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2-FMA

2-FMA molecule structure2-FMA molecule structure
2-Fluoromethamphetamine
Psychoactive Class
Chemical Class

2-FMA is a synthetic stimulant of the substituted amphetamine class, structurally related to methamphetamine through fluorination at the 2-position.citation needed Available as a research chemical since approximately 2012, it is frequently compared to lisdexamfetamine (Vyvanse) for its utility as a productivity and study aid. 2-FMA is generally regarded as less euphoric and less recreationally appealing than traditional amphetamines. Little formal research on the substance exists.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~5 mg
Light5-15 mg
Moderate15-30 mg
Strong30-50 mg
Heavy50+ mg

Duration

Onset20-60 minutes
Come Up15-40 minutes
Peak2.5-4 hours
Offset2-3 hours
After Effects4-12 hours
Total7-9 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

In comparison to other substituted amphetamines, 2-FMA is particularly free of side effects such as nausea, high blood pressure, anxiety and an uncomfortable offset. It is considered to be an extremely functional and effective psychoactive substance for performing general productivity tasks of any sort. However, at higher doses, it becomes less of a productivity boost and more for recreational purposes due to the intensity of its euphoria and stimulation.

Physical

The physical effects of 2-FMA can be broken down into several components which progressively intensify proportional to dosage.

Cognitive

The cognitive effects of 2-FMA can be broken down into several components which progressively intensify proportional to dosage.

Forked from Subjective Effect Documentation byJosie Kins September 2015.

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow1 → orange2
Mecke(ME)
white → yellow1
Mandelin(MD)
yellow2 → brown2 → yellow2
Liebermann(LB)
white → orange2
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Pharmacology

Pharmacodynamics

2-FMA has not been formally studied to the same extent as traditional amphetamines, and its precise mechanism of action remains unconfirmed.citation needed It is believed to function primarily as a dopamine and norepinephrine releasing agent and reuptake inhibitor. Additional activity at VMAT2 and TAAR1 has been suggested but remains unverified.

Pharmacokinetics

There have been no studies on the pharmacokinetic profile of 2-FMA and the metabolism of 2-FMA is unknown.

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

2C-T-x compounds5-MeO-xxT tryptaminesAMTAlcoholCaffeineCannabisCocaineDOx compoundsDXMKetamineMAOIsMethoxetamineNBOMe compoundsOpioidsPCPTramadol
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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Prolonged repeated use can produce tolerance to many effects, so comparable results may require higher doses.
Baseline Reset
1-2 weeks
Half Tolerance
3-7 days
Cross Tolerance

Dopaminergic stimulants

Harm Potential

Addiction & Dependence

Psychological

Moderate

Chronic use can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. Compulsive redosing is reported as a potential cognitive effect.

Physical

Low

When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. The substance is primarily associated with psychological rather than physical dependence.

Toxicity

Cardiovascular

Elevated blood pressure, increased heart rate, abnormal heartbeat, and vasoconstriction are reported, particularly at doses above the heavy dosage range; infrequent use of common doses likely poses minimal cardiovascular risk for healthy individuals.

Psychosis Risk

Use of amphetamine-class compounds at high dosages for prolonged periods can potentially result in stimulant psychosis presenting with paranoia, hallucinations, or delusions. Anxiety and paranoia typically occur with overly high doses or after redosing and staying awake for extended periods. A review of amphetamine-induced psychosis found approximately 5-15% of users fail to recover completely, though antipsychotic medications effectively resolve symptoms of acute psychosis.citation needed

Seizure Risk

Seizure risk may increase at high doses, though this is not commonly reported at typical use levels.

History & Culture

2-FMA emerged on the online research chemical market in August 2007, appearing alongside other fluorinated amphetamines such as 2-FA and 4-FA.citation needed That same month, forensic analysis of capsules delivered to Royal Adelaide Hospital in Australia revealed the presence of

Trip Reports

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Legality

International

2-FMA is not listed under the 1961 Single Convention on Narcotic Drugs. It is not listed under the 1971 Convention on Psychotropic Substances. It is not listed under the 1988 Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.

By Country

Illegal16
Belgium flagBelgiumIllegal (analog/blanket ban)
Canada flagCanadaIllegal (analog/blanket ban)
Chile flagChileIllegal (analog/blanket ban)
China flagChinaIllegal
Finland flagFinlandIllegal
Germany flagGermanyIllegal
Ireland flagIrelandIllegal (analog/blanket ban)
Netherlands flagNetherlandsIllegal (analog/blanket ban)
New Zealand flagNew ZealandIllegal (analog/blanket ban)
Norway flagNorwayIllegal
Poland flagPolandIllegal (analog/blanket ban)
Singapore flagSingaporeIllegal
Switzerland flagSwitzerlandIllegal
Turkey flagTurkeyIllegal
Ukraine flagUkraineIllegal
United Kingdom flagUnited KingdomIllegal
Not scheduled2
United States flagUnited StatesNot scheduled
France flagFranceNot scheduled

References

Source Pages

  1. Bluelight: 2-FMA Megathread
  2. Erowid Experience: A Clean Productivity Stimulant
  3. Erowid Experience: A College Student's Best Friend
  4. Erowid Experience: A More Functional Adderall
  5. Erowid Experience: Best of The Bunch
  6. Isomer Design (TiHKAL/PiHKAL)
  7. PsychonautWiki
  8. The Drug Classroom
  9. TripSit Factsheets
  10. Wikipedia

Citations

  1. Andrew Camilleri, Martin R Johnston, Michael Brennan, Sean Davis, David G E Caldicott, Martin R. Johnston, & David G.E. Caldicott. (2010). Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, α-phthalimidopropiophenone and N-ethylcathinone. Forensic Science International. https://doi.org/10.1016/j.forsciint.2009.12.0481
  2. EMCDDA, & Europol. (2013). New drugs in Europe, 2012: EMCDDA-Europol 2012 Annual Report on the implementation of Council Decision 2005/387/JHA. Publications Office of the European Union. https://www.euda.europa.eu/system/files/publications/734/EMCDDA-Europol_2012_Annual_Report_final_439477.pdf1
  3. Royal Decree of 6 September 2017 regulating narcotic drugs and/or psychotropic substances. ejustice.just.fgov.be (n.d.). https://www.ejustice.just.fgov.be/eli/arrete/2017/09/06/2017031231/justel1
  4. Royal Decree of 6 September 2017 regulating narcotic drugs and/or psychotropic substances. famhp.be (n.d.). https://www.famhp.be/en/human_use/particular_products/specially_reglemented_substances/narcotics_psychotropics/legislation_substances1
  5. Royal Decree of 6 September 2017 regulating narcotic drugs and/or psychotropic substances. famhp.be (n.d.). https://www.famhp.be/sites/default/files/content/INSP/NARC/annex%20IV_non%20official%20consolidated%20version.pdf1
  6. Legislative Services Branch. (2022-03-31). Controlled Drugs and Substances Act — Schedule I. laws-lois.justice.gc.ca. https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-9.html1
  7. Controlled Drugs and Substances Act — section 2. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-2.html1
  8. Health Canada’s Controlled Substances Status Determination Process. canada.ca (n.d.). https://www.canada.ca/en/health-canada/corporate/mandate/regulatory-role/what-health-canada-regulates-1/controlled-substances-precursors/overview-substance-control-status-determination-process.html1
  9. PubChem PUG REST — 2-Fluoromethamphetamine (CID 24257263). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/24257263/property/IUPACName,CanonicalSMILES,MolecularFormula/JSON1
  10. PubChem PUG REST — Methamphetamine (CID 10836). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/10836/property/IUPACName,CanonicalSMILES,MolecularFormula/JSON1

Further Reading

  1. Qualitative study on NPS self-medication, Addict Behav 138:107468 (2023)
  2. Reddit: r/tripreports – 2-FMA report emphasising insomnia & dose-response (2022)
  3. Shanks et al. - In-vitro metabolism of fluorinated amphetamines, Drug Test Anal 7:203-212 (2015)

Article Status

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    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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    A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.

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    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes8 human edits · latest

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11 August 2026

  1. Lyrea · Updated the article

  2. Lyrea · Updated the article

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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