Pyrazolam

8-bromo-1-methyl-6-(2-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

SH-I-04

Psychoactive Class

Depressant Anxiolytic GABAergic Muscle Relaxant

Chemical Class

Pyrazolam is a research chemical depressant of the triazolobenzodiazepine class. Originally developed at Hoffmann-La Roche in the 1970s, it emerged on the research chemical market around 2012¹. Pyrazolam is distinguished from other benzodiazepines by its predominantly anxiolytic profile, producing comparatively less sedation and euphoria at common doses. It is structurally related to alprazolam and bromazepam and is notably reported to pass through the body unmetabolized¹.

Dosage & Duration

Dosage

Threshold~0.5 mg

Light0.5-0.75 mg

Moderate0.75-1.5 mg

Strong1.5-3 mg

Heavy3+ mg

Duration

Onset10-15 minutes

After Effects1-12 hours

Total5-8 hours

Subjective Effects

Effects vary widely by individual, dose, and context.

Physical

The physical effects of pyrazolam can be broken down into several components which progressively intensify proportional to dosage.

Dizziness Motor control loss Muscle relaxation Respiratory depression

Cognitive

The general head space of pyrazolam is described by many as one of mild sedation and proportionlly intense anxiety suppression. It contains a large number of typical depressant cognitive effects.

Amnesia Anxiety suppression Thought deceleration Disinhibition Information processing suppression Compulsive redosing

Forked from Subjective Effect Documentation

by Josie KinsSeptember 2015.

Reagent Testing

Loading reagent data

Expected colorimetric results are being prepared.

Pharmacology

Pharmacodynamics

Pyrazolam acts as a positive allosteric modulator at the GABAA receptor via the benzodiazepine binding site, enhancing the inhibitory signaling of GABA.¹² It is most selective for the α2 and α3 subtypes of the GABAA receptor, which is consistent with its predominantly anxiolytic profile. The anticonvulsant properties observed with benzodiazepines as a class may be partly attributable to interaction with voltage-dependent sodium channels rather than the benzodiazepine site itself.³

Pharmacokinetics

Pyrazolam does not appear to undergo metabolism and is instead excreted unchanged in the urine. As a result, it does not interact with liver enzymes, which may make it comparatively safer for individuals with reduced hepatic function.

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AlcoholGHB/GBLOpioidsTramadol

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

DiphenhydraminePCP

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

DXMKetamineMXE

TripSit

Tolerance

Full Tolerance

Sedative-hypnotic tolerance can appear after only a few days of uninterrupted use.

Cross Tolerance

Benzodiazepines

Baseline Reset

Tolerance typically returns to baseline within 7-14 days after cessation, though this period may be significantly longer for individuals with extended or intensive use histories.

Harm Potential

Addiction & Dependence

Psychological

High

Pyrazolam is described as extremely psychologically addictive, with compulsive redosing commonly reported as a cognitive effect. However, its comparatively limited sedative and euphoric effects relative to other benzodiazepines may somewhat reduce recreational appeal and abuse potential.

Physical

Extremely High

Physical dependence develops with regular use. Withdrawal following a few weeks or longer of steady dosing can be potentially life-threatening, with symptoms including hypertension and seizures⁴; abrupt discontinuation after extended use may result in death. Gradual tapering over weeks is strongly recommended.⁴

Seizure Risk

While benzodiazepines have anticonvulsant properties during use⁴, abrupt discontinuation after regular use can cause potentially fatal seizures.⁴⁵ Paradoxical seizure reactions during use are rare in the general population, with an incidence rate below 1%, occurring more frequently in epileptics and high-dosage regimes.

History & Culture

Pyrazolam was originally developed during the 1970s by a research team led by Leo Sternbach at Hoffman-La Roche⁶, the pharmaceutical company responsible for discovering many clinically significant benzodiazepines. Despite its initial synthesis during this prolific…

Trip Reports

Legality

By Country

CanadaSchedule IV (CDSA)

Controlled under the Controlled Drugs and Substances Act as part of the blanket scheduling of all benzodiazepines. Possession, trafficking, and production without authorization carry criminal penalties.

RussiaSchedule III

Listed as a Schedule III controlled substance since 2017. Production, distribution, and possession are regulated under federal drug control legislation.

SwitzerlandVerzeichnis E

Specifically named as a controlled substance under Verzeichnis E (Schedule E) of Swiss narcotics legislation. Unauthorized possession and distribution are prohibited.

United KingdomClass C

Controlled as a Class C substance under the Misuse of Drugs Act 1971 since May 31, 2017.⁹ Prior to this, a Temporary Class Drug Order (TCDO) issued in December 2016 had already prohibited personal possession, not just import and supply. It is illegal to possess, produce, or supply.

GermanyNpSG controlled

Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) since July 18, 2019.⁸ Production, import with intent to market, administration to others, and trading are punishable offenses. Possession is technically illegal but not subject to criminal penalty.

SwedenControlled substance

Classified as a controlled narcotic substance under Swedish drug legislation. Possession, sale, and distribution are prohibited.

TurkeyIllegal

Classified as an illegal drug under Turkish drug control laws. Possession, production, supply, and importation are all criminal offenses.

References

Source Pages

Citations

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