white → brown2 → black3
DiPT
N,N-Diisopropyltryptamine
DiPT is a psychedelic substance of the tryptamine class and a structural analog of DMT.1 First described in the scientific literature in 1959, its psychoactive properties in humans were characterized by Alexander Shulgin in the mid-1970s and detailed in his 1997 book TiHKAL. DiPT is distinctive among psychedelics for producing primarily auditory rather than visual effects, including perceived shifts in pitch and harmonic distortion. Individual sensitivity varies considerably, and it has been sold as a research chemical.
Dosage & Duration
Dosage
Threshold~15 mg
Light15-25 mg
Moderate25-50 mg
Strong50-150 mg
Heavy150+ mg
Intensity of effects at a given dose varies widely between individuals; some users report overpowering effects at 50 mg while others report only mild effects at 100 mg. Start low to gauge individual sensitivity.
Subjective Effects
In a preliminary study of nine adult volunteers, orally administered DiPT produced a predominantly auditory syndrome. At active doses, participants commonly reported lethargy, a desire to lie down, emotional distance, little or no euphoria, and distortion of pitch and timbre. The study reported no visual-field distortion and no eyes-closed imagery.[cite:pmid-6949674]
Physical
At active oral doses in the preliminary study, lethargy and a desire to lie down were characteristic. Across the preliminary trials, two participants reported mild nausea, three reported muscular hyperreflexia, and slight pupil dilation occurred in most participants.[cite:pmid-6949674] Separate archival self-reports described ear pressure at 18 mg oral, poor handwriting at 25 mg oral, mild diarrhea five to ten hours after 100 mg oral, and tongue numbness after 8 mg smoked.[cite:url-erowid-org-tihkal04-shtml]
Uncomfortable
Cognitive
Participants in the preliminary study described distance from their surroundings or their own feelings, with little or no euphoria, and the experience was characterized as neutral rather than clearly pleasant or unpleasant.[cite:pmid-6949674] A later archival self-report at 250 mg oral described marked foreboding and an ominous, unreal quality; this high-dose report should not be generalized to usual doses.[cite:url-erowid-org-tihkal04-shtml]
Auditory
Auditory disturbance was the consistent finding of the preliminary study and, at the doses studied, essentially the entire sensory signature.[cite:pmid-6949674]
Tactile
Pharmacology
Pharmacodynamics
DiPT acts primarily as a full agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors, with 5-HT2A activation appearing to principally mediate its psychedelic effects in animal models. It also shows weak activity at the 5-HT1A receptor and functions as a weak serotonin reuptake inhibitor. Additional binding affinities have been reported at dopamine receptors, adrenergic receptors, and the dopamine and norepinephrine transporters, though the contribution of these interactions to its overall effects remains unclear. The mechanisms underlying DiPT's characteristic selective alterations of auditory perception are unknown.
Pharmacokinetics
DiPT has not received a formal human pharmacokinetic characterization. A preliminary study in nine volunteers reported oral effects beginning after 20–30 minutes and peaking after about 1.5–2 hours, but it did not measure blood or urine concentrations, bioavailability, clearance, or elimination half-life.1 The authors of that study proposed that the bulky N-isopropyl groups might resist N-dealkylation or oxidative deamination, but explicitly framed this as a hypothesis requiring kinetic and metabolic studies.1 A 2022 Drug Enforcement Administration review likewise stated that metabolism studies had not been conducted for DiPT.8
Interactions
Interactions not written up yet
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Full Tolerance
Tolerance to the effects of DiPT develops almost immediately following ingestion.
Baseline Reset
Approximately 7 days without further consumption
Half Tolerance
Approximately 3 days
Cross Tolerance
Serotonergic psychedelics
Harm Potential
Addiction & Dependence
Psychological
Extremely LowDiPT is not habit-forming and the desire to use it can actually decrease with use. It is described as most often self-regulating.
Physical
No information exists regarding physical dependence or withdrawal symptoms. Unusually among psychedelics, DiPT did not show evidence of behavioral tolerance in rodent studies.9
Toxicity
Auditory System
DiPT is known to chronically alter the perception of sound and speech in some users, which may persist beyond the acute effects; ear pressure ranging from mild to painful has been reported, particularly when combined with MDMA.
Psychosis Risk
At typical doses, DiPT is described as producing lucid and clear-headed cognitive effects compared to other tryptamines. At very high doses (250mg), one report described delusional spiritual experiences including feeling spoken to by spirits and perceiving an 'anti-universe.'11 Confusion has been noted at higher doses.
Seizure Risk
DiPT produces convulsions at high doses in rodent studies.7 No human seizure cases are documented in the available literature.
History & Culture
Discovery and Development
DiPT was first characterized in the scientific literature by R.B. Barlow and colleagues in 1959.12 Alexander Shulgin began investigating the compound's effects in humans during the mid-1970s, with his initial findings dating to 1974 and basic properties…
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Legality
By Country
United StatesNot scheduled
Federally unscheduled,43 though it may be considered an analogue of DET or 5-MeO-DiPT under the Controlled Substances Act. Sales for human consumption or possession with intent to ingest could potentially be prosecuted under the Federal Analogue Act.44 Specifically listed as Schedule I in Florida and Louisiana (since June 2013).
By state
Across the 50 states, the District of Columbia, and the permanent territories, most jurisdictions treat DiPT consistently with federal control; listed entries record independently verified differences in classification or coverage.
ArizonaIllegaldangerous_drug_named
District of ColumbiaNot schedulednot_listed_no_analogue_provision
IdahoNot schedulednot_listed_schedule_I
MaineNot scheduledunscheduled
New YorkNot scheduledNot state-scheduled
North CarolinaIllegalschedule_i_substituted_tryptamine
OregonNot scheduledfederal_schedule_incorporation_only
DenmarkIllegal (analog/blanket ban)Liste B
Bekendtgørelse om euforiserende stoffer (bekendtgørelse nr. 405 af 26. marts 2026)15
DiPT is controlled in Denmark as a psychoactive simple derivative of DPT, which is included in List B of the Executive Order on Euphoric Substances. List B substances may be used only for medical or scientific purposes, and their import, export, sale, receipt, manufacture, processing, and possession are permitted only under the order's authorization rules. The order entered into force on 29 March 2026.
GermanyIllegalAnlage
Neue-psychoaktive-Stoffe-Gesetz17
Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) as of July 18, 2019.18 Production, import with intent to distribute, administration to others, and trading are punishable offenses. Possession is prohibited but not subject to criminal penalties.
IrelandIllegal (analog/blanket ban)Schedule 1
DiPT is controlled in Ireland under Schedule 1 of the Misuse of Drugs Regulations 2017 because it is structurally derived from tryptamine and has alkyl substitution at the side-chain nitrogen. The Regulations prohibit its production, supply, importation and exportation; possession without a statutory or regulatory authority is an offence under the Misuse of Drugs Act 1977. The Regulations have applied since 4 May 2017.
JapanIllegalDesignated Substance
Controlled as a Designated Substance (Shitei-Yakubutsu) under the Pharmaceutical Affairs Law. Both possession and sale are prohibited.
NetherlandsNot scheduledLijst I en IA
Opiumwet28
DiPT (N,N-diisopropyltryptamine) is not listed in List I or List II of the Dutch Opium Act. It also does not fall within List IA, whose blanket controls cover only derivatives of 2-phenethylamine, synthetic cannabinoids, and derivatives of 4-aminopiperidine. The Act's prohibitions on import, export, preparation, sale, supply, transport, possession, and manufacture therefore do not apply to DiPT under those schedules.
NorwayIllegalNarkotikalisten
Forskrift om narkotika30
N,N-diisopropyltryptamine (DiPT) is listed in Norway's narcotics list in the Regulation on Narcotics. The regulation treats the listed substance as a narcotic drug subject to Norway's narcotics controls.
PortugalIllegalAnexo
Portaria n.º 154/201333
Diisopropiltriptamina (DIPT) is listed in the annex to Portaria n.º 154/2013 as a new psychoactive substance. The listing prohibits the production, import, export, advertising, distribution, sale, possession and availability of the substance.
South KoreaIllegalAppendix 4
Enforcement Decree of the Narcotics Control Act38
Diisopropyltryptamine (DiPT) is listed as a psychotropic drug in Appendix 4 to the Enforcement Decree of the Narcotics Control Act. It is consequently controlled under the Narcotics Control Act.
SwitzerlandUncontrolled
Not listed under Buchstabe A, B, C, or D of controlled substances legislation. May be considered legal to possess, though sale for human consumption could still raise regulatory issues.
BelgiumIllegal (analog/blanket ban)Annexe IVa
DiPT is controlled in Belgium as a tryptamine derivative under Annexe IVa to the Royal Decree of 6 September 2017 regulating narcotic, psychotropic and soporific substances. The annex’s generic definition covers 2-(1H-indol-3-yl)ethanamine derivatives with each of the two amine substituents being CnH2n+1 (n=1–5), which includes DiPT’s two isopropyl substituents; manufacture, possession, supply, import and export are regulated under the decree’s authorization regime.
FinlandRestrictedLiite
Valtioneuvoston asetus 1130/201416
Di-isopropyylitryptamiini (DIPT) is listed as a psychoactive substance prohibited from the consumer market in the annex to Government Decree 1130/2014. Its placing on the consumer market is prohibited under Finland's consumer-market psychoactive-substances regime.
IndiaNot scheduledSchedule
DiPT (N,N-diisopropyltryptamine) is not listed in the Schedule to the Narcotic Drugs and Psychotropic Substances Act, 1985. The Act limits its definition of a psychotropic substance to a substance or material included in that Schedule; it does not create a general analogue category that extends the Schedule to unlisted substances.
IsraelIllegal (analog/blanket ban)Part A §B
Dangerous Drugs Ordinance [New Version], 5733–197323
DiPT is a structural derivative of N,N-dimethyltryptamine, which is listed in Part A, Section B of the First Schedule to the Dangerous Drugs Ordinance [New Version], 5733–1973. It is therefore a dangerous drug: its possession, use, manufacture, import, export, supply, and trade are prohibited except as permitted by the Ordinance, regulations, or a licence from the Director-General.
LatviaIllegal (analog/blanket ban)I saraksts
Listed as a Schedule I controlled substance under national drug control legislation.
New ZealandClass CCitation needed
Classified as a Class C controlled substance due to its structural relationship to DMT, which is covered under analogue provisions in New Zealand drug law.29
PolandIllegal (analog/blanket ban)VI-NPS
Regulation of the Minister of Health of 17 August 2018 on the list of psychotropic substances, narcotic drugs and new psychoactive substances (consolidated text, Dz.U. 2024 poz. 1139)3132
DiPT (N,N-diisopropyltryptamine) is covered as a tryptamine derivative in group VI-NPS of the Regulation of the Minister of Health of 17 August 2018 on the list of psychotropic substances, narcotic drugs and new psychoactive substances. The group definition covers indole-3-alkylamines with alkyl substituents of up to six carbons at both amine positions, which encompasses DiPT's two isopropyl substituents. The regulation has been in force since 21 August 2018; under the Act on Counteracting Drug Addiction, unlawful possession of a new psychoactive substance is punishable by a fine, while unlawful manufacture and placing it on the market carry criminal penalties.
SingaporeIllegalClass A ¶19(10)
N,N-Diisopropyltryptamine (DiPT) is expressly named at paragraph 19(10) of the current First Schedule’s Class A drugs. Paragraph 19 also controls the defined tryptamine structural group, including its ethers, salts, stereoisomers, and preparations or products; DiPT is therefore controlled as the named substance itself, not merely as an inferred analogue. The Act defines First Schedule substances as controlled drugs and, except as authorised, makes their import or export an offence; CNB records that the tryptamine group was moved to Class A on 1 May 2016.
SwedenProposed for schedulingCitation needed
Sweden's public health agency recommended classifying DiPT as a hazardous substance on May 15, 2019. Current legal status may have changed following this recommendation.
References
Source Pages
Citations
- A T Shulgin, & M F Carter. (1980). N, N-Diisopropyltryptamine (DIPT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT). Two orally active tryptamine analogs with CNS activity. Communications in Psychopharmacology, 4(5), 363–369. https://bibliography.maps.org/resources/download/88441234567891011121314151617181920
- dose.wiki generation draft: dipt__dosage_duration.yaml, 24 July 2026, lines 53-104. github.com (n.d.). https://github.com/josikinzz/dosewiki-admin/blob/main/runs/gap-generation-2026-07-24/drafts/wave-02/dipt__dosage_duration.yaml#L53-L10412
- dose.wiki earlier article export: DiPT, 2 August 2026, lines 43-59. github.com (n.d.). https://github.com/josikinzz/dosewiki-admin/blob/main/runs/article-review-2026-08-02/articles/dipt.md#L43-L5912
- PsychonautWiki. psychonautwiki.org (n.d.). https://psychonautwiki.org/wiki/DiPT12
- DiPT structured drug record. tripbot.tripsit.me (n.d.). https://tripbot.tripsit.me/api/tripsit/getDrug/dipt12
- Bruce E. Blough, Antonio Landavazo, Ann M. Decker, John S. Partilla, Michael H. Baumann, & Richard B. Rothman. (October 2014). Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes. Psychopharmacology, 231(21), 4135–4144. https://doi.org/10.1007/s00213-014-3557-71
- Michael B. Gatch, Michael J. Forster, Aaron Janowsky, & Amy J. Eshleman. (July 2011). Abuse liability profile of three substituted tryptamines. The Journal of Pharmacology and Experimental Therapeutics, 338(1), 280–289. https://doi.org/10.1124/jpet.111.17970512
- Drug Enforcement Administration. federalregister.gov (n.d.). https://www.federalregister.gov/documents/full_text/text/2022/01/14/2022-00713.txt12
- Douglas A. Smith, Jessica M. Bailey, Diarria Williams, & William E. Fantegrossi. (December 2014). Tolerance and cross-tolerance to head twitch behavior elicited by phenethylamine- and tryptamine-derived hallucinogens in mice. J Pharmacol Exp Ther, 351(3), 485–491. https://doi.org/10.1124/jpet.114.2193371
- Simon L. Hill, & Simon H. L. Thomas. (October 2011). Clinical toxicology of newer recreational drugs. Clinical Toxicology, 49(8), 705–719. https://doi.org/10.3109/15563650.2011.6153181
- TiHKAL: Tryptamines I Have Known and Loved. 403–406 (1997). https://www.erowid.org/library/books_online/tihkal/tihkal04.shtml123456789101112131415161718
- R. B. BARLOW, & I. KHAN. (March 1959). Actions of some analogues of tryptamine on the isolated rat uterus and on the isolated rat fundus strip preparations. British Journal of Pharmacology and Chemotherapy, 14(1), 99–107. https://doi.org/10.1111/j.1476-5381.1959.tb00934.x1
- Royal Decree of 6 September 2017 regulating narcotic, psychotropic and soporific substances. etaamb.openjustice.be (n.d.). https://etaamb.openjustice.be/fr/2017031231.html1
- Royal Decree of 6 September 2017 regulating narcotic, psychotropic and soporific substances. afmps.be (n.d.). https://www.afmps.be/fr/humain/produits_particuliers/subst_specialement_reglementees/stupefiants_et_psychotropes/substances1
- Bekendtgørelse om euforiserende stoffer (bekendtgørelse nr. 405 af 26. marts 2026). retsinformation.dk (n.d.). https://www.retsinformation.dk/eli/lta/2026/405/dan/pdf1
- Valtioneuvoston asetus 1130/2014. finlex.fi (n.d.). https://finlex.fi/fi/lainsaadanto/saadoskokoelma/2014/11301
- Neue-psychoaktive-Stoffe-Gesetz. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/NpSG.pdf1
- Neue-psychoaktive-Stoffe-Gesetz (NpSG) — Anlage (Stoffgruppen). Bundesministerium der Justiz / Bundesamt für Justiz (n.d.). https://www.gesetze-im-internet.de/npsg/BJNR261510016.html1
- Narcotic Drugs and Psychotropic Substances Act, 1985. indiacode.nic.in (n.d.). https://www.indiacode.nic.in/handle/123456789/1791?locale=en1
- Narcotic Drugs and Psychotropic Substances Act, 1985. cbn.gov.in (n.d.). https://www.cbn.gov.in/en/notifications/acts_rules/1
- Misuse of Drugs Regulations 2017 (S.I. No. 173 of 2017). irishstatutebook.ie (n.d.). https://www.irishstatutebook.ie/eli/2017/si/173/made/en/print1
- Misuse of Drugs Regulations 2017 (S.I. No. 173 of 2017). revisedacts.lawreform.ie (n.d.). https://revisedacts.lawreform.ie/eli/1977/act/12/section/3/revised/en/html1
- Dangerous Drugs Ordinance [New Version], 5733–1973. main.knesset.gov.il (n.d.). https://main.knesset.gov.il/apps/legislation/main/laws/20009011
- Ministerial Ordinance Designating Substances. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/bunya/iyakuhin/yakubuturanyou/scheduled-drug/index.html1
- Ministerial Ordinance Designating Substances. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001073965.pdf1
- Law On the Procedures for the Coming into Force and Application of the Criminal Law, Annex 2. likumi.lv (n.d.). https://likumi.lv/ta/id/50539-par-kriminallikuma-speka-stasanas-un-piemerosanas-kartibu#piel21
- Law On the Procedures for the Coming into Force and Application of the Criminal Law, Annex 2. likumi.lv (n.d.). https://likumi.lv/ta/id/40283-par-narkotisko-un-psihotropo-vielu-un-zalu-likumigas-aprites-kartibu#p51
- Opiumwet. wetten.overheid.nl (n.d.). https://wetten.overheid.nl/BWBR0001941/2025-07-011
- Misuse of Drugs Act 1975 (NZ), Schedule 3 — Class C controlled drugs. New Zealand Parliamentary Counsel Office (n.d.). https://www.legislation.govt.nz/act/public/1975/0116/latest/DLM436723.html1
- Forskrift om narkotika. lovdata.no (n.d.). https://lovdata.no/dokument/SF/forskrift/2013-02-14-199/KAPITTEL_1-11
- Regulation of the Minister of Health of 17 August 2018 on the list of psychotropic substances, narcotic drugs and new psychoactive substances (consolidated text, Dz.U. 2024 poz. 1139). isap.sejm.gov.pl (n.d.). https://isap.sejm.gov.pl/isap.nsf/download.xsp/WDU20240001139/O/D20241139.pdf1
- Regulation of the Minister of Health of 17 August 2018 on the list of psychotropic substances, narcotic drugs and new psychoactive substances (consolidated text, Dz.U. 2024 poz. 1139). isap.sejm.gov.pl (n.d.). https://isap.sejm.gov.pl/isap.nsf/download.xsp/WDU20230001939/O/D20231939.pdf1
- Portaria n.º 154/2013. files.dre.pt (n.d.). https://files.dre.pt/1s/2013/04/07500/0225402257.pdf1
- Misuse of Drugs Act 1973. sso.agc.gov.sg (n.d.). https://sso.agc.gov.sg/Act/MDA1973?ProvIds=Sc1-1
- Misuse of Drugs Act 1973. sso.agc.gov.sg (n.d.). https://sso.agc.gov.sg/Act/MDA1973?ProvIds=pr2-1
- Misuse of Drugs Act 1973. sso.agc.gov.sg (n.d.). https://sso.agc.gov.sg/Act/MDA1973?ProvIds=pr7-1
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- Enforcement Decree of the Narcotics Control Act. law.go.kr (n.d.). https://www.law.go.kr/flDownload.do?bylClsCd=200201&flNm=%5B%EB%B3%84%ED%91%9C+4%5D+%ED%96%A5%EC%A0%95%EC%8B%A0%EC%84%B1%EC%9D%98%EC%95%BD%ED%92%88+%EC%A2%85%EB%A5%98&flSeq=1334673611
- Misuse of Drugs Act 1971, Schedule 2 Part I — Class A drugs. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/schedule/212
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- Controlled Substances Act. dea.gov (n.d.). https://www.dea.gov/drug-information/drug-scheduling1
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- Schedules of Controlled Substances: Placement of 4-OH-DiPT, 5-MeO-AMT, 5-MeO-MiPT, 5-MeO-DET, and DiPT in Schedule I; Withdrawal of Proposed Rule and Notice of Hearing. Drug Enforcement Administration, Federal Register Vol. 87, No. 143 (July 27, 2022) (n.d.). https://www.govinfo.gov/content/pkg/FR-2022-07-27/pdf/2022-16102.pdf1
- Ariz. Rev. Stat. § 13-3401(6)(a)(xxx). azleg.gov (n.d.). https://www.azleg.gov/ars/13/03401.htm1
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- D.C. Code § 48-902.04. code.dccouncil.gov (n.d.). https://code.dccouncil.gov/us/dc/council/code/sections/48-902.041
- D.C. Code § 48-904.01. code.dccouncil.gov (n.d.). https://code.dccouncil.gov/us/dc/council/code/sections/48-904.011
- Idaho Code § 37-2705(d) (Schedule I hallucinogenic substances). legislature.idaho.gov (n.d.). https://legislature.idaho.gov/statutesrules/idstat/title37/t37ch27/sect37-2705/1
- Idaho Code § 37-2705(d) (Schedule I hallucinogenic substances). legislature.idaho.gov (n.d.). https://legislature.idaho.gov/statutesrules/idstat/title37/t37ch27/sect37-2701/1
- 17-A M.R.S. § 1102, Schedule X. legislature.maine.gov (n.d.). https://legislature.maine.gov/statutes/17-A/title17-Asec1102.html1
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- New York Public Health Law §§ 3302(4) and 3306 (current text). nysenate.gov (n.d.). https://www.nysenate.gov/legislation/laws/PBH/33021
- New York Public Health Law §§ 3302(4) and 3306 (current text). nysenate.gov (n.d.). https://www.nysenate.gov/legislation/laws/PBH/33061
- New York Public Health Law §§ 3302(4) and 3306 (current text). regs.health.ny.gov (n.d.). https://regs.health.ny.gov/content/subpart-9-1-synthetic-phenethylamines-and-synthetic-cannabinoids-prohibited1
- N.C. Gen. Stat. § 90-89(3)(nn). ncleg.gov (n.d.). https://www.ncleg.gov/EnactedLegislation/Statutes/HTML/BySection/Chapter_90/GS_90-89.html1
- Or. Rev. Stat. §§ 475.005(6), 475.035. oregonlegislature.gov (n.d.). https://www.oregonlegislature.gov/bills_laws/ors/ors475.html1
Further Reading
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