Skip to main content
Lyrea avatar

Not yet reviewed — this article is pending editorial review by Lyrea.

Citation noticeOur citation system is being overhauled

References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.

PRO-LAD

This article is a stubmissing:
Pharmacology
Tolerance
History & Culture
PRO-LAD molecule structurePRO-LAD molecule structure
6-Propyl-6-nor-lysergic acid diethylamide
N-PropylnorLSD, 6-propyl-6-nor-LSD
Psychoactive Class
Chemical Class

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold20 µg
Light50-100 µg
Moderate100-150 µg
Strong150-200 µg
Heavy350+ µg

Duration

Onset30-45 minutes
Total6-8 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Forked from Subjective Effect Documentation work byJosie Kins August 2016.

See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)

Pharmacology

Pharmacology not written up yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

Powered by TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

Formal studies are lacking, but PRO-LAD is described as having low habit-forming potential, and repeated use may reduce desire for further use.

Toxicity

Lethal Dosage

The exact toxic dose is described as unknown, and long-term health effects have not been studied in a scientific context.

central nervous system

Combining PRO-LAD with MDMA is described as unpredictable and likely neurotoxic.

Psychosis Risk

Low

Psychosis is described mainly as a risk with discouraged combinations such as lithium, cannabis, or stimulants.

Seizure Risk

Low

Seizure is described as very rare, likely limited to predisposed people or risky combinations; no documented cases with PRO-LAD were noted.

History & Culture

History & Culture not written up yet

Legality

By Country

Illegal5
Austria flagAustriaIllegal (analog/blanket ban)
Germany flagGermanyIllegal (analog/blanket ban)
Latvia flagLatviaIllegal (analog/blanket ban)
Switzerland flagSwitzerlandIllegal
United Kingdom flagUnited KingdomIllegal

References

Source Pages

  1. Erowid TiHKAL Entry #51: PRO-LAD
  2. Isomer Design (TiHKAL/PiHKAL)
  3. PsychonautWiki
  4. Shulgin A, Shulgin A (1997). TiHKAL: Tryptamines I Have Known And Loved
  5. TripSit Factsheets
  6. TripSit: Drug Combination Chart
  7. Wikipedia

Citations

  1. PubChem PUG REST — PRO-LAD (CID 44457803) synonyms. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/44457803/synonyms/JSON1
  2. Neue-Psychoaktive-Substanzen-Verordnung § 1 — Bundesrecht konsolidiert. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40187178/NOR40187178.html1
  3. Neue-Psychoaktive-Substanzen-Verordnung, current Anlage II — BGBl. II Nr. 106/2024. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40261441/II_106_2024_Anlage_II.pdf1
  4. BGBl. II Nr. 73/2023 — amendment of the Neue-Psychoaktive-Substanzen-Verordnung. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/Dokumente/BgblAuth/BGBLA_2023_II_73/BGBLA_2023_II_73.html1
  5. Neue-Psychoaktive-Substanzen-Gesetz § 4 — Bundesrecht konsolidiert. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40134447/NOR40134447.html1
  6. Neue-Psychoaktive-Substanzen-Gesetz § 5 — Bundesrecht konsolidiert. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40148040/NOR40148040.pdf1
  7. Neue-psychoaktive-Stoffe-Gesetz (NpSG), Anlage 1. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/anlage_1.html1
  8. Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes vom 12. Juli 2019, BGBl. I 2019 S. 1083. bundesgesundheitsministerium.de (n.d.). https://www.bundesgesundheitsministerium.de/fileadmin/Dateien/3_Downloads/Gesetze_und_Verordnungen/GuV/N/NPS_BtM_RegV_Bgbl.pdf1
  9. Neue-psychoaktive-Stoffe-Gesetz (NpSG), § 2 Begriffsbestimmungen. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__2.html1
  10. Neue-psychoaktive-Stoffe-Gesetz (NpSG), § 3 Unerlaubter Umgang mit neuen psychoaktiven Stoffen. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__3.html1

Further Reading

  1. Hoffman AJ, Nichols DE (1985). Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives. Journal of Medicinal Chemistry 28(9):1252-1255

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

All changes to this article · Site-wide recent changes

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the PRO-LAD article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.