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2C-T-4

2,5-Dimethoxy-4-isopropylthiophenethylamine

T-4

Psychoactive Class

Psychedelic

Chemical Class

2C-X Phenethylamine (substituted)

2C-T-4 is a synthetic psychedelic of the substituted phenethylamine and 2C-x families.¹ First described by Alexander Shulgin and colleagues in 1991² and later detailed in his book PiHKAL,³ it is an orally administered research chemical. Compared to more commonly encountered members of the 2C-T-x series such as 2C-T-2 and 2C-T-7, it is distinguished by a notably longer onset and duration of effects.³

Dosage & Duration

Dosage

Threshold~5 mg

Light5-10 mg

Moderate10-15 mg

Strong15-20 mg

Heavy20+ mg

Individual sensitivity to 2C-T-4 varies substantially, with some users reporting highly intense effects at doses as low as 12 mg. The onset of effects may be gradual, potentially requiring up to two hours to reach full intensity.

Duration

Onset30-120 minutes

After Effects4-8 hours

Total10-18 hours

Subjective Effects

2C-T-4 produces a long, gradually unfolding psychedelic experience with an onset that can stretch over three hours, followed by a decline as gradual and gentle as the climb. The character of the experience is dominated by mental clarity, insight, and a calm, benign emotional tone, with visual effects that are relatively modest for the intensity of the state. At a dose of 12 mg it has been documented as capable of producing a full 'plus-four' peak experience, and residual stimulation can persist into the night, interfering with sleep. Higher doses can introduce a mentally difficult period during the come-up, and some experiences shift toward dark, dysphoric territory.

Physical

The body load is generally comfortable, with less of the pushy body-energy that makes related compounds difficult for some, though residual chemical push can cause tiredness and sleeplessness at the end of the experience. Persistent cold extremities and an uncertain stomach when moving around have been reported, along with slowness and a need for napping the following day.

Stimulation

Cognitive

The headspace is notably rational, good-humored, and lucid, with growing clarity of thought and impressive insights; users remain capable of phone calls and other everyday tasks at moderate doses. This calm can give way to difficulty at higher doses, including feeling locked into illogical patterns of thought or a darkening of mood that resists reasoning away.

Emotional

Enhancements

Visual

Visual effects are mild relative to the depth of the mental state; some experiences feature no particular visuals at all, while others include brilliant color trails.

Enhancements

Auditory

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)

Mecke(ME)

Mandelin(MD)

Robadope(RB)

PROtestkit.eu

Pharmacology

Pharmacodynamics

In a receptor and transporter panel using cells expressing human targets, 2C-T-4 showed a predominantly serotonergic profile, including potent partial agonism at 5-HT2A and partial agonism at 5-HT2B, together with binding at 5-HT2C, 5-HT1A and adrenergic receptors. The same study found no potent interaction with monoamine transporters and interaction with rodent, but not human, TAAR1. These are in-vitro findings and do not by themselves establish human receptor occupancy, clinical potency or safety. [S1]

Pharmacokinetics

Human pharmacokinetics and metabolism have not been established for 2C-T-4 in the reviewed sources. A cited enzyme study found MAO-A and MAO-B involvement for several other 2C compounds, including 2C-T-2 and 2C-T-7, but did not test 2C-T-4; applying that result to 2C-T-4 remains an unverified class inference. [S2]

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AMTLithiumPCP

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

AmphetaminesCocaineDXMTramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

2C-x compounds5-MeO-xxT tryptaminesCannabisDOx compoundsMAOIsMDMAMescalineMXENBOMe compounds

TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Toxicity

Lethal Dosage

No lethal-dose or LD50 data were identified. MAOIs may potentiate 2C drugs and may result in overdose and serious toxicity; combining with MAOIs may create a medical emergency.

Gastrointestinal

A qualitative report described an unsettled stomach while moving around.⁴

Peripheral and sleep-related effects

Reports describe persistent cold feet, strong stimulation near bedtime, tiredness, reduced sleep, and next-day slowing with need for a nap.

History & Culture

2C-T-4 was first documented in the scientific literature by Alexander Shulgin and his colleagues in a 1991 journal article.² Later that same year, Shulgin provided a more comprehensive account of the compound in his book PiHKAL (Phenethylamines I Have Known…

Legality

By Country

United StatesIllegalSchedule I (DEA code 7532)

21 CFR § 1308.11(d)(43)¹¹

2C-T-4 is listed as a Schedule I hallucinogenic substance under 21 CFR § 1308.11(d)(43).

ChinaControlled substance

Added to the national list of controlled substances in October 2015. Manufacturing, distribution, and possession are prohibited.

GermanyIllegal (analog/blanket ban)2-Phenethylamin derivative

Neue-psychoaktive-Stoffe-Gesetz (NpSG), Anlage⁶⁷

2C-T-4 falls within the NpSG group for compounds derived from 2-phenethylamine: its phenyl ring bears methoxy and methylsulfanyl substituents permitted by the group definition. Section 3 prohibits trading, placing on the market, manufacturing, importing, acquiring, possessing, and administering covered substances, subject to the statute's stated exceptions.

SwedenIllegalhälsofarlig vara

Förordning (1999:58) om förbud mot vissa hälsofarliga varor⁹

2C-T-4 is expressly listed as a health-hazardous good in the appendix to Förordning (1999:58) om förbud mot vissa hälsofarliga varor. Section 2 of that regulation provides that goods in the appendix are health-hazardous goods under lagen (1999:42) om förbud mot vissa hälsofarliga varor.

CanadaSchedule III (CDSA)

Designated as a controlled substance under Schedule III of the Controlled Drugs and Substances Act effective October 31, 2016.⁵ Possession, trafficking, and production carry criminal penalties.

DenmarkSchedule B

Listed as a Schedule B controlled substance under Danish drug control legislation. This classification restricts possession and distribution.

NorwayIllegal2C-T-4

Forskrift om narkotika (narkotikaforskriften), Narkotikalisten⁸

Norway’s Narkotikalisten expressly lists 2C-T-4 under the chemical name 2,5-dimetoksy-4-isopropyltiofenetylamin. The substance is therefore a named narcotic under the narcotics regulation, rather than being classified solely through an analogue provision.

UkraineIllegal (analog/blanket ban)Table I · List 2

Cabinet of Ministers Resolution No. 770 (List of narcotic drugs, psychotropic substances and precursors)¹⁰

Ukraine’s official controlled-substance list places 2C-T-2 and 2C-T-7 in List I, Schedule No. 2, for especially dangerous psychotropic substances whose circulation is prohibited. The list’s note also includes homologs of listed narcotic drugs and psychotropic substances where such homologs can exist, unless separately excluded. 2C-T-4 is treated as a homolog of listed 2C-T-2 under that provision.

References

Source Pages

Citations

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2C-T-4

2,5-Dimethoxy-4-isopropylthiophenethylamine

T-4

2C-T-4