2C-B
2C-B is a synthetic psychedelic of the phenethylamine class and perhaps the most well-known member of the 2C-x family, which are structurally related to mescaline.12 First synthesized by Alexander Shulgin in 1974, it initially saw use as an aid in psychiatric therapy. 2C-B is characterized by warm, colorful visuals, mild entactogenic qualities, and a prominent body component. It is generally considered more manageable than classical psychedelics like LSD or psilocybin, though it is notably dose-sensitive.
Contents
Dosage & Duration
Dosage3
2C-B exhibits a notably steep dose-response relationship, particularly within the 12–24 mg range, where differences of just 2 mg can substantially alter both the intensity and qualitative nature of the experience. Careful, incremental dosing is recommended when establishing individual sensitivity.
Duration3
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
The physical effects of 2C-B can be broken down into five components all of which progressively intensify proportional to dosage.
Cognitive
The head space of 2C-B is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.
Visual
Enhancements
2C-B presents a full and complete array of possible visual enhancements.
Geometry
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of LSD than that of 2C-E, psilocin, or ayahuasca. They can be comprehensively described as unstructured in their organization, algorithmic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and angular in their corners. They seem high in algorithmic visuals such as fractals and at higher dosages are significantly more likely to result in states of Level 7A visual geometry over Level 7B.
Hallucinatory States
Like LSD, while 2C-B is capable of producing a full range of low and high level hallucinatory states, this is extremely rare and inconsistent at higher levels but common at lower levels.
Auditory
The auditory effects of 2C-B are more common than some psychedelics in their occurrence and are capable of producing a full range of effects.
Reagent Testing
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Pharmacology
Pharmacodynamics
2C-B functions primarily as a partial agonist at the serotonin 5-HT2 receptor family, with potent binding at 5-HT2A, 5-HT2C, and to a lesser degree 5-HT2B.4 Some studies have reported low efficacy or antagonism at 5-HT2A and 5-HT2C, while others have consistently measured near-full efficacy at these sites.2 Beyond the 5-HT2 receptors, 2C-B shows modest affinity for 5-HT1A and 5-HT1B receptors and has been characterized as a non-competitive serotonin transporter inhibitor of very low potency. Research in rat models has also demonstrated that 2C-B increases dopamine levels, which may contribute to its psychoactive profile.5
Pharmacokinetics
2C-B appears to have relatively low oral bioavailability as a result of substantial first-pass metabolism in the liver. It is metabolized by hepatocytes through oxidative deamination and demethylation, with deamination catalyzed by both MAO-A and MAO-B.62 Species differences exist in the metabolic products; human, monkey, and rabbit hepatocytes produce the demethylated metabolite B-2-HMPE, while dog, rat, and mouse hepatocytes do not.7 The primary metabolite BDMPAA reaches plasma concentrations approximately 280-fold higher than 2C-B itself after oral dosing. The elimination half-life in humans ranges from 1.2 to 2.5 hours.8
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Partial cross-tolerance with serotonergic psychedelics (asymmetric; other psychedelics may reduce 2C-B effects, but 2C-B typically does not diminish effects of subsequent psychedelic use)
Harm Potential
Reported adverse effects of 2C-B include visual focusing difficulty, trembling, sweating, nausea, abdominal pain, tachycardia, jaw clenching, dizziness, confusion, and memory impairment.8 At oral doses over 20 to 30 mg, 2C-B may cause frightening hallucinations, tachycardia, hypertension, and hyperthermia.28
Addiction & Dependence
Psychological
Extremely Low2C-B is considered non-addictive with a low potential for abuse. Like other serotonergic psychedelics, it possesses a self-regulating quality that discourages compulsive use patterns.
Physical
Extremely Low2C-B does not produce physical dependence. Withdrawal effects following discontinuation have not been reported.
Toxicity
Acute cardiovascular effects including elevated blood pressure, increased heart rate, and hyperthermia occur during intoxication, particularly at higher doses; theoretical risk of cardiac valvulopathy exists with frequent long-term use due to 5-HT2B agonism, though this has not been documented in 2C-B users specifically.8
At typical recreational doses, 2C-B is unlikely to be neurotoxic; severe neurological impairment has been reported in isolated case reports involving unknown doses or possible adulterants.9
Psychosis Risk
Adverse psychological reactions including anxiety, paranoia, delusions, and psychosis are possible, particularly in those predisposed to mental disorders. One case report documents persistent psychosis following a single dose.10 Individuals with a family history of schizophrenia or early onset mental illness should exercise extreme caution.
Seizure Risk
Seizures are rare but have been documented in at least one case report involving an unknown dose that also produced serotonin syndrome.9 Risk may increase in susceptible individuals or when combined with seizure threshold-lowering substances.
History & Culture
Discovery and Early Research
2C-B was first synthesized in 1974 by American chemist Alexander Shulgin while investigating novel psychedelic compounds based on the chemical structure of mescaline, specifically exploring homologues of DOB. Its psychoactive properties were discovered on June 25, 1975, when Shulgin tested the…
Trip Reports
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Legality
International
UN Convention on Psychotropic Substances Schedule II (added March 2001)13
By Country
References
Source Pages
Citations
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