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2C-P

2C-P molecule structure2C-P molecule structure
2,5-Dimethoxy-4-propylphenethylamine
2cp
Psychoactive Class

2C-P (2,5-dimethoxy-4-propylphenethylamine) is a synthetic psychedelic of the phenethylamine class and a member of the 2C-x family.citation needed First synthesized by Alexander Shulgin in 1974 and documented in PiHKAL, it stands out as one of the most potent and longest-lasting compounds in its series, with effects spanning 10-20 hours. 2C-P is notably dose-sensitive with a narrow margin between adequate and excessive doses, and is associated with intense body load including nausea and muscle tension. Volumetric dosing is strongly recommended due to its potency.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold1-3 mg
Light2-4 mg
Moderate4-6 mg
Strong6-10 mg
Heavy16+ mg

2C-P has a steep dose-response curve, with only a few milligrams separating a manageable dose from an overdose. Accurate milligram scales or volumetric liquid dosing are advised over visual estimation. Because of the slow onset, redosing earlier than 3 hours is discouraged, and increments above a previously evaluated dose should be small. A 16 mg dose has been described as a clear overdose with physical consequences.

Duration

Onset1-3 hours
Come Up2-4 hours
Peak4-8 hours
Offset3-6 hours
After Effects8-48 hours
Total10-20 hours
Half-life
~19 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

Increased bodily controlTactile enhancementTemperature regulation loss

Cognitive

The head space of 2C-P is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.

Visual

Geometry

The visual geometry of 2C-P can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B, or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, fast and smooth in motion, colourful in scheme, glossy in colour, sharp in their edges and equally rounded and angular in their corners. They give off a contradictory natural and synthetic feel that at higher dosages are significantly more likely to result in states of Level 7B visual geometry over Level 7A. The visual geometry is distinct from 2C-E, psilocin and ayahuasca and can be described as faster moving and more intense in proportion to the present cognitive and physical effects than 2C-E.

Hallucinatory States

2C-P produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics, particularly in comparison to other substances within the phenethylamine family.

External hallucinations

Auditory

The auditory effects of 2C-P are more common in their occurrence than many commonly used psychedelics.

Forked from Subjective Effect Documentation byJosie Kins September 2013.

See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow2
Mecke(ME)
white → yellow2 → green2 → brown2 → brown3
Mandelin(MD)
yellow2 → green2
Robadope(RB)
orange1 → pink1 → pink1 → pink2
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Pharmacology

Pharmacodynamics

2C-P acts as an agonist at serotonin 5-HT2 receptors, which is believed to underlie its psychedelic effects.citation needed It also binds to the serotonin 5-HT1A receptor with approximately 14-fold lower affinity than for the 5-HT2A receptor.1 The substance shows high affinity for the rat trace amine-associated receptor 1 (TAAR1) and lower but still high affinity for mouse TAAR1.citation needed Unlike many other psychedelics, 2C-P has demonstrated reinforcing effects in rodents, producing dose-dependent conditioned place preference in mice and self-administration in rats. This appears to involve decreased dopamine transporter expression and increased DAT phosphorylation in the nucleus accumbens, which may result in reduced dopamine reuptake and increased extracellular dopamine levels through reverse transport. The substance shows little or no affinity for monoamine transporters and only weakly inhibits monoamine oxidases.

Pharmacokinetics

2C-P biotransformation research has proposed N-acetylation; deamination followed by reduction to an alcohol or oxidation to a carboxylic acid; mono- and bis-hydroxylation; mono- and bis-O-demethylation; and subsequent glucuronidation and/or sulfation, including combinations of these steps.citation needed Human kinetic evidence remains limited: a single intoxication case used two blood concentrations to estimate an elimination half-life of 19 hours. This case estimate should not be presented as a population oral half-life.

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

2C-T-x compounds5-MeO-xxT tryptaminesAmphetaminesCannabisCocaineDOx compoundsMAOIsMescalineNBOMe compounds
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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Tolerance to the effects develops almost immediately after ingestion. Notably, some sources suggest there is minimal tolerance attributed to this substance, potentially allowing for consecutive day use, though this is impractical given the slow onset and extended duration.
Baseline Reset
Approximately 7 days
Half Tolerance
Approximately 3 days
Cross Tolerance

Serotonergic psychedelics

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

2C-P is not known to be associated with compulsive use. As a serotonergic psychedelic, it is considered to have a low potential for abuse. Users report a self-regulating quality to the experience.

Physical

Extremely Low

Physical dependence is extremely unlikely. 2C-P does not appear to be physically addictive.citation needed

Toxicity

Central Nervous System

2C-P has been found to produce neurotoxicity at high doses in rodent studies2; relevance to typical human recreational doses is not established.

Cardiovascular

Acute cardiovascular effects including vasoconstriction, increased blood pressure, and significantly elevated heart rate have been reported during intoxication.citation needed

Psychosis Risk

2C-P can produce severe mental confusion, disturbing hallucinations, anxiety, fear, paranoia, and overwhelming thoughts, particularly at higher doses.citation needed The steep dose-response curve increases the risk of experiencing these adverse psychological reactions.

History & Culture

Synthesis and Documentation

2C-P was first synthesized by American chemist Alexander Shulgin in 1974. The compound was subsequently documented in Shulgin's 1991 book PiHKAL (Phenethylamines I Have Known and Loved), where he detailed his findings on its psychoactive properties. Published qualitative reports characterize the

Trip Reports

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Legality

International

1961 Single Convention: 2C-P is not individually scheduled.

1971 Convention on Psychotropic Substances: 2C-P is not individually scheduled.

1988 Convention: 2C-P is not listed in precursor Tables I or II.

By Country

Illegal11
United States flagUnited StatesIllegal
Austria flagAustriaIllegal (analog/blanket ban)
Canada flagCanadaIllegal
China flagChinaIllegal
Denmark flagDenmarkIllegal
Germany flagGermanyIllegal
Japan flagJapanIllegal
Latvia flagLatviaIllegal
Netherlands flagNetherlandsIllegal
Turkey flagTurkeyIllegal
United Kingdom flagUnited KingdomIllegal
Controlled / restricted2
Finland flagFinlandRestricted
Switzerland flagSwitzerlandRestricted

References

Source Pages

  1. Disregard Everything I Say
  2. Erowid
  3. Erowid: 2C-P Dosage
  4. Erowid: 2C-P Effects
  5. Isomer Design (TiHKAL/PiHKAL)
  6. PiHKAL #36 (Shulgin)
  7. PsychonautWiki
  8. PsychonautWiki: 2C-P Summary
  9. TripSit Factsheets
  10. TripSit Wiki
  11. TripSit: 2C-P Factsheet
  12. Wikipedia

Citations

  1. Anna Rickli, Dino Luethi, Julian Reinisch, Danièle Buchy, Marius C. Hoener, & Matthias E. Liechti. (December 2015). Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs). Neuropharmacology, 99, 546–553. https://doi.org/10.1016/j.neuropharm.2015.08.0341
  2. Young-Jung Kim, Shi-Xun Ma, Kwang-Hyun Hur, Youyoung Lee, Yong-Hyun Ko, Bo-Ram Lee, Seon-Kyung Kim, Su-Jeong Sung, Kyeong-Man Kim, Hyoung-Chun Kim, Seok-Yong Lee, & Choon-Gon Jang. (April 2021). New designer phenethylamines 2C-C and 2C-P have abuse potential and induce neurotoxicity in rodents. Archives of Toxicology, 95(4), 1413–1429. https://doi.org/10.1007/s00204-021-02980-x123
  3. Rapper Ceon Broughton wins appeal against manslaughter conviction following festival death of Louella Fletcher-Michie. Garden Court Chambers (2020-08-18). https://gardencourtchambers.co.uk/rapper-ceon-broughton-wins-appeal-against-manslaughter-conviction-following-festival-death-of-louella-fletcher-michie/1
  4. NIH PubChem CID 44350080 property record — 2,5-Dimethoxy-4-propylphenethylamine. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/44350080/property/IUPACName,Title,CanonicalSMILES,IsomericSMILES,MolecularFormula/JSON1
  5. NIH PubChem CID 44350080 synonyms — 2C-P. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/44350080/synonyms/JSON1
  6. Neue-Psychoaktive-Substanzen-Verordnung (NPSV), consolidated Austrian text, version 28 August 2026. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/geltendefassung/bundesnormen/20007642/npsv%2C%20fassung%20vom%2028.08.2026.pdf1
  7. NPSV Anlage II, BGBl. II Nr. 106/2024, operative Annex II text. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/Dokumente/Bundesnormen/NOR40261441/II_106_2024_Anlage_II.pdf1
  8. Suchtgiftverordnung (SV), consolidated Austrian regulation, version 28 August 2026. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/geltendefassung/bundesnormen/10011053/suchtgiftverordnung%2C%20fassung%20vom%2028.08.2026.pdf1
  9. Suchtgiftverordnung Annex V, current RIS text, version 28 August 2026. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Anlage=5&Artikel=&FassungVom=2026-08-28&Gesetzesnummer=10011053&Paragraf=&Uebergangsrecht=&ShowPrintPreview=True1
  10. Neue-Psychoaktive-Substanzen-Gesetz (NPSG), consolidated Austrian statute, version 28 August 2026. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/geltendefassung/bundesnormen/20007605/npsg%2C%20fassung%20vom%2028.08.2026.pdf1

Further Reading

  1. PiHKAL Mirror: 2C-P
  2. PubChem: 2,5-Dimethoxy-4-propylphenethylamine

Article Status

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    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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Recent changes7 human edits · latest

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24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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