2C-T

2,5-Dimethoxy-4-methylthiophenethylamine

Tesseract

Psychoactive Class

Chemical Class

2C-T is a lesser-known psychedelic of the substituted phenethylamine class and a member of the 2C-x family, which are closely related to mescaline. It was first described in the scientific literature by David E. Nichols and Alexander Shulgin in 1976,¹ with further detail published in Shulgin's 1991 book PiHKAL.² Among the 2C psychedelics, 2C-T is notable for its relatively low potency and comparatively short duration of effects.²

Dosage & Duration

Dosage

Threshold~20 mg

Light20-60 mg

Moderate60-90 mg

Strong90-120 mg

Heavy120+ mg

Duration

Onset15-60 minutes

Peak30-115 minutes

Offset1-2 hours

After Effects1-4 hours

Total3-6 hours

Subjective Effects

2C-T produces a rapid but quiet onset, with effects noticeable within roughly fifteen minutes and developing without dramatic intensity. The experience is unusual among psychedelics in that it feels distinctly psychedelic while producing little to nothing in the way of visual effects; instead it centers on tactile warmth, easy conversation, and an MDMA-like sense of emotional openness, leading some to consider it a possible MDMA substitute. The character has been described as somewhat generic and sharper-edged than 2C-B, with a total duration of roughly five to six hours and a notably relaxed comedown that can pass into deep, dream-filled sleep.

Physical

The body feeling is generally warm and pleasant, with a very relaxed offset. Stomach discomfort or uncertainty can occur, particularly during the come-up.

Cognitive

The headspace combines conversational ease and a sense of things feeling opened up with a consistently reported emotional removal, in which the intellect tends to be more evident than the heart. Some users describe a subtle, transparent sense of separation from their surroundings, and appreciation of poetry may be increased.

Emotional

Tactile

Reagent Testing

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Expected colorimetric results are being prepared.

Pharmacology

Pharmacodynamics

2C-T acts as an agonist at serotonin 5-HT2A and 5-HT2B receptors, with its psychedelic effects primarily attributed to 5-HT2A receptor activity.³ It has also been characterized as a partial agonist at 5-HT2A.³ The compound shows broader affinity for the 5-HT2 receptor family but does not appear to bind monoamine transporters.³ Based on structural similarity to related 2C-T-x compounds, 2C-T may possess some monoamine oxidase inhibitor (MAOI) activity, though this has not been directly established.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AMTLithium

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Tramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

2C-T-x compounds5-MeO-xxT tryptaminesAmphetaminesCannabisCocaineDOx compoundsMAOIsMescalineNBOMe compounds

TripSit

Tolerance

Full Tolerance

Tolerance to the effects of 2C-T develops almost immediately following ingestion.

Baseline Reset

Approximately 7 days

Half Tolerance

Approximately 3 days

Cross Tolerance

Serotonergic psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

2C-T is not habit-forming⁴. With repeated use, the urge to take it may lessen, and use is typically self-limiting.

History & Culture

2C-T emerged from collaborative research between pharmacologist David E. Nichols and chemist Alexander Shulgin, with the compound first appearing in scientific literature in 1976.¹ The substance was subsequently documented in greater detail in Shulgin's 1991 book…

Legality

By Country

United StatesUnscheduled (Federal Analog Act applies)

Not explicitly scheduled under federal law; however, its structural and pharmacological similarity to scheduled compounds such as 2C-T-7 may subject possession and sale to prosecution under the Federal Analog Act when intended for human consumption. Operation Web Tryp, commenced in 2004, resulted in prosecutions and convictions of online vendors selling similar phenethylamine compounds.

United KingdomClass A

Controlled under the Misuse of Drugs Act 1971.⁶ Designated as Class A due to the phenethylamine catch-all clause, which captures structurally related phenethylamine compounds regardless of explicit scheduling.⁶

CanadaSchedule III

Classified as a controlled substance under Schedule III of the Controlled Drugs and Substances Act as of October 31, 2016.⁵ Listed as a derivative of 2,5-dimethoxyphenethylamine.⁵

References

Source Pages

Citations

Automated synthesis
Information aggregated and synthesized using an autonomous workflow built by Josie Kins.

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2C-T

2,5-Dimethoxy-4-methylthiophenethylamine

Tesseract

2C-T

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