2C-G
2C-G is a psychedelic phenethylamine of the 2C-x family first synthesized by Alexander Shulgin.citation needed It is an exceptionally rare research chemical distinguished by its remarkably long duration of action and its unusual effect profile relative to other psychedelics. Unlike most substances in its class, 2C-G produces minimal to no visual activity and is instead characterized primarily as an insight-enhancing compound.1 It is structurally related to both 2C-D and Ganesha.citation needed
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
2C-G is characterized as an insight-enhancing psychedelic in which the cognitive and introspective components dominate while visual effects remain muted or absent. The experience reaches a plateau within roughly two hours and then holds there for an exceptionally long time, with a total duration of 18 to 30 hours and residual aftereffects that can take a day or more to fully resolve. This extreme length is widely regarded as the primary factor limiting its use, despite the depth and quality of the headspace it produces.
Physical
Mental and physical stimulation are present, sometimes manifesting as a strong internal energy tremor even while the body remains generally at ease. A sensation of non-physical heat may be felt at onset, and stomach queasiness, appetite suppression, muscle tension, sweating and chills, and difficulty sleeping are reported.
Stimulation
Uncomfortable
Cognitive
The headspace is insight-oriented and introspective, with euphoria, enhanced empathy, and a softening of the ego commonly reported. Despite the depth of the mental effects, confusion can also occur.
Analytical
The insight-enhancing character of the experience is its defining feature, lending itself to introspective and potentially therapeutic use.
Emotional
Visual
Visual effects are characteristically weak for a phenethylamine psychedelic and are muted or absent for many users, though mild visuals can occur.
Tactile
See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)
Pharmacology
Pharmacodynamics
2C-G has been analytically identified and structurally characterized, but the located substance-specific peer-reviewed study did not test receptor binding or functional activity. A 2C-G-specific receptor profile or mechanism therefore cannot currently be stated from that evidence.2
Pharmacokinetics
No 2C-G-specific human pharmacokinetic or experimental metabolism study was identified in the literature reviewed. Metabolic pathways reported for other 2C phenethylamines should not be presented as established 2C-G metabolism.23
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Serotonergic psychedelics, Other 5-HT2A agonists
Harm Potential
Toxicity
A qualitative report described mild stomach queasiness during a prolonged plateau.1
Reported or listed effects include tremor, restlessness, sweating or chills, muscle tension, pupil dilation, and physical stimulation.
Reports describe insomnia, an 18- to 30-hour duration, delayed return to baseline, and needing additional time for recovery.
History & Culture
2C-G was first synthesized by Alexander Shulgin and initially described in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).citation needed The compound, also designated as 2C-G-0 or 3-methyl-2C-D, shares structural and pharmacodynamic characteristics with both 2C-D and its…
Legality
By Country
United StatesIllegal
CanadaIllegal (analog/blanket ban)
GermanyIllegal (analog/blanket ban)
References
Source Pages
Citations
- Shulgin, Alexander T., & Shulgin, Ann. (1991). PiHKAL: A Chemical Love Story. Transform Press. https://www.thevespiary.org/library/Files_Uploaded_by_Users/llamabox/PiHKAL.pdf123
- Identification and characterization of 2,5-dimethoxy-3,4-dimethyl-β-phenethylamine (2C-G)—a new designer drug. doi.org (n.d.). https://doi.org/10.1002/dta.139612
- Analysis of 2,5-dimethoxy-amphetamines and 2,5-dimethoxy-phenethylamines aiming their determination in biological matrices: a review. link.springer.com (n.d.). https://doi.org/10.1007/s11419-022-00638-61
- Schedule III, Controlled Drugs and Substances Act, item 35. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-sched95602.html1
- Neue-psychoaktive-Stoffe-Gesetz (NpSG), Anlage 1 Nr. 1; § 2 Nr. 1 Buchstabe a; § 3 Abs. 1 Nr. 1. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/anlage_1.html1
- Neue-psychoaktive-Stoffe-Gesetz (NpSG), Anlage 1 Nr. 1; § 2 Nr. 1 Buchstabe a; § 3 Abs. 1 Nr. 1. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__2.html1
- Neue-psychoaktive-Stoffe-Gesetz (NpSG), Anlage 1 Nr. 1; § 2 Nr. 1 Buchstabe a; § 3 Abs. 1 Nr. 1. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__3.html1
- Misuse of Drugs Act 1971, Schedule 2, Part I — Class A Drugs. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/schedule/212
- Schedule I, Controlled Substances Act (21 CFR § 1308.11). ecfr.gov (n.d.). https://www.ecfr.gov/current/title-21/chapter-II/part-1308/section-1308.111
- Schedule I, Controlled Substances Act (21 CFR § 1308.11). deadiversion.usdoj.gov (n.d.). https://www.deadiversion.usdoj.gov/schedules/orangebook/c_cs_alpha.pdf1
Further Reading
Article Status
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Recent changes8 human edits · latest
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31 July 2026
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24 January 2026
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Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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