5-MeO-DMT
5-Methoxy-N,N-dimethyltryptamine
The God Molecule, Toad, Jaguar, O-methylbufotenin, Mebufotenin
Psychotria viridis; Mimosa tenuiflora
5-MeO-DMT is a naturally occurring psychedelic of the tryptamine class, found in numerous plant species and in the venom of the Colorado River toad (Incilius alvarius).1 It has been used in South American shamanic snuff preparations for centuries and was first identified in the plant Dictyoloma incanescens.1 Reputed to produce among the most powerful and intense psychedelic states within its class,1 it is considerably more potent by weight than its close relative DMT — a confusion between the two can lead to dangerous overdoses.
Contents
Dosage & Duration
Dosage
Threshold1-2 mg
Light2-5 mg
Moderate5-10 mg
Strong10-20 mg
Heavy20+ mg
Doses of 20-30 mg have been associated with psychological and mental difficulties lasting several weeks.
Duration?
Onset5-60 seconds
Come Up30-60 seconds
Peak5-15 minutes
Offset10-20 minutes
After Effects15-60 minutes
Total20-40 minutes
Subjective Effects
In comparison to its often relatively mild accompanying cognitive and visual effects, 5-MeO-DMT seems to have by far the most proportionally intense and overwhelming physical sensations found within the known psychedelic experience.
Physical
The physical effects of 5-MeO-DMT can be broken down into ten components all of which progressively intensify proportional to dosage.
Cognitive
Visual
Distortions
Enhancements
Geometry
The visual geometry that is present throughout this trip does not usually occur and never extends beyond level 7 at its highest state. It is very similar to DMT although significantly smaller in size and more likely to manifest in darkness or without distractions. In terms of appearance, it can be comprehensively described through its variations as intricate in complexity, abstract in form, equally organic and digital in feel, structured in organization, brightly lit, multicoloured in scheme, glossy in shading, equal in sharp and soft edges, small in size, fast in speed, smooth in motion, equal in rounded and angular corners, immersive in depth and consistent in its intensity.
Auditory
The auditory effects of 5-MeO-DMT are common in their occurrence and exhibit a full range of effects.
Reagent Testing
Loading reagent data
Expected colorimetric results are being prepared.
Pharmacology
Pharmacodynamics
5-MeO-DMT acts as a non-selective serotonin receptor agonist with activity at the 5-HT1A, 5-HT2A, 5-HT2B, and 5-HT2C receptors.23 It displays approximately 1,000-fold greater affinity for the 5-HT1A receptor compared to the 5-HT2A receptor4 and potently suppresses the firing of dorsal raphe serotonin neurons.5 Beyond the serotonin system, 5-MeO-DMT is an agonist at melatonin MT1 and MT2 receptors. It also functions as a weak serotonin reuptake inhibitor (IC50 of 2,184 nM)6 but does not appear to act as a monoamine releasing agent.6
Pharmacokinetics
5-MeO-DMT is lipophilic and is thought to readily cross the blood-brain barrier.7 It undergoes O-demethylation by CYP2D6 to produce the active metabolite bufotenin.7 Monoamine oxidase inhibitors substantially reduce its metabolism, prolonging its activity and allowing it to become orally active.7 The elimination half-life following sublingual administration is approximately 28 minutes.
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Full Tolerance
Develops almost immediately after a single dose, greatly diminishing effects if one attempts to redose.
Baseline Reset
Returns to baseline within 2 hours in the absence of further consumption. Some sources suggest full tolerance reset occurs within 24 hours.
Half Tolerance
Approximately 1 hour
Harm Potential
Addiction & Dependence
Psychological
Extremely Low5-MeO-DMT is considered non-addictive with low abuse potential. Animal self-administration studies, which predict abuse liability, have been unsuccessful, indicating it lacks the pharmacology to initiate or maintain dependence.1
Physical
Extremely Low5-MeO-DMT is not physically addicting and does not produce physical dependence or withdrawal symptoms.
Toxicity
Respiratory
Smoking 5-MeO-DMT can cause throat and lung irritation due to the harsh nature of the vapor; severe lung pain has been reported in rare cases, though risk is generally low given the small doses typically used.
Cardiovascular
Acute cardiovascular effects including increased heart rate and elevated blood pressure occur during intoxication; possible cardiotoxic properties have been suggested but remain unconfirmed.2
Psychosis Risk
5-MeO-DMT can trigger latent psychoses in predisposed individuals and may cause lasting psychological effects including PTSD-type reactions, chronic anxiety, and difficulty integrating experiences.1 Documented cases include multi-day psychotic episodes requiring antipsychotic medication, typically associated with high doses.2 Permanent disturbances in self- and reality recognition are possible, and extreme caution is warranted for people with schizophrenia in their family history or early-onset mental illness.
Seizure Risk
Convulsions have been documented in at least one case involving combination with MAOIs,7 but seizure risk from 5-MeO-DMT alone is not established in the available literature. Muscle contractions, spasms, and tremors are reported physical effects.
History & Culture
Traditional Use
5-MeO-DMT has a lengthy history of human use spanning over a millennium. Archaeological evidence from a burial site in Northern Chile, dated to approximately the 8th century A.D., revealed snuffing paraphernalia alongside traces of N,N-DMT, 5-MeO-DMT, and bufotenine. Additional archaeological sites…
Legality
International
5-MeO-DMT is not internationally scheduled under the 1961, 1971, or 1988 UN drug conventions. It is absent from the INCB Yellow List for the 1961 Convention, the INCB Green List for the 1971 Convention, and the INCB Red List of Tables I and II to the 1988 Convention.
By Country
United StatesIllegalSchedule I
Added to Schedule I of the Controlled Substances Act effective January 19, 2011.71 Manufacturing, buying, possessing, or distributing without a DEA license is illegal. Several states including Florida, Louisiana, Nebraska, Oklahoma, and South Dakota had independently scheduled it prior to federal action.
By state
5-MeO-DMT is a federal Schedule I substance, and most states list it in their own schedules or adopt federal scheduling by reference. Pennsylvania and the Northern Mariana Islands do not include it in their controlled-substance schedules.
Northern Mariana IslandsNot schedulednot_scheduled
PennsylvaniaNot schedulednot_scheduled
AustriaIllegal (analog/blanket ban)
Neue-Psychoaktive-Substanzen-Verordnung (NPSV), Anlage II Z 6; Neue-Psychoaktive-Substanzen-Gesetz (NPSG) § 4101112
5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), when synthetically produced, is covered as a tryptamine derivative by Anlage II Z 6 of Austria’s Neue-Psychoaktive-Substanzen-Verordnung, a blanket category in force since 1 January 2012. For-profit production, import, export, supply, or procurement for psychoactive use is punishable under NPSG § 4 by up to two years’ imprisonment. The substance is subject to confiscation unless a lawful, non-psychoactive use is substantiated.
BrazilIllegalLista F2
Possession, production, and sale are prohibited under Portaria SVS/MS nº 344.
ChileRestrictedLista I
Decree No. 73 of 2014, amending Supreme Decree No. 405 of 198317
5-MeO-DMT is included in List I of Chile's psychotropic-substances regulation. Decree No. 73 added the substance to the controlled list and took effect on publication in the Official Gazette.
ColombiaNot scheduledResolución 0116 de 2026 del Ministerio…
5-MeO-DMT is not listed in Annex 1 to Ministry of Health Resolution 0116 of 2026, Colombia’s current controlled-substances list. The Annex separately lists DMT as 3-[2-(dimetilamino)etil]indol in Lista Verde, Lista I, but assigns no list to 5-MeO-DMT. Annex 4 extends listed substances only to salts, hydrates, and stereoisomers within the specific chemical designation, not to structural analogues.
DenmarkIllegalListe B
Legally restricted to medical or scientific purposes since December 2004. General possession and sale are prohibited.
FranceIllegalAnnexe IV
Décision du 12/05/2026 portant modification de la liste des substances classées comme stupéfiants262728
5-MeO-DMT, also called 5-méthoxy-N,N-diméthyltryptamine or méthylbufoténine, is classified as a narcotic in Annexe IV by the ANSM Decision of 12 May 2026. Since 10 June 2026, its production, manufacture, transport, import, export, possession, supply, transfer, acquisition, and use are prohibited unless expressly authorized.
GreeceIllegalΠίνακας Α
Law 3459/2006, Article 1(2), Table A (Government Gazette A 103/25 May 2006), preserved by Article 99 of Law 4139/2013 (Government Gazette A 74/20 March 2013)3031
5-MeO-DMT is expressly listed in Table A (Πίνακας Α) of Article 1(2) of Law 3459/2006, a provision retained in force by Law 4139/2013; the listing has applied since 25 May 2006. Production, possession, transport, storage, supply, processing, circulation, and trafficking of Table A substances are the exclusive right of the State through the National Organisation for Medicines, and supply is limited to laboratories or hospitals conducting approved programmes. Unauthorised possession, manufacture, sale, distribution, import, export, and transport of scheduled narcotics constitute criminal drug trafficking.
IndonesiaNot scheduledPeraturan Menteri Kesehatan Nomor 15…
As of 28 November 2025, 5-MeO-DMT is not listed in Indonesia’s current narcotics classifications. The annex separately lists N,N-dimethyltryptamine (DMT) as a Class I narcotic under its distinct chemical name, rather than 5-MeO-DMT. Its residual entry extends only to salts of the narcotics listed in the class, not structural analogues. 5-MeO-DMT is also absent from the current psychotropics classifications.
JapanIllegal指定薬物
Ministerial Ordinance designating substances under the Pharmaceuticals and Medical Devices Act43
Controlled as a Shitei-Yakubutsu (Designated Substance) under the Pharmaceutical Affairs Law. Possession and sale are illegal without authorization.
NetherlandsAmbiguous (potentially List I)
While not explicitly named in the Opium List, it may be considered a List I controlled substance as an ether of bufotenin. Despite this legal ambiguity, it reportedly remains available through online research chemical vendors.
NorwayIllegal
5-MeO-DMT is listed in Norway's national narcotics list. Listed narcotics are subject to the regulation's prohibition and licensing controls for possession, manufacture, import, export, and other handling.
RomaniaIllegal (Analogue Act)
Prohibited under the controlled substance analogue act since February 2010. Production and sale are illegal.
SingaporeIllegalFirst Schedule
5-Methoxy-N,N-dimethyltryptamine is listed in the First Schedule to Singapore's Misuse of Drugs Act. The Act controls possession, manufacture, importation, exportation, trafficking, and consumption of scheduled drugs.
South KoreaIllegalSchedule 3
Enforcement Decree of the Narcotics Control Act, Schedule 359
5-MeO-DMT is expressly listed in Schedule 3 as a psychotropic drug. Its manufacture, handling, possession, import, and export are controlled under the Narcotics Control Act.
SwitzerlandIllegalVerzeichnis e
Specifically named as a controlled substance in Verzeichnis E (Schedule E) of Swiss narcotics legislation.
UkraineIllegalСписок I
Cabinet of Ministers Resolution No. 770 of 6 May 200066
Listed as a controlled substance under Ukrainian drug legislation.
United KingdomIllegal (analog/blanket ban)Class A
Misuse of Drugs Act 1971, Schedule 268
Controlled under the Misuse of Drugs Act 1971 as a Class A drug because it is an ether of 5-HO-DMT (bufotenin), which falls under the tryptamine catch-all clause.68 Buying or possessing without a license is illegal.
AustraliaSchedule 9
Classified as a prohibited substance under the Poisons Standard as a structural analog of N,N-dimethyltryptamine (DMT). No therapeutic use is recognized.
BelgiumUncontrolled (unconfirmed)
Reportedly not explicitly controlled under Belgian law, although DMT itself is scheduled under the 1971 UN Convention. This status remains unconfirmed.
CanadaNot scheduled
Controlled Drugs and Substances Act15
Not scheduled under the Controlled Drugs and Substances Act.16 Possession and sale are not specifically prohibited under federal drug law.
ChinaIllegal增补目录
Supplemental Catalogue of Non-Medical Narcotic Drugs and Psychotropic Substances18
Classified as a controlled substance effective October 2015 under national drug regulations.
Czech RepublicLegal
Not listed in Government Regulation n. 463/2013 (Nařízení vlády č. 463/2013 Sb), making it legal to possess and sell.
FinlandIllegal
5-MeO-DMT is listed as a narcotic in Government Decree 543/2008. Its manufacture, import, export, sale, and possession require the authorisation provided by Finland's narcotics legislation.
GermanyIllegalAnlage I
Betäubungsmittelgesetz, Anlage I29
5-MeO-DMT is listed in Anlage I to the Betäubungsmittelgesetz. Anlage I substances are non-marketable narcotics and may be handled only under the statutory authorisation framework.
IndiaNot scheduled
5-MeO-DMT is not included in the Schedule to the Narcotic Drugs and Psychotropic Substances Act, 1985. The Act defines a psychotropic substance as one included in that Schedule and contains no general analogue or blanket new-psychoactive-substance category. The Act's NDPS prohibitions on psychotropic substances therefore do not apply to 5-MeO-DMT solely on the basis of its relationship to N,N-dimethyltryptamine (DMT).
IsraelIllegal (analog/blanket ban)Part A, Section B
Since the 2017 amendment to the First Schedule, 5-MeO-DMT is covered as a structural derivative of N,N-dimethyltryptamine in Part A, Section B of the Dangerous Drugs Ordinance [New Version], 5733–1973. Possession, use, manufacture, import, export, trade, and supply of a dangerous drug are prohibited unless authorized by the Ordinance, its regulations, or a licence from the Director.
LatviaIllegal (analog/blanket ban)I saraksts
5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) is covered as a tryptamine derivative by List I of Annex 2 to the Law On the Coming into Force and Application of the Criminal Law. List I covers prohibited especially dangerous narcotic substances and allied psychotropic substances, and its generic tryptamine definition encompasses the substance’s substituted indole ring and N,N-dimethyl amino group. The current statutory Annex took effect on 1 June 2021. Latvia’s Criminal Law provides penalties for unauthorised manufacture, acquisition, possession, transport, forwarding, and sale of narcotic or psychotropic substances.
New ZealandIllegalClass A
Misuse of Drugs Act 1975, Schedule 147
Classified as a Class A controlled substance, carrying the most severe legal penalties for possession and distribution in New Zealand.
PolandIllegalI-P
Regulation of the Minister of Health of 17 August 2018 on the list of psychotropic substances, narcotic drugs and new psychoactive substances, consolidated 20245051
5-MeO-DMT is listed as a Group I-P psychotropic substance. Unauthorized possession of a psychotropic substance is a criminal offence under Poland's anti-drug law.
RussiaIllegal (analog/blanket ban)Список I
Government Resolution No. 681 of 30 June 199852
Became a controlled substance in October 2011 under federal drug legislation.
South AfricaIllegal (analog/blanket ban)Schedule 2 Part III
Drugs and Drug Trafficking Act 140 of 1992, as amended by the Drugs and Drug Trafficking Amendment Act 14 of 202255565758
Since 28 March 2014, 5-MeO-DMT (O-methylbufotenin) is captured in Schedule 2 Part III as an ether of listed Bufotenine. The 2022 amendment retained this class-wide ether and homologue coverage when it substituted the schedules. Use, possession, and dealing—including manufacture, supply, importation, and sale—are prohibited except under the Act’s statutory medicinal and permit-based exceptions.
SwedenRestrictedFörordning (1999:58) om förbud mot vissa…
Förordning (1999:58) om förbud mot vissa hälsofarliga varor60
Classified under the Act on the Prohibition of Certain Goods Dangerous to Health (Lagen om förbud mot vissa hälsofarliga varor) via regulation SFS 2004:696 effective October 1, 2004. Sale and possession are prohibited.
TurkeyIllegalBazı Maddelerin 2313 Sayılı Uyuşturucu…
Bazı Maddelerin 2313 Sayılı Uyuşturucu Maddelerin Murakabesi Hakkında Kanun Hükümlerine Tabi Tutulması Hakkında Karar, No. 2013/5742636465
5-MeO-DMT is item 79 of the list annexed to Council of Ministers Decision No. 2013/5742, which subjects it to Law No. 2313 on the Control of Narcotic Drugs. The decision has applied since publication in Official Gazette No. 28893 on 25 January 2014. Unlicensed manufacture, import, export, sale, transfer, transport, storage, and possession of narcotic or stimulant substances are criminal offences under Articles 188 and 191 of the Turkish Penal Code.
United Arab EmiratesIllegalTable 5
Federal Decree-Law No. 30 of 2021 on Combating Narcotic Drugs and Psychotropic Substances67
5-MeO-DMT is listed as a psychotropic substance in Table 5 of the Federal Decree-Law. The Decree-Law prohibits import, export, transport, production, manufacture, possession, and other dealings in substances in Table 5 except as authorized.
References
Source Pages
Citations
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