2C-B-FLY
2C-B-FLY is a lesser-known psychedelic in the phenethylamine and benzodihydrodifuran classes1; Aaron P. Monte synthesized it in 1996. It is a dihydrofuran analog of 2C-B, with effects described as combining features of 2C-B, mescaline, and MDA, including mild psychedelia, entactogenic body sensations, and a positive mood push. Its popularity was temporarily impacted around 2009 when deaths caused by Bromo-DragonFLY were erroneously attributed to it2.
Dosage & Duration
Dosage
Individual sensitivity to 2C-B-FLY varies considerably. Some individuals report pronounced effects at doses typically classified as light, whereas others may require amounts in the moderate-to-strong range to achieve similar intensity.
Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
Cognitive
Visual
Auditory
Reagent Testing
Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.
Pharmacology
Pharmacodynamics
2C-B-FLY acts as a potent partial agonist at the serotonin 5-HT2A receptor, with this interaction considered the primary basis for its psychedelic effects.3 It is additionally a potent agonist at 5-HT2B and 5-HT2C, displaying biased agonism at 5-HT2C.34 The compound shows notably high affinity for the 5-HT1D receptor (unusual among 2C-series compounds), alongside weaker affinity for 5-HT1A, 5-HT1B, and 5-HT1E.53
Pharmacokinetics
No pharmacokinetic studies have been performed and little is known about its metabolism.
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Psychedelics (all psychedelics will have a reduced effect following 2C-B-FLY consumption)
Harm Potential
Addiction & Dependence
Psychological
Extremely Low2C-B-FLY is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.6
Toxicity
The toxicity of 2C-B-FLY in humans is unknown, and the exact toxic dose has not been established. Two deaths occurred in October 2009 in Denmark and the United States after ingestion of a substance sold as 2C-B-FLY, but the material actually consisted of Bromo-DragonFLY contaminated with a small amount of unidentified impurities, not 2C-B-FLY itself.
History & Culture
Discovery and Synthesis
2C-B-FLY was first described in the scientific literature in 1995 by Aaron Phillip Monte and David E. Nichols along with colleagues at Purdue University.7 Monte, a Professor of Chemistry at the University of Wisconsin-La Crosse, synthesized this novel compound as part of…
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Legality
International
2C-B-FLY does not appear in the INCB lists of substances controlled by the 1961 Single Convention, the 1971 Convention on Psychotropic Substances, or Tables I and II of the 1988 Convention. UNODC identifies 2C-B-FLY as a phenethylamine, but that classification is not international scheduling.
By Country
References
Source Pages
Citations
- Corazza O, Schifano F, Farre M, Deluca P, Davey Z, Torrens M, Demetrovics Z, Di Furia L, Flesland L, Siemann H, Skutle A, van der Kreeft P, & Scherbaum N. (2011). Designer drugs on the internet: a phenomenon out-of-control? The emergence of hallucinogenic drug Bromo-Dragonfly. Current Clinical Pharmacology, 6(2), 125–129. https://doi.org/10.2174/1574884117961511291
- Caffrey CR, & Lank PM. (2018). When good times go bad: managing ‘legal high’ complications in the emergency department. Open Access Emergency Medicine, 10, 9–23. https://doi.org/10.2147/oaem.s1201201
- Anna Rickli, Simone Kopf, Marius C Hoener, & Matthias E Liechti. (July 2015). Pharmacological profile of novel psychoactive benzofurans. British Journal of Pharmacology, 172(13), 3412–3425. https://doi.org/10.1111/bph.13128123
- Emma M. Bonniwell, Rana Alabdali, Joseph J. Hennessey, John L. McKee, Natalie G. Cavalco, Josie C. Lammers, Ethan J. Moore, Luca Franchini, Cesare Orlandi, & John D. McCorvy. (October 2025). Serotonin 5-HT2C Receptor Signaling Analysis Reveals Psychedelic Biased Agonism. ACS Chem Neurosci, 16(19), 3899–3914. https://doi.org/10.1021/acschemneuro.5c006471
- Thomas S. Ray. (February 2010). Psychedelics and the human receptorome. PLOS ONE, 5(2). https://doi.org/10.1371/journal.pone.00090191
- Nichols DE. (2016). Psychedelics. Pharmacological Reviews, 68(2), 264–355. https://doi.org/10.1124/pr.115.0114781
- Aaron P. Monte, Danuta Marona-Lewicka, Matthew A. Parker, David B. Wainscott, David L. Nelson, & David E. Nichols. (July 1996). Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups. Journal of Medicinal Chemistry, 39(15), 2953–2961. https://doi.org/10.1021/jm960199j12
- Decreto 122/2026, Anexo I (sustituting Anexo I of Decreto 560/2019); Ley 23.737. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-122-2026-423520/texto1
- Official source 2. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-560-2019-326675/actualizacion1
- Official source 3. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-560-2019-326675/normas-modifican1
- Decreto 122/2026, Anexo I (sustituting Anexo I of Decreto 560/2019); Ley 23.737. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/423520_dec122_jpg/archivo1
- Neue-Psychoaktive-Substanzen-Verordnung (NPSV), Anlage II. ris.bka.gv.at (n.d.). https://ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Anlage=2&Artikel=&FassungVom=2026-02-16&Gesetzesnummer=20007642&Paragraf=&Uebergangsrecht=1
- Official source 2. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/GeltendeFassung.wxe?Abfrage=Bundesnormen&Gesetzesnummer=20007605&ShowPrintPreview=True1
- Royal Decree of 6 September 2017 regulating narcotic drugs and psychotropic substances, Annex IVB (as amended by the Royal Decree of 8 February 2023). ejustice.just.fgov.be (n.d.). https://www.ejustice.just.fgov.be/eli/arrete/2017/09/06/2017031231/justel1
- Royal Decree of 6 September 2017 regulating narcotic drugs and psychotropic substances, Annex IVB (as amended by the Royal Decree of 8 February 2023). ejustice.just.fgov.be (n.d.). https://www.ejustice.just.fgov.be/cgi_loi/article.pl?cn_search=2023020806&language=fr&lg_txt=f1
- Royal Decree of 6 September 2017 regulating narcotic drugs and psychotropic substances, Annex IVB (as amended by the Royal Decree of 8 February 2023). etaamb.openjustice.be (n.d.). https://etaamb.openjustice.be/fr/arrete-royal-du-08-fevrier-2023_n2023040722.html1
- Royal Decree of 6 September 2017 regulating narcotic drugs and psychotropic substances, Annex IVB (as amended by the Royal Decree of 8 February 2023). afmps.be (n.d.). https://www.afmps.be/sites/default/files/content/INSP/NARC/annex%20IV_non%20official%20consolidated%20version.pdf1
- Portaria SVS/MS nº 344/1998, Anexo I, Lista F2(d), as currently consolidated in ANVISA RDC nº 1.036, de 9 de julho de 2026. anvisalegis.datalegis.net (n.d.). https://anvisalegis.datalegis.net/action/ActionDatalegis.php?acao=abrirTextoAto&tipo=RDC&numeroAto=00001036&seqAto=000&valorAno=2026&orgao=RDC/DC/ANVISA/MS&codTipo=&desItem=&desItemFim=&cod_menu=1696&cod_modulo=1341
- Official source 2. gov.br (n.d.). https://www.gov.br/anvisa/pt-br/assuntos/medicamentos/controlados/lista-substancias1
- Official source 3. anvisalegis.datalegis.net (n.d.). https://anvisalegis.datalegis.net/action/ActionDatalegis.php?acao=abrirTextoAto&tipo=RDC&numeroAto=00000581&seqAto=000&valorAno=2021&orgao=RDC/DC/ANVISA/MS&cod_menu=1696&cod_modulo=1341
- Official source 4. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/2C-B-FLY/property/IUPACName,CanonicalSMILES/JSON1
- Controlled Drugs and Substances Act. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-11.html1
- Official source 2. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/FullText.html1
- Decreto Supremo Nº 867 de 2007, Reglamento de la Ley Nº 20.000, modificado por Decreto Supremo Nº 220 de 2022. directemar.cl (n.d.). https://www.directemar.cl/directemar/site/docs/20170126/20170126122722/tm_014_a_actualizado_al_16_septiembre_2023.pdf1
- Official source 2. bcn.cl (n.d.). https://www.bcn.cl/leychile/navegar?idNorma=2355071
- Official source 3. nuevo.leychile.cl (n.d.). https://nuevo.leychile.cl/servicios/Consulta/Exportar?exportar_con_notas_al_pie=False&exportar_con_notas_bcn=False&exportar_con_notas_originales=False&exportar_formato=pdf&hddResultadoExportar=1181246.2022-09-13.0.0%23&nombrearchivo=Decreto-220_13-SEP-2022&radioExportar=Normas1
- Government Regulation No. 463/2013 Coll., Annex 4 (current consolidated text); Act No. 167/1998 Coll., § 39(2)(e); Criminal Code No. 40/2009 Coll., § 284. e-sbirka.gov.cz (n.d.). https://e-sbirka.gov.cz/sb/2013/463/2026-06-251
- Government Regulation No. 463/2013 Coll., Annex 4 (current consolidated text); Act No. 167/1998 Coll., § 39(2)(e); Criminal Code No. 40/2009 Coll., § 284. e-sbirka.gov.cz (n.d.). https://e-sbirka.gov.cz/sb/1998/1671
- Government Regulation No. 463/2013 Coll., Annex 4 (current consolidated text); Act No. 167/1998 Coll., § 39(2)(e); Criminal Code No. 40/2009 Coll., § 284. e-sbirka.gov.cz (n.d.). https://e-sbirka.gov.cz/sb/2009/401
- Bekendtgørelse om euforiserende stoffer (BEK nr 405 af 26/03/2026). retsinformation.dk (n.d.). https://www.retsinformation.dk/eli/lta/2026/405/dan/pdf1
- Government Decree on Psychoactive Substances Banned from the Consumer Market (1130/2014), Annex as replaced by Decree 152/2025 and subsequently amended by Decree 650/2026. finlex.fi (n.d.). https://www.finlex.fi/api/media/statute/87257/mainPdf/main.pdf?timestamp=2014-12-19T00%3A00%3A00.000Z1
- Official source 2. finlex.fi (n.d.). https://www.finlex.fi/api/media/statute/690146/mainPdf/main.pdf?timestamp=2025-04-09T21%3A00%3A00.000Z1
- Official source 3. finlex.fi (n.d.). https://www.finlex.fi/en/legislation/collection/2026/6501
- Official source 4. valtioneuvosto.fi (n.d.). https://valtioneuvosto.fi/paatokset/paatos?decisionId=65861
- Official source 5. stm.fi (n.d.). https://stm.fi/en/narcotics-control1
- Neue-psychoaktive-Stoffe-Gesetz. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/anlage_1.html1
- Neue-psychoaktive-Stoffe-Gesetz. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__3.html1
- Neue-psychoaktive-Stoffe-Gesetz. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/npsg/__4.html1
- Neue-psychoaktive-Stoffe-Gesetz (NpSG), BGBl. I S. 2615, in force 26 November 2016. Bundesministerium der Justiz (2016). https://www.gesetze-im-internet.de/npsg/BJNR261510016.html12
- Criminal Justice (Psychoactive Substances) Act 2010, sections 1–3; commenced by the Criminal Justice (Psychoactive Substances) Act 2010 (Commencement) Order 2010 (S.I. No. 401/2010). revisedacts.lawreform.ie (n.d.). https://revisedacts.lawreform.ie/eli/2010/act/22/revised/en/html1
- Criminal Justice (Psychoactive Substances) Act 2010, sections 1–3; commenced by the Criminal Justice (Psychoactive Substances) Act 2010 (Commencement) Order 2010 (S.I. No. 401/2010). irishstatutebook.ie (n.d.). https://www.irishstatutebook.ie/eli/2010/si/401/made/en/print1
- Criminal Justice (Psychoactive Substances) Act 2010, sections 1–3; commenced by the Criminal Justice (Psychoactive Substances) Act 2010 (Commencement) Order 2010 (S.I. No. 401/2010). irishstatutebook.ie (n.d.). https://www.irishstatutebook.ie/eli/2022/si/211/made/en/print1
- Criminal Justice (Psychoactive Substances) Act 2010, sections 1–3; commenced by the Criminal Justice (Psychoactive Substances) Act 2010 (Commencement) Order 2010 (S.I. No. 401/2010). irishstatutebook.ie (n.d.). https://www.irishstatutebook.ie/eli/2025/si/406/made/en/print1
- Criminal Justice (Psychoactive Substances) Act 2010, sections 1–3; commenced by the Criminal Justice (Psychoactive Substances) Act 2010 (Commencement) Order 2010 (S.I. No. 401/2010). cfsre.org (n.d.). https://www.cfsre.org/nps-discovery/monographs/2c-b-fly1
- Ministerial Decree of 6 August 2021 updating the tables under DPR 309/1990. gazzettaufficiale.it (n.d.). https://www.gazzettaufficiale.it/atto/vediMenuHTML?atto.codiceRedazionale=21A05064&atto.dataPubblicazioneGazzetta=2021-08-21&tipoSerie=serie_generale&tipoVigenza=originario1
- 医薬品、医療機器等の品質、有効性及び安全性の確保等に関する法律第二条第十五項に規定する指定薬物及び同法第七十六条の四に規定する医療等の用途を定める省令(平成19年厚生労働省令第14号). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001714395.pdf1
- Official source 2. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/bunya/iyakuhin/yakubuturanyou/scheduled-drug/index.html1
- Opiumwet. wetten.overheid.nl (n.d.). https://wetten.overheid.nl/BWBR0001941/2025-07-011
- Regulations on narcotics, amendment of 4 July 2016 No. 875. lovdata.no (n.d.). https://lovdata.no/forskrift/2016-07-04-8751
- Rozporządzenie Ministra Zdrowia z dnia 17 sierpnia 2018 r. w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych (tekst jednolity: Dz.U. 2024 poz. 1139). eli.gov.pl (n.d.). https://eli.gov.pl/api/acts/DU/2024/1139/text.html1
- Rozporządzenie Ministra Zdrowia z dnia 17 sierpnia 2018 r. w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych (tekst jednolity: Dz.U. 2024 poz. 1139). api.sejm.gov.pl (n.d.). https://api.sejm.gov.pl/eli/acts/DU/2023/1939/text.html1
- Portaria n.º 232/2022, de 7 de setembro (lista de novas substâncias psicoativas aprovada pela Portaria n.º 154/2013). diariodarepublica.pt (n.d.). https://diariodarepublica.pt/dr/detalhe/portaria/232-2022-2007343311
- Portaria n.º 232/2022, de 7 de setembro (lista de novas substâncias psicoativas aprovada pela Portaria n.º 154/2013). files.dre.pt (n.d.). https://files.dre.pt/1s/2022/09/17300/0000400008.pdf1
- Official source 3. infarmed.pt (n.d.). https://www.infarmed.pt/documents/15786/1070504/070-C_Port_154_2013.pdf1
- Official source 4. infarmed.pt (n.d.). https://www.infarmed.pt/pt/web/infarmed/legislacao/legislacao-farmaceutica-compilada/titulo-iii-medicamentos/capitulo-iii-estupefacientes-e-psicotropicos1
- Government Decree of 30 June 1998 No. 681, List I, as amended by Government Decree of 6 October 2011 No. 822. ips.pravo.gov.ru (n.d.). https://ips.pravo.gov.ru/api/ips/legislation/document?baseid=None&hash=4f3e2b09ec67c44a6cf6a43dadfa2bb8f18b308deee875a951cc59a78f8eb6501
- Government Decree of 30 June 1998 No. 681, List I, as amended by Government Decree of 6 October 2011 No. 822. base.garant.ru (n.d.). https://base.garant.ru/12190578/1
- Government Decree of 30 June 1998 No. 681, List I, as amended by Government Decree of 6 October 2011 No. 822. aipsin.com (n.d.). https://aipsin.com/newsubstance/877/1
- Misuse of Drugs Act 1973. sso.agc.gov.sg (n.d.). https://sso.agc.gov.sg/Act/MDA1973?WholeDoc=11
- Enforcement Decree of the Narcotics Control Act, Appendix 3. law.go.kr (n.d.). https://www.law.go.kr/LSW/flDownload.do?bylClsCd=110201&flSeq=1610662711
- Enforcement Decree of the Narcotics Control Act, Appendix 3. elaw.klri.re.kr (n.d.). https://elaw.klri.re.kr/eng_mobile/viewer.do?hseq=70787&key=31&type=sogan1
- Enforcement Decree of the Narcotics Control Act, Appendix 3. mfds.go.kr (n.d.). https://www.mfds.go.kr/brd/m_100/view.do?company_cd=&company_nm=&itm_seq_1=0&itm_seq_2=0&multi_itm_seq=0&page=41&seq=33158&srchFr=&srchTo=&srchTp=&srchWord=1
- Ordinance (1992:1554) on Control of Narcotic Drugs. riksdagen.se (n.d.). https://www.riksdagen.se/sv/dokument-och-lagar/dokument/svensk-forfattningssamling/forordning-19921554-om-kontroll-av-narkotika_sfs-1992-1554/1
- Ordinance (1992:1554) on Control of Narcotic Drugs. svenskforfattningssamling.se (n.d.). https://svenskforfattningssamling.se/sites/default/files/sfs/2018-12/SFS2018-2057.pdf1
- Cabinet of Ministers of Ukraine Resolution No. 770 of 6 May 2000, On Approval of the List of Narcotic Drugs, Psychotropic Substances and Precursors. zakon.rada.gov.ua (n.d.). https://zakon.rada.gov.ua/laws/show/770-2000-%D0%BF1
- Cabinet of Ministers of Ukraine Resolution No. 770 of 6 May 2000, On Approval of the List of Narcotic Drugs, Psychotropic Substances and Precursors. zakon.rada.gov.ua (n.d.). https://zakon.rada.gov.ua/laws/show/530-161
- Psychoactive Substances Act 2016, section 2 — Meaning of 'psychoactive substance'. UK Parliament (2016). https://www.legislation.gov.uk/ukpga/2016/2/section/212
- Psychoactive Substances Act 2016, section 4 — Producing a psychoactive substance. UK Parliament (2016). https://www.legislation.gov.uk/ukpga/2016/2/section/412
- Controlled Substances Act. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?req=%28title%3A21+section%3A802+edition%3Aprelim%291
- Controlled Substances Act. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?edition=prelim&num=0&req=granuleid%3AUSC-prelim-title21-section8131
- Controlled Substances Act. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?req=%28title%3A21+section%3A812+edition%3Aprelim%291
- Oregon Revised Statutes, chapter 475 (2025 edition). oregonlegislature.gov (n.d.). https://www.oregonlegislature.gov/bills_laws/ors/ors475.html1
- West Virginia Code § 60A-1-101. code.wvlegislature.gov (n.d.). https://code.wvlegislature.gov/60A-1-101/1
- West Virginia Code § 60A-2-204. code.wvlegislature.gov (n.d.). https://code.wvlegislature.gov/60A-2-204/1
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