Deschloroetizolam

Etizolam-2

Psychoactive Class

Depressant Anxiolytic GABAergic Muscle Relaxant

Chemical Class

Deschloroetizolam is a thienotriazolodiazepine and the dechlorinated analog of etizolam.¹ It first appeared through grey market research chemical vendors in 2014 and is not prescribed for any medical use. It produces depressant, anxiolytic, sedative, muscle relaxant, and amnesic effects through modulation of GABA receptors. Compared to its parent compound etizolam, it is roughly half as potent but exhibits approximately twice the duration of action.

Dosage & Duration

Dosage

Threshold~1 mg

Light2-4 mg

Moderate4-6 mg

Strong6-12 mg

Heavy12+ mg

Duration

Onset15-30 minutes

Come Up30-60 minutes

Peak3-4 hours

Offset3-4 hours

After Effects3-6 hours

Total8-10 hours

Subjective Effects

Effects vary widely by individual, dose, and context.

Physical

The physical effects of deschloroetizolam can be broken down into several components which progressively intensify proportional to dosage.

Respiratory depression Muscle relaxation Dizziness

Cognitive

The cognitive effects of deschloroetizolam can be broken down into several components which progressively intensify proportional to dosage. The general head space of deschloroetizolam is described by many as one of intense sedation and decreased inhibition. It contains a large number of typical depressant cognitive effects. Paradoxical reactions to benzodiazepines such as increased seizures (in epileptics), aggression, increased anxiety, violent behavior, loss of impulse control, irritability and suicidal behavior sometimes occur (although they are rare in the general population, with an incidence rate below 1%). These paradoxical effects occur with greater frequency in recreational abusers, individuals with mental disorders, children, and patients on high-dosage regimes.

Amnesia Anxiety suppression Thought deceleration Disinhibition Information processing suppression Euphoria Compulsive redosing

Forked from Subjective Effect Documentation

by Josie KinsAugust 2015.

Reagent Testing

Loading reagent data

Expected colorimetric results are being prepared.

Pharmacology

Pharmacodynamics

Deschloroetizolam acts as a positive allosteric modulator at GABA-A receptors via the benzodiazepine binding site.² By enhancing the efficiency of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) at these receptors, it produces its characteristic depressant and anxiolytic effects.² It is the dechlorinated analog of etizolam and is reported to be approximately half as potent as that parent compound.²

Pharmacokinetics

Limited pharmacokinetic data is available for deschloroetizolam.³ It is reported to have a bioavailability similar to that of its parent compound etizolam.

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AlcoholGHB/GBLOpioidsTramadol

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

DiphenhydraminePCP

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

DXMKetamineMXE

TripSit

Tolerance

Full Tolerance

Tolerance to sedative-hypnotic effects can appear after only several days of uninterrupted deschloroetizolam use.

Cross Tolerance

Benzodiazepines, Thienodiazepines

Baseline Reset

Tolerance typically returns to baseline within 7-14 days after cessation, though this may take significantly longer depending on the duration and intensity of long-term use.

Harm Potential

Addiction & Dependence

Psychological

High

Deschloroetizolam is described as extremely psychologically addictive. Compulsive redosing is commonly reported as a characteristic effect, and the drug is classified as habit-forming.

Physical

Extremely High

Deschloroetizolam produces severe physical dependence with regular use. Sudden discontinuation can be life-threatening, potentially resulting in seizures or death.⁴ Withdrawal symptoms may occur after a few weeks of steady dosing, and a gradual taper over weeks is strongly recommended rather than abrupt cessation.⁴

Psychosis Risk

Paradoxical reactions including delusions may occur but are rare in the general population, with an incidence rate below 1%.⁵ These effects occur with greater frequency in recreational abusers, individuals with mental disorders, children, and patients on high-dosage regimes.⁵ Delusions may also occur as a symptom of overdose.

Seizure Risk

While deschloroetizolam itself has anticonvulsant properties, paradoxical increased seizures may rarely occur in epileptic individuals. The primary seizure risk is associated with discontinuation after regular use rather than acute administration.⁴ Drugs which lower the seizure threshold should be avoided during withdrawal.

History & Culture

Deschloroetizolam is a designer thienotriazolodiazepine that emerged as a novel psychoactive substance in 2014.⁶ The compound is structurally derived from etizolam, differing only by the removal of a chlorine atom from the parent molecule—hence the "deschloro" prefix…

Legality

By Country

CanadaNot scheduled

Thienodiazepines are not scheduled under Canadian controlled substances legislation. However, sale or provision for human consumption is prohibited as deschloroetizolam lacks approval as a medical drug.

RussiaSchedule III

Listed as a Schedule III controlled substance since 2017 under Russian drug control legislation.¹²

TurkeyIllegal

Classified as a controlled drug under Turkish law.¹⁴ Possession, production, supply, and import are all prohibited activities.

GermanyNpSG controlled

Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) since July 18, 2019.⁹¹⁰ Production and import with intent to market, administration to others, and trading constitute criminal offenses.¹¹ Possession is prohibited but not subject to criminal penalty.¹¹

SwitzerlandVerzeichnis E

Specifically named as a controlled substance under Verzeichnis E of Swiss narcotics scheduling.¹³

United KingdomPsychoactive Substances Act

Controlled under the Psychoactive Substances Act 2016, effective May 26, 2016.¹⁵ Production, supply, and import are criminal offenses.¹⁶¹⁷¹⁸ Personal possession is not criminalized under this legislation, though the substance remains in a legal grey area.

References

Source Pages

Citations

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Deschloroetizolam

Etizolam-2

Psychoactive Class

Depressant Anxiolytic GABAergic Muscle Relaxant

Chemical Class

Thienotriazolodiazepine