LSZ

Lysergic acid 2,4-dimethylazetidide

LA-SS-Az, Lambda, Diazedine

Psychoactive Class

Chemical Class

LSZ is a semi-synthetic psychedelic of the lysergamide class developed in the 2000s by a team led by David E. Nichols at Purdue University¹ as a rigid analog of LSD, with its diethylamide group constrained into an azetidine ring.¹ Like LSD, it is extremely potent and active in the microgram range.² It appeared on research chemical markets around 2012 and is commonly described as producing LSD-like effects with a somewhat more introspective character.

Dosage & Duration

Dosage

Threshold~10 μg

Light10-100 μg

Moderate100-250 μg

Strong250-400 μg

Heavy400+ μg

Dosage guidelines for LSZ remain provisional owing to the compound's limited history of human use. LSZ did not see broad availability until 2013, and the resulting documentation is sparse. Individual responses can differ considerably; some user accounts indicate that LSZ may be modestly more potent than LSD on a weight-for-weight basis, although this has not been conclusively verified.

Duration

Onset20-60 minutes

Come Up15-30 minutes

Peak3-5 hours

Offset2-3 hours

After Effects2-5 hours

Total6-10 hours

Subjective Effects

Effects vary widely by individual, dose, and context.

Forked from Subjective Effect Documentation work

by Josie KinsAugust 2016.

Reagent Testing

Loading reagent data

Expected colorimetric results are being prepared.

Pharmacology

Pharmacodynamics

LSZ acts as a non-selective serotonin receptor agonist with especially high affinity for the 5-HT2A, 5-HT2C, and 5-HT1A receptors¹³. It is a potent agonist of the 5-HT2A¹⁴ and 5-HT2C receptors with potency and efficacy comparable to LSD, though it has also been characterized as a 5-HT2A partial agonist. LSZ may be more potent than LSD at the 5-HT1A receptor, and it fully substitutes for LSD in rodent drug discrimination assays at approximately 1.8-fold greater potency⁴². The compound also interacts with dopamine receptors³ and has demonstrated anti-inflammatory effects in preclinical research.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Lithium

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Tramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

AmphetaminesCannabisCocaineDiphenhydramineMephedronePregabalin

TripSit

Tolerance

Full Tolerance

Tolerance to the effects of LSZ develops almost immediately after ingestion.

Baseline Reset

Approximately 7 days

Half Tolerance

Approximately 3 days

Cross Tolerance

Serotonergic psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

LSZ is not considered habit-forming and the desire to use it may actually decrease with repeated use. It is typically self-regulating in nature.⁵

Physical

Extremely Low

LSZ is not considered physiologically addictive. No physical dependence or withdrawal symptoms have been documented.⁵⁶

Psychosis Risk

Adverse psychological reactions including severe anxiety, paranoia, and psychosis are possible, particularly in individuals predisposed to mental illness. As a psychological amplifier, LSZ can intensify existing mental states and may produce paranoia or distressing experiences such as feelings of dying.

History & Culture

Development as a Research Tool

The development of LSZ traces back to efforts by David E. Nichols and colleagues at Purdue University to create conformationally restricted analogues of LSD for use as pharmacological research tools.¹ The goal was to better understand how LSD orients itself when binding…

Legality

International

Not scheduled under the UN Convention on Psychotropic Substances 1971

Not scheduled under the UN Single Convention on Narcotic Drugs 1961

By Country

United StatesUnscheduled (Federal Analogue Act applies)

LSZ is not specifically scheduled at the federal level. However, as a structural analogue of LSD, it may be prosecuted under the Federal Analogue Act when sold for human consumption or possessed with intent to ingest. No cases for simple possession alone have been reported.

GermanyNpSG (Neue-psychoaktive-Stoffe-Gesetz)

Controlled under the New Psychoactive Substances Act as of July 18, 2019.¹⁰ Production, import with intent to market, administration to others, and trading are punishable offenses. Possession is prohibited but not subject to criminal penalty.

LatviaIllegal (LSD analogue)

Controlled as a structural analogue of LSD under an amendment enacted on June 1, 2015. Although not officially scheduled by name, analogue provisions make it a controlled substance.

SwitzerlandControlled (Verzeichnis E)

Specifically named and added to Verzeichnis E (Schedule E) of the controlled substances ordinance as of December 1, 2015.¹²

United KingdomClass A (Schedule 1)

Specifically named as a controlled substance under the Misuse of Drugs Act 1971 as of January 7, 2015.¹³ As a Class A substance, it carries the most severe penalties for possession, supply, and production.

DenmarkIllegal

Specifically named on the list of controlled substances as of August 25, 2015. Possession, distribution, and manufacture are prohibited.

JapanControlled

Regulated under the Pharmaceutical Affairs Law (Pharmaceutical and Medical Device Act). Possession and sale are illegal without proper authorization.

SwedenControlled substance

Classified as a narcotic substance as of January 26, 2016, following its emergence on the designer drug market.¹¹ Manufacturing, trade, and possession are prohibited.

TurkeyIllegal

Classified as a controlled drug under national drug legislation. Possession, production, supply, and importation are prohibited.

References

Source Pages

Citations

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LSZ

Lysergic acid 2,4-dimethylazetidide

LA-SS-Az, Lambda, Diazedine

Psychoactive Class

Psychedelic

Chemical Class

Lysergamide