3-FEA
3-FEA is a novel synthetic entactogen and stimulant of the substituted amphetamine class.citation needed It is the 3-fluorinated analog of ethylamphetamine and belongs to a series of designer fluorinated amphetamines. Anecdotal reports characterize it as a moderately potent serotonin-dominant triple monoamine releaser, producing a combination of entactogenic and mild stimulant effects. Very little formal research exists regarding its pharmacology, toxicity, or safety profile in humans.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
3-FEA produces a mixed stimulant and entactogen-leaning experience consistent with its action as a releaser of serotonin, dopamine, and norepinephrine. Its relatively strong serotonin release compared to other ethylamphetamine derivatives lends the experience a warmer, mood-elevating character than that of purely dopaminergic stimulants, though its effects are generally regarded as mild and short-lived relative to classical entactogens. Detailed phenomenological documentation of this compound remains limited.
Physical
Cognitive
The headspace is typically described as a gentle mood lift with mild euphoria and a subtle sense of emotional warmth and sociability, without significant alteration of thought structure. In high dosages it becomes much more like that of an entactogen such as MDMA due to its triple monoamine release.
Pharmacology
Pharmacodynamics
3-FEA acts primarily as a monoamine releasing agent, elevating levels of serotonin, dopamine, and norepinephrine in the brain.citation needed It may also partially inhibit reuptake at these transporters, though this has not been formally confirmed. Relative to unsubstituted ethylamphetamine, 3-FEA shows enhanced serotonin release, though available characterizations differ regarding its relative dopamine and norepinephrine releasing potencies. In animal studies, it produced the strongest reinforcing effects among a range of 3-substituted ethamphetamine derivatives tested, despite not being the most potent dopamine releaser in that series.
Pharmacokinetics
There have been no studies on the pharmacokinetic profile of 3-FEA and the metabolism of 3-FEA is unknown.
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Dopaminergic stimulants, Serotonergic stimulants, Entactogens (including MDMA), Amphetamines
Harm Potential
Addiction & Dependence
Psychological
ModerateDescribed as likely moderately addictive with a high potential for abuse, capable of causing psychological dependence in some users. Compulsive redosing is commonly reported, particularly during or immediately following the peak effects. Cravings may develop with chronic use.
Physical
LowWithdrawal effects may occur if use is suddenly stopped after dependence has developed, though available reports emphasize psychological rather than physical dependence mechanisms.citation needed
Toxicity
Due to its serotonin-releasing entactogenic properties, 3-FEA may display significant activity at the 5-HT2B receptor, which could make it cardiotoxic with long-term or heavy use, similar to MDMA and fenfluramine;citation needed acute cardiovascular strain during intoxication has also been reported.
Psychosis Risk
As an amphetamine derivative, abuse at high dosages for prolonged periods can potentially result in stimulant psychosis presenting with paranoia, hallucinations, or delusions. Based on reviews of amphetamine-induced psychosis, approximately 5-15% of affected users fail to recover completely, though antipsychotics effectively resolve acute symptoms.citation needed Psychosis very rarely arises from cautious, sparing use at moderate doses.
History & Culture
3-Fluoroethamphetamine belongs to a series of designer fluorinated amphetamine derivatives that emerged in the 2010s, which includes related compounds such as 2-FA, 2-FMA, 3-FA, 4-FMA, and 4-FA. These substances were developed as novel psychoactive compounds for the research chemical market.…
Legality
By Country
References
Source Pages
Citations
- RIS - Neue-Psychoaktive-Substanzen-Verordnung § 1 - Bundesrecht konsolidiert, Fassung vom 28.08.2026. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Anlage=&Artikel=&FassungVom=2026-08-28&Gesetzesnummer=20007642&Paragraf=1&Uebergangsrecht=1
- RIS - Neue-Psychoaktive-Substanzen-Verordnung Anlage II, BGBl. II Nr. 106/2024. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40261441/II_106_2024_Anlage_II.pdf1
- RIS - Neue-Psychoaktive-Substanzen-Gesetz § 2 - Bundesrecht konsolidiert, Fassung vom 28.08.2026. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Anlage=&Artikel=&FassungVom=2026-08-28&Gesetzesnummer=20007605&Paragraf=2&Uebergangsrecht=1
- RIS - Neue-Psychoaktive-Substanzen-Gesetz § 4 - Bundesrecht konsolidiert, Fassung vom 28.08.2026. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Anlage=&Artikel=&FassungVom=2026-08-28&Gesetzesnummer=20007605&Paragraf=4&Uebergangsrecht=1
- RIS - Neue-Psychoaktive-Substanzen-Gesetz § 5 - Bundesrecht konsolidiert, Fassung vom 28.08.2026. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Anlage=&Artikel=&FassungVom=2026-08-28&Gesetzesnummer=20007605&Paragraf=5&Uebergangsrecht=1
- RIS - Suchtgiftverordnung Anhang IV - Bundesrecht konsolidiert, current RIS text. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Anlage=4&Artikel=&Gesetzesnummer=10011053&Paragraf=&Uebergangsrecht=1
- RIS - Suchtgiftverordnung Anhang IV, NOR40279095 (BGBl. II Nr. 180/2026). ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/Dokumente/Bundesnormen/NOR40279095/NOR40279095.pdf1
- PubChem CID 57458869 compound properties for 3-FEA. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/57458869/property/IUPACName,CanonicalSMILES,IsomericSMILES,MolecularFormula,InChIKey/JSON1
- PubChem CID 57458869 synonyms for 3-FEA. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/57458869/synonyms/JSON1
- Controlled Drugs and Substances Act, current Schedule I. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-sched95314.html1
Further Reading
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass review
A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes8 human edits · latest
Times are UTCNewest first
29 August 2026
Lyrea · Reworded 21 words in Subjective Effects › Notes › Cognitive
Lyrea · Updated the article
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the 3-FEA article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.
Wish to give generalised feedback? You can do so here.