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2C-B-FLY-NBOMe

2C-B-FLY-NBOMe molecule structure2C-B-FLY-NBOMe molecule structure
2-(8-Bromo-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b']difuran-4-yl)-N-(2-methoxybenzyl)ethanamine
NBOMe-2C-B-FLY, Cimbi-31, 2CBFly-NBOMe
hidden

2C-B-FLY-NBOMe is a synthetic psychedelic of the N-benzylated phenethylamine and benzodifuran classes. It functions as a serotonin receptor modulatorcitation needed and is structurally derived from the hallucinogen 2C-B, combining features of benzodifuran compounds like 2C-B-FLY with the N-benzyl substitution pattern characteristic of the NBOMe series. First discovered in 2002, it was researched by Ralf Heim at the Free University of Berlin and later investigated by David Nichols' team at Purdue University. It remains a poorly characterized research chemical.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~100 µg

Available documentation suggests a threshold dose in the range of approximately 100–200 µg when insufflated. Human data for this compound remain extremely limited, and there is insufficient evidence to establish intermediate or higher dose tiers with any confidence. Given the unknown safety profile, redosing should be avoided.

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

2C-B-FLY-NBOMe acts as a potent partial agonist at the serotonin 5-HT2A receptor, consistent with its classification as an N-benzylated phenethylamine psychedelic.citation needed

Pharmacokinetics

Controlled pharmacokinetic data are limited to animals. After a 1 mg/kg subcutaneous dose in adult male Wistar rats, peak measured concentrations occurred at 30 minutes in serum and 60 minutes in brain tissue; parent 2C-B-FLY-NBOMe remained detectable in brain tissue at 8 hours. In separate metabolism experiments, isolated human liver microsomes, rat urine, and Cunninghamella elegans produced 35 phase-I and nine phase-II metabolites. The principal detected transformations were mono- and poly-hydroxylation, O-demethylation, oxidative debromination, and, to a lesser extent, N-demethoxybenzylation, followed by glucuronidation and/or N-acetylation. These animal and in-vitro findings do not establish pharmacokinetic parameters or duration in humans.12

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

2C-T-x compounds5-MeO-xxT tryptaminesAmphetaminesCannabisCocaineDOx compoundsMAOIsMescalineNBOMe compounds
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Tolerance

Tolerance not written up yet

Harm Potential

Toxicity

Lethal Dosage

No lethal-dose or LD50 data were identified. More research is needed for this chemical, and general safety cautions apply.

History & Culture

2C-B-FLY-NBOMe was discovered in 2002 and subsequently researched by Ralf Heim at the Free University of Berlin.citation needed The compound was later investigated in greater detail by a research team at Purdue University led by pharmacologist David E. Nichols. Structurally, the substance represents a hybrid design that combines the rigid benzodifuran ring system characteristic of the FLY series with the N-benzyl substitution pattern found in NBOMe compounds.

Legality

International

As of 23 August 2026, the complete current INCB lists for the 1961, 1971, and 1988 Conventions contain no entry for 2C-B-FLY-NBOMe, NBOMe-2C-B-FLY, Cimbi-31, or 2CBFly-NBOMe. UNODC identifies 2CBFly-NBOMe as a distinct hybrid of the benzodifuranyl and NBOMe families; the Green List's NBOMe entries are the separately defined 25B-NBOMe, 25C-NBOMe, and 25I-NBOMe. The 2026 CND changes add N-pyrrolidino isotonitazene and N-desethyl etonitazene to Schedule I of the 1961 Convention and MDMB-FUBINACA to Schedule II of the 1971 Convention, with the latter taking effect on 25 November 2026; none covers this substance.

By Country

Illegal10
Argentina flagArgentinaIllegal (analog/blanket ban)
Australia flagAustraliaIllegal (analog/blanket ban)
Austria flagAustriaIllegal (analog/blanket ban)
Brazil flagBrazilIllegal (analog/blanket ban)
Canada flagCanadaIllegal (analog/blanket ban)
Germany flagGermanyIllegal (analog/blanket ban)
Netherlands flagNetherlandsIllegal (analog/blanket ban)
Singapore flagSingaporeIllegal (analog/blanket ban)
South Africa flagSouth AfricaIllegal (analog/blanket ban)
United Kingdom flagUnited KingdomIllegal
Controlled / restricted1
United States flagUnited StatesRestricted

References

Source Pages

  1. Bluelight: The Big & Dandy 2C-B-FLY-NBOMe thread
  2. Erowid: 2C-B-FLY vault
  3. TripSit Factsheets

Citations

  1. Kateřina Syrová, Klára Šíchová, Hynek Danda, Eva Lhotková, Pascal Jorratt, Nikola Pinterová-Leca, Čestmír Vejmola, Lucie Olejníková-Ladislavová, Kateřina Hájková, Martin Kuchař, Jiří Horáček, & Tomáš Páleníček. (2023). Acute pharmacological profile of 2C-B-Fly-NBOMe in male Wistar rats—pharmacokinetics, effects on behaviour and thermoregulation. https://doi.org/10.3389/fphar.2023.11204191
  2. 2C-B-Fly-NBOMe Metabolites in Rat Urine, Human Liver Microsomes and C. doi.org (n.d.). https://doi.org/10.3390/metabo111107751
  3. Portaria SVS/MS nº 344/1998, Anexo I, Lista F2, item d(1), as republished by RDC Anvisa nº 1.036/2026. anvisalegis.datalegis.net (n.d.). https://anvisalegis.datalegis.net/action/UrlPublicasAction.php?acao=abrirAtoPublico&num_ato=00001036&sgl_tipo=RDC&sgl_orgao=RDC/DC/ANVISA/MS&vlr_ano=2026&seq_ato=000&cod_modulo=134&cod_menu=16961
  4. Portaria SVS/MS nº 344/1998, Anexo I, Lista F2, item d(1), as republished by RDC Anvisa nº 1.036/2026. gov.br (n.d.). https://www.gov.br/anvisa/pt-br/assuntos/medicamentos/controlados/lista-substancias1
  5. Portaria SVS/MS nº 344/1998, Anexo I, Lista F2, item d(1), as republished by RDC Anvisa nº 1.036/2026. gov.br (n.d.). https://www.gov.br/anvisa/pt-br/assuntos/medicamentos/controlados/lista/arquivos-controlados/6537json-file-1/@@display-file/file1
  6. Controlled Drugs and Substances Act, Schedule III, item 35. laws.justice.gc.ca (n.d.). https://laws.justice.gc.ca/eng/acts/C-38.8/FullText.html1
  7. Neue-Psychoaktive-Substanzen-Verordnung (NPSV), Anlage II Nr. 2. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=200076421
  8. Neue-Psychoaktive-Substanzen-Verordnung (NPSV), Anlage II Nr. 2. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40261441/II_106_2024_Anlage_II.pdf1
  9. Neue-Psychoaktive-Substanzen-Verordnung (NPSV), Anlage II Nr. 2. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=200076051
  10. Neue-psychoaktive-Stoffe-Gesetz (NpSG), Anlage 1 Nr. 1 und § 3. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/anlage_1.html1

Further Reading

  1. PubMed: 36969854
  2. Richter LHJ et al. Tools for studying the metabolism of new psychoactive substances

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

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24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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