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1cP-LSD

1cP-LSD molecule structure1cP-LSD molecule structure
1-Cyclopropionyl-d-lysergic acid diethylamide
1-CPA-LSD, 1-cyclopropanoyl-LSD
Psychoactive Class
Chemical Class

1cP-LSD is a semisynthetic psychedelic of the lysergamide class and an acylated derivative of LSD.citation needed It was first developed by Lizard Labs around 2019 as a legal alternative following the anticipated prohibition of 1P-LSD in Germany. It is structurally related to other LSD analogs such as 1P-LSD, 1B-LSD, and ALD-52.1 Research has demonstrated that it functions as a prodrug of LSD,citation needed with anecdotal reports describing near-identical effects.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~15 µg
Light15-75 µg
Moderate75-150 µg
Strong150-250 µg
Heavy250+ µg

Duration

Onset20-60 minutes
Come Up45-120 minutes
Peak3-5 hours
Offset3-5 hours
After Effects6-24 hours
Total8-12 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

Increased bodily control

Cognitive

In comparison to other psychedelics such as Psilocin, LSA and Ayahuasca, 1cP-LSD is significantly more stimulating and fast paced in terms of the specific style of thought stream which it produces and contains a large number of potential effects.

Visual

Geometry

The visual geometry of 1cP-LSD can be described as more similar in appearance to that of 2C-B and the 2C-x family than psilocin, LSA, or DMT. They can be comprehensively described as unstructured in organization, algorithmic and digital in geometric style, intricate in complexity, large in size, fast and smooth in motion, multicoloured in scheme, bright and flat in colour, and sharp in their edges with extremely angular corners. At higher dosages they consistently result in states of Level 7A visual geometry.

Hallucinatory States

1cP-LSD is capable of producing a full range of low and high level hallucinatory states in a fashion that is significantly less consistent and reproducible than that of many other commonly used psychedelics.

External hallucinations

Auditory

Adapted from the LSD subjective effects documentation. 1cP-LSD is a prodrug of LSD and is reported to produce an effectively identical experience. Forked from Subjective Effect Documentation byJosie Kins October 2012.

See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
No reaction
No reaction
Mecke(ME)
No reaction
No reaction
Mandelin(MD)
No reaction
No reaction
Liebermann(LB)
No reaction
No reaction
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Pharmacology

Pharmacodynamics

1cP-LSD is a prodrug of LSD, with its psychedelic effects mediated through the activity of LSD at serotonin 5-HT2A receptors, where it acts as a partial agonist.citation needed In rodent studies, 1cP-LSD produces the head-twitch response (a behavioral marker of 5-HT2A receptor activation) with potency comparable to 1P-LSD.1 Direct pharmacological characterization of 1cP-LSD at specific receptor targets remains limited.

Pharmacokinetics

Incubation with human serum formed LSD, supporting the interpretation of 1cP-LSD as an LSD prodrug. In a separate human-liver-microsome experiment, researchers detected 1cP-LSD and 10 metabolites; the parent compound declined with an in-vitro microsomal half-life of 5 minutes, and carboxylesterase activity accounted for most of that decrease. The five-minute value is an in-vitro microsomal result, not a human plasma elimination half-life, and these studies did not determine oral bioavailability or a clinical elimination half-life.

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Develops almost immediately after ingestion.
Baseline Reset
14 days
Half Tolerance
5-7 days
Cross Tolerance

Serotonergic psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

Presumed to be non-addictive with low abuse potential, similar to LSD. Animal studies with LSD show no self-administration behavior, indicating it lacks the pharmacology to initiate or maintain dependence.citation needed

Physical

Extremely Low

Virtually no withdrawal syndrome is reported when chronic use of LSD or its analogs is stopped, suggesting 1cP-LSD carries minimal physical dependence potential.citation needed

Psychosis Risk

May act as a trigger for psychotic episodes in individuals with underlying mental disorders or a family history of mental illness.citation needed Higher doses increase the risk of adverse psychological reactions, including anxiety, delusions, and panic attacks. People with a personal or family history of mental illness are generally advised to avoid using this substance.

Seizure Risk

Seizure risk is largely extrapolated from LSD reports and is primarily a concern for those genetically predisposed, particularly when accompanied by physically taxing conditions such as dehydration, fatigue, undernourishment, or overheating.citation needed

History & Culture

1cP-LSD was developed by Lizard Labs, a research chemical laboratory based in the Netherlands, as a legal alternative to LSD. The compound emerged on the grey market around 2019, reportedly created in anticipation of the impending prohibition of 1P-LSD in Germany. Like its predecessor, 1cP-LSD is

Trip Reports

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Legality

By Country

Illegal4
Japan flagJapanIllegal
Sweden flagSwedenIllegal
Turkey flagTurkeyIllegal
United Kingdom flagUnited KingdomIllegal (analog/blanket ban)
Controlled / restricted1
Germany flagGermanyRestricted
Not scheduled2
Canada flagCanadaNot scheduled
Czech Republic flagCzech RepublicNot scheduled

References

Source Pages

  1. Bluelight: ‘Lysergamides Help’ thread – community discussion on 1cP-LSD potency (2019)
  2. Drug Users Bible by Dominic Milton Trott
  3. Erowid: 1cP-LSD Experience Vault
  4. Erowid: 1cP-LSD Experience Vault – User Reports (accessed 2025-07-29)
  5. Isomer Design (TiHKAL/PiHKAL)
  6. PsychonautWiki
  7. TripSit Factsheet: 1CP-LSD
  8. TripSit Factsheets
  9. Wikipedia

Citations

  1. Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal, Alexander Stratford, Anna U. Odland, Adam K. Klein, Geraldine Dowling, Nicola M. Dempster, Jason Wallach, Torsten Passie, & Adam L. Halberstadt. (June 2020). Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD). Drug Testing and Analysis, 12(6), 812–826. https://doi.org/10.1002/dta.278912
  2. 1-Cyclopropionyl lsd — PubChem CID 155884675. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/compound/155884675123
  3. PubChem PUG-REST identity properties for CID 155884675. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/155884675/property/IUPACName,MolecularFormula,MolecularWeight/JSON1
  4. Controlled Drugs and Substances Act, S.C. 1996, c. 19, consolidated Justice Laws text. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/FullText.html1
  5. Health Canada's controlled substances status determination process. canada.ca (n.d.). https://www.canada.ca/en/health-canada/corporate/mandate/regulatory-role/what-health-canada-regulates-1/controlled-substances-precursors/overview-substance-control-status-determination-process.html1
  6. Drug Classification - Health Canada's Drug Analysis Platform. health-infobase.canada.ca (n.d.). https://health-infobase.canada.ca/drug-analysis-service/drug-classification.html1
  7. PubChem PUG REST identity properties for 1cP-LSD. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/1cP-LSD/property/IUPACName,MolecularFormula,MolecularWeight,CanonicalSMILES/JSON1
  8. Government Regulation No. 463/2013 Coll. — current consolidated text. e-sbirka.gov.cz (n.d.). https://e-sbirka.gov.cz/sb/2013/463/2026-06-25?zalozka=text1
  9. e-Sbírka open-data ELI record for Regulation No. 463/2013. opendata.eselpoint.gov.cz (n.d.). https://opendata.eselpoint.gov.cz/esel-esb/eli/cz/sb/2013/4631
  10. Government Regulation No. 11/2025 Coll. — current consolidated classified-psychoactive list. e-sbirka.gov.cz (n.d.). https://e-sbirka.gov.cz/sb/2025/11/2026-06-25?zalozka=text1

Further Reading

  1. Halberstadt AL et al. - Pharmacological studies of LSD derivatives (2020)
  2. Henriquez-Hernandez L et al. - 1cP-LSD for canine anxiety pilot study (2024)
  3. Henríquez-Hernández L et al. Single-dose 1cP-LSD administration for canine anxiety: a pilot study (2024)
  4. PubChem Compound: 156536462

Article Status

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    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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    Step 2 · First-pass review

    A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.

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Recent changes8 human edits · latest

Times are UTCNewest first

3 September 2026

  1. Lyrea · Changed a word in Dosage & DurationRoutes 1 › Dose ranges › Heavy

  2. Lyrea · Changed a word in Dosage & DurationRoutes 1 › Dose ranges › Strong

  3. Lyrea · Changed a word in Dosage & DurationRoutes 1 › Dose ranges › Moderate

  4. Lyrea · Changed a word in Dosage & DurationRoutes 1 › Dose ranges › Light

24 July 2026

  1. Lyrea · Updated the article · also 1cP-AL-LAD, 1cP-MiPLA, 1P-ETH-LAD

13 July 2026

  1. Lyrea · Updated the article

  2. Lyrea · Updated the article · also 1P-LSD

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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