Skip to main content
dose.wiki is still in beta. Entries may contain inaccuracies and/or lack citations. See our docs for more info.

DOET

DOET molecule structureDOET molecule structure
2,5-Dimethoxy-4-ethylamphetamine
DOE, Hecate, DMEA
Psychoactive Class
PsychedelicStimulant

DOET is a potent, long-acting psychedelic stimulant of the substituted amphetamine and phenethylamine classes, belonging to the DOx family.citation needed First discovered by Alexander Shulgin in the 1960s, it is closely related to DOM and is a synthetic analogue of mescaline. DOET was briefly studied by Dow Chemical as a potential 'psychic energizer' before its development was halted following the 1967 DOM street drug crisis. Individual responses to this substance vary considerably.1

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~1 mg
Light2-4 mg
Moderate4-6 mg
Strong6-10 mg
Heavy10+ mg

These dosage values are provisional and based on a limited number of anecdotal accounts. Reports of doses exceeding 7 mg suggest that physical side effects intensify without a corresponding increase in desired effects.

Duration

Onset1-3 hours
Come Up1-3 hours
Peak1-2 hours
Offset2-5 hours
After Effects12-72 hours
Total12-30 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

DOET occupies an unusual position among the DOx compounds: at low doses it functions primarily as a subtle mood energizer, producing mild euphoria, enhanced self-awareness, and talkativeness with little overt hallucinogenic activity, while higher doses bring on a fuller psychedelic state with sensory enhancement, heightened emotion, and rich eyes-closed imagery. The onset is notably slow and gradual, with full effects taking around three hours to develop, and users may initially forget they have taken anything at all. Throughout the experience, intellect and emotional functioning tend to remain intact and usable, and sleep can be difficult afterward.

Physical

Mild mental and physical stimulation with little to no body load is characteristic, alongside pupil dilation, decreased appetite, muscle tension, and sweating or chills. Restlessness and insomnia are common, and a washed-out feeling can follow the experience.

Autonomic

Pupil dilationAppetite suppression

Cardiovascular

Stimulation

Cognitive

The headspace is typically clear and functional, marked by euphoria, empathy, insight, a softening of the ego, and heightened emotions that can shift rapidly. Racing thoughts, talkativeness, and occasional confusion, anxiety, or restlessness are also reported, with nervousness becoming more prominent at higher doses.

Emotional

Enhancements

Visual

Visual effects range from simple color brightening and mild closed-eye imagery at low doses to rich, self-generating eyes-closed visions at higher doses; open-eye distortion is usually minimal but can occasionally become intense and disorienting.

Tactile

Tactile enhancement

Olfactory

See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)

Pharmacology

Pharmacodynamics

DOET acts as a selective serotonin 5-HT2 receptor agonist with high affinity for the 5-HT2A receptor (Ki = 12 nM) and moderate affinity for the 5-HT2C receptor (Ki = 108 nM).2 It functions as a full agonist at the 5-HT2A receptor (Emax 99%) and as a high-efficacy partial agonist at the 5-HT2B and 5-HT2C receptors.citation needed Affinity for the 5-HT1A receptor is substantially lower (Ki = 9,727 nM). DOET shows very weak or no activity at human trace amine-associated receptor 1 (TAAR1) and does not bind to the monoamine transporters.

Pharmacokinetics

DOET crosses the blood-brain barrier in rodentscitation needed and is metabolized by oxidation of the ethyl group at the 4 position.3 It appears to be metabolized more quickly than DOM.citation needed In humans, approximately 10 to 40% of the drug is excreted unchanged in urine within 24 hours, with the greatest excretion rate occurring between 3 and 6 hours after administration.

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AMTLithium

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

AmphetaminesCocaineDXMPCPTramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

2C-T-x compounds2C-x compounds5-MeO-xxT tryptaminesCaffeineCannabisDiphenhydramineMAOIsMDMAMephedroneMescalineMXENBOMe compoundsPregabalin
Powered by TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Cross Tolerance

Serotonergic psychedelics (DOM, LSD, psilocybin, mescaline), Other 5-HT2A agonists

Harm Potential

Addiction & Dependence

Psychological

Low

Euphoria and stimulant-like subjective effects are reported, while low-dose literature did not mention disturbing hints of abusability.

Toxicity

Cardiovascular

Higher-dose effects include increased heart rate and blood pressure; low-dose clinical reports observed pupil dilation but no marked heart-rate or blood-pressure changes.

Thermoregulatory

Rodent pharmacology findings report serotonin receptor-dependent hyperthermic effects.citation needed

Psychosis Risk

Moderate

Psychedelic effects, closed- and open-eye visuals, confusion, rapid mood changes, and difficulty finding a stable point of reference are reported. Persistent psychosis is not established.

History & Culture

Discovery and Development

DOET was discovered by Alexander Shulgin during the 1960s while he was employed at Dow Chemical Company. Following his synthesis of the structurally related compound DOM in 1963 and the subsequent recognition of its psychoactive properties in 1964, Shulgin began systematically assessing similar…

Legality

International

DOET is listed in Schedule I of the Convention on Psychotropic Substances, 1971. It is not listed in the schedules to the 1961 Single Convention on Narcotic Drugs or the precursor tables of the 1988 Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.

By Country

Illegal16
United States flagUnited StatesIllegal
Austria flagAustriaIllegal
Brazil flagBrazilIllegal
Finland flagFinlandIllegal
Germany flagGermanyIllegal
India flagIndiaIllegal
Ireland flagIrelandIllegal
Japan flagJapanIllegal
Netherlands flagNetherlandsIllegal
Norway flagNorwayIllegal
Singapore flagSingaporeIllegal
South Africa flagSouth AfricaIllegal
Spain flagSpainIllegal
Switzerland flagSwitzerlandIllegal
Ukraine flagUkraineIllegal
United Kingdom flagUnited KingdomIllegal

References

Source Pages

  1. Bluelight: DOET 2.5 mg trip report
  2. Erowid: PiHKAL entry #66 DOET
  3. Isomer Design (TiHKAL/PiHKAL)
  4. Wikipedia
  5. Wikipedia: 2,5-Dimethoxy-4-ethylamphetamine

Citations

  1. PiHKAL: A Chemical Love Story. 978 (September 1991). https://erowid.org/library/books_online/pihkal/pihkal066.shtml1
  2. Dino Luethi, Grant C Glatfelter, Eline Pottie, Francesca Sellitti, Alexander D Maitland, Nicholas R Gonzalez, Lindsay A Kryszak, Shelley N Jackson, Marius C Hoener, Christophe P Stove, Matthias E Liechti, Martin Smieško, Michael H Baumann, Linda D Simmler, & Deborah Rudin. (November 2025). The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects. Mol Psychiatry, 31(3), 1799–1809. https://doi.org/10.1038/s41380-025-03325-11
  3. Alexander T. Shulgin. (1978). Stimulants. 243–333. https://doi.org/10.1007/978-1-4757-0510-2_61
  4. Keeper Trout, & Paul F Daley. (December 2024). The origin of 2,5-dimethoxy-4-methylamphetamine (DOM, STP). Drug Test Anal, 16(12), 1496–1508. https://doi.org/10.1002/dta.36671
  5. Suchtgiftverordnung. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Gesetzesnummer=100110531
  6. Portaria SVS/MS No. 344/1998. gov.br (n.d.). https://www.gov.br/anvisa/pt-br/assuntos/medicamentos/controlados/lista-substancias1
  7. Government Decree on substances, preparations and plants considered narcotics (543/2008). finlex.fi (n.d.). https://www.finlex.fi/fi/lainsaadanto/2008/5431
  8. Betäubungsmittelgesetz (BtMG), Anlage I. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html1
  9. Narcotic Drugs and Psychotropic Substances Act, 1985. indiacode.nic.in (n.d.). https://www.indiacode.nic.in/bitstream/123456789/1791/1/A1985-61.pdf1
  10. Misuse of Drugs Regulations 2017. irishstatutebook.ie (n.d.). https://www.irishstatutebook.ie/eli/2017/si/173/made/en/print1

Further Reading

  1. Analysis of 2,5-dimethoxy-amphetamines, J Anal Toxicol 2022
  2. Bonson KR et al., DOET human study
  3. FASEB J 2022 - Monoamine receptor and transporter interactions
  4. Front Psychiatry 2017 - Novel Psychoactive Substances review
  5. Monoamine receptor & transporter interaction, FASEB J 2022
  6. Nature Communications 2020 - Structure of 5-HT2A complex
  7. Neuropharmacology 2020 - Head-twitch potency correlation
  8. Novel Psychoactive Substances – progress review, Front Psychiatry 2017
  9. PMC: 2016 - Psychedelics safety overview
  10. PMC: 2022 - Serotonin syndrome and MAOI interactions
  11. Psychedelics & the Human Receptorome, PLoS ONE 2010
  12. Psychopharmacologia 1975 - DOET discrimination study
  13. Structure of hallucinogen-activated 5-HT2A complex, Nat Commun 2020
  14. Structure-activity of 5-HT2A agonists, Wiley 2024
  15. Tripsitter: DOET profile
  16. Wiley 2024 - Structure-activity of 5-HT2A agonists

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Lyrea avatar
    Step 2 · First-pass review

    A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes8 human edits · latest

Times are UTCNewest first

31 July 2026

  1. Lyrea · Updated the article

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

All changes to this article · Site-wide recent changes

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the DOET article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.