5-MeO-DMT

Added to Schedule I of the Controlled Substances Act effective January 19, 2011.⁹⁰ Manufacturing, buying, possessing, or distributing without a DEA license is illegal. Several states including Florida, Louisiana, Nebraska, Oklahoma, and South Dakota had independently scheduled it prior to federal action.

5-MeO-DMT is expressly named in the current Commonwealth Customs Schedule 4 and ordinary importation is prohibited under regulation 5(1) absent the required licence, permission, documentary, timing and quantity conditions. Regulation 5(1) is expressly subject to subregulations 5(2) and 5(2A), which disapply it for approved imports under subregulation 5(3), qualifying prescribed passenger medicines for a person or another passenger, qualifying regulation 5F imports, and qualifying prescribed veterinary medicines for an imported animal. It is also expressly listed as a Queensland Schedule 2 dangerous drug, with unlawful possession criminalized under the Queensland Act. The current June 2026 Poisons Standard expressly lists DMT in Schedule 9 and explains derivative inclusion, but its derivative guidance requires a balanced determination; 5-MeO-DMT is not expressly named in SUSMP Schedule 9.

5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), when synthetically produced, is covered as a tryptamine derivative by Anlage II Z 6 of Austria’s Neue-Psychoaktive-Substanzen-Verordnung, a blanket category in force since 1 January 2012. For-profit production, import, export, supply, or procurement for psychoactive use is punishable under NPSG § 4 by up to two years’ imprisonment. The substance is subject to confiscation unless a lawful, non-psychoactive use is substantiated.

5-MeO-DMT is 2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethanamine. Its N,N-dimethyl substitution, 5-methoxy indole substitution and unsubstituted indole nitrogen match Annex IVA item 5's generic tryptamine-derivative structure. The Royal Decree's authorization regime therefore applies: activities require prior authorization limited to scientific or medical purposes. AFMPS warns that its consolidated annex is non-official; the published Belgian Official Journal annexes and amendments control.

Possession, production, and sale are prohibited under Portaria SVS/MS nº 344.

Classified as a controlled substance effective October 2015 under national drug regulations.

Legally restricted to medical or scientific purposes since December 2004. General possession and sale are prohibited.

5-MeO-DMT is listed as a narcotic in Government Decree 543/2008. Its manufacture, import, export, sale, and possession require the authorisation provided by Finland's narcotics legislation.

5-MeO-DMT, also called 5-méthoxy-N,N-diméthyltryptamine or méthylbufoténine, is classified as a narcotic in Annexe IV by the ANSM Decision of 12 May 2026. Since 10 June 2026, its production, manufacture, transport, import, export, possession, supply, transfer, acquisition, and use are prohibited unless expressly authorized.

5-MeO-DMT is listed in Anlage I to the Betäubungsmittelgesetz. Anlage I substances are non-marketable narcotics and may be handled only under the statutory authorisation framework.

5-MeO-DMT is expressly listed in Table A (Πίνακας Α) of Article 1(2) of Law 3459/2006, a provision retained in force by Law 4139/2013; the listing has applied since 25 May 2006. Production, possession, transport, storage, supply, processing, circulation, and trafficking of Table A substances are the exclusive right of the State through the National Organisation for Medicines, and supply is limited to laboratories or hospitals conducting approved programmes. Unauthorised possession, manufacture, sale, distribution, import, export, and transport of scheduled narcotics constitute criminal drug trafficking.

Since the 2017 amendment to the First Schedule, 5-MeO-DMT is covered as a structural derivative of N,N-dimethyltryptamine in Part A, Section B of the Dangerous Drugs Ordinance [New Version], 5733–1973. Possession, use, manufacture, import, export, trade, and supply of a dangerous drug are prohibited unless authorized by the Ordinance, its regulations, or a licence from the Director.

Controlled as a Shitei-Yakubutsu (Designated Substance) under the Pharmaceutical Affairs Law. Possession and sale are illegal without authorization.

5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) is covered as a tryptamine derivative by List I of Annex 2 to the Law On the Coming into Force and Application of the Criminal Law. List I covers prohibited especially dangerous narcotic substances and allied psychotropic substances, and its generic tryptamine definition encompasses the substance’s substituted indole ring and N,N-dimethyl amino group. The current statutory Annex took effect on 1 June 2021. Latvia’s Criminal Law provides penalties for unauthorised manufacture, acquisition, possession, transport, forwarding, and sale of narcotic or psychotropic substances.

NIH PubChem identifies 5-MeO-DMT as O-methylbufotenine (CID 1832), with formula C13H18N2O and IUPAC name 2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethanamine. The current Dutch List I names N,N-dimethyltryptamine (DMT) and separately states that the ethers, esters and enantiomers of the above-mentioned substances are included; the official National Drug Monitor table specifically places 5-MeO-DMT on List I since 2003 via esters and ethers, with a footnote that DMT esters and ethers are prohibited under the current Opiumwet. The status is prohibited. Article 2 prohibits importing/exporting, preparing/processing, selling/delivering/supplying/transporting, possessing and manufacturing List I substances. For intentional conduct, Article 10 provides up to six years' imprisonment or a fifth-category fine for possession (Article 2(C)), up to eight years or a fifth-category fine for the Article 2(B)/(D) conduct (including preparation, sale, supply, transport and manufacture), and up to twelve years or a fifth-category fine for import/export (Article 2(A)); Article 10(1) separately provides up to six months' detention or a fourth-category fine for non-intentional violation of Article 2. Article 1(2) equates salts with the substances, and Article 6 permits a ministerial exemption from Article 2, so the prohibition is subject to lawful exemption rather than a claim that no exception can ever exist. The current Wetten.nl metadata states the consolidated Opiumwet is valid from 9 July 2026 through the present and was modified 14 August 2026. The consolidated Opiumwet's legal history includes a 27 January 2026 Staatsblad amendment.

Classified as a Class A controlled substance, carrying the most severe legal penalties for possession and distribution in New Zealand.

5-MeO-DMT is listed in Norway's national narcotics list. Listed narcotics are subject to the regulation's prohibition and licensing controls for possession, manufacture, import, export, and other handling.

5-MeO-DMT is listed as a Group I-P psychotropic substance. Unauthorized possession of a psychotropic substance is a criminal offence under Poland's anti-drug law.

Became a controlled substance in October 2011 under federal drug legislation.

5-Methoxy-N,N-dimethyltryptamine is listed in the First Schedule to Singapore's Misuse of Drugs Act. The Act controls possession, manufacture, importation, exportation, trafficking, and consumption of scheduled drugs.

Since 28 March 2014, 5-MeO-DMT (O-methylbufotenin) is captured in Schedule 2 Part III as an ether of listed Bufotenine. The 2022 amendment retained this class-wide ether and homologue coverage when it substituted the schedules. Use, possession, and dealing—including manufacture, supply, importation, and sale—are prohibited except under the Act’s statutory medicinal and permit-based exceptions.

5-MeO-DMT is expressly listed in Schedule 3 as a psychotropic drug. Its manufacture, handling, possession, import, and export are controlled under the Narcotics Control Act.

Specifically named as a controlled substance in Verzeichnis E (Schedule E) of Swiss narcotics legislation.

5-MeO-DMT is item 79 of the list annexed to Council of Ministers Decision No. 2013/5742, which subjects it to Law No. 2313 on the Control of Narcotic Drugs. The decision has applied since publication in Official Gazette No. 28893 on 25 January 2014. Unlicensed manufacture, import, export, sale, transfer, transport, storage, and possession of narcotic or stimulant substances are criminal offences under Articles 188 and 191 of the Turkish Penal Code.

Listed as a controlled substance under Ukrainian drug legislation.

5-MeO-DMT is listed as a psychotropic substance in Table 5 of the Federal Decree-Law. The Decree-Law prohibits import, export, transport, production, manufacture, possession, and other dealings in substances in Table 5 except as authorized.

Controlled under the Misuse of Drugs Act 1971 as a Class A drug because it is an ether of 5-HO-DMT (bufotenin), which falls under the tryptamine catch-all clause.⁸⁷ Buying or possessing without a license is illegal.

5-MeO-DMT is included in List I of Chile's psychotropic-substances regulation. Decree No. 73 added the substance to the controlled list and took effect on publication in the Official Gazette.

Classified under the Act on the Prohibition of Certain Goods Dangerous to Health (Lagen om förbud mot vissa hälsofarliga varor) via regulation SFS 2004:696 effective October 1, 2004. Sale and possession are prohibited.

Not scheduled under the Controlled Drugs and Substances Act.¹⁸ Possession and sale are not specifically prohibited under federal drug law.

5-MeO-DMT is not listed in Annex 1 to Ministry of Health Resolution 0116 of 2026, Colombia’s current controlled-substances list. The Annex separately lists DMT as 3-[2-(dimetilamino)etil]indol in Lista Verde, Lista I, but assigns no list to 5-MeO-DMT. Annex 4 extends listed substances only to salts, hydrates, and stereoisomers within the specific chemical designation, not to structural analogues.

5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine; O-methylbufotenine) is not expressly listed in any of the eight schedules of the current Regulation No. 463/2013 Coll. Czech Annex 4 names DMT and several other 5-MeO tryptamines separately, and extends coverage only to stereoisomers and salts/esters of listed substances; that wording does not make 5-MeO-DMT a DMT entry or a generic tryptamine analogue. Accordingly, the schedule status is unscheduled; this does not mean that possession, sale, import or other conduct is generally lawful. Other Czech legal regimes and fact-specific rules may still apply.

5-MeO-DMT is not included in the Schedule to the Narcotic Drugs and Psychotropic Substances Act, 1985. The Act defines a psychotropic substance as one included in that Schedule and contains no general analogue or blanket new-psychoactive-substance category. The Act's NDPS prohibitions on psychotropic substances therefore do not apply to 5-MeO-DMT solely on the basis of its relationship to N,N-dimethyltryptamine (DMT).

As of 28 November 2025, 5-MeO-DMT is not listed in Indonesia’s current narcotics classifications. The annex separately lists N,N-dimethyltryptamine (DMT) as a Class I narcotic under its distinct chemical name, rather than 5-MeO-DMT. Its residual entry extends only to salts of the narcotics listed in the class, not structural analogues. 5-MeO-DMT is also absent from the current psychotropics classifications.

The official Romanian schedule does not prohibit 5-MeO-DMT under a controlled-substance analogue act from February 2010. The ANMDMR consolidation incorporates amendments through Legea nr. 30/25.03.2025 and defines nationally controlled substances as those in Tables I-IV; it classifies only Tables I-II drugs as high-risk. Tables I-IV do not list the exact 5-MeO-DMT identity or PubChem synonyms, while DMT and 5-MeO-DALT appear as separate Table I entries. The schedule's closing generic note expressly covers salts and conditioned products containing listed substances, but does not establish an analogue-structure rule. The classification is unscheduled on this schedule, without establishing unrestricted legality or resolving any fact-specific application of other Romanian product or psychoactive-effects laws. The Law 143 penalties apply to listed high-risk drugs, not to the exact 5-MeO-DMT compound merely because DMT is listed. The ANMDMR index and consolidated PDF were current as of 28.08.2026; the index contains no later schedule amendment.