25C-NBOH

2-(4-Chloro-2,5-dimethoxyphenyl)-N-[(2-hydroxyphenyl)methyl]ethanamine

2C-C-NBOH, NBOH-2C-C

Psychoactive Class

Chemical Class

25C-NBOH is a synthetic psychedelic of the substituted phenethylamine class, produced through N-benzylation of the psychedelic 2C-C.¹ First synthesized in 2011 by Martin Hansen at the University of Copenhagen, it has since appeared as a designer drug.¹ It is known for producing predominantly visual and stimulating psychedelic effects, with serotonin receptor affinity comparable to its structural relative 25C-NBOMe.

Dosage & Duration

Dosage

Threshold~100 μg

Light100-500 μg

Moderate500-750 μg

Strong750-1000 μg

Heavy1000+ μg

25C-NBOH and related NBOH compounds are not orally bioavailable. A bitter, metallic taste and noticeable numbing of the mouth are commonly reported, with the numbness typically lasting around an hour after the dose is absorbed. This substance has a steep dose-response relationship, and subjective effects can vary considerably even between doses of similar size.

Duration

Onset15-45 minutes

Come Up30-90 minutes

After Effects3-6 days

Total5-7 hours

Subjective Effects

25C-NBOH produces a stimulating psychedelic experience broadly typical of the NBOH series, combining euphoria, empathy, and a general alteration of perception with prominent visual effects visible with both open and closed eyes. The headspace tends toward insight and a softening of ego boundaries, though confusion can occur, and mental and physical stimulation often persists long enough to interfere with sleep.

Physical

The body experience is distinctly stimulating and can include restlessness, muscle tension, and alternating sweating and chills. Appetite is suppressed, pupils dilate, and insomnia is common while effects remain active.

Pupil dilation

Stimulation

Stimulation is both mental and physical, and can manifest as restlessness.

Uncomfortable

Muscle tensionAppetite suppression

Cognitive

The mental state is euphoric and empathogenic, with an insight-oriented, introspective character and a softening of the sense of self. Confusion is reported by some users, particularly as perception becomes more altered.

Confusion

Emotional

Euphoria Empathy enhancement

Visual

Visual effects are a core feature of the experience, spanning brightened colors and visuals that appear with eyes both open and closed.

Tactile

Tactile sensation is enhanced, with touch and texture feeling more pronounced.

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)

Mecke(ME)

Mandelin(MD)

Liebermann(LB)

PROtestkit.eu

Pharmacology

Pharmacodynamics

In vitro receptor assays found that 25C-NBOH bound human 5-HT2A receptors with pKi 9.4 and activated them with pEC50 9.43. In the same study, its affinity at rat 5-HT2C receptors was lower (pKi 7.8). These measurements characterize receptor binding and functional activity in assay systems; they do not establish human pharmacokinetics, metabolism, clinical potency, or safety.²

Pharmacokinetics

There have been no studies on the pharmacokinetic profile of 25C-NBOH and the metabolism of 25C-NBOH is unknown.

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AMTLithiumPregabalin

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

AmphetaminesCocaineDXMTramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

2C-T-x compounds2C-x compounds5-MeO-xxT tryptaminesCaffeineCannabisDiphenhydramineDOx compoundsMAOIsMDMAMescalineMXE

TripSit

Tolerance

Full Tolerance

Develops almost immediately after ingestion.

Baseline Reset

Approximately 2 weeks in the absence of further consumption

Half Tolerance

Approximately 1 week

Cross Tolerance

Serotonergic psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

25C-NBOH is generally not regarded as habit forming, and repeated use may make taking it again less appealing. Its use is usually self-limiting rather than reinforcing.

Physical

Extremely Low

No evidence of physical dependence or withdrawal symptoms has been documented.

Toxicity

Cardiovascular

Acute cardiovascular effects including elevated blood pressure, increased heart rate, abnormal heartbeat, and vasoconstriction occur during intoxication;³⁴ these effects may pose significant risk at higher doses or in individuals with pre-existing cardiovascular conditions.

Thermoregulatory

Temperature regulation suppression and increased body temperature occur during intoxication, which may contribute to dangerous hyperthermia, particularly at high doses or in warm environments with physical activity.³

Psychosis Risk

Anxiety and paranoia appear to occur more readily with 25C-NBOH than with many other psychedelics, possibly related to its stimulating properties. At high doses, confusion, amnesia, and sensory overload may occur, potentially increasing vulnerability to adverse psychological reactions.

Seizure Risk

Seizures are documented as a possible effect.³⁵ The unpredictable dose-response relationship of this substance may contribute to seizure risk at unexpectedly high effect levels.

History & Culture

25C-NBOH was first synthesized and documented in 2011 by Martin Hansen at the University of Copenhagen. The compound is a derivative of the phenethylamine psychedelic 2C-C,¹ distinguished by the addition of an N-benzyl group bearing a hydroxyl substituent on the…

Legality

By Country

BrazilControlled (Portaria SVS/MS nº 344)

Added to Portaria SVS/MS nº 344 on December 10, 2018, which is Brazil's regulatory framework for controlled substances.⁶ Possession, distribution, and use are prohibited under federal law.

SwedenSchedule I (Narcotic)

Classified under Schedule I of the Narcotic Drugs Punishments Act since August 18, 2015, following action by the Riksdag. This scheduling applies to substances, plant materials, and fungi that normally have no accepted medical use. Published by the Medical Products Agency in regulation HSLF-FS 2015:12.

United KingdomClass A

Controlled as a Class A substance under the Misuse of Drugs Act 1971 through the N-benzylphenethylamine catch-all clause.¹⁰ Class A drugs carry the most severe penalties, including up to 7 years imprisonment for possession and life imprisonment for supply offenses.

GermanyNpSG (Controlled)

Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) since November 26, 2016.⁷ Production and importation with intent to market, administration to others, and commercial trading are criminally punishable.⁸ Possession is technically illegal but carries no criminal penalty.

SwitzerlandControlled (Verzeichnis E)

Specifically named as a controlled substance under Verzeichnis E (Schedule E) of Swiss narcotics legislation.⁹ Unauthorized possession, production, and distribution are prohibited.

References

Source Pages

Citations

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25C-NBOH

2-(4-Chloro-2,5-dimethoxyphenyl)-N-[(2-hydroxyphenyl)methyl]ethanamine

2C-C-NBOH, NBOH-2C-C

Psychoactive Class

Psychedelic Hallucinogen

Chemical Class

Phenethylamine (N-benzylated)NBOH