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Deschloroetizolam

Deschloroetizolam molecule structureDeschloroetizolam molecule structure
Deschloroetizolam
Etizolam-2

Deschloroetizolam is a thienotriazolodiazepine and the dechlorinated analog of etizolam.1 It first appeared through grey market research chemical vendors in 2014 and is not prescribed for any medical use. It produces depressant, anxiolytic, sedative, muscle relaxant, and amnesic effects through modulation of GABA receptors. Compared to its parent compound etizolam, it is roughly half as potent but exhibits approximately twice the duration of action.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~1 mg
Light1-4 mg
Moderate4-6 mg
Strong6-12 mg
Heavy12+ mg

Duration

Onset15-30 minutes
Come Up30-60 minutes
Peak3-4 hours
Offset3-4 hours
After Effects3-6 hours
Total8-10 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

The physical effects of deschloroetizolam can be broken down into several components which progressively intensify proportional to dosage.

Cognitive

The cognitive effects of deschloroetizolam can be broken down into several components which progressively intensify proportional to dosage. The general head space of deschloroetizolam is described by many as one of intense sedation and decreased inhibition. It contains a large number of typical depressant cognitive effects. Paradoxical reactions to benzodiazepines such as increased seizures (in epileptics), aggression, increased anxiety, violent behavior, loss of impulse control, irritability and suicidal behavior sometimes occur (although they are rare in the general population, with an incidence rate below 1%). These paradoxical effects occur with greater frequency in recreational abusers, individuals with mental disorders, children, and patients on high-dosage regimes.

Forked from Subjective Effect Documentation byJosie Kins August 2015.

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
No reaction
No reaction
Mecke(ME)
No reaction
No reaction
Mandelin(MD)
No reaction
No reaction
Liebermann(LB)
No reaction
No reaction
Powered by PROtestkit.eu

Pharmacology

Pharmacodynamics

Deschloroetizolam acts as a positive allosteric modulator at GABA-A receptors via the benzodiazepine binding site.citation needed By enhancing the efficiency of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) at these receptors, it produces its characteristic depressant and anxiolytic effects. It is the dechlorinated analog of etizolam and is reported to be approximately half as potent as that parent compound.2

Pharmacokinetics

Limited pharmacokinetic data is available for deschloroetizolam.3 It is reported to have a bioavailability similar to that of its parent compound etizolam.

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AlcoholGHB/GBLOpioidsTramadol

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

DXMKetamineMXE
Powered by TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Tolerance to sedative-hypnotic effects can appear after only several days of uninterrupted deschloroetizolam use.
Cross Tolerance

Benzodiazepines, Thienodiazepines

Baseline Reset
Tolerance typically returns to baseline within 7-14 days after cessation, though this may take significantly longer depending on the duration and intensity of long-term use.

Harm Potential

Addiction & Dependence

Psychological

High

Deschloroetizolam is described as extremely psychologically addictive. Compulsive redosing is commonly reported as a characteristic effect, and the drug is classified as habit-forming.

Physical

Extremely High

Deschloroetizolam produces severe physical dependence with regular use. Sudden discontinuation can be life-threatening, potentially resulting in seizures or death.citation needed Withdrawal symptoms may occur after a few weeks of steady dosing, and a gradual taper over weeks is strongly recommended rather than abrupt cessation.

Psychosis Risk

Paradoxical reactions including delusions may occur but are rare in the general population, with an incidence rate below 1%.citation needed These effects occur with greater frequency in recreational abusers, individuals with mental disorders, children, and patients on high-dosage regimes. Delusions may also occur as a symptom of overdose.

Seizure Risk

While deschloroetizolam itself has anticonvulsant properties, paradoxical increased seizures may rarely occur in epileptic individuals. The primary seizure risk is associated with discontinuation after regular use rather than acute administration.citation needed Drugs which lower the seizure threshold should be avoided during withdrawal.

History & Culture

Deschloroetizolam is a designer thienotriazolodiazepine that emerged as a novel psychoactive substance in 2014.citation needed The compound is structurally derived from etizolam, differing only by the removal of a chlorine atom from the parent molecule, hence the "deschloro" prefix in its

Legality

By Country

Illegal2
Canada flagCanadaIllegal (analog/blanket ban)
Turkey flagTurkeyIllegal
Controlled / restricted3
Germany flagGermanyNpSG controlled
Russia flagRussiaSchedule III
Switzerland flagSwitzerlandVerzeichnis E
Not scheduled1
United Kingdom flagUnited KingdomPsychoactive Substances Act

References

Source Pages

  1. Isomer Design (TiHKAL/PiHKAL)
  2. IsomerDesign: Explore the structures and analogues of Deschloroetizolam
  3. PsychonautWiki
  4. TripSit Factsheets
  5. TripSit: Deschloroetizolam Factsheet
  6. Wikipedia

Citations

  1. Brunetti P, Giorgetti R, Tagliabracci A, Huestis MA, & Busardò FP. (2021). Designer Benzodiazepines: A Review of Toxicology and Public Health Risks. Pharmaceuticals (Basel), 14(6), 560. https://doi.org/10.3390/ph140605601
  2. Orsolini L, Corkery JM, Chiappini S, Guirguis A, Vento A, De Berardis D, Papanti D, & Schifano F. (2020). 'New/Designer Benzodiazepines': An Analysis of the Literature and Psychonauts' Trip Reports. Current Neuropharmacology. https://doi.org/10.2174/1570159x186662001101213331
  3. Edinoff AN, Nix CA, Odisho AS, Babin CP, Derouen AG, Lutfallah SC, Cornett EM, Murnane KS, Kaye AM, & Kaye AD. (2022). Novel Designer Benzodiazepines: Comprehensive Review of Evolving Clinical and Adverse Effects. Neurology International, 14(3), 648–663. https://doi.org/10.3390/neurolint140300531
  4. NIH PubChem CID 827322 identity properties. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/827322/property/IUPACName,MolecularFormula,MolecularWeight,IsomericSMILES/JSON1
  5. NIH PubChem CID 827322 synonyms. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/827322/synonyms/JSON1
  6. Controlled Drugs and Substances Act, section 2 definitions. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-2.html1
  7. Controlled Drugs and Substances Act, current Schedule IV. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-sched95660.html1
  8. Health Canada, Status determination of benzodiazepines. canada.ca (n.d.). https://www.canada.ca/en/health-canada/corporate/mandate/regulatory-role/what-health-canada-regulates-1/controlled-substances-precursors/overview-substance-control-status-determination-process/benzodiazepines.html1
  9. Health Canada controlled-substance status determination process. canada.ca (n.d.). https://www.canada.ca/en/health-canada/corporate/mandate/regulatory-role/what-health-canada-regulates-1/controlled-substances-precursors/overview-substance-control-status-determination-process.html1
  10. Benzodiazepines and Other Targeted Substances Regulations index. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/regulations/SOR-2000-217/index.html1

Further Reading

  1. Characterization of designer benzodiazepines - Huppertz et al. 2015
  2. NDEWS: Alert - Deschloroetizolam
  3. New Designer Benzodiazepines - PMC
  4. PubMed: Designer benzodiazepines' pharmacological effects

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Lyrea avatar
    Step 2 · First-pass review

    A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes8 human edits · latest

Times are UTCNewest first

19 August 2026

  1. Lyrea · Reworded 2 words in History & CultureContent

  2. Lyrea · Changed a word in Dosage & DurationRoutes 1 › Dose ranges › Light

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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