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5-MeO-MiPT

5-MeO-MiPT molecule structure5-MeO-MiPT molecule structure
5-Methoxy-N-methyl-N-isopropyltryptamine
Moxy
Psychoactive Class
Chemical Class

5-MeO-MiPT is a synthetic psychedelic and entactogenic substance of the tryptamine class. Its synthesis and human psychopharmacology were first published by Shulgin, Repke, and colleagues in 1985citation needed, with further documentation in Shulgin's 1997 book TiHKAL1. The substance is characterized by its notably stimulating and body-oriented effects, including pronounced tactile and sexual enhancementcitation needed, while generally producing fewer visual distortions than typical psychedelics.2 It is almost exclusively obtained as a research chemical through online vendors.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~2 mg
Light2-5 mg
Moderate5-10 mg
Strong10-15 mg
Heavy15+ mg

Users report steep dosage curve. Start lower than expected.

Duration

Onset15-40 minutes
Come Up15-60 minutes
Peak1-3 hours
Offset1-3 hours
After Effects2-4 hours
Total4-8 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

The physical effects of 5-MeO-MiPT can be broken down into three components all of which progressively intensify proportional to dosage.

Cognitive

The head space of 5-MeO-MiPT is described by many as one which is both insightful and moderately relaxing, but at some points quite stimulating.

Visual

Geometry

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of psilocin, 4-AcO-DMT, or ayahuasca than that of LSD or 2C-B. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, equal in blurred and sharp edges, and equal in rounded and angular corners. At higher dosages, they are significantly more likely to result in states of level 7B visual geometry over level 7A. In terms of their manifestation, they are progressive in nature and continuously self-complexify in settings with little to no visual input and disturbances.

Hallucinatory States

5-MeO-MiPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics.

External hallucinations

Auditory

The auditory effects of 5-MeO-MiPT are common in their occurrence and exhibit a full range of effects.

Forked from Subjective Effect Documentation byJosie Kins December 2013.

See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → orange2 → brown2
Mecke(ME)
white → orange2 → red2
Mandelin(MD)
yellow2 → brown2
Ehrlich(EH)
white → purple2
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Pharmacology

Pharmacodynamics

5-MeO-MiPT acts primarily as a serotonin receptor agonist, with its psychedelic effects thought to result mainly from partial agonism at the 5-HT2A receptor.citation needed The compound shows its strongest binding affinity at the 5-HT1A receptor and also interacts with 5-HT2C and 5-HT2B receptors at lower potencies. One study reported modest affinity for the serotonin transporter, suggesting possible serotonin-norepinephrine reuptake inhibition, while another found no significant activity at the monoamine transporters at concentrations up to 10 μM;3 the compound is also inactive as a monoamine releasing agent.citation needed Inhibition of monoamine oxidase has been speculated as an additional mechanism but remains undemonstrated.

Pharmacokinetics

5-MeO-MiPT undergoes extensive phase I hepatic metabolism mediated by cytochrome P450 enzymes. The major metabolic pathways include O-demethylation, N-demethylation, hydroxylation, and N-oxide formation.4 Multiple metabolites have been detected in human urine5 within two hours of exposure, and blood concentrations are measurable within one hour, suggesting relatively rapid metabolism and elimination. Renal excretion is thought to be a major route of elimination.

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AMTMAOIsPCP

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

AmphetaminesCocaineDXMTramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

2C-T-x compounds2C-x compoundsCannabisDOx compoundsMDMAMescalineNBOMe compoundsPregabalin
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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Tolerance develops almost immediately after ingestion, though 5-MeO-MiPT appears to produce less tolerance than many other psychedelics. Some users report successful experiences on consecutive days, suggesting tolerance buildup is more moderate than typical for the class.
Baseline Reset
7 days of abstinence typically restores baseline sensitivity, though some sources suggest 5-7 days may be sufficient for most users.
Half Tolerance
Approximately 3 days
Cross Tolerance

Serotonergic psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

5-MeO-MiPT is not typically associated with habit formation, and interest in taking it may lessen after repeated experiences. Its use is usually self-limiting, though some people may still use it more often than feels comfortable.

Physical

Extremely Low

5-MeO-MiPT is not physically addictive. There is no evidence of physical dependence or withdrawal symptoms associated with its use.citation needed

Toxicity

Central Nervous System

Doses approximately 10 times above normal recreational ranges have been shown to induce cell toxicity in brain tissue in animal studies; low-dose use did not cause any serious histopathological effects in this organ.citation needed

Hepatic

High doses well above normal ranges have been shown to produce cell toxicity in liver tissue in animal studies; low-dose use did not cause serious histopathological effects.citation needed

Renal

High doses well above normal ranges have been shown to produce cell toxicity in kidney tissue in animal studies; low-dose use did not cause serious histopathological effects.citation needed

Cardiovascular

Vasoconstriction, increased heart rate, and elevated blood pressure are commonly reported during acute intoxication; cardiac problems including tachycardia and chest pain have been reported particularly after doses exceeding 10 mg.

Psychosis Risk

Temporary psychosis, confusion, disorientation, and agitation have been documented in several clinical case reports, typically associated with high doses or combination with other substances.citation needed One case involved a 32-year-old male found disoriented and aggressive after confirmed use. People with schizophrenia in their family history or a history of early-onset mental illness should be extremely cautious, because psychedelics may bring underlying psychological vulnerabilities to the surface.

Seizure Risk

People with seizure or convulsive disorders could face increased health risks from psychedelic use, although the literature does not provide specific seizure risk data for 5-MeO-MiPT.

History & Culture

Discovery and Public Introduction

5-MeO-MiPT, commonly known as "Moxy," was first synthesized and characterized in 1985 when David Repke, Donald Grotjahn, and Alexander Shulgin published its synthesis and pharmacological profile in the Journal of Medicinal Chemistry.citation needed This publication represented

Trip Reports

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Legality

International

1961 Single Convention: 5-MeO-MiPT is not individually scheduled.

1971 Convention on Psychotropic Substances: 5-MeO-MiPT is not individually scheduled.

1988 Convention: 5-MeO-MiPT is not listed in precursor Tables I or II.

By Country

Illegal10
United States flagUnited StatesProhibited
Australia flagAustraliaProhibited
Austria flagAustriaIllegal (analog/blanket ban)
Brazil flagBrazilProhibited
China flagChinaProhibited
Germany flagGermanyIllegal (analog/blanket ban)
Japan flagJapanIllegal
Latvia flagLatviaProhibited
Turkey flagTurkeyProhibited
United Kingdom flagUnited KingdomProhibited
Controlled / restricted1
New Zealand flagNew ZealandControlled under analogue or structural rule
Prescription3
Finland flagFinlandRestricted
Romania flagRomaniaRestricted/controlled
Switzerland flagSwitzerlandRestricted
Not scheduled3
Canada flagCanadaUnscheduled
Luxembourg flagLuxembourgNot scheduled
Poland flagPolandI-P

References

Source Pages

  1. Disregard Everything I Say
  2. Erowid
  3. Isomer Design (TiHKAL/PiHKAL)
  4. PsychonautWiki
  5. Shulgin & Shulgin 1997: TiHKAL #40
  6. The Drug Classroom
  7. TripSit Factsheet
  8. TripSit Factsheet: 5-MeO-MiPT
  9. TripSit Factsheets
  10. Wikipedia

Citations

  1. Aragón M. (2024-01-09). Meet Moxy: The Novel Psychedelic the DEA Tried To Ban. DoubleBlind Mag. https://doubleblindmag.com/what-is-moxy/12
  2. David B. Repke, Douglas B. Grotjahn, & Alexander T. Shulgin. (July 1985). Psychotomimetic N-methyl-N-isopropyltryptamines. Effects of variation of aromatic oxygen substituents. Journal of Medicinal Chemistry, 28(7), 892–896. https://doi.org/10.1021/jm00145a0071
  3. Bruce E. Blough, Antonio Landavazo, Ann M. Decker, John S. Partilla, Michael H. Baumann, & Richard B. Rothman. (n.d.). Reference (doi:10.1007/s00213-014-3557-7). https://doi.org/10.1007/s00213-014-3557-71
  4. Sen Zhao, Yanjiao Wang, Chenhao Zhong, Jinyuan Chen, & Liang Meng. (n.d.). The predicted human percent unbound to blood plasma Protein|proteins was 45.5%, compared to 31.6% in mice. The predicted volume of distribution. https://doi.org/10.1016/j.jpba.2024.1159871
  5. Katharina Elisabeth Grafinger, Marianne Hädener, Stefan König, & Wolfgang Weinmann. (n.d.). At lower doses of 0.27 mg/kg, concentrations of the parent compound remained below the limit of quantification in all samples. In one human c. https://doi.org/10.1002/dta.22451234
  6. Anlage II, Neue-Psychoaktive-Substanzen-Verordnung (BGBl. II Nr. 106/2024). ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40261441/II_106_2024_Anlage_II.pdf1
  7. § 1 Neue-Psychoaktive-Substanzen-Verordnung, consolidated federal law (RIS). ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40187178/NOR40187178.html1
  8. Neue-Psychoaktive-Substanzen-Verordnung Anl. 2, Bundesrecht konsolidiert, Fassung vom 08.09.2026 (RIS). ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Gesetzesnummer=20007642&Anlage=2&FassungVom=2026-09-081
  9. Anlage I Neue-Psychoaktive-Substanzen-Verordnung, consolidated federal law (RIS). ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40215405/NOR40215405.html1
  10. § 2 Neue-Psychoaktive-Substanzen-Gesetz, consolidated federal law (RIS). ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40134445/NOR40134445.html1

Further Reading

  1. Chemical Collective 5-MeO-MiPT Product Information
  2. Pharmaco-toxicological Effects Study (PMC)

Article Status

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Recent changes8 human edits · latest

Times are UTCNewest first

6 September 2026

  1. Contributor · Updated the article: Update 5-MeO-MiPT

13 July 2026

  1. Lyrea · Updated the article

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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