3C-E

3C-E is not separately named in the DEA alphabetical controlled-substances list dated 27 August 2026. Under 21 U.S.C. §§ 802(32) and 813, it may instead be treated as a Schedule I controlled substance only if it satisfies the statutory definition of a controlled substance analogue and is intended for human consumption. When those conditions are met, 21 U.S.C. §§ 841(a)(1) and 844(a) prohibit its unauthorized possession, manufacture, distribution, dispensing, and possession with intent to manufacture, distribute, or dispense. This classification concerns United States federal law and does not determine the law of any state, the District of Columbia, territory, or locality.

3C-E is covered by the generic structural definition for compounds derived from 2-phenethylamine in Anlage 1 Nr. 1 of the Neue-psychoaktive-Stoffe-Gesetz (NpSG), rather than by an exact-name listing. The NpSG took effect on 26 November 2016. Section 3(1) prohibits trade, placing on the market, manufacture, import, export, transit, acquisition, possession, and administration to another person. Under § 4(1), trade, placing on the market, administration to another person, and manufacture or import for the purpose of placing on the market are punishable by imprisonment for up to three years or a fine; simple acquisition and possession are not standalone criminal offenses under § 4. Recognized commercial, industrial, scientific, and official uses specified in § 3(2) are excepted, and qualifying medicinal products and narcotic drugs governed by the BtMG are excluded from the NpSG.

3C-E and its salts are listed as designated substances under Article 1, item 100 of 医薬品、医療機器等の品質、有効性及び安全性の確保等に関する法律第二条第十五項に規定する指定薬物及び同法第七十六条の四に規定する医療等の用途を定める省令（平成十九年厚生労働省令第十四号）, which expressly names 1-(4-ethoxy-3,5-dimethoxyphenyl)propan-2-amine. The designation took effect on 4 April 2015. Manufacture, import, sale, transfer, possession, purchase, acquisition, and use are prohibited when intended for, or undertaken for, purposes outside the medical and other uses permitted by ministerial ordinance.

3C-E is covered by the generic structural definition for Phenylalkylamine compounds in Annex 6, Verzeichnis e, number 315, of the Betäubungsmittelverzeichnisverordnung, rather than by an exact-name listing. Verzeichnis e substances are subject to the control measures applicable to Verzeichnis a narcotics. Unauthorized cultivation, manufacture, import, export, storage, use, or placing on the market is punishable by up to three years' imprisonment or a monetary penalty. Industrial and scientific use are exempt from the generic entry's control, but private use is expressly not exempt.

3C-E falls within the generic structural definition in Schedule 2 Part I paragraph 1(c) of the Misuse of Drugs Act 1971 and is therefore a Class A controlled drug. This classification has applied since 20 September 1977. Its possession, production, supply, import and export are prohibited, subject to the licences, regulations, exceptions and defences stated in the Act.