2C-B-FLY-NBOMe
2C-B-FLY-NBOMe is a synthetic psychedelic of the N-benzylated phenethylamine and benzodifuran classes. It functions as a serotonin receptor modulator12 and is structurally derived from the hallucinogen 2C-B, combining features of benzodifuran compounds like 2C-B-FLY with the N-benzyl substitution pattern characteristic of the NBOMe series. First discovered in 2002, it was researched by Ralf Heim at the Free University of Berlin and later investigated by David Nichols' team at Purdue University. It remains a poorly characterized research chemical.
Contents
Dosage & Duration
Dosage
Documentation indicates only a threshold range of approximately 100-200 ug. Extremely limited human data exists for this compound. Insufficient evidence to establish intermediate dose tiers. Avoid redosing due to unknown safety profile.
Subjective Effects
Reagent Testing
Loading reagent data
Pharmacology
Pharmacodynamics
2C-B-FLY-NBOMe acts as a potent partial agonist at the serotonin 5-HT2A receptor, consistent with its classification as an N-benzylated phenethylamine psychedelic.12
Pharmacokinetics
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Harm Potential
Toxicity
No lethal-dose or LD50 data were identified. More research is needed for this chemical, and general safety cautions apply.
History & Culture
2C-B-FLY-NBOMe was discovered in 2002 and subsequently researched by Ralf Heim at the Free University of Berlin.3 The compound was later investigated in greater detail by a research team at Purdue University led by pharmacologist David E. Nichols. Structurally, the substance represents a hybrid design that combines the rigid benzodifuran ring system characteristic of the FLY series with the N-benzyl substitution pattern found in NBOMe compounds.
Legality
By Country
References
Source Pages
Citations
- (January 2011). Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor. Journal of Computer-Aided Molecular Design, 25(1), 51–66. https://doi.org/10.1007/s10822-010-9400-212
- (April 2011). Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT (2A) agonist PET tracers. European Journal of Nuclear Medicine and Molecular Imaging, 38(4), 681–93. https://doi.org/10.1007/s00259-010-1686-812
- (2023). Acute pharmacological profile of 2C-B-Fly-NBOMe in male Wistar rats—pharmacokinetics, effects on behaviour and thermoregulation. https://doi.org/10.3389/fphar.2023.11204191
- (n.d.). The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014. UK Government. https://www.legislation.gov.uk/uksi/2014/1106/made1
- (n.d.). Regulated Drugs Rule. Vermont Department of Health. http://healthvermont.gov/regs/documents/regulated_drugs_rule_20160101.pdf1
Further Reading
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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