2C-T-7
2C-T-7 is a 2C-x substituted phenethylamine psychedelic with both psychedelic and entactogenic properties. Alexander Shulgin developed it, later included it in PiHKAL, and it appeared in the scientific literature around 1990. He counted it among his "magical half-dozen" - the phenethylamines he regarded as most significant. The compound is especially sensitive to dose, and users often describe prominent visuals alongside a heavy somatic load.
Contents
Dosage & Duration
Dosage
Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
Cognitive
The head space of 2C-T-7 is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.
Visual
Geometry
The visual geometry of 2C-T-7 can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and equally rounded and angular in their corners. They give off a contradictory natural and synthetic feel with slightly more mystical and shamanic undertones to them in comparison to other phenethylamines. At higher dosages they are equally likely to result in states of Level 7A visual geometry and Level 7B. The visual geometry is extremely similar to 2C-E and 2C-P and can be described as equal in intensity or complexity.
Hallucinatory States
2C-T-7 produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics, particularly in comparison to other substances within the phenethylamine family.
Auditory
The auditory effects of 2C-T-7 are more common in their occurrence than many more commonly used psychedelics.
Reagent Testing
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Pharmacology
Pharmacodynamics
2C-T-7 acts as a partial agonist at the serotonin 5-HT2A receptor, which is considered the primary mechanism responsible for its psychedelic effects.12 The 2,5-desmethoxy derivative of 2C-T-7 has been shown to be a moderate monoamine oxidase A (MAO-A) inhibitor, and 2C-T-7 itself is widely thought to possess some degree of MAO-A inhibitory activity as well, though this has not been directly confirmed for the parent compound.
Pharmacokinetics
2C-T-7 is metabolized by the monoamine oxidase enzymes MAO-A and MAO-B.3
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Serotonergic psychedelics
Harm Potential
Addiction & Dependence
Psychological
Extremely Low2C-T-7 is not habit-forming and is unlikely to cause psychological dependence. The desire to use it often decreases with repeated use, and it is described as self-regulating by most users.
Physical
Extremely Low2C-T-7 is not physically addicting. Withdrawal effects following discontinuation have not been reported.
Toxicity
Insufflation of 2C-T-7 causes intense burning pain lasting 5-15 minutes, leaves an unpleasant drip, and can lead to sinus and throat infections with repeated use; oral administration does not carry this risk.
Psychosis Risk
At high doses, 2C-T-7 can produce severe dissociation and delirium4 characterized by complete disorientation, memory loss, confusion about having ingested a substance, and in some cases belligerent or violent behavior. These effects are dose-dependent and primarily associated with doses exceeding typical recreational ranges, particularly via insufflation. At typical oral doses, the headspace is described as relatively clear and insightful. Individuals with a family history of schizophrenia or early onset mental illness are advised to exercise extreme caution as psychedelics may trigger latent psychological conditions.
Seizure Risk
Muscle tremors and convulsions are listed among possible negative effects.45 Individuals with pre-existing seizure or convulsive disorders are warned they may be at elevated risk when using this substance.
History & Culture
Discovery and Development
2C-T-7 was developed around 1980 by Alexander Shulgin and Peyton Jacob III as part of Shulgin's extensive research program into substituted phenethylamines. The compound was first described in scientific literature by Myron Stolaroff by 1990, with more detailed characterization published by Shulgin…
Trip Reports
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Legality
International
2C-T-7 is not listed under the 1961 Single Convention on Narcotic Drugs. It is listed in Schedule II of the 1971 Convention on Psychotropic Substances. It is not listed under the 1988 Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.
By Country
References
Source Pages
Citations
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- (May 2018). Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs). Neuropharmacology, 134(Pt A), 141–148. https://doi.org/10.1016/j.neuropharm.2017.07.0121
- (January 2007). Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series). Biochemical Pharmacology, 73(2), 287–297. https://doi.org/10.1016/j.bcp.2006.09.0221
- (n.d.). == Interactions == {{See also|Psychedelic drug#Interactions|Trip killer#Serotonergic psychedelic antidotes}} 2C-T-7 is [[drug metabolism|metabolized]] by the [[monoamine oxidase]]. https://doi.org/10.1007/s13181-013-0295-x12
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Further Reading
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