2C-B-FLY
2C-B-FLY is a lesser-known psychedelic in the phenethylamine and benzodihydrodifuran classes1; Aaron P. Monte synthesized it in 1996. It is a dihydrofuran analog of 2C-B, with effects described as combining features of 2C-B, mescaline, and MDA, including mild psychedelia, entactogenic body sensations, and a positive mood push. Its popularity was temporarily impacted around 2009 when deaths caused by Bromo-DragonFLY were erroneously attributed to it2.
Contents
Dosage & Duration
Dosage
Individual sensitivity to 2C-B-FLY varies considerably. Some individuals report pronounced effects at doses typically classified as light, whereas others may require amounts in the moderate-to-strong range to achieve similar intensity.
Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
Cognitive
Visual
Auditory
Reagent Testing
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Pharmacology
Pharmacodynamics
2C-B-FLY acts as a potent partial agonist at the serotonin 5-HT2A receptor, with this interaction considered the primary basis for its psychedelic effects.3 It is additionally a potent agonist at 5-HT2B and 5-HT2C, displaying biased agonism at 5-HT2C.34 The compound shows notably high affinity for the 5-HT1D receptor (unusual among 2C-series compounds), alongside weaker affinity for 5-HT1A, 5-HT1B, and 5-HT1E.53
Pharmacokinetics
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Psychedelics (all psychedelics will have a reduced effect following 2C-B-FLY consumption)
Harm Potential
Addiction & Dependence
Psychological
Extremely Low2C-B-FLY is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.6
Toxicity
The toxicity of 2C-B-FLY in humans is unknown, and the exact toxic dose has not been established. Two deaths occurred in October 2009 in Denmark and the United States after ingestion of a substance sold as 2C-B-FLY, but the material actually consisted of Bromo-DragonFLY contaminated with a small amount of unidentified impurities, not 2C-B-FLY itself.
History & Culture
Discovery and Synthesis
2C-B-FLY was first described in the scientific literature in 1995 by Aaron Phillip Monte and David E. Nichols along with colleagues at Purdue University.7 Monte, a Professor of Chemistry at the University of Wisconsin-La Crosse, synthesized this novel compound as part of…
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Legality
By Country
References
Source Pages
Citations
- Corazza O, Schifano F, Farre M, Deluca P, Davey Z, Torrens M, Demetrovics Z, Di Furia L, Flesland L, Siemann H, Skutle A, van der Kreeft P, & Scherbaum N. (2011). Designer drugs on the internet: a phenomenon out-of-control? The emergence of hallucinogenic drug Bromo-Dragonfly. Current Clinical Pharmacology, 6(2), 125–129. https://doi.org/10.2174/1574884117961511291
- Caffrey CR, & Lank PM. (2018). When good times go bad: managing ‘legal high’ complications in the emergency department. Open Access Emergency Medicine, 10, 9–23. https://doi.org/10.2147/oaem.s1201201
- (July 2015). Pharmacological profile of novel psychoactive benzofurans. British Journal of Pharmacology, 172(13), 3412–3425. https://doi.org/10.1111/bph.13128123
- (October 2025). Serotonin 5-HT2C Receptor Signaling Analysis Reveals Psychedelic Biased Agonism. ACS Chem Neurosci, 16(19), 3899–3914. https://doi.org/10.1021/acschemneuro.5c006471
- (February 2010). Psychedelics and the human receptorome. PLOS ONE, 5(2). https://doi.org/10.1371/journal.pone.00090191
- Nichols DE. (2016). Psychedelics. Pharmacological Reviews, 68(2), 264–355. https://doi.org/10.1124/pr.115.0114781
- (July 1996). Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups. Journal of Medicinal Chemistry, 39(15), 2953–2961. https://doi.org/10.1021/jm960199j12
- (2016). Controlled Drugs and Substances Act (SC 1996, c. 19) — Schedule III, item 35 (2C-phenethylamines). Government of Canada. https://laws-lois.justice.gc.ca/eng/acts/c-38.8/page-11.html1
- (2016). Neue-psychoaktive-Stoffe-Gesetz (NpSG), BGBl. I S. 2615, in force 26 November 2016. Bundesministerium der Justiz. https://www.gesetze-im-internet.de/npsg/BJNR261510016.html12
- (2016). Psychoactive Substances Act 2016, section 2 — Meaning of 'psychoactive substance'. UK Parliament. https://www.legislation.gov.uk/ukpga/2016/2/section/21
- (2016). Psychoactive Substances Act 2016, section 4 — Producing a psychoactive substance. UK Parliament. https://www.legislation.gov.uk/ukpga/2016/2/section/41
Further Reading
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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