2C-G
2C-G is a psychedelic phenethylamine of the 2C-x family first synthesized by Alexander Shulgin.1 It is an exceptionally rare research chemical distinguished by its remarkably long duration of action1 and its unusual effect profile relative to other psychedelics. Unlike most substances in its class, 2C-G produces minimal to no visual activity1 and is instead characterized primarily as an insight-enhancing compound.1 It is structurally related to both 2C-D and Ganesha.1
Contents
Dosage & Duration
Dosage
Duration
Subjective Effects
2C-G is characterized as an insight-enhancing psychedelic in which the cognitive and introspective components dominate while visual effects remain muted or absent. The experience reaches a plateau within roughly two hours and then holds there for an exceptionally long time, with a total duration of 18 to 30 hours and residual aftereffects that can take a day or more to fully resolve. This extreme length is widely regarded as the primary factor limiting its use, despite the depth and quality of the headspace it produces.
Physical
Mental and physical stimulation are present, sometimes manifesting as a strong internal energy tremor even while the body remains generally at ease. A sensation of non-physical heat may be felt at onset, and stomach queasiness, appetite suppression, muscle tension, sweating and chills, and difficulty sleeping are reported.
Stimulation
Uncomfortable
Cognitive
The headspace is insight-oriented and introspective, with euphoria, enhanced empathy, and a softening of the ego commonly reported. Despite the depth of the mental effects, confusion can also occur.
Analytical
The insight-enhancing character of the experience is its defining feature, lending itself to introspective and potentially therapeutic use.
Emotional
Visual
Visual effects are characteristically weak for a phenethylamine psychedelic and are muted or absent for many users, though mild visuals can occur.
Tactile
Reagent Testing
Loading reagent data
Pharmacology
Pharmacodynamics
2C-G is a psychedelic phenethylamine of the 2C family reported to have pharmacodynamic properties similar to those of 2C-D. Specific receptor binding data and detailed mechanistic characterization are not well-documented in available literature.2
Pharmacokinetics
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Serotonergic psychedelics, Other 5-HT2A agonists
Harm Potential
Toxicity
A qualitative report described mild stomach queasiness during a prolonged plateau.1
Reported or listed effects include tremor, restlessness, sweating or chills, muscle tension, pupil dilation, and physical stimulation.
Reports describe insomnia, an 18- to 30-hour duration, delayed return to baseline, and needing additional time for recovery.
History & Culture
2C-G was first synthesized by Alexander Shulgin and initially described in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).1 The compound, also designated as 2C-G-0 or 3-methyl-2C-D, shares structural and pharmacodynamic characteristics with both 2C-D and its…
Legality
By Country
References
Source Pages
Citations
- Shulgin, Alexander T., & Shulgin, Ann. (1991). PiHKAL: A Chemical Love Story. Transform Press. https://www.thevespiary.org/library/Files_Uploaded_by_Users/llamabox/PiHKAL.pdf12345678910
- (n.d.). 2C-G. NCATS Inxight Drugs. https://drugs.ncats.io/drug/DTG7FMO01J1
- (n.d.). Controlled Drugs and Substances Act, Schedule III, Item 35 — 2C-phenethylamines. Government of Canada / Justice Laws Website. https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-11.html1
- (n.d.). Misuse of Drugs Act 1971, Schedule 2, Part I — Class A Drugs. UK Government / legislation.gov.uk. https://www.legislation.gov.uk/ukpga/1971/38/schedule/21
- (February 2023). Lists of: Scheduling Actions - Controlled Substances - Regulated Chemicals. Drug Enforcement Administration. https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf1
Further Reading
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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