yellow2 → orange2 → red2 → brown2 → yellow2
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WARNINGDANGER OF DEATH
High doses alone or ordinary doses in combination with other depressants can fatally stop breathing.
U-47700
trans-3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide
U4, Pink, Pinky, Pink Heroin
U-47700 is a synthetic opioid of the benzamide chemical class that produces analgesic, sedating, and euphoric effects.citation needed Developed by Upjohn in the 1970s through extensive structure-activity research, it demonstrates approximately 7.5 times the potency of morphine. Despite its research origins, U-47700 has very little history of human use and limited toxicity data. Reports indicate unusual caustic properties that may cause significant tissue damage, particularly when injected.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Threshold~5 mg
Light5-7.5 mg
Moderate7.5-15 mg
Strong15-25 mg
Heavy25+ mg
Duration
Onset15 minutes
After Effects1-4 hours
Total5-7 hours
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
U-47700 has not been formally studied in humans, and documentation of its subjective effects rests on user reports and expectation from its opioid pharmacology. The experience is described as euphoric and mood-lifting alongside marked relaxation and pain relief. Sedation and respiratory depression are among the effects anticipated with potent opioid agonists, the latter carrying serious risk of harm or death.
Physical
Analgesia, relaxation, and sedation dominate the physical experience, accompanied by dry mouth, itching, constipation, pupil constriction, and in some cases an increased heart rate.
Autonomic
Sedation
Uncomfortable
Cognitive
The mental state is characterized by euphoria and an elevation of mood.
Pharmacology
Pharmacodynamics
U-47700 is a selective agonist of the μ-opioid receptor, with approximately 7.5 to 10 times the potency of morphine in animal models1 despite having 2 to 4 times weaker binding affinity at all three opioid receptors.citation needed The compound possesses significantly lower affinity for the κ-opioid and δ-opioid receptors.1 As with other opioids, U-47700 exerts its effects by binding to and activating the μ-opioid receptor, structurally mimicking endogenous endorphins to produce analgesia, sedation, and euphoria.
Pharmacokinetics
U-47700 undergoes hepatic metabolism involving mono- and didesmethylation followed by hydroxylation.citation needed The desmethyl metabolites have negligible affinity for opioid receptors and are not thought to contribute to the pharmacological activity of the parent compound.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Full Tolerance
Tolerance to many of the effects of U-47700 develops with prolonged and repeated use. The rate at which this occurs varies for different effects, with tolerance to constipation-inducing effects developing particularly slowly compared to other effects. This results in users needing to administer increasingly large doses to achieve the same effects.
Baseline Reset
1-2 weeks
Half Tolerance
3-7 days
Cross Tolerance
Opioids
Harm Potential
Addiction & Dependence
Psychological
HighU-47700 has a high potential for abuse and is capable of causing psychological dependence.citation needed The short duration of effects combined with the addictive properties of opioids creates a strong risk of compulsive redosing.
Physical
HighPhysical dependence can develop in a short period with chronic use.2 Withdrawal symptoms emerge within 2-4 hours after the last dose and can be especially painful.citation needed Cravings and withdrawal effects occur if use is suddenly stopped.
Toxicity
Respiratory
Respiratory depression with U-47700 is reported to be significantly stronger compared to other common opioids such as heroin and morphine at relative doses;citation needed severe overdoses can result in coma or death without immediate medical attention.
Nasal/Mucosal
U-47700 crystals are particularly corrosive and caustic to mucous membranes; even with regular saline washing, multiday insufflation can create bleeding sores and scabs in the septum and nasal lining that may persist for days after cessation.
History & Culture
Discovery and Development
U-47700 was developed by a research team at the Upjohn pharmaceutical company during the 1970s.citation needed The compound emerged from extensive work elucidating the quantitative structure-activity relationship of the benzamide scaffold. Upjohn researchers systematically identified the key…
Legality
International
U-47700 is listed in Schedule I of the 1961 Single Convention; the CND added it in 2017.
U-47700 is not listed in any schedule of the 1971 Convention on Psychotropic Substances.
U-47700 is not listed in Table I or Table II of the 1988 Convention against Illicit Traffic.
By Country
Illegal27
United StatesIllegal21 CFR 1308.1154
Temporarily placed in Schedule I effective November 14, 2016, following DEA emergency scheduling.55 Permanently placed into Schedule I in April 2018.56 Prior to federal scheduling, Ohio emergency scheduled the substance on May 3, 2016, Florida on September 27, 2016, and South Dakota on February 9, 2017.
ArgentinaIllegalDecreto 560/2019, Annex I4
U-47700 is incorporated into Argentina's controlled psychotropic-substance lists. The listing subjects the substance to the national narcotics-control regime.
AustraliaIllegalU-47700 is a prohibited substance in Australia. The Poisons Standard lists it in Schedule 9 under its systematic name, 3,4-dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide (CAS No. 82657-23-6). Schedule 9 covers substances which may be abused or misused and whose manufacture, possession, supply or use should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with the approval of Commonwealth and/or state or territory health authorities. Schedule 9 separately captures the wider chemical class of N,N-dialkylaminocyclohexyl alkyl benzamides except where a member is specified elsewhere in the schedules, and the Poisons Standard takes effect through the poisons and drugs legislation of each state and territory rather than applying of its own force.
AustriaIllegalSuchtgiftverordnung (SV)8
Possession, production, and sale prohibited under the Suchtmittelgesetz (Austrian Narcotics Act) since June 26, 2019.
BelgiumIllegalArrêté royal du 6 septembre 2017 réglementant les substances stupéfiantes et psychotropes, Annexe IA (as amended by the Arrêté royal du 9 décembre 2019)9101112
U-47700 is listed by name in Annexe IA of Belgium's Royal Decree of 6 September 2017 regulating narcotic and psychotropic substances, the annex reserved for substances in Table I of the 1961 Single Convention. It was inserted there by the Royal Decree of 9 December 2019, in force since 16 January 2020, and the Federal Agency for Medicines and Health Products' consolidated Annexe IA valid from 29 March 2026 still names it. Listing makes it an offence to import, export, transport, manufacture, produce, hold, sell or offer for sale, supply, deliver or acquire the substance without a prior activities authorisation from the Minister, which is issued only for scientific or medical purposes. Control attaches to U-47700 itself and, where chemically possible, to its isomers, esters, ethers and salts; breaches carry the penalties of Article 2bis of the Law of 24 February 1921.
BrazilIllegalU-47700 is a proscribed narcotic substance in Brazil under Lista F1 of Portaria SVS/MS nº 344/1998. RDC nº 143/2017 added U-47700 to that list, where it remains in force under Anvisa's current controlled-substances update record. Its manufacture, import, export, prescription, supply, and other handling are prohibited except as authorized under the controlled-substances regime.
CanadaIllegalControlled Drugs and Substances Act, Schedule I16
U-47700 is a Schedule I controlled substance. Possession, trafficking, importation, exportation and production are prohibited unless authorized by the Act or its regulations.
ChinaIllegalAnnouncement on Publishing the Catalogue of Non-Medical Narcotic Drugs and Psychotropic Substances (21 July 2025)171819
China lists U-47700 (CAS 121348-98-9) as item 121 of the Catalogue of Non-Medical Narcotic Drugs and Psychotropic Substances. Non-medical listed substances may be used for experimental research under the Regulation on the Administration of Narcotic Drugs and Psychotropic Substances, but may not be produced, operated, used, stored, or transported.
Czech RepublicIllegalNařízení vlády č. 463/2013 Sb., o seznamech návykových látek20
Classified as a Schedule I controlled substance under national drug legislation.
DenmarkIllegalU-47700 is a List B euphoriant substance in Denmark, appearing as entry 445 of annex 1 to the Executive Order on Euphoriant Substances under its exact chemical name 3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide, printed with the shorthand "U-4770". List B substances may be used in the country only for medical or scientific purposes, and import, export, sale, purchase, supply, receipt, manufacture, processing and possession are lawful only in accordance with the order's licensing and prescribing provisions. The control extends to the substance's salts and simple derivatives with euphoriant effect and to any preparation containing or made from it. U-47700 was inserted into List B on 15 June 2017, and breaches are punished under the Euphoriant Substances Act or, in aggravated circumstances, under section 191 of the Criminal Code.
FinlandIllegalValtioneuvoston asetus huumausaineina pidettävistä aineista, valmisteista ja kasveista 543/200823
Listed as an Annex 1 drug, making sale, production, and importation illegal.
FranceIllegalArrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants24
U-47700 is classified as a narcotic substance in France. The classification subjects the substance to the French narcotics-control regime.
GermanyIllegalBetäubungsmittelgesetz (BtMG), Anlage II25
Controlled under Anlage II of the Betäubungsmittelgesetz (Narcotics Act). Manufacturing, importing, possessing, selling, or transferring without a license is prohibited.
IndiaIllegalNarcotic Drugs and Psychotropic Substances Act, 1985, sections 2(xi)(b), 2(xiv), and 8(c), read with S.O. 823(E) dated 27 February 20182627
S.O. 823(E) declares U-47700, identified as 3,4-dichloro-N-(2-dimethylamino-cyclohexyl)-N-methyl-benzamide, and its salts and preparations to be manufactured drugs. The Act defines manufactured drugs as narcotic drugs, and section 8(c) prohibits producing, manufacturing, possessing, selling, purchasing, transporting, using, consuming, importing, exporting, or transhipping narcotic drugs except for medical or scientific purposes as provided by the Act, rules, orders, and any required licence, permit, or authorisation.
IrelandIllegalMisuse of Drugs Act 1977 (Controlled Drugs) (Declaration) Order 2017 (S.I. No. 531 of 2017); Misuse of Drugs Regulations 2017 (S.I. No. 173 of 2017), Schedule 1 as substituted by the Misuse of Drugs (Amendment) Regulations 2022 (S.I. No. 210 of 2022); Misuse of Drugs Act 1977 (Controlled Drugs) (Designation) Order 2022 (S.I. No. 211 of 2022)282930
U-47700 is a controlled drug in Ireland, declared as such by the Government under section 2(2) of the Misuse of Drugs Act 1977. It is listed by name in Schedule 1 to the Misuse of Drugs Regulations 2017, the schedule reserved for substances with no accepted medicinal use, so it is not available on prescription and any dealing with it requires a licence from the Minister for Health. A designation order under section 13 of the Act makes its manufacture, production, preparation, sale, supply, distribution and possession unlawful except for research, forensic analysis, or use as an essential intermediate or starting material in an industrial manufacturing process. The controls extend to any stereoisomeric form, ester, ether or salt of the substance and to any preparation or product containing it.
ItalyIllegalDecreto del Ministro della salute 18 maggio 2018 (18A03836), art. 1, amending DPR 9 ottobre 1990, n. 309, Tabella I3132
Italy lists U-47700 in Tabella I of the consolidated narcotics law. The 2018 ministerial decree identifies U-47700 by its common name, chemical name, and the alternate name U-47,700; the statute applies its controls to listed Table I substances and their isomers, esters, ethers, salts, stereoisomers, and products, mixtures, or blends containing them.
JapanIllegalNarcotics and Psychotropics Control Act; Cabinet Order Designating Narcotics, Narcotic Plants, Psychotropics, Narcotic/Psychotropic Raw Materials, etc. (Cabinet Order No. 238 of 1990)33343536
U-47700 is a narcotic in Japan: the Cabinet Order expressly lists 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide and its salts, the substance known as U-47700. The Narcotics and Psychotropics Control Act subjects narcotics to a licensing and control regime for import, export, manufacture, distribution, possession, and use; U-47700 is not regulated as a designated substance under the PMD Act.
NetherlandsIllegalOpiumwet, Lijst I (as amended by the Besluit van 9 april 2018 houdende wijziging van lijst I, behorende bij de Opiumwet, Stb. 2018, 110)3738
U-47700 is listed by name in List I of the Dutch Opium Act (Opiumwet), the schedule reserved for substances presenting unacceptable risk. It was added to that list by a royal decree of 9 April 2018, published in Staatsblad 2018, 110 and in force from 27 April 2018, implementing the March 2017 UN Commission on Narcotic Drugs scheduling decisions. Article 2 of the Opiumwet forbids importing or exporting, cultivating, preparing, processing, selling, delivering, supplying, transporting, possessing and manufacturing any List I substance. The listing names U-47700 itself in the "andere benamingen" column, with no separate entry limiting control to particular preparations or products.
New ZealandIllegalMisuse of Drugs Act 1975, Schedule 139
U-47700 is a Class A controlled drug in New Zealand. Its Schedule 1 classification brings it within the Act's controls on possession, supply, manufacture and importation.
NorwayIllegalRegulations on narcotics (Forskrift om narkotika)40
U-47700 is included in Norway's narcotics list. Dealings with listed narcotics are controlled under the narcotics regulations.
PolandIllegalRegulation of the Minister of Health of 17 August 2018 on the list of psychotropic substances, narcotic drugs and new psychoactive substances, Annex 2, Group I-N (consolidated text Dz. U. 2024 poz. 1139, as amended by Dz. U. 2025 poz. 598 and Dz. U. 2026 poz. 934)41424344
U-47700 is listed as item 186 among the Group I-N narcotic drugs in Annex 2 to the Minister of Health's regulation of 17 August 2018 on the list of psychotropic substances, narcotic drugs and new psychoactive substances, identified by the chemical designation 3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide. The Group I-N listing also covers isomers, esters, ethers and salts of the substances it names where such forms are chemically possible and are not scheduled elsewhere. Possession of a narcotic drug contrary to the Act on Counteracting Drug Addiction of 29 July 2005 is punishable under Article 62 by up to three years' imprisonment, rising to between one and ten years where a significant quantity is involved. Later amendments to the regulation add further substances to Group I-N but leave the U-47700 entry unchanged.
RussiaIllegalПостановление Правительства РФ от 30 июня 1998 г. № 68145
Classified as a Schedule I controlled substance under Russian federal drug control legislation.
SingaporeIllegalMisuse of Drugs Act 1973, First Schedule46
U-47700 is specified as a Class A controlled drug in Singapore's Misuse of Drugs Act. Unauthorized possession, trafficking, importation, exportation and manufacture are offences under that Act.
SwedenIllegalFolkhälsomyndighetens föreskrifter om förteckning över narkotika49
Classified as a narcotic substance on January 26, 2016, following its emergence as a designer drug.
SwitzerlandIllegalBetäubungsmittelverzeichnisverordnung des EDI (BetmVV-EDI), Anhang 650
Specifically named as a controlled substance under Verzeichnis D of Swiss narcotics regulations.
UkraineIllegalCabinet of Ministers of Ukraine Resolution No. 770 of 6 May 2000, On approval of the List of narcotic drugs, psychotropic substances and precursors5152
Ukraine lists U-47700 in List No. 1 of Table I of the national List of narcotic drugs, psychotropic substances and precursors, as an especially dangerous narcotic drug. Its circulation is prohibited, subject only to the statutory exceptions applicable to Table I substances. Under the controlling law, circulation includes manufacture, storage, transport, dispatch, acquisition, sale, import, export, transit, use and destruction.
Controlled / restricted1
SpainRestrictedU-47700 is a narcotic drug under Spain’s Ley 17/1967 because it is included in Schedule I of the 1961 Single Convention. The law places its production, manufacture, storage, transport, distribution, import, export, possession, use and consumption under State intervention and permits only authorized industrial, therapeutic, scientific and teaching uses. Operations contrary to the law are illicit trafficking; U-47700 is not one of the Schedule IV narcotics that article 2.2 calls prohibited articles outright.
References
Source Pages
Citations
- Michael T. Truver, Christina R. Smith, Nancy Garibay, Theresa A. Kopajtic, Madeleine J. Swortwood, & Michael H. Baumann. (October 2020). Pharmacodynamics and pharmacokinetics of the novel synthetic opioid, U-47700, in male rats. Neuropharmacology, 177. https://doi.org/10.1016/j.neuropharm.2020.10819512
- WHO Expert Committee on Drug Dependence. (2016). U-47700: Critical Review Report, 38th Expert Committee on Drug Dependence. World Health Organization. https://ecddrepository.org/en/u-477001
- Saeed K. Alzghari, Steven W. Fleming, Kerry Anne Rambaran, James E. Long, Samantha Burkhart, Jie An, & Jakub Furmaga. (October 2017). U-47700: An Emerging Threat. Cureus, 9(10). https://doi.org/10.7759/cureus.17911
- Decreto 560/2019, Annex I. boletinoficial.gob.ar (n.d.). https://www.boletinoficial.gob.ar/detalleAviso/primera/214129/201908141
- Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, Schedule 9—Prohibited substances. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/latest/text1
- Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, Schedule 9—Prohibited substances. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/latest/details1
- Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, Schedule 9—Prohibited substances. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/asmade/2026-05-28/text/original/epub/OEBPS/document_1/document_1.html1
- Suchtgiftverordnung (SV). ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/eli/bgbl/II/2019/158/201906261
- Arrêté royal du 6 septembre 2017 réglementant les substances stupéfiantes et psychotropes, Annexe IA (as amended by the Arrêté royal du 9 décembre 2019). ejustice.just.fgov.be (n.d.). https://www.ejustice.just.fgov.be/eli/arrete/2017/09/06/2017031231/justel1
- Arrêté royal du 6 septembre 2017 réglementant les substances stupéfiantes et psychotropes, Annexe IA (as amended by the Arrêté royal du 9 décembre 2019). ejustice.just.fgov.be (n.d.). https://www.ejustice.just.fgov.be/eli/arrete/2019/12/09/2019042972/justel1
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16 August 2026
Lyrea · Updated the article
Lyrea · Changed a word in Dosage & Duration › Routes 2 › Dose ranges › Light
Lyrea · Changed a word in Dosage & Duration › Routes 2 › Dose ranges › Threshold
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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