dosages, however, it becomes dysfunctional and recreational due to the intensity of its euphoria and stimulation.

Forked from Subjective Effect Documentation byJosie Kins August 2015.

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Mandelin(MD)
yellow2 → orange2 → red2 → brown2 → yellow2
Liebermann(LB)
white → orange3 → red2
Morr(MO)
pink2 → green1
Marquis(MQ)
No reaction
No reaction
Powered by PROtestkit.eu

Pharmacology

Pharmacodynamics

4-FA acts as a releasing agent and reuptake inhibitor of dopamine, serotonin, and norepinephrine.1 Its monoamine-releasing profile is most potent at the norepinephrine transporter (EC50 = 37 nM), followed by dopamine (EC50 = 200 nM) and serotonin (EC50 = 730 nM), with corresponding reuptake inhibition at each transporter.1 The substance also displays low affinity for serotonin 5-HT2A and 5-HT2C receptors1, very low-potency partial agonism at the 5-HT2B receptor, and weak inhibitory activity at monoamine oxidase A.citation needed

Pharmacokinetics

The fluorine substituent at the 4-position of the phenyl ring is thought to resist metabolic deactivation by hepatic cytochrome P450 oxidase, distinguishing 4-FA from other haloamphetamines in its metabolic susceptibility.citation needed

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

2C-T-x compounds5-MeO-xxT tryptaminesAMTAlcoholCaffeineCannabisCocaineDOx compoundsDXMKetamineMAOIsMethoxetamineNBOMe compoundsOpioidsPCPTramadol
Powered by TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Prolonged repeated use can reduce sensitivity to many effects, so comparable effects may require larger doses. Tolerance to stimulating effects and entactogenic effects may rise and fade at different rates, with entactogenic tolerance potentially lasting longer.
Baseline Reset
1-2 weeks for stimulant effects to return to baseline. Tolerance to entactogenic effects may require a longer period to fully reset.
Half Tolerance
3-7 days
Cross Tolerance

Dopaminergic stimulants

Harm Potential

Addiction & Dependence

Psychological

Moderate

Chronic use of 4-FA can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. Compulsive redosing is commonly reported. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Physical

Withdrawal effects have been reported upon cessation of chronic use.

Toxicity

Cardiovascular

Acute cardiovascular toxicity appears to be an especially high risk with 4-FA, even at moderate doses; reported complications include arrhythmias (sinus arrhythmia, ventricular extrasystoles, conduction disturbances), acute cardiac failure, cardiomyopathy including reverse takotsubo syndrome, cerebral hemorrhage, and stroke.citation needed Some users in the Netherlands have died from cardiac arrest or suffered severe brain damage from stroke.

Central Nervous System

Animal studies suggest 4-FA has relatively low potential for neurotoxicity compared to related halogenated amphetamines; it does not cause long-lasting depletion of brain serotonin, unlike its analogs 4-CA and 4-BA.citation needed

Nasal and Respiratory Mucosa

4-FA is particularly caustic compared to other compounds and can cause chemical burns within the nasal passage and throat when insufflated.

Gastrointestinal

One fatal case of extensive bowel ischemia has been reported following chronic 4-FA use.

Psychosis Risk

4-FA, like other stimulants, can result in stimulant psychosis that may present with paranoia, hallucinations, or delusions. Based on research on related amphetamines, approximately 5-15% of users who develop stimulant psychosis may fail to recover completely.citation needed Delirium and confusion typically only occur with overly high doses, particularly when combined with temperature dysregulation and overheating in physically strenuous environments. Antipsychotic medications have been shown to effectively resolve symptoms of acute amphetamine psychosis.3

Seizure Risk

Seizures are a rare effect but are thought to be able to occur in those predisposed to them, especially when taking heavier-than-recommended doses or redosing while in physically taxing conditions such as being dehydrated, fatigued, undernourished, or overheated.

History & Culture

Synthesis and Early Research

4-Fluoroamphetamine was first synthesized in the early 1940s,1 though no records exist of the compound being tested in humans for many years following its initial preparation. During the 1960s, researchers began investigating 4-FA alongside other

Legality

International

1961 Single Convention: 4-FA is not individually scheduled.

1971 Convention on Psychotropic Substances: Schedule II.

1988 Convention: 4-FA is not listed in precursor Tables I or II.

By Country

Illegal27
United States flagUnited StatesIllegal
Australia flagAustraliaIllegal
Austria flagAustriaIllegal
Belgium flagBelgiumIllegal
Brazil flagBrazilIllegal
Bulgaria flagBulgariaIllegal
Canada flagCanadaIllegal
Chile flagChileIllegal
China flagChinaIllegal
Croatia flagCroatiaIllegal
Czech Republic flagCzech RepublicIllegal
Finland flagFinlandIllegal
France flagFranceIllegal
Germany flagGermanyIllegal
Hungary flagHungaryIllegal
Israel flagIsraelIllegal
Italy flagItalyIllegal
Netherlands flagNetherlandsIllegal
New Zealand flagNew ZealandIllegal (analog/blanket ban)
Poland flagPolandIllegal
Serbia flagSerbiaIllegal
Slovakia flagSlovakiaIllegal
South Korea flagSouth KoreaIllegal
Sweden flagSwedenIllegal
Switzerland flagSwitzerlandIllegal
Turkey flagTurkeyIllegal
United Kingdom flagUnited KingdomIllegal

References

Source Pages

  1. Bluelight: 4-FA dosage discussion (2011)
  2. Bluelight: 4-FA megathread
  3. Drug Users Bible by Dominic Milton Trott
  4. Erowid
  5. Erowid: 4-Fluoroamphetamine Vault
  6. Isomer Design (TiHKAL/PiHKAL)
  7. PsychonautWiki
  8. The Drug Classroom
  9. TripSit Factsheets
  10. TripSit: Combo Chart
  11. Wikipedia

Citations

  1. Brandt SD, Poovendran D, & Kershaw S. (2017). 4-Fluoroamphetamine (4-FA) Critical Review Report, Agenda Item 4.3. World Health Organization, Expert Committee on Drug Dependence, Thirty-ninth Meeting. https://researchonline.ljmu.ac.uk/id/eprint/7380/1/WHO_2017_CR_4.3_4-FA_Critical_Review.pdf12345678910
  2. Bosma KA, Verschoor A, & Menting TP. (2014). Cardiogenic shock after use of fluoroamphetamine confirmed with serum and urine levels. BMJ Case Reports. https://doi.org/10.1136/bcr-2014-2043281
  3. Shoptaw SJ, Kao U, & Ling W. (2009). Treatment for amphetamine psychosis. Cochrane Database of Systematic Reviews. https://pmc.ncbi.nlm.nih.gov/articles/PMC7004251/1
  4. Felix Linsen et al.. (2015). 4-Fluoroamphetamine in the Netherlands: more than a one-night stand. Addiction, 110(7), 1138-1143. https://doi.org/10.1111/add.1293212
  5. Criminal Code Regulations 2019 (Cth), regulation 11 and Schedule 1 clause 1 (Controlled drugs and quantities) — Compilation No. 6, compilation date 13 December 2025. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2019L00561/2025-12-13/2025-12-13/text/original/epub/OEBPS/document_1/document_1.html1
  6. Criminal Code Act 1995 (Cth), the Criminal Code, Chapter 9 Part 9.1 (Serious drug offences) sections 300.3, 300.4, 301.1, 302.4, 305.5 and 308.1 — Compilation No. 174, compilation date 30 June 2026, volume 2. legislation.gov.au (n.d.). https://www.legislation.gov.au/C2004A04868/2026-06-30/2026-06-30/text/original/epub/OEBPS/document_2/document_2.html1
  7. Criminal Code Act 1995 (Cth), the Criminal Code, Part 2.7 Division 15 section 15.2 (Extended geographical jurisdiction—category B) — Compilation No. 174, compilation date 30 June 2026, volume 1. legislation.gov.au (n.d.). https://www.legislation.gov.au/C2004A04868/2026-06-30/2026-06-30/text/original/epub/OEBPS/document_1/document_1.html1
  8. Customs (Prohibited Imports) Regulations 1956, compilation dated 13 July 2026. legislation.gov.au (n.d.). https://www.legislation.gov.au/F1996B03651/2026-07-13/2026-07-13/text/original/epub/OEBPS/document_1/document_1.html1
  9. Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 (Cth), Reader's guide introduction, Part 1 sections 1, 2, 4 and 7, Schedule 8 and Schedule 9. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/asmade/2026-05-28/text/original/epub/OEBPS/document_1/document_1.html1
  10. Federal Register of Legislation register entry — Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 (F2026L00633). legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/latest1

Further Reading

  1. 4-FA vs MDMA cardiovascular study (J Psychopharmacol 2022)
  2. Drug-induced serotonin syndrome (U.S. Pharmacist 2010)
  3. Drugs-Forum: 4-FA experiences thread
  4. Dutch Health Institute alert on 4-FA risks (RIVM 2017)
  5. Jellinek Institute 4-FA factsheet
  6. PubChem: 4-Fluoroamphetamine
  7. Safety and neurocognition after acute 4-FA (Front Pharmacol 2018)

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Lyrea avatar
    Step 2 · First-pass review

    A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

All changes to this article · Site-wide recent changes

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the 4-FA article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.