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LSA

LSA molecule structureLSA molecule structure
d-Lysergic acid amide
Ergine, LA-111, d-Lysergamide
Psychoactive Class
Chemical Class

LSA is a naturally occurring psychedelic alkaloid of the lysergamide family, found primarily in morning glory and Hawaiian baby woodrose seeds.citation needed Structurally related to LSD1, it was first assayed for human activity by Albert Hofmann in 1947. Its traditional use by indigenous Mexican peoples dates back to Aztec times, as documented by Richard Schultes in 1941.2 LSA is reported to produce mental effects resembling LSD1, though with notably diminished visual activity.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~1 seeds
Light1-2 seeds
Moderate2-6 seeds
Strong6-12 seeds
Heavy12+ seeds

Duration

Onset30-180 minutes
Peak2-7 hours
Offset1-2 hours
After Effects2-24 hours
Total4-10 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

Physical euphoriaNauseaVasoconstriction

Cognitive

The head space of LSA is described by many as extremely relaxing yet lucid and clear headed in its style when compared to other commonly used psychedelics such as LSD or Psilocin. Although it is primarily sedating, it is accompanied by fast paced bursts of thought.

Visual

Distortions

Visual distortions and alterations are significantly more simplistic than open eye distortions found with other psychedelics.

Colour shifting

Geometry

The geometry of LSA can be described through its variations as simplistic in complexity, abstract in form, synthetic in style, multicoloured in scheme, soft in edges, equal in rounded and angular corners, small in size, slow in speed, smooth in motion, immersive in depth and consistent in intensity.

Hallucinatory States

LSA produces a full range of high level hallucinatory states in a fashion that is very consistent when taken in large doses.

Auditory

The auditory effects of LSA are common in their occurrence and exhibit a full range of effects.

Forked from Subjective Effect Documentation byJosie Kins September 2013.

See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)

Pharmacology

Pharmacodynamics

LSA (ergine) is an ergoline alkaloid structurally related to LSDcitation needed, with approximately one-tenth the potency. Synthetic LSA in isolation has been characterized as only mildly psychedelic, suggesting that the more pronounced psychoactivity of natural seed sources such as morning glory and Hawaiian baby woodrose may result from a mixture of co-occurring lysergamides rather than LSA alone. LSA is also known to produce vasoconstriction.

Pharmacokinetics

Human disposition data for LSA are sparse. In a study of orally ingested Argyreia nervosa seeds, serum LSA concentrations were 0.66–3.15 ng/mL at approximately 2 hours; LSA was detected in urine from 1 to 24 hours and was not detected at 48 hours. Iso-LSA was also detected in serum and urine in varying ratios. These observations are analytical detection data from a mixed seed preparation: they do not establish oral bioavailability, Tmax, clearance, elimination half-life, responsible enzymes, or the duration of subjective effects.citation needed

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Tolerance develops almost immediately after ingestion, preventing the full effects from being experienced more frequently than every 4-7 days without significantly increasing the dose.
Cross Tolerance

Serotonergic psychedelics34

Baseline Reset
With repeated use over short periods, it can take up to 3 days of abstinence for the body to return to baseline.citation needed The psychoactive effects weaken with frequent use while vasoconstriction effects accumulate.

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

LSA is non-habit-formingcitation needed and the desire to use it typically decreases with use. It is most often self-regulating.

Toxicity

Cardiovascular

Vasoconstriction5 can cause reduced blood flow to muscles, particularly noticeable as soreness in the legs; these effects may build up with repeated use over short periods.

History & Culture

Traditional Use in the Americas

The use of LSA-containing morning glory seeds by indigenous peoples of Mexico and Latin America dates back to pre-Columbian times.citation needed Seeds from Ipomoea corymbosa (known as ololiuhqui) and Ipomoea tricolor (tlitliltzin) were employed in shamanic rituals across the region for

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Legality

By Country

Illegal4
Australia flagAustraliaIllegal
Netherlands flagNetherlandsIllegal
Poland flagPolandIllegal (analog/blanket ban)
United Kingdom flagUnited KingdomClass A
Controlled / restricted1
Canada flagCanadaRestricted
Not scheduled2
New Zealand flagNew ZealandNot scheduled
Sweden flagSwedenNot scheduled

References

Source Pages

  1. Bluelight: The Big & Dandy LSA Thread
  2. Disregard Everything I Say
  3. Drug Users Bible by Dominic Milton Trott
  4. Erowid: LSA Dosage
  5. Erowid: LSA Effects
  6. Erowid: LSA Vault
  7. PsychonautWiki: LSA
  8. TripSit Wiki: LSA
  9. Wikipedia
  10. Wikipedia: Ergine

Citations

  1. Castro PSCC, Leopoldo K, Pedro MOP, & et al.. (2025). Lysergic Acid Amide (LSA), an LSD Analog: Systematic Review of Pharmacological Effects, Adverse Outcomes, and Therapeutic Potentials. https://doi.org/10.3390/pharmacy1304009812
  2. Hofmann A. (1970). The Discovery of LSD and Subsequent Investigations on Naturally Occurring Hallucinogens. J.B. Lippincott Company. https://www.psychedelic-library.org/hofmann.htm1
  3. Passie T, Halpern JH, Stichtenoth DO, Emrich HM, & Hintzen A. (2008). The Pharmacology of Lysergic Acid Diethylamide: A Review. CNS Neuroscience & Therapeutics, 14(4), 295-314. https://doi.org/10.1111/j.1755-5949.2008.00059.x1
  4. Nichols, D.E.. (2016). Psychedelics. 68(2), 264-355. https://doi.org/10.1124/pr.115.0114781
  5. Oliver JW, Abney LK, Strickland JR, & Linnabary RD. (1993). Vasoconstriction in bovine vasculature induced by the tall fescue alkaloid lysergamide. 71(10), 2708-2713. https://doi.org/10.2527/1993.71102708x1
  6. Asha Jyoti Bharati, & Yogendra Kumar Bansal. (2014). Phytochemical investigation of natural and in vitro raised Vṛddhadāruka plants. 34(2), 80-84. https://pmc.ncbi.nlm.nih.gov/articles/PMC4389397/1
  7. NIH PubChem CID 442072 property record — Lysergic acid amide. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/442072/property/IUPACName,Title,CanonicalSMILES,IsomericSMILES/JSON1
  8. NIH PubChem CID 442072 synonyms record. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/442072/synonyms/JSON1
  9. Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 (Cth). legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/asmade/2026-05-28/text/original/epub/OEBPS/document_1/document_1.html1
  10. Criminal Code Regulations 2019 — Federal Register latest in-force page. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2019L00561/latest1

Further Reading

  1. Drugs-Forum: LSA Wiki
  2. Klinke et al. 2010: LSA Intoxication Cases (DOI)
  3. Lysergic Acid Amide (LSA), an LSD Analog: Systematic Review (MDPI, 2025)
  4. Paulke et al. 2013: Analysis of LSA in Human Serum and Urine (DOI)

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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    A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes8 human edits · latest

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24 July 2026

  1. Lyrea · Updated the article

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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