Methoxetamine

Federally scheduled on July 6, 2022 under the Controlled Substances Act.⁶⁹ Prior to federal scheduling, multiple states enacted their own controls including Alabama (2015), Arizona (2014), Florida (2012), Indiana (2012), Louisiana (2013), Minnesota (2012), North Dakota (2012), Ohio (2012), Virginia (2012), and Utah.

Prohibited under the Suchtmittelgesetz since June 26, 2019.⁴ Possession, production, and sale are criminal offenses.

Listed as a controlled substance on February 18, 2014 alongside several other novel psychoactive substances. Possession, production, and sale are illegal.

The CDSA provides the relevant Schedule I analogue heading, defines analogue by substantially similar chemical structure, and prohibits possession when a substance is included in Schedule I. However, MXE is not named in the current Schedule I text, and official Health Canada materials direct parties to a substance-specific status-confirmation process for unlisted substances. MXE's analogue exposure is therefore conditional and its status unresolved; it has no definitive Schedule I classification or blanket prohibition.

Chile’s current consolidated text of Decreto Supremo No. 867 lists 2-(3-metoxifenil)-2-(etilamino)ciclohexanona (Metoxetamina) in Article 1. Article 1 classifies its listed substances as narcotic or psychotropic drugs capable of producing physical or psychological dependence and serious toxic effects or considerable harm to health, for the purposes of Article 1(1) of Law No. 20.000.

Methoxetamine is currently listed by exact chemical name, English name, CAS number and MXE abbreviation as item 93 in China's non-medical narcotic and psychotropic directory on the Shenzhen Public Security Bureau catalogue page updated for 1 July 2026. It is not a Category I medicinal psychotropic substance: Article 3 reserves the Category I/II distinction for medicinal psychotropics and provides a separate non-medical directory. The ordinary Article 4 rule prohibits production, operation, use, storage and transport of listed non-medical substances, while regulated experimental research remains possible only through the Article 10 conditions and approval.

Methoxetamine (metoksetamin; MXE) is expressly listed in Odjeljak 1 of Croatia's official list of drugs, psychotropic substances, and plants from which drugs may be obtained. The listing identifies methoxetamine by its chemical name, 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone, and places it under Croatia's controlled-drugs regime.

Listed in the national drug control law since 2012. Possession, production, and distribution are prohibited.

The current official consolidated text of Government Regulation No. 463/2013 Sb. lists Methoxetamin (MXE), with the chemical name 2-(ethylamino)-2-(3-methoxyfenyl)cyklohexanon, in Annex No. 4, the list of psychotropic substances. The regulation classifies Annex No. 4 as a list of psychotropic substances and states that it includes additional psychotropic substances whose handling is permitted only for limited research, scientific, and very limited therapeutic purposes specified in a handling authorization. The listing applies directly to methoxetamine rather than only to an analogue or a specified product.

Covered by the Executive Order on Euphoriant Substances, making possession, production, and distribution illegal.

Metoksetamiini is included in Finland’s official narcotics schedule.

Methoxetamine is classified as a stupéfiant in Annex IV of France's national list of narcotic substances. The classification places methoxetamine under France's narcotics-control regime.

Controlled under the Betäubungsmittelgesetz since July 2013.²³ Manufacturing, importing, possessing, selling, or transferring without license is prohibited.

Methoxetamine (MXE) is expressly listed at serial no. 110N in the Schedule of psychotropic substances to India's Narcotic Drugs and Psychotropic Substances Act, 1985. The Central Bureau of Narcotics' official Schedule compilation records the listing's insertion by S.O. 821(E) of 27 February 2018. This is a direct listing of methoxetamine and MXE, rather than control based only on an analogue or product category.

Methoxetamine (Metoksetamina; MXE) is expressly listed as item 102 in Indonesia’s Group I narcotics schedule. Group I narcotics may be used only for scientific development, not therapy, and have a very high dependence potential.

Methoxetamine is designated as a controlled drug in Ireland’s Misuse of Drugs regime.

Listed in the table of controlled drugs since 2016. Possession, production, and distribution are prohibited.

Classified as a narcotic drug effective June 26, 2016. Earlier controls from July 2012 restricted importation, production, and distribution while possession for personal use remained in a legal grey area.

Added to List I of the Opium Law in July 2015. Possession, production, transport, import, export, and sale are prohibited.

Metoksetamin is included in Norway’s narcotics list and marked prohibited under section 5.

Methoxetamine (MXE) is listed in the Philippines’ official controlled-substances schedule.

The current official regulator text places methoxetamine expressly in List I, not List II. Unauthorized possession is prohibited under Article 228, the no-sale offense, which uses the Government's substance-specific thresholds; Article 228.1 separately covers production, sale and dispatch. Under the current quantity table, the column labels are grams over 0.2 g, 1 g and 500 g. The exact methoxetamine entry includes a qualifying derivative class; Article 1's analogue definition is a separate framework and does not automatically treat every related compound as an analogue. Roszdravnadzor officially posted Resolution No. 681 on 30 March 2026; the resolution was revised 11 June 2025, with amendments effective 27 July 2025. The table in Resolution No. 1002 is dated 11 June 2025, and the Criminal Code consolidation is marked 4 August 2026. Under Articles 228 and 228.1, exact charging depends on the facts, amount, intent and date.

Methoxetamine is expressly listed as a controlled drug in paragraph 1(17)(28) of the Fourth Schedule to Singapore's Misuse of Drugs Regulations. The Fourth Schedule subjects controlled drugs to the requirements in regulations 10, 11, 12, 13, 14, 15 and 28.

Listed as a controlled substance per Official Gazette of the Republic of Slovenia No. 62/2013.

Metoxetamina is included in List II of Spain’s controlled-substances schedule and is subject to the applicable control measures and criminal sanctions.

Controlled under the Narcotic Drugs Control Act (SFS 1992-860) and the Narcotic Drugs Control Ordinance (SFS 1994:1554).

The current annex identifies methoxetamine in the d schedule; the regulation's Article 1 defines substances in its annexes as controlled substances.

Methoxetamine (MXE) is listed as a Category 1 narcotic in Thailand.

Turkey's official Narkotik 2013 national report identifies methoxetamine as prohibited. Turkey's official Narkotik 2013 national report reproduces the 2013/4827 Annex 1 entry that expressly names Metoxetamine and its chemical identity as one of the substances subjected to Law No. 2313. The listing is explicit and does not rely on analogue status. The official 2025 Türkiye Uyuşturucu Raporu identifies TCK Articles 188, 190 and 191 together with Law No. 2313 as the principal framework, describes the TUBIM Early Warning System route for placing NPS under Law No. 2313, says generic classification began in 2015, and reports 1,078 NPS included through 31 July 2025. Under the current Ministry of Justice TCK publication, unlicensed manufacture, import or export is punishable under Article 188(1) by 20–30 years' imprisonment and 2,000–20,000 days' judicial fine; domestic sale, offer, giving, dispatch, transport, storage, purchase, acceptance or possession is covered by Article 188(3) with at least 10 years' imprisonment and 1,000–20,000 days' judicial fine. Article 191 separately covers purchase, acceptance, possession for use or use with 2–5 years' imprisonment, subject to the statutory five-year public-prosecution postponement and supervision/treatment/testing regime. Article 188(4)(a)'s half-increase categories include synthetic cannabinoids, synthetic cathinones, synthetic opioids and amphetamines and their derivatives; MXE is not classified into any of those categories, so the half-increase does not apply on that basis. The prohibition concerns unlicensed or recreational conduct; statutory authorization and conduct-specific charging qualifications remain relevant.

Ukraine's current official schedule lists Метоксетамін (MXE, 3-Meo-2-Oxo-PCE) in Table I, List 2. That list is for especially dangerous psychotropic substances whose circulation is prohibited. Resolution No. 600 of 10 July 2019 standardized the substance's name and synonym in the schedule.

Permanently classified in February 2013 following a Temporary Class Drug Order issued in April 2012.⁶⁴⁶⁵ The Advisory Council on the Misuse of Drugs recommended scheduling after reviewing emerging evidence of harm.⁶⁶

Metoxetamina (MXE) is listed in Colombia’s Green List II of psychotropic substances.

Metoxetamina is named in Mexico’s official health-secretariat import and export control list.

Methoxetamine is expressly listed in Table II-A of Portugal’s controlled-substances schedules through Lei n.º 7/2017. For scheduled substances, personal consumption, acquisition, and possession for personal use are administrative offences under Lei n.º 30/2000; the controlled-substances regime otherwise remains applicable.