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TMA-6

TMA-6 molecule structureTMA-6 molecule structure
2,4,6-Trimethoxyamphetamine
ψ-TMA-2
Chemical Class

TMA-6 is a psychedelic amphetamine first documented by Alexander Shulgin in his 1991 book PiHKAL, where he described it as one of the most rewarding of the methoxylated amphetamines.citation needed It produces a distinctive combination of stimulant, hallucinogenic, and entactogenic effects that set it apart from related phenethylamine psychedelics such as the 2C-x and DOx series. It remains an exceptionally rare research chemical with very limited availability.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~15 mg
Light15-20 mg
Moderate20-35 mg
Strong35-50 mg
Heavy50+ mg

Duration

Onset30-90 minutes
Come Up1.5-3 hours
Peak5-8 hours
Offset3-5 hours
After Effects6-18 hours
Total10-16 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

TMA-6 produces a long-lasting psychedelic amphetamine experience that builds in intensity over roughly the first four hours and can leave users intoxicated for most of a day, with sleep remaining difficult even after other effects have faded. The experience is marked by an unusually strong current of humor — mundane tasks can become hilarious — alongside a forceful introspective drive capable of surfacing deep personal insights. Emotional tone can be unstable, with plateaus, exuberance, and strong negative feelings replacing one another, and intensity may vary considerably between sessions at the same dose.

Physical

Body effects include whole-body tingling, an energetic stimulation with restlessness, and a pronounced inner chill accompanied by sweating that can persist for hours. Stomach queasiness on the come-up, muscle tension, unsteady gait, appetite suppression, and post-experience insomnia are also reported.

Autonomic

Pupil dilationAppetite suppression

Stimulation

Uncomfortable

Cognitive

The headspace is heavily intoxicated at moderate doses, with a halting quality to thought and difficulty accomplishing simple tasks, though some reports describe clear and steady conversation. Laughter, emotional openness, and probing introspection are recurring themes.

Confusion

Emotional

EuphoriaEmpathy enhancement

Enhancements

Visual

Visuals are dose-dependent and somewhat inconsistent — nearly absent in some sessions, vivid and colorful in others at the same dose.

Tactile

See also: Psychedelic Intensity Scale, Effects of psychedelics (visual, cognitive, miscellaneous)

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow2 → orange2
Mecke(ME)
white → yellow2 → orange2 → red2
Mandelin(MD)
yellow2 → orange2 → red2
Liebermann(LB)
white → brown2
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Pharmacology

Pharmacodynamics

TMA-6 acts as a potent full agonist at the serotonin 5-HT2A receptor, with an EC50 of 29.2 nM and maximal efficacy of 107%. It shows no meaningful affinity for the 5-HT1A or dopamine D2 receptors.1 TMA-6 is also a potent inhibitor of monoamine oxidase A (MAO-A), with an IC50 of 400 nM, while being inactive as a monoamine reuptake inhibitor or releasing agent in rat brain synaptosomes.citation needed In rodent drug discrimination assays, TMA-6 fully substitutes for the psychedelics DOM and 5-MeO-DMT and partially substitutes for dextroamphetamine.

Pharmacokinetics

TMA-6 has been included as a parent analyte in an LC-MS method for trimethoxyamphetamines in human urine, but that analytical method does not establish absorption, bioavailability, distribution, elimination half-life, clearance, urinary recovery, or a TMA-6-specific metabolite profile.citation needed A separate rat-urine metabolism study concerns TMA-2 (2,4,5-trimethoxyamphetamine), not TMA-6 (2,4,6-trimethoxyamphetamine). Its metabolic pathways should not be presented as confirmed TMA-6 metabolism.2 Controlled human pharmacokinetic parameters and experimentally confirmed TMA-6-specific metabolites therefore remain unestablished in the located evidence.citation needed

Metabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

5-HTPLithiumMAOIsSNRIsSSRIsSerotonin releasersStimulantsTramadol
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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Tolerance to the effects of TMA-6 develops almost immediately following ingestion.
Baseline Reset
Approximately 7 days without further consumption
Half Tolerance
Approximately 3 days
Cross Tolerance

Psychedelics, Stimulants

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

TMA-6 is generally regarded as non-habit-forming, and users report that interest in taking it may decrease after use. Its use is typically self-regulating.

History & Culture

TMA-6 emerged from Alexander Shulgin's systematic exploration of trimethoxyamphetamines. After discovering that relocating a single methoxy group from the original TMA (3,4,5-trimethoxyamphetamine) to create TMA-2 resulted in a ten-fold increase in potency,3 Shulgin

Legality

By Country

Illegal1
Turkey flagTurkeyIllegal
Controlled / restricted2
Germany flagGermanyNpSG (Controlled)
Switzerland flagSwitzerlandRestricted

References

Source Pages

  1. Bluelight: TMA Series Thread
  2. Erowid: TMA-6 Comparison Information
  3. Erowid: TMA-6 Experience Vault
  4. Isomer Design (TiHKAL/PiHKAL)
  5. Isomer Design PiHKAL Entry #162 TMA-6
  6. PsychonautWiki
  7. TripSit Factsheets
  8. Wikipedia

Citations

  1. Kolaczynska KE, Trachsel D, Hoener MC, Liechti ME, & Luethi D. (2025). Receptor interaction profiles of 4-alkoxy-2,6-dimethoxyphenethylamines (Psi derivatives) and related amphetamines. https://doi.org/10.3389/fphar.2025.17034801
  2. Designer drug 2,4,5-trimethoxyamphetamine (TMA-2): studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques. pubmed.ncbi.nlm.nih.gov (n.d.). https://pubmed.ncbi.nlm.nih.gov/16810708/1
  3. Shulgin, Alexander, & Shulgin, Ann. (1991). PiHKAL: A Chemical Love Story — #158 TMA-2. Transform Press. https://www.erowid.org/library/books_online/pihkal/pihkal158.shtml12
  4. Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe (NpSG). Bundesanzeiger Verlag (2016). https://www.bgbl.de/xaver/bgbl/start.xav?startbk=Bundesanzeiger_BGBl&jumpTo=bgbl116s2615.pdf1
  5. § 4 NpSG. (2019). https://www.gesetze-im-internet.de/npsg/__4.html12
  6. NIH PubChem CID 31015 compound properties. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/31015/property/IUPACName,CanonicalSMILES,IsomericSMILES,MolecularFormula/JSON1
  7. PubChem synonyms for CID 31015. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/31015/synonyms/JSON12
  8. Fedlex BetmVV-EDI SR 812.121.11, consolidated version stand 13 March 2026. fedlex.data.admin.ch (n.d.). https://fedlex.data.admin.ch/filestore/fedlex.data.admin.ch/eli/cc/2011/363/20260313/de/pdf-a/fedlex-data-admin-ch-eli-cc-2011-363-20260313-de-pdf-a.pdf1
  9. Swissmedic Listen und Verzeichnisse, section 4.1. swissmedic.ch (n.d.). https://www.swissmedic.ch/swissmedic/de/home/services/listen_neu.html1
  10. Swissmedic Schutz vor Designerdrogen: Weitere psychoaktive Stoffe verboten, 13 March 2026. swissmedic.ch (n.d.). https://www.swissmedic.ch/swissmedic/de/home/news/mitteilungen/schutz-vor-designerdrogen.html1

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Recent changes8 human edits · latest

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31 July 2026

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24 January 2026

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  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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