1P-ETH-LAD
1P-ETH-LAD is a semisynthetic psychedelic of the lysergamide class and a suspected prodrug of ETH-LAD1, structurally related to both LSD and 1P-LSD. Developed as a designer drug, it is reported to be moderately to significantly more potent than LSD. Its effects are often described as more visual and synaesthetic, with a deeper, less emotionally-charged headspace. It remains largely unresearched1 and is classified as a research chemical.
Dosage & Duration
Dosage
Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
Cognitive
Visual
Distortions
Hallucinatory States
1P-ETH-LAD is capable of producing a full range of low and high level hallucinatory states in a fashion that is significantly less consistent and reproducible than that of many other commonly used psychedelics. These effects include:
Auditory
by Josie KinsAugust 2016.Pharmacology
Pharmacodynamics
Direct receptor pharmacology of intact 1P-ETH-LAD has not been measured; the located 1P-ETH-LAD study was an analytical and serum-incubation study rather than a receptor assay.1 Formation of ETH-LAD in human serum supports a possible prodrug mechanism, consistent with findings reported for other 1-acyl-substituted LSD derivatives, but it does not establish that ETH-LAD alone mediates the effects of 1P-ETH-LAD in humans.2
Pharmacokinetics
In an in-vitro experiment, 1P-ETH-LAD was incubated in human serum at 37 °C and sampled hourly from 0 to 6 hours, with an additional sample at 24 hours. ETH-LAD was detectable at the first one-hour sampling point, while parent 1P-ETH-LAD remained detectable at 24 hours.1 These findings support possible in-vivo prodrug conversion but do not establish human bioavailability, conversion fraction, clearance, plasma half-life, or clinical effect duration.1
Tolerance
Serotonergic psychedelics, Tryptamines, Lysergamides
Harm Potential
Addiction & Dependence
Psychosis Risk
Delusions are listed among possible cognitive effects during the experience. No quantified data exists on standalone psychosis risk.
History & Culture
1P-ETH-LAD emerged on the research chemical market in early 2016, with virtually no documented history of human usage prior to January of that year. The compound appeared alongside other novel lysergamide derivatives such as 1P-LSD and ETH-LAD, marketed primarily through online research chemical…
Legality
By Country
References
Source Pages
Citations
- It is the 1- propionyl chemical derivative|derivative of ETH-LAD and is thought to act as a prodrug of ETH-LAD analogously to how 1P-LSD acts as a prodrug of LSD. (n.d.). https://doi.org/10.1002/dta.2196123456
- Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD). pmc.ncbi.nlm.nih.gov (n.d.). https://doi.org/10.1016/j.neuropharm.2019.1078561
- David E Nichols. (2016). Psychedelics. 68(2), 264-355. https://doi.org/10.1124/pr.115.01147812
- Anne K Schlag, Jacob Aday, Iram Salam, Jo C Neill, & David J Nutt. (2022). Adverse effects of psychedelics: From anecdotes and misinformation to systematic science. 36(3), 258-272. https://doi.org/10.1177/0269881121106910012
- Anlage 1 NpSG (Stoffgruppen), Gruppe 5.2 Delta-9,10-Ergolene. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/anlage_1.html1
- Änderungen an Neue-psychoaktive-Stoffe-Gesetz (NpSG) – chronologische Übersicht. buzer.de (n.d.). https://www.buzer.de/gesetz/12250/l.htm1
- § 4 NpSG. (2019). https://www.gesetze-im-internet.de/npsg/__4.html12
- § 3 NpSG - Unerlaubter Umgang mit neuen psychoaktiven Stoffen. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__3.html1
- Cumhurbaşkanı Kararı: Karar Sayısı: 1335. (2019). https://resmigazete.gov.tr/eskiler/2019/07/20190720-19.pdf1
- Psychoactive Substances Act 2016. Legislation.gov.uk (n.d.). http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted123
- The Psychoactive Substances Act 2016 (Commencement) Regulations 2016 (SI 2016/553). Legislation.gov.uk (n.d.). https://www.legislation.gov.uk/uksi/2016/553/made1
- 21 U.S. Code § 812 - Schedules of controlled substances. Legal Information Institute, Cornell Law School (n.d.). https://www.law.cornell.edu/uscode/text/21/8121
- 21 U.S. Code § 813 - Treatment of controlled substance analogues. Legal Information Institute, Cornell Law School (n.d.). https://www.law.cornell.edu/uscode/text/21/8131
- 21 U.S. Code § 802 - Definitions (controlled substance analogue, para. 32). Legal Information Institute, Cornell Law School (n.d.). https://www.law.cornell.edu/uscode/text/21/8021
Further Reading
- Reviewed & approved
Reviewed, edited, and approved by subject-matter expert Lyrea.
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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