DOM

2,5-Dimethoxy-4-methylamphetamine

STP, Serenity, Tranquility, and Peace

Psychoactive Class

Chemical Class

Amphetamine (psychedelic)Phenethylamine (substituted)

DOM is a psychedelic amphetamine of the DOx family¹², first synthesized by Alexander Shulgin in 1963³ and later documented in his 1991 book PiHKAL⁴. It gained notoriety during the 1967 Summer of Love in San Francisco, where high-dosed tablets caused hospitalizations due to its characteristically slow onset and extremely long duration³. Shulgin considered it one of his "magical half-dozen" — his personal favorite compounds. It produces stimulant effects at lower doses and hallucinogenic effects at higher doses³².

Dosage & Duration

Dosage

Threshold~0.5 mg

Light1-2.5 mg

Moderate2.5-5 mg

Strong5-7.5 mg

Heavy7.5+ mg

DOM exhibits pronounced dose-sensitivity and is considerably more potent by weight than most other phenethylamine psychedelics. Tolerance to its effects builds quickly following use and typically requires around one week without further dosing to fully reset.

Duration

Onset60-120 minutes

Come Up120-180 minutes

Peak6-8 hours

Offset3-5 hours

After Effects4-16 hours

Total12-16 hours

Subjective Effects

Effects vary widely by individual, dose, and context.

Physical

The physical effects of DOM can be broken down into several components which progressively intensify proportional to dosage.

Bodily control enhancement Increased heart rate Increased blood pressure Pupil dilation

Cognitive

The cognitive effects of DOM are described by many as a combination of extreme mental stimulation and a powerful enhancement of a person's current mental state.

Analysis enhancement Thought acceleration Time distortion Novelty enhancement Conceptual thinking Immersion enhancement Thought connectivity Current mind state enhancement Personal bias suppression Memory suppression Ego death Wakefulness

Visual

Distortions

Tracers After images Symmetrical texture repetition Colour shifting Scenery slicing

Enhancements

DOM presents a full and complete array of possible visual enhancements.

Acuity enhancement Colour enhancement Pattern recognition enhancement

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B or 2C-I. It can be comprehensively described through its variations as intricate in style, equally algorithmic and abstract in form, equally synthetic and organic in style, structured in organization, brightly lit in lighting, multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, equal in rounded and angular corners, non-immersive in depth and consistent in intensity. Higher dosages are significantly more likely to result in states of Level 8A visual geometry over Level 8B.

Hallucinatory States

DOM produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family.

Transformations

Auditory

The auditory effects of DOM are common in their occurrence and exhibit a full range of effects.

Enhancements Distortions Hallucinations

Forked from Subjective Effect Documentation

by Josie KinsSeptember 2015.

Reagent Testing

Loading reagent data

Expected colorimetric results are being prepared.

Pharmacology

Pharmacodynamics

DOM selectively targets the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors as an agonist, with its psychedelic effects primarily attributed to 5-HT2A activation.⁵ Sources differ on whether DOM functions as a full or partial agonist at these receptors.⁵ R-(−)-DOM is the more active enantiomer.⁴ Outside of the 5-HT2 family, DOM is inactive as a monoamine reuptake inhibitor and releasing agent⁶ and shows only very weak inhibition of MAO-A with no activity at MAO-B.⁷ Its high selectivity for the 5-HT2 receptor subfamily has made it a widely used pharmacological research tool, and it has also been reported to possess potent anti-inflammatory properties.⁸

Pharmacokinetics

The pharmacokinetics of DOM have been only limitedly studied in humans. The drug undergoes demethylation, producing the pharmacologically active metabolites 2-O-desmethyl-DOM and 5-O-desmethyl-DOM, which may contribute to its delayed onset and long duration of action.⁹ There is also evidence suggesting that metabolic conversion may occur in the lungs prior to central nervous system activity. Approximately 5 to 20% of a dose is excreted unchanged.

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AMTLithium

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

AmphetaminesCocaineDXMPCPTramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

2C-T-x compounds2C-x compounds5-MeO-xxT tryptaminesCaffeineCannabisDiphenhydramineMAOIsMDMAMephedroneMescalineMXENBOMe compoundsPregabalin

TripSit

Tolerance

Full Tolerance

Tolerance to the effects of DOM develops almost immediately after ingestion. Clinical studies have demonstrated that with daily administration over three consecutive days, subjective effects diminish dramatically—ranging from 'moderately strong' responses to complete absence of effects by the third day, with one subject actually sleeping through the experience.

Baseline Reset

Approximately 7 days of abstinence

Half Tolerance

Approximately 3 days

Cross Tolerance

Psychedelics (all serotonergic psychedelics will have reduced effects following DOM consumption)

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

DOM is not habit-forming and the desire to use it typically decreases with use. It exhibits a self-regulating quality that discourages compulsive redosing or frequent administration.

Physical

Extremely Low

DOM is not physically addictive and does not produce physical dependence or withdrawal symptoms.

Toxicity

Cardiovascular

DOM produces pronounced cardiovascular stimulation including large increases in heart rate and blood pressure during intoxication;¹⁰ these effects are described as more worrisome than those seen with classic psychedelics like LSD, and severe vasoconstriction may develop at high doses.¹⁰

Psychosis Risk

DOM can induce psychotic states particularly at high doses, manifesting as an amphetamine psychosis-like condition with bizarre, delusional, and sometimes violent behavior. Frequent use carries risk of persistent reality distortion and may trigger latent psychoses in predisposed individuals. The exceptionally long duration increases psychological burden and likelihood of adverse psychological reactions.

Seizure Risk

Seizures are a potential risk primarily at high or overdose-level doses. Those predisposed to seizures may be at elevated risk, particularly when DOM is combined with other substances that lower seizure threshold.

History & Culture

Discovery and Synthesis

DOM was first synthesized by Alexander Shulgin in 1963.¹¹ The initial step of the synthesis was performed by his then fifteen-year-old son Theodore "Ted" Shulgin at Dow Chemical Company on June 22, 1963, during a brief period when the younger Shulgin had developed an…

Trip Reports

Legality

International

1961 Single Convention: DOM/STP is not scheduled.

1971 Convention on Psychotropic Substances: Schedule I.

1988 Convention: DOM/STP is not listed in precursor Tables I or II.

By Country

United StatesIllegalSchedule I hallucinogen

21 CFR § 1308.11(d)²⁰

Current official legislation expressly controls DOM/STP in United States; unauthorised possession, supply, or manufacture is prohibited.

AustriaIllegal

Controlled under the SMG (Suchtmittelgesetz Österreich). Possession, production, and sale are prohibited.

BrazilIllegal

Listed on Portaria SVS/MS nº 344 under the name 'STP'.¹² Possession, production, and sale are prohibited.

Czech RepublicSchedule I

Classified as a Schedule I controlled substance under national drug legislation.

ItalyTabella ICitation needed

Listed in Tabella I of the 'Tabelle delle sostanze stupefacenti e psicotrope'.¹⁵ Possession, purchase, and sale are illegal.

New ZealandClass ACitation needed

Controlled as a Class A substance, the most restrictive classification under New Zealand's Misuse of Drugs Act.¹⁷

SwitzerlandVerzeichnis D

Specifically named as a controlled substance under Verzeichnis D of Swiss narcotics legislation.

AustraliaIllegalCitation needed

Prohibited under a blanket ban covering all substituted phenethylamines, which includes the entire DOx family of compounds.

BelgiumSchedule I

Listed under HOOFDSTUK II of Belgian controlled substances legislation. Possession, distribution, and production are prohibited.

CanadaSchedule I

Controlled substance under the Controlled Drugs and Substances Act.¹³ Possession, trafficking, and production are criminal offenses.

GermanyIllegalAnlage I controlled substance

Betäubungsmittelgesetz, Anlage I¹⁴

Current official legislation expressly controls DOM/STP in Germany; unauthorised possession, supply, or manufacture is prohibited.

LatviaSchedule I

Classified as a Schedule I controlled substance under Latvian drug control legislation.¹⁶

RussiaSchedule I

Classified as a Schedule I substance in the Russian Federation.¹⁸ Buying, selling, or possessing without a license is illegal.

United KingdomClass ACitation needed

Controlled under the Misuse of Drugs Act 1971.¹⁹ Buying, selling, or possessing without a license is prohibited.

References

Source Pages

Citations

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DOM

2,5-Dimethoxy-4-methylamphetamine

STP, Serenity, Tranquility, and Peace

Psychoactive Class

Psychedelic Stimulant

Chemical Class

Amphetamine (psychedelic)Phenethylamine (substituted)