2C-D

Federally controlled under the Controlled Substances Act⁶⁰ since July 9, 2012, when the Food and Drug Administration Safety and Innovation Act was signed into law.⁶¹ Manufacturing, buying, possessing, or distributing requires a DEA license.⁶² Additionally controlled at state level in Alabama, Florida, Louisiana, Oklahoma, Pennsylvania, and Vermont.

2C-D is treated as an estupefaciente under Decree No. 560/2019 because its 2,5-dimethoxy-4-methylphenethylamine structure falls within Annex II's substituted phenethylamines chemical group. Since the decree's publication on 15 August 2019, unauthorized production, manufacture, preparation, commercial dealing, distribution, supply, and possession of an estupefaciente are punishable under Law No. 23,737.

2C-D (2,5-dimethoxy-4-methylphenethylamine) is an alkoxyphenylethylamine listed by class in Schedule 4 to the Customs (Prohibited Imports) Regulations 1956. Its importation into Australia is prohibited unless the importer holds a licence and permission under regulation 5. The current Poisons Standard also places alkoxyphenylethylamines and substituted alkoxyphenylethylamines in Schedule 9, the schedule of prohibited substances.

Prohibited under the Neue-Psychoaktive-Substanzen-Gesetz (New Psychoactive Substances Act). Schedule II of the accompanying NPSV regulation explicitly bans all substituted phenethylamines.¹⁶

Listed on Portaria SVS/MS nº 344 as of February 18, 2014. Possession, production, and sale are prohibited.

Controlled under Schedule III of the Controlled Drugs and Substances Act as of October 31, 2016, as a derivative of 2,5-dimethoxyphenethylamine.¹⁹²⁰

2C-D is expressly listed as a non-medical controlled substance, not in the medical Category I psychotropic list. The 2025 directory replaced the former supplementary non-medical directory, and the official Shenzhen Public Security Bureau's 2026-07-17 reproduction of the current directory lists 2C-D as item 4 and reports the post-2026-07-01 framework. The current regulation permits non-medical controlled substances only for regulated experimental research and otherwise prohibits production, operation, use, storage and transport; the Drug Control Law also prohibits unlawful production, sale, transport, storage, provision, possession and use and prohibits smuggling. The 2015 control measure expressly prohibited production, buying/selling, transport, use, storage and import/export, effective 2015-10-01. The current directory has broad structural classes only for fentanyl, synthetic cannabinoids and nitazenes; 2C-D is individually named, and the directory note covers its possible salts, stereoisomers and salts of stereoisomers. The current directory does not list a general 2C/phenethylamine analogue class, so unlisted analogues should not be automatically treated as covered from these sources alone. Criminal penalty provisions are conduct- and quantity-dependent: Criminal Law Article 347 makes smuggling, sale, transport and manufacture of drugs criminal regardless of quantity, with ranges from up to 3 years for small amounts (higher for serious circumstances), 7+ years for larger amounts, and 15 years/life/death for the listed aggravated cases; Article 348 supplies possession ranges keyed to 'other drugs' quantity. The official provisions do not publish a 2C-D-specific quantity threshold, so no threshold is inferred. Article 82 of the current regulation provides, where a violation causes controlled substances to enter illicit channels and is not criminal, a 50,000-100,000 yuan fine, confiscation of proceeds, and for serious cases a 2-5x proceeds fine plus licence cancellation.

Listed as a Schedule B controlled substance under Danish drug legislation.

Banned in December 2014 under a government decree on psychoactive substances prohibited from the consumer market.

Listed in Anlage I of the Betäubungsmittelgesetz (Narcotics Act)³¹ as of December 13, 2014. Manufacturing, possession, importation, exportation, purchase, sale, procurement, and dispensation without a license is prohibited.³²

2C-D (2,5-dimethoxy-4-methylphenethylamine) is a designated controlled drug because it is structurally derived from phenethylamine with methyl and alkoxy substitutions in the ring, a class included in Schedule 1 of the Misuse of Drugs Act 1977 (Controlled Drugs) (Designation) Order 2022. The Order makes its manufacture, production, preparation, sale, supply, distribution and possession unlawful except for research or the other specified special purposes, subject to applicable licensing provisions.

NIH PubChem identifies 2C-D as 2-(2,5-dimethoxy-4-methylphenyl)ethanamine (CID 135740; C11H17NO2). An official Israeli government gazette lists 4-methyl-2,5-dimethoxyphenethylamine in the dangerous-drug schedule and the Ministry of Health's 2013 urgent declaration covers the 2C x,y-dimethoxyphenethylamine family (x and y at ring positions 2-6). The latest official First Schedule amendment is the 8 June 2025 Gazette; it adds other named substances and changes the chemical-group definition, and does not repeal the 2C-D listing. Under sections 6, 7 and 13, unauthorized production, possession/use, import/export, trade, other transactions and supply are prohibited. Section 7(c) provides a maximum of 20 years' imprisonment for unlawful possession/use generally and 3 years for possession/use solely for personal consumption; section 19A provides a maximum of 20 years for violations of the trade/import/export/supply provisions. These are statutory maximums, not automatic sentences, and licences or statutory exceptions can alter the result. The Ministry of Health published the ordinance text in a 2017 reference edition; a January 2026 Ministry of Health disciplinary decision confirms the 20-year section 19A maximum for supplying a dangerous drug. The 2013 urgent declaration itself was time-limited, so current classification rests on the dangerous-drug schedule and the later 2025 amendment/current import-order framework, not on that declaration alone.

2C-D (2-(2,5-dimethoxy-4-methylphenyl)ethanamine) and its salts have been a Designated Drug under Japan's Act on Securing Quality, Efficacy and Safety of Products Including Pharmaceuticals and Medical Devices since 21 January 2016. Except for specified medical and other permitted uses, the Act prohibits its manufacture, import, sale, supply, possession, purchase, receipt, and use; advertising is also restricted.

Listed as a Schedule I controlled substance under Latvian drug control legislation.⁴⁵

2C-D is controlled in the Netherlands through Lijst IA of the Opiumwet as a substance derived from 2-fenethylamine; its 2,5-dimethoxy-4-methylphenethylamine structure has the permitted phenyl-ring methoxy and methyl substitutions and unsubstituted aminoethyl side chain. Since 1 July 2025, the Act prohibits importing or exporting, preparing, processing, selling, supplying, transporting, possessing, or manufacturing a substance in that group or a preparation containing it, subject to the statutory exceptions.

Norway lists 2C-D, identified as 2,5-dimethoxy-4-methylphenethylamine, in the national narcotics list. The listing makes the substance subject to Norway's narcotics controls.

2C-D is listed as a Group II-P psychotropic substance in the Polish Minister of Health regulation. Under the Act on Counteracting Drug Addiction, Group II-P psychotropic substances may be used only for medical, industrial, or research purposes; possession contrary to the Act is punishable by up to three years’ imprisonment. The regulation entered into force on 21 August 2018 and remains in force in its consolidated text.

Classified as a health hazard by the Statens folkhälsoinstitut under the Act on the Prohibition of Certain Goods Dangerous to Health (Lagen om förbud mot vissa hälsofarliga varor)⁵³ as of March 1, 2005, in regulation SFS 2005:26. Sale and possession are illegal.

Specifically named as a controlled substance under Verzeichnis E of Swiss narcotics legislation.

Classified as a drug under Turkish law.⁵⁶ Possession, production, supply, and importation are prohibited.

Controlled under the Misuse of Drugs Act 1971 as a result of the phenethylamine catch-all clause, which covers substituted phenethylamine derivatives.⁵⁸