TMA-2

2,4,5-Trimethoxyamphetamine

DOMeO, 2,5-Dimethoxy-4-methoxyamphetamine

Psychoactive Class

Chemical Class

Amphetamine (psychedelic)Phenethylamine (substituted)

TMA-2 is a synthetic psychedelic of the substituted amphetamine class and a member of the trimethoxyamphetamine family. First synthesized by Viktor Bruckner in 1933, its psychoactive properties were identified by Alexander Shulgin in 1962.¹ Structurally related to mescaline but considerably more potent,¹ it produces a distinctive combination of hallucinogenic, stimulant, and entactogenic effects. TMA-2 remains an obscure research chemical that is rarely encountered outside of online vendor markets.

Dosage & Duration

Dosage

Threshold~5 mg

Light5-20 mg

Moderate20-40 mg

Strong40-60 mg

Heavy60+ mg

TMA-2 exhibits considerable unpredictability in its effects and demonstrates pronounced dose sensitivity. The margin between doses that produce psychoactive effects and those that may cause toxicity is reported to be narrow. User accounts describe variable responses that commonly include significant body load, nausea, and overstimulation.

Duration

Onset20-120 minutes

Peak4-6 hours

Offset2-4 hours

After Effects4-24 hours

Total8-12 hours

Subjective Effects

TMA-2 produces a mescaline-like psychedelic state layered over mild stimulation, with a notably slow onset — effects may take an hour or more to appear before building to full intensity over the following hour. The character of the experience is frequently described as calm, benign, and peaceful, with an absence of dark or threatening undercurrents, and a somewhat hypnotic quality that can leave users unusually receptive to suggestion. The total duration runs roughly ten to twelve hours, with a fairly rapid drop-off in the later hours at some doses.

Physical

Mental and physical stimulation accompany the experience, alongside come-up discomforts such as nausea, light tremors, and brief intestinal cramping. Pupil dilation, appetite suppression, muscle tension, sweating and chills, and difficulty sleeping toward the end of the experience are also reported.

Autonomic

Appetite suppression

Uncomfortable

Muscle tension

Cognitive

The headspace is calm and lucid, with clear thinking, euphoria, enhanced empathy, insight, and a gently cosmic or ego-softening quality. Time can seem to pass very slowly in the first hours, and mild, non-troublesome confusion is sometimes reported.

Emotional

Empathy enhancement

Enhancements

Visual

Visuals are moderate and well-mannered rather than overwhelming, closely resembling mescaline apart from less intense color enhancement.

Auditory

Tactile

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)

Mecke(ME)

Mandelin(MD)

Liebermann(LB)

PROtestkit.eu

Pharmacology

Pharmacodynamics

TMA-2 acts as a partial agonist at serotonin 5-HT2A receptors, which is believed to be the primary mechanism underlying its psychedelic effects.² It also shows broader activity at the 5-HT2 receptor family.²

Pharmacokinetics

In rat studies, the 4-methoxyl group undergoes preferential O-demethylation, with approximately 20% of that methoxyl carbon appearing as expired carbon dioxide. This rate is roughly four times that observed for either of the other two methoxyl groups, indicating the 4-position is the primary site of oxidative demethylation.³

Metabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check

TripSit

Tolerance

Full Tolerance

Tolerance to the effects of TMA-2 develops almost immediately after ingestion.

Baseline Reset

Approximately 7 days in the absence of further consumption

Half Tolerance

Approximately 3 days

Cross Tolerance

Psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

TMA-2 is considered to have extremely low addiction potential due to its psychedelic nature. It is not habit-forming and the desire to use it can actually decrease with repeated use, making it largely self-regulating.

Toxicity

Cardiovascular

High doses in rats caused bradycardia and hypothermia;¹ in humans, vasoconstriction and increased blood pressure have been reported at higher doses, though human data remains extremely limited.

Psychosis Risk

Mental health risks are assumed to be similar to those associated with other hallucinogens. Psychedelic-crisis management is appropriate for acute anxiety and panic reactions. More severe psychotic reactions may occur, especially when someone's family history includes schizophrenia or early-onset mental illness, since psychedelics have been known to trigger latent psychological conditions.

Seizure Risk

Toxicity studies in rats showed that doses of 80 mg/kg induced frequent clonic convulsions.¹ Given the reported narrow margin between active and toxic doses,¹ seizure risk may be elevated at higher dosages. Individuals with seizure or convulsive disorders are advised to exercise particular caution.

History & Culture

TMA-2 was first synthesized by Hungarian chemist Viktor Bruckner in 1933⁴, but its psychoactive properties remained unrecognized for nearly three decades. Alexander Shulgin independently synthesized the compound in…

Legality

International

The current official Green List is exhaustive for substances under the 1971 Convention. It lists TMA as (±)-3,4,5-trimethoxy-alpha-methylphenethylamine in Schedule I, but does not list TMA-2 / 2,4,5-trimethoxyamphetamine.

By Country

United StatesIllegalSchedule I

21 CFR § 1308.11(d); Controlled Substances Act⁴³⁴⁴⁴⁵

Controlled as a positional isomer of TMA, which is explicitly listed as a Schedule I hallucinogen under the Controlled Substances Act.⁴⁶ Manufacturing, possession, and distribution are prohibited.

AustraliaIllegalControlled drug

Criminal Code Regulations 2019⁹

Australia expressly lists TMA-2 by its chemical name, 2,4,5-trimethoxyamphetamine, as a controlled drug under the Criminal Code Regulations 2019. Schedule 1 assigns commercial, marketable, and trafficable quantities of 0.75 kilograms, 250 grams, and 0.75 grams respectively.

BelgiumIllegal (analog/blanket ban)amphetamine derivative

Royal Decree of 6 September 2017 regulating narcotic and psychotropic substances, Annex IVa¹⁰¹¹

Added to the list of illegal psychotropic substances on November 8, 2004.¹

ChileIllegal (analog/blanket ban)Isomer covered

Decreto Supremo N.º 867 de 2007, Reglamento de la Ley N.º 20.000, artículo 1¹³

Chile's current consolidated Decreto 867 lists dl-3,4,5-trimetoxi-alfa-metilfeniletilamina (TMA) among the article 1 drugs deemed capable of causing serious toxic effects or considerable harm to health. The same article expressly extends its list to the isomers, esters, and ethers of listed substances unless excepted; TMA-2 (2,4,5-trimethoxyamphetamine) is a positional isomer of the listed 3,4,5-TMA and is therefore covered by that isomer clause rather than named as TMA-2.

FinlandIllegalNarcotic

Valtioneuvoston asetus huumausaineina pidettävistä aineista, valmisteista ja kasveista (543/2008), Annex III as replaced by 244/2024, current with later amendments through 1119/2025¹⁶¹⁷¹⁸

Classified as a controlled substance under Finnish drug legislation.¹

GreeceIllegalTable A

Article 1 substance tables of Law 3459/2006, as in force under Law 4139/2013²⁰

Became a controlled substance on February 18, 2003.¹

ItalyTabella ICitation needed

Added to Tabella I (list of prohibited plants and substances) by Ministry of Health decree on January 11, 2005.¹

NetherlandsIllegalList I

Opiumwet (Opium Act), List I²⁷

TMA-2 is expressly listed in List I of the Dutch Opium Act under the name 2,4,5-trimethoxyamfetamine. Article 2 prohibits importing, exporting, preparing, processing, selling, supplying, transporting, possessing, and manufacturing List I substances, subject to statutory exemptions and licences.

PortugalIllegalTable II-A

Decreto-Lei n.º 15/93, de 22 de janeiro, Tabela II-A, as amended by Lei n.º 14/2005²⁹³⁰

Control measures enacted in January 2005 alongside 2C-I, 2C-T-2, and 2C-T-7.¹

SlovakiaIllegalPsychotropic Group I

Act No. 139/1998 Coll. on Narcotic Drugs, Psychotropic Substances and Preparations, Annex 1³⁴

The official consolidated text effective 1 January 2026 expressly lists TMA-2 (2,4,5-trimethoxyamphetamine) among Group I psychotropic substances in Annex 1. Group I substances are not used as active ingredients in medicines; handling is limited to licensed research, teaching, and expert activities, and handling outside the Act is unlawful. The list also covers salts and stereoisomers of Group I substances where they can exist. The former “Grade 2” description is therefore incorrect.

SpainIllegalList I

Orden SCO/2359/2004, de 2 de julio³⁷

Use, manufacture, import, transit, trade and possession are prohibited; scientific research requires prior authorization.

SwitzerlandControlled (Verzeichnis D)

Specifically named as a controlled substance under Verzeichnis D of Swiss controlled substances legislation.⁴⁰

United KingdomIllegal (analog/blanket ban)Class A

Misuse of Drugs Act 1971, Schedule 2, Part I, paragraph 1(c)⁴²

Controlled as a Class A drug under the Misuse of Drugs Act 1971.⁴² Covered by the generic phenethylamine definition as a positional isomer of the UN-controlled drug TMA. Class A classification carries the most severe penalties.

ArgentinaIllegal (analog/blanket ban)Estupefaciente

Decreto 560/2019, artículo 2 y Anexo II⁷⁸

Argentina treats substances within the chemical groups in Annex II of Decree 560/2019 as estupefacientes. Annex II's substituted-phenethylamines definition permits an alpha alkyl substituent and one or more ring alkoxy substituents, encompassing TMA-2's alpha-methyl and 2,4,5-trimethoxy substitution pattern; it also expressly covers enantiomers, diastereomers, and their salts.

AustriaIllegal (SMG)

Prohibited under the Suchtmittelgesetz (Narcotics Act). Possession, production, and sale are illegal.¹

CanadaIllegalSchedule I

Controlled Drugs and Substances Act, Schedule I, item 19(7)¹²

TMA-2 is expressly listed as 2,4,5-trimethoxyamphetamine under the amphetamines entry in Schedule I of Canada's Controlled Drugs and Substances Act. Unauthorized possession, trafficking, import/export, and production are prohibited; activities may occur only as authorized by the Act, regulations, or an exemption.

DenmarkIllegalList B

Bekendtgørelse om euforiserende stoffer nr. 405 af 26. marts 2026, bilag 1, liste B¹⁴¹⁵

TMA-2 is expressly listed as B440 under List B of Denmark's controlled euphoriant substances, under the names 2,4,5-trimethoxyamphetamine and 1-(2,4,5-trimethoxyphenyl)propan-2-amine. List B substances may be used only for medical and scientific purposes.

GermanyIllegalnicht verkehrsfähiges Betäubungsmittel

Betäubungsmittelgesetz (BtMG), Anlage I¹⁹

Controlled under Anlage I of the Betäubungsmittelgesetz (Narcotics Act) since October 10, 1999.¹⁹ Manufacturing, possession, import, export, purchase, sale, procurement, and dispensing without a license are illegal.

IrelandIllegal (analog/blanket ban)Controlled drug

Misuse of Drugs Act 1977, Schedule 1A(l); Misuse of Drugs Act 1977 (Controlled Drugs) (Designation) Order 2022 (S.I. No. 211/2022)^21222324

Ireland applies Misuse of Drugs Act controls to TMA-2 through its status as a positional isomer of UN-listed TMA, comparable to UK scheduling.¹

JapanIllegalNarcotic

麻薬、麻薬原料植物、向精神薬、麻薬向精神薬原料等を指定する政令（平成二年政令第二百三十八号）²⁵²⁶

Japan's current designation order lists 2,4,5-trimethoxy-α-methylphenethylamine, the substance commonly known as TMA-2, as a narcotic under Article 1. The listing expressly includes its salts. A Ministry of Health, Labour and Welfare implementation notice identifies the same chemical name with the street name TMA-2 and states that the designation took effect on 13 October 2006.

PolandIllegalGroup I-P

Rozporządzenie Ministra Zdrowia z dnia 17 sierpnia 2018 r. w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych (consolidated text, Dz.U. 2024 poz. 1139)²⁸

Poland lists TMA-2 by name as 2,4,5-trimethoxyamphetamine ("2,4,5-trimetoksyamfetamina") in Annex 1 among Group I-P psychotropic substances. The same Group I-P provision also covers salts where possible and stereoisomers permitted by the listed chemical designation.

SingaporeIllegalClass A controlled drug

Misuse of Drugs Act 1973; Misuse of Drugs Regulations³¹³²³³

TMA-2 is expressly named as 2,4,5-trimethoxy-α-methylphenethylamine in Singapore's controlled-drug legislation, together with its trimethoxy positional isomers in the phenyl ring. The current Misuse of Drugs Regulations place it in the Fourth Schedule of controlled drugs subject to specified licensing, documentation, record-keeping and related requirements; the Misuse of Drugs Act prohibits unauthorised possession, trafficking, manufacture, import, export and consumption of controlled drugs.

South AfricaIllegal (analog/blanket ban)undesirable substance homologue

Drugs and Drug Trafficking Act 140 of 1992, Schedule 2 Part III, as substituted by Drugs and Drug Trafficking Amendment Act 14 of 2022³⁵³⁶

TMA-2 is not individually named in Schedule 2 Part III, but 2,5-dimethoxyamphetamine (DMA) is expressly listed. Part III extends every listed substance to all chemically related homologues incorporating a similar structural fragment or exhibiting similar pharmacodynamic properties, which covers TMA-2 as the 4-methoxy homologue of DMA. The Act prohibits use, possession, and dealing in undesirable dependence-producing substances except under its stated lawful exceptions.

SwedenIllegalNarcotic

Förordning (1992:1554) om kontroll av narkotika³⁸³⁹

Placed into Class I (most restrictive category) as of March 16, 2004.¹

TurkeyIllegal

Classified as a controlled drug under Turkish law. Possession, production, supply, and import are prohibited.⁴¹

References

Source Pages

Citations

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