25D-NBOMe

2-(2,5-Dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine

2C-D-NBOMe, NBOMe-2C-D, Divination, N-Bomb

Psychoactive Class

Chemical Class

25D-NBOMe is a synthetic psychedelic of the substituted phenethylamine class¹, derived from 2C-D through the addition of an N-benzyl methoxy group¹. It was discovered in 2003 by Ralf Heim at the Free University of Berlin and emerged as a recreational substance around 2010 through online research chemical vendors. It acts as a potent partial agonist at the 5-HT2A receptor, producing primarily visual and stimulating effects with roughly sixteen-fold greater potency than its parent compound.

Dosage & Duration

Dosage

Threshold~100 ug

Light100-500 ug

Moderate500-1000 ug

Strong1000-1200 ug

Heavy1200+ ug

This substance must be administered sublingually, with an absorption period of approximately 15 to 25 minutes; swallowing renders it inactive. Users typically experience a pronounced metallic taste and numbness in the mouth that may persist for up to an hour. Doses in the heavy range present a serious risk of overdose and have been associated with deaths. Nasal insufflation is strongly advised against due to the rapid rate of absorption, the difficulty of accurately measuring such small quantities, and the significant potential for fatal overdose.

Duration

Onset20-40 minutes

Peak1-2 hours

Offset1-2 hours

After Effects6-24 hours

Total4-6 hours

Subjective Effects

Effects vary widely by individual, dose, and context.

Physical

The physical effects of 25D-NBOMe can be broken down into several components which progressively intensify proportional to dosage.

Perception of increased weight Tactile hallucinationsVasoconstriction Increased heart rate Pupil dilation Wakefulness

Cognitive

The cognitive effects of 25D-NBOMe are remarkably light and underwhelming in comparison to more traditional psychedelics. It is not uncommon for people to report feeling that their thought stream has maintained general normality in its specific style throughout moderate to high doses. At heavy doses, however, mild cognitive alterations become present; this dose seems to be lower in proportion to physical effects when compared to 25I-NBOMe.

Analysis enhancement Thought deceleration Time distortion Novelty enhancement Conceptual thinking Emotion enhancement Personal bias suppression Memory suppression Ego death

Visual

Distortions

Tracers After images Symmetrical texture repetition Colour shifting Diffraction

Enhancements

25D-NBOMe presents a mild array of possible visual enhancements.

Visual acuity enhancement Colour enhancement Pattern recognition enhancement

Geometry

The visual geometry that is present throughout this trip is often described as very similar in appearance to that of DOM. It can be comprehensively described as smooth and organic in style, simple in complexity, fine and zoomed out in detail, slow and fluid in motion, structured in shape, colourful in scheme, bright in colour, and rounded across its corners. In terms of its behaviour, 25D-NBOMe's geometry leads onto level 8A visual geometry with level 8B remaining so far unconfirmed within this substance. It also seems to consistently build up in visual intensity when the tripper stares at a central point. This eventually envelopes the visual field and creates the sensation that the tripper has broken through into a continuously shifting geometric landscape or structure with a vast sense of physical size attributed to it.

Hallucinatory States

25D-NBOMe is capable of producing a full range of hallucinatory states within the level 1 - 3 range extremely consistently within doses higher than of 2mg.

Transformations

Forked from Subjective Effect Documentation

by Josie KinsJune 2016.

Reagent Testing

Loading reagent data

Expected colorimetric results are being prepared.

Pharmacology

Pharmacodynamics

25D-NBOMe acts as a partial agonist at serotonin 5-HT2A receptors, with broader activity reported across the 5-HT2 receptor family.¹ The N-benzylmethoxy (NBOMe) substitution confers approximately sixteen-fold greater potency relative to its parent compound 2C-D. Rodent studies have also found that 25D-NBOMe increases dopaminergic signaling in the nucleus accumbens.²

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AMTLithiumPregabalin

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

AmphetaminesCocaineDXMTramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

2C-T-x compounds2C-x compounds5-MeO-xxT tryptaminesCaffeineCannabisDiphenhydramineDOx compoundsMAOIsMDMAMescalineMXE

TripSit

Tolerance

Full Tolerance

Develops immediately after use. The rapid onset of tolerance contributes to a self-regulating quality that makes compulsive use patterns difficult to maintain.

Cross Tolerance

Serotonergic psychedelics, Other 5-HT2A agonists

Baseline Reset

Approximately 2-3 weeks for tolerance to fully reset after a single experience.

Harm Potential

Addiction & Dependence

Psychological

Low

While formal studies are lacking, 25D-NBOMe appears to have self-regulating qualities due to rapid tolerance buildup lasting 2-3 weeks, which makes compulsive use difficult. However, animal studies have demonstrated reinforcing effects including conditioned place preference, self-administration, and increased dopaminergic signaling in the nucleus accumbens.²³

Toxicity

Cardiovascular

Acute cardiovascular stress including elevated blood pressure, tachycardia, abnormal heartbeat, and significant vasoconstriction occurs during intoxication;⁴⁵ at overdose levels, these effects can become dangerous and may progress to cardiac arrest.⁶

Psychosis Risk

Anxiety and paranoia occur more readily than with many classical psychedelics, possibly due to prominent stimulating properties. Overdose can produce confusion, delusions, panic attacks, and aggressive behavior. Feelings of impending doom may occur during comedowns or at high doses.

Seizure Risk

NBOMes are known to cause seizures and have shown a tendency to cause severe seizures.⁶⁵ Overdose is often accompanied by seizures.⁶ The unpredictable dose-response relationship increases seizure risk at doses that might otherwise be considered within normal range.

History & Culture

25D-NBOMe is a derivative of the phenethylamine psychedelic 2C-D, created through the addition of an N-benzyl methoxy group to the parent compound. The substance emerged on the designer drug market around 2010, appearing for sale online before formal scientific characterization had been…

Legality

International

25D-NBOMe is not listed under the 1961 Single Convention on Narcotic Drugs. It is not listed under the 1971 Convention on Psychotropic Substances. It is not listed under the 1988 Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.

By Country

United StatesUnscheduledCitation needed

Not specifically scheduled at the federal or state level. However, prosecution under the Federal Analogue Act may be possible when sold for human consumption due to structural and functional similarity to the controlled substance 2C-D.

AustriaRestrictedAnlage I

Neue-Psychoaktive-Substanzen-Gesetz, Anlage I⁹

Controlled under the Neue-Psychoaktive-Substanzen-Gesetz (New Psychoactive Substances Act). Possession, production, and sale are prohibited.

CanadaIllegalSchedule III

Controlled Drugs and Substances Act, Schedule III¹³

Considered a Schedule III substance under the Controlled Drugs and Substances Act as a derivative of 2,5-dimethoxyphenethylamine.¹⁴

FinlandRestrictedAnnex

Government Decree on Psychoactive Substances Banned from the Consumer Market¹⁶

Listed in the government decree on prohibited psychoactive substances in consumer markets.

GermanyRestrictedAnlage 1

Neue-psychoaktive-Stoffe-Gesetz (NpSG)^1819202122

25D-NBOMe is covered by Anlage 1 of Germany’s Neue-psychoaktive-Stoffe-Gesetz (NpSG) as a 2-phenethylamine-derived compound, a defined substance group encompassing its 2C-D scaffold and N-(2-methoxybenzyl) substitution. Under the current consolidated NpSG, last amended on 7 January 2026, section 3 prohibits trading, placing on the market, manufacturing, import, export, acquisition, possession, and administering covered substances to another person; section 4 criminalizes specified commercial, supply, manufacture, and import violations.

LatviaIllegalList I

Cabinet Regulation No. 847, Regulations Regarding Narcotic Substances, Psychotropic Substances and Precursors to be Controlled in Latvia²⁴

Classified as a Schedule I controlled substance under national drug legislation.

NorwayIllegalVedlegg I

Forskrift om narkotika (narkotikaforskriften)²⁷²⁸

25D-NBOMe is a narcotic drug in Norway under the Narcotics Regulation (Forskrift om narkotika). The regulation's Appendix I expressly lists 2C-D-NBOMe, the alternative name for 25D-NBOMe, and the listed substances are treated as narcotics. Unauthorised possession, manufacture, importation, exportation, acquisition, sale, and transfer of narcotics are prohibited under Norway's narcotics-control framework.

South KoreaIllegalSchedule 3

Narcotics Control Act Enforcement Decree³¹³²

25D-NBOMe is a psychotropic drug listed in Schedule 3 of the Narcotics Control Act Enforcement Decree. The listing identifies it as 25디-엔비오엠이 (25D-NBOMe) and gives its chemical name as 2-(2,5-dimethoxy-4-methylphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine. As a scheduled psychotropic drug, its manufacture, possession, use, import, export, sale, and other handling are prohibited except as authorized under the Narcotics Control Act.

SwitzerlandIllegalVerzeichnis E

Narcotics List Ordinance, List E³⁵

Specifically named as a controlled substance under Verzeichnis E of the Swiss narcotics scheduling system.

United KingdomIllegalClass A

Misuse of Drugs Act 1971, Schedule 2, Part I³⁶

Controlled as a Class A substance under the Misuse of Drugs Act 1971 via the N-benzylphenethylamine catch-all clause.³⁷ Initially placed under a Temporary Class Drug Order on June 10, 2013 before permanent scheduling.³⁸

AustraliaIllegalSchedule 9

Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026⁸

25D-NBOMe is captured in Schedule 9 as a substance structurally derived from methoxy-phenylethylamine. Schedule 9 classifies prohibited substances whose manufacture, possession, supply and use should be prohibited by law, except for approved medical or scientific research and analytical, teaching or training purposes; implementation varies between the states and territories.

BrazilIllegalLista F2

ANVISA RDC No. 970 of 19 March 2025, updating Annex I to SVS/MS Ordinance No. 344/1998¹⁰¹¹¹²

25D-NBOMe is listed in Lista F2, Brazil's list of prohibited psychotropic substances. Brazil's Drug Law prohibits, without authorization or contrary to legal or regulatory rules, producing, importing, exporting, selling, transporting, possessing, or supplying controlled drugs; the applicable schedule is Annex I to SVS/MS Ordinance No. 344/1998 as updated by ANVISA.

ChinaIllegalControlled list

Announcement on the Classification and Control of Non-medical-use Narcotic Drugs and Psychotropic Substances¹⁵

Designated as a controlled substance as of October 2015.

FranceIllegal (analog/blanket ban)Annexe IV

Arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants, annexe IV¹⁷

France classifies as narcotics every phenethylamine-derived molecule substituted on the phenyl ring, subject to the exceptions in the schedule. 25D-NBOMe is a substituted phenethylamine and is covered by that blanket classification. Its unauthorised possession, production, and supply are subject to the French narcotics-control regime.

JapanRestrictedDesignated drug

Ministerial Ordinance Designating Substances under the Pharmaceuticals and Medical Devices Act²³

Designated as a controlled substance effective March 25, 2015.

NetherlandsIllegal (analog/blanket ban)lijst IA

Opiumwet²⁵²⁶

25D-NBOMe is prohibited in the Netherlands as a substance derived from 2-phenethylamine under List IA of the Opium Act. Its 2-phenethylamine structure, substituted phenyl ring, and N-(2-methoxybenzyl) substituent fall within the List IA structural definition. The prohibition has applied since 1 July 2025 and covers import, export, preparation, processing, sale, supply, transport, possession, and manufacture, subject to the statutory exemptions.

PolandIllegalGrupa I-P

Rozporządzenie Ministra Zdrowia z dnia 17 sierpnia 2018 r. w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych (tekst jednolity: Dz. U. 2024 poz. 1139)²⁹³⁰

25D-NBOMe is listed as a psychotropic substance in Group I-P under the Minister of Health regulation. Under the Act on Counteracting Drug Addiction, unauthorised possession, manufacture, and trade in psychotropic substances are criminally controlled.

SwedenIllegalSchedule I

LVFS 2013:15, Medical Products Agency regulations on lists of narcotic drugs³³

Added to Schedule I (substances without recognized medical use) as of August 1, 2013, as published by the Medical Products Agency in regulation LVFS 2013:15.³⁴

TurkeyIllegal

Classified as a controlled drug. Possession, production, supply, and importation are prohibited.

References

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Citations

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25D-NBOMe

2-(2,5-Dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine

2C-D-NBOMe, NBOMe-2C-D, Divination, N-Bomb

Psychoactive Class

Psychedelic Hallucinogen

Chemical Class

Phenethylamine (N-benzylated)NBOMe