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Methoxphenidine

This article is a stubmissing:
Pharmacology
Interactions
Tolerance
History & Culture
Methoxphenidine molecule structureMethoxphenidine molecule structure

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold30-50 mg
Light50-75 mg
Moderate75-120 mg
Strong120-150 mg
Heavy200+ mg

Duration

Onset30-60 minutes
After Effects1-3 hours
Total6-8 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

Physical autonomyDizziness

Cognitive

The head space of MXP is often described as particularly clear headed even at heavy dosages. It is far more controllable, less disorientating and confusing at dosages of equal subjective intensity to that of MXE, DXM and Ketamine.

Visual

Hallucinatory States

Auditory

The auditory effects of MXP are common in their occurrence but unlike other more commonly used dissociatives, they are unlikely to suppress or distort auditory input.

Forked from Subjective Effect Documentation byJosie Kins March 2014.

Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Addictive potential has not been established, though the substance is categorized as habit-forming. Strong tolerance development may contribute to compulsive redosing patterns.

Toxicity

Cardiovascular

Acute intoxication can produce hypertension and tachycardia; elevated blood pressure has been observed during use, along with peripheral vasoconstriction.

Psychosis Risk

Psychotic episodes have been reported, including at least one case associated with violent behavior resulting in a murder in June 2014. Acute intoxication has been reported to produce confusion.

Seizure Risk

Seizures have been reported at high doses according to user reports, warranting additional caution with dosing.

History & Culture

History & Culture not written up yet

Trip Reports

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Legality

International

Legal grey area

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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