2C-T-2

2,5-Dimethoxy-4-ethylthiophenethylamine

Rosy

Psychoactive Class

Chemical Class

2C-T-2 is a synthetic psychedelic of the substituted phenethylamine class and a member of the 2C-x family¹, derived from systematic modification of the mescaline molecule. First synthesized by Alexander Shulgin in 1981 and later described in his book PiHKAL², it is one of his "magical half-dozen" — his self-rated most important phenethylamine compounds. 2C-T-2 is notably dose-sensitive and recognized for its strong visual effects and intense body load².

Dosage & Duration

Dosage

Threshold~3 mg

Light3-10 mg

Moderate10-20 mg

Strong20-25 mg

Heavy25+ mg

Onset can be slow, with some reports describing an hour or more before effects fully develop.

Duration

Onset30-60 minutes

Peak2.5-5 hours

Offset1-2 hours

After Effects2-4 hours

Total5-10 hours

Subjective Effects

Effects vary widely by individual, dose, and context.

Physical

Tactile enhancementStomach cramps Vasoconstriction Temperature regulation loss

Cognitive

The head space of 2C-T-2 is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.

Current mind state enhancement Thought acceleration Feelings of fascination, importance and awe Time distortionPersonal bias suppression Conceptual thinking Ego suppression, loss and death Thought loops Feelings of interdependent opposites Delusions Unity and interconnectedness

Visual

Distortions

Tracers After images Symmetrical texture repetition Colour shifting Scenery slicing

Enhancements

Visual acuity enhancement Colour enhancement Pattern recognition enhancement

Geometry

The visual geometry of 2C-T-2 can be described as somewhat similar in appearance to that of ayahuasca, psilocin, and 4-AcO-DMT, with mystical and shamanic undertones which combine with synthetic digital undertones reminiscent of LSD or 2C-E. 2C-T-2's geometry can be comprehensively described as intricate in complexity, abstract in form, organic but somewhat synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, rounded in edges, large in size, fast in speed, smooth in motion, mostly angular in corners, immersive in depth and consistent in intensity. The visuals have a contradictory 'natural' and 'synthetic' feel to them which is reminiscent of DOC or 2C-P. Higher dosages are more likely to result in states of Level 8B visual geometry, but may also lead into Level 8A visual geometry.

Hallucinatory States

2C-T-2 produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics, particularly in comparison to other substances within the phenethylamine family.

Transformations

Auditory

The auditory effects of 2C-T-2 are more common in their occurrence than many more commonly used psychedelics.

Enhancements Distortions Hallucinations

Forked from Subjective Effect Documentation

by Josie KinsNovember 2014.

Reagent Testing

Loading reagent data

Expected colorimetric results are being prepared.

Pharmacology

Pharmacodynamics

2C-T-2 acts primarily as an agonist at serotonin 5-HT2 receptors, including the 5-HT2A, 5-HT2B, and 5-HT2C subtypes.³⁴ Partial agonist activity has been reported at the 5-HT2A receptor, and this activity is considered the most likely basis for its psychedelic effects.⁴ 2C-T-2 has also been shown to act as a partial agonist at adrenergic receptors. Based on structural analogy with other alkylthio-substituted phenethylamines that act as selective MAO-A inhibitors, 2C-T-2 has been speculated to possess monoamine oxidase inhibitory activity, though this has not been experimentally confirmed.

Pharmacokinetics

2C-T-2 is metabolized by the monoamine oxidase enzymes MAO-A and MAO-B.⁵

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AMTLithiumPCP

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

AmphetaminesCocaineDXMTramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

2C-x compounds5-MeO-xxT tryptaminesCannabisDOx compoundsMAOIsMDMAMescalineMXENBOMe compounds

TripSit

Tolerance

Full Tolerance

2C-T-2 can produce tolerance almost immediately after use. With consecutive daily use, roughly twice the dose may be needed each time to produce comparable effects.

Baseline Reset

Full baseline tolerance is typically restored after 5-7 days of abstinence, with some sources indicating complete return to baseline within 7 days.

Half Tolerance

Approximately 3 days after use, tolerance is estimated to reduce to half of its peak level.

Cross Tolerance

Serotonergic psychedelics, Other 5-HT2A agonists

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

2C-T-2 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating, though some individuals may use it more frequently than intended.

Physical

Extremely Low

2C-T-2 is not physically addicting. Withdrawal effects following discontinuation have not been reported.

Toxicity

Central Nervous System

In vitro studies have demonstrated potential neurotoxicity to serotonergic and dopaminergic neurons, though the concentrations used (>50 μM) are unlikely to translate to recreational use of the compound.

Psychosis Risk

As with other serotonergic psychedelics, 2C-T-2 may trigger latent psychological and mental conditions in predisposed individuals. Those with a family history of schizophrenia or early onset mental illness should exercise extreme caution. Severe intoxication has been associated with intense hallucinations, agitation, aggression, violence, and dysphoria.⁶

Seizure Risk

Seizures have been reported as part of severe intoxication with 2C series drugs.⁶ Individuals with a seizure or convulsive disorder may be at higher risk when taking 2C-T-2.

History & Culture

Discovery and Synthesis

2C-T-2 was first synthesized by Alexander Shulgin in 1981.⁷ That same year, Shulgin discovered its psychedelic properties through self-experimentation, establishing the compound's activity in humans.⁷

Legality

International

EU Council Decision 2003/847/JHA (December 6, 2003) - Member states required to implement control measures and criminal penalties for 2C-T-2, 2C-I, 2C-T-7, and TMA-2¹⁰

By Country

United StatesSchedule I

Federally scheduled under SEC. 1152 of the Food and Drug Administration Safety and Innovation Act of 2012 (S.3187), signed into law in July 2012.¹⁶ Possession, manufacture, and import are illegal. Additional state-level controls exist in Alabama (February 2013), Louisiana (June 2013), Oklahoma (May 2011), Pennsylvania, and Vermont (July 2012).

AustraliaSchedule 9

Classified as a prohibited substance under the Poisons Standard since 2005. Schedule 9 substances are those which may be abused or misused and are prohibited except for approved medical or scientific research, analytical, teaching, or training purposes with government authorization.

BelgiumIllegal

Added to the list of controlled psychotropic substances on November 8, 2004.

CanadaSchedule III (CDSA)

Controlled under the Controlled Drugs and Substances Act¹¹ as of October 31, 2016. Classified as a derivative of 2,5-dimethoxyphenethylamine.¹¹

DenmarkCategory B

Added to Category B of the controlled substances list on August 23, 2003.

FinlandNarcotic drug

Classified as a narcotic substance under Finnish drug control legislation.

ItalyTabella I

Added to Tabella I (the list of prohibited plants and substances) by Ministry of Health statement on January 11, 2005.

LatviaSchedule I

Listed as a Schedule I controlled substance under national drug legislation.

PortugalControlled substance

Law enacted in January 2005 to control 2C-T-2, 2C-I, 2C-T-7, and TMA-2.

SwedenSchedule I (Narcotic)

First regulated on April 1, 1999 under the Act on the Prohibition of Certain Goods Dangerous to Health (SFS 1999:58), making sale and possession illegal. Subsequently added to Schedule I of the Narcotic Drugs Punishments Act on March 16, 2004, as published in MPA regulation LVFS 2004:3.

United KingdomClass A

Controlled as a Class A substance under the Misuse of Drugs Act 1971 through the phenethylamine catch-all clause.¹⁴ All compounds featured in PiHKAL are prohibited. Class A carries the most severe penalties for possession, manufacture, and import.¹⁵

ArgentinaControlled substance

Listed as a controlled substance alongside other phenethylamines including 2C-B and 2C-I.

AustriaIllegal (SMG)

Prohibited under the Suchtmittelgesetz (Narcotics Act). Possession, production, and sale are illegal.

BrazilIllegal

Controlled as of February 18, 2014. Listed on Portaria SVS/MS nº 344, making possession, production, and sale illegal.

ChinaControlled substance

Added to the list of controlled substances as of October 2015.

EstoniaSchedule I

Added to Schedule I in February 2011 alongside several other phenethylamines and synthetic cannabinoids.

GermanyAnlage I BtMG

Listed in Anlage I (Schedule I) of the Betäubungsmittelgesetz (Narcotics Act)¹² since October 1998. Represents the highest level of control¹²; manufacturing, possession, import, export, purchase, sale, procurement, and dispensing without license are prohibited.

JapanDesignated Substance (Shitei-Yakubutsu)

Controlled under the Pharmaceutical Affairs Law. Possession and sale are illegal.

NetherlandsList I (Opiumwet)

The Netherlands was the first country to ban 2C-T-2, classifying it as a hard drug under List I of the Opium Law¹³ in April 1999. Unlicensed manufacture, sale, import, trade, and possession can be prosecuted.¹³

SlovakiaGrade 2

Added to Grade 2 (equivalent to Schedule II under the 1971 UN Convention on Psychotropic Substances) in October 2009.

SwitzerlandControlled (Verzeichnis D)

Specifically named as a controlled substance under Verzeichnis D of the Swiss narcotics legislation.

References

Source Pages

Citations

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2C-T-2

2,5-Dimethoxy-4-ethylthiophenethylamine

Rosy

Psychoactive Class

Psychedelic Entactogen (mild)

Chemical Class

2C-X Phenethylamine (substituted)