2C-B-FLY
2C-B-FLY is a lesser-known psychedelic in the phenethylamine and benzodihydrodifuran classescitation needed; Aaron P. Monte synthesized it in 1996. It is a dihydrofuran analog of 2C-B, with effects described as combining features of 2C-B, mescaline, and MDA, including mild psychedelia, entactogenic body sensations, and a positive mood push. Its popularity was temporarily impacted around 2009 when deaths caused by Bromo-DragonFLY were erroneously attributed to it.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Individual sensitivity to 2C-B-FLY varies considerably. Some individuals report pronounced effects at doses typically classified as light, whereas others may require amounts in the moderate-to-strong range to achieve similar intensity.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Effects vary widely by individual, dose, and context.
Physical
Cognitive
Visual
Auditory
See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)
Reagent Testing
Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.
Pharmacology
Pharmacodynamics
2C-B-FLY acts as a potent partial agonist at the serotonin 5-HT2A receptor, with this interaction considered the primary basis for its psychedelic effects.citation needed It is additionally a potent agonist at 5-HT2B and 5-HT2C, displaying biased agonism at 5-HT2C. The compound shows notably high affinity for the 5-HT1D receptor (unusual among 2C-series compounds), alongside weaker affinity for 5-HT1A, 5-HT1B, and 5-HT1E.
Pharmacokinetics
No pharmacokinetic studies have been performed and little is known about its metabolism.
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Psychedelics (all psychedelics will have a reduced effect following 2C-B-FLY consumption)
Harm Potential
Addiction & Dependence
Psychological
Extremely Low2C-B-FLY is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.citation needed
Toxicity
The toxicity of 2C-B-FLY in humans is unknown, and the exact toxic dose has not been established. Two deaths occurred in October 2009 in Denmark and the United States after ingestion of a substance sold as 2C-B-FLY, but the material actually consisted of Bromo-DragonFLY contaminated with a small amount of unidentified impurities, not 2C-B-FLY itself.
History & Culture
Discovery and Synthesis
2C-B-FLY was first described in the scientific literature in 1995 by Aaron Phillip Monte and David E. Nichols along with colleagues at Purdue University.citation needed Monte, a Professor of Chemistry at the University of Wisconsin-La Crosse, synthesized this novel compound as part of research…
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Legality
International
2C-B-FLY does not appear in the INCB lists of substances controlled by the 1961 Single Convention, the 1971 Convention on Psychotropic Substances, or Tables I and II of the 1988 Convention. UNODC identifies 2C-B-FLY as a phenethylamine, but that classification is not international scheduling.
By Country
References
Source Pages
Citations
- Decreto 122/2026, Anexo I (sustituting Anexo I of Decreto 560/2019); Ley 23.737. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-122-2026-423520/texto1
- Official source 2. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-560-2019-326675/actualizacion1
- Official source 3. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-560-2019-326675/normas-modifican1
- Decreto 122/2026, Anexo I (sustituting Anexo I of Decreto 560/2019); Ley 23.737. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/423520_dec122_jpg/archivo1
- Neue-Psychoaktive-Substanzen-Verordnung (NPSV), Anlage II. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Anlage=2&Artikel=&FassungVom=2026-02-16&Gesetzesnummer=20007642&Paragraf=&Uebergangsrecht=1
- Official source 2. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=20007605&ShowPrintPreview=True1
- Royal Decree of 6 September 2017 regulating narcotic drugs and psychotropic substances, Annex IVB (as amended by the Royal Decree of 8 February 2023). ejustice.just.fgov.be (n.d.). https://www.ejustice.just.fgov.be/eli/arrete/2017/09/06/2017031231/justel1
- Royal Decree of 6 September 2017 regulating narcotic drugs and psychotropic substances, Annex IVB (as amended by the Royal Decree of 8 February 2023). ejustice.just.fgov.be (n.d.). https://www.ejustice.just.fgov.be/cgi_loi/article.pl?cn_search=2023020806&language=fr&lg_txt=f1
- Royal Decree of 6 September 2017 regulating narcotic drugs and psychotropic substances, Annex IVB (as amended by the Royal Decree of 8 February 2023). etaamb.openjustice.be (n.d.). https://etaamb.openjustice.be/fr/arrete-royal-du-08-fevrier-2023_n2023040722.html1
- Royal Decree of 6 September 2017 regulating narcotic drugs and psychotropic substances, Annex IVB (as amended by the Royal Decree of 8 February 2023). afmps.be (n.d.). https://www.afmps.be/sites/default/files/content/INSP/NARC/annex%20IV_non%20official%20consolidated%20version.pdf1
Further Reading
Article Status
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Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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