Tactile suppression is a decrease in one's ability to feel their sense of touch in a manner which can result in a general numbness across the body. At higher levels, this can eventually increase to the point where physical sensations have been completely blocked and the body is fully anaesthetized. Tactile suppression is often accompanied by other coinciding effects such as pain relief and physical euphoria. It is most commonly induced under the influence of moderate dosages of dissociative compounds, such as ketamine, PCP, and DXM. However, it can also occur under the influence of opioids and certain GABAergic depressants.