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5-MAPB

5-MAPB molecule structure5-MAPB molecule structure
5-(2-methylaminopropyl)benzofuran
Psychoactive Class

5-MAPB is a synthetic entactogen of the substituted benzofuran and amphetamine classes.citation needed It is the N-methylated form of 5-APB, structurally analogous to how MDMA relates to MDA. First encountered as a designer drug around 2010, it produces euphoric, entactogenic, stimulating, and mildly hallucinogenic effects. It has been described as one of the closest known analogues to MDMA in terms of subjective quality and has been patented for potential therapeutic use.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~20 mg
Light20-50 mg
Moderate50-70 mg
Strong70-100 mg
Heavy100+ mg

Dosage figures are tentative. 5-MAPB is commonly found as the succinate and hydrochloride salts; the hydrochloride salt is approximately 36% more potent by mass, so doses should be adjusted accordingly. This dosage table is for 5-MAPB HCl.

Duration

Onset20-60 minutes
Come Up45-90 minutes
Peak2-4 hours
Offset1.5-3 hours
After Effects6-48 hours
Total5-8 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

5-MAPB produces a classically entactogenic experience frequently compared to MDMA, and has been described as the closest known analogue to MDMA in both its effects and its characteristic 'magic.' The experience centers on pronounced euphoria, emotional openness, and a strong desire to communicate and connect, accompanied by heightened appreciation of music and touch. Notably, it is less physically stimulating than MDMA and most other euphoric stimulants at equivalent levels of empathogenesis, with some users pairing it with mild stimulants to compensate for its comparatively subdued energy. Common doses are reported as roughly comparable to a standard ecstasy pill at 30 mg and a strong one at 50 mg.

Physical

The body load is comparatively gentle, with pleasant waves of tactile sensation and only mild stimulation. Less pleasant physical effects include sweating, jaw tension and bruxism, cold extremities, tremors, nausea when taken orally, and insomnia when redosing.

Pupil dilation

Cardiovascular

Stimulation

5-MAPB is only mildly stimulating, providing wakefulness and alertness without the pronounced physical energy of MDMA or amphetamine-type stimulants.

Uncomfortable

Cognitive

The headspace is warm, open, and sociable, marked by empathy, a party-ready positive attitude, and increased associative and creative thinking. Negative cognitive effects can include anxiety, confusion, moodiness, and a notable urge to redose more times than intended.

Confusion

Emotional

The emotional core of the experience is euphoric, empathetic, and open, though anxiety and moodiness can occur.

Anxiety

Enhancements

Visual

Visual effects are subtle and enhancement-oriented; users describe colors as slightly brighter or sharper alongside minor visual shifts, with true hallucinations being uncommon.

Enhancements

Auditory

Auditory enhancement is prominent, with a markedly increased appreciation of music that users describe as enrapturing.

Tactile

Touch is strongly enhanced, with pleasant waves of sensation flowing through the body and heightened sensual and erotic appreciation.

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → purple3 → black3
Mecke(ME)
white → black3
Mandelin(MD)
yellow2 → black3
Liebermann(LB)
white → black3
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Pharmacology

Pharmacodynamics

5-MAPB acts primarily as a serotonin-norepinephrine-dopamine releasing agent, with EC50 values of 24 nM for norepinephrine, 41 nM for dopamine, and 64 nM for serotonin in rat brain synaptosomes.citation needed It has also been characterized as a triple monoamine reuptake inhibitor.1 Beyond its transporter-mediated activity, 5-MAPB is a partial agonist at the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors, and a potent agonist at the 5-HT1B receptor.

Pharmacokinetics

Limited formal pharmacokinetic data is available for 5-MAPB. In rats, the major metabolites have been identified as 5-APB and 3-carboxymethyl-4-hydroxymethamphetamine.2 Unlike MDMA, 5-MAPB does not form the α-methyldopamine metabolite which is thought to cause neurotoxicity.

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

5-HTPAlcoholDXMDissociativesMAOIsMDMAMXENBOMe compoundsSNRIsSSRIsSerotonin releasersStimulantsTramadol
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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Repeated 5-MAPB use over time can produce tolerance to many effects, so users may need larger doses to obtain similar effects.
Baseline Reset
1-2 weeks
Half Tolerance
3-7 days
Cross Tolerance

Dopaminergic stimulants

Harm Potential

Addiction & Dependence

Psychological

Moderate

Chronic use may be moderately habit-forming, with high abuse potential and a risk of psychological dependence. Cravings and repeated redosing can occur, although 5-MAPB's less stimulating profile compared with MDMA appears to make compulsive redosing somewhat less pronounced than with related drugs.

Physical

Low

Withdrawal effects may occur if a person suddenly stops usage after addiction has developed, though specific physical dependence symptoms are not well characterized due to limited research history.

Toxicity

Cardiovascular

Long-term use may be cardiotoxic due to 5-HT2B receptor agonism, which has been associated with valvular heart disease;citation needed this risk is theoretical based on the mechanism shared with other 5-HT2B agonists rather than documented cases specific to 5-MAPB.

Central Nervous System

Rodent studies indicate dose-dependent serotonergic neurotoxicity similar to MDMA, and the compound may also be a dopaminergic neurotoxin; relevance to occasional human use at typical doses remains unclear.

Psychosis Risk

As with other amphetamine-class compounds, abuse at high dosages for prolonged periods can potentially result in stimulant psychosis presenting with paranoia, hallucinations, or delusions. Approximately 5-15% of those experiencing amphetamine-induced psychosis may not fully recover, though psychosis very rarely arises from typical use patterns.

History & Culture

5-MAPB emerged on the designer drug market around 2010 as part of the wave of novel benzofuran entactogens developed as alternatives to controlled substances like MDMA.citation needed The compound was first formally identified and documented by researchers in 2013, with the initial scientific

Legality

By Country

Illegal9
Canada flagCanadaPotentially illegal (analogue)
China flagChinaIllegal
France flagFranceNarcotic
Germany flagGermanyIllegal (analog/blanket ban)
Japan flagJapanIllegal
Netherlands flagNetherlandsIllegal (analog/blanket ban)
Poland flagPolandIllegal
Singapore flagSingaporeIllegal
United Kingdom flagUnited KingdomIllegal
Controlled / restricted3
Finland flagFinlandRestricted
Sweden flagSwedenRestricted
Switzerland flagSwitzerlandRestricted
Not scheduled2
United States flagUnited StatesUnscheduled (Analogue Act may apply)
Luxembourg flagLuxembourgNot scheduled

References

Source Pages

  1. Bluelight: The Main 5-MAPB Thread
  2. Erowid
  3. Erowid: Experience Vaults - 5-MAPB
  4. Isomer Design (TiHKAL/PiHKAL)
  5. PsychonautWiki
  6. TripSit Factsheets
  7. Wikipedia

Citations

  1. Hans Emanuel Oeri. (May 2021). Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy. Journal of Psychopharmacology, 35(5), 512–536. https://doi.org/10.1177/02698811209204201
  2. Jessica Welter, Pierce Kavanagh, Markus R. Meyer, & Hans H. Maurer. (February 2015). Benzofuran analogues of amphetamine and methamphetamine: studies on the metabolism and toxicological analysis of 5-APB and 5-MAPB in urine and plasma using GC-MS and LC-(HR)-MS(n) techniques. Analytical and Bioanalytical Chemistry, 407(5), 1371–1388. https://doi.org/10.1007/s00216-014-8360-01
  3. Controlled Drugs and Substances Act — Schedule I. Government of Canada (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-9.html1
  4. 公安部: 非药用类麻醉药品和精神药品列管办法. gaj.panjin.gov.cn (n.d.). https://gaj.panjin.gov.cn/2015_10/08_00/content-235605.html1
  5. PubChem compound record: 5-MAPB, CID 102336592. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/compound/5-MAPB1
  6. PubChem PUG-REST identity properties for CID 102336592. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/102336592/property/IUPACName,MolecularFormula,MolecularWeight,CanonicalSMILES/JSON1
  7. Finlex current consolidated annex to Government Decree 1130/2014. opendata.finlex.fi (n.d.). https://opendata.finlex.fi/finlex/avoindata/v1/akn/fi/act/statute-consolidated/2014/1130/fin%40latest/media/8500.pdf1
  8. Finlex current consolidated Government Decree 1130/2014. opendata.finlex.fi (n.d.). https://opendata.finlex.fi/finlex/avoindata/v1/akn/fi/act/statute-consolidated/2014/1130/fin%40latest1
  9. Finlex Act 932/2023 amending the 1130/2014 annex. opendata.finlex.fi (n.d.). https://opendata.finlex.fi/finlex/avoindata/v1/akn/fi/act/statute/2023/932/fin%401
  10. Finlex current consolidated Narcotics Act 373/2008, sections 3(1)(5)(e) and 3(3). opendata.finlex.fi (n.d.). https://opendata.finlex.fi/finlex/avoindata/v1/akn/fi/act/statute-consolidated/2008/373/fin%40latest1

Further Reading

  1. Fuwa et al. (2016) - Benzofurans Increase Extracellular Serotonin

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