Skip to main content
dose.wiki is still in beta. Entries may contain inaccuracies and/or lack citations. See our docs for more info.

HXE

HXE molecule structureHXE molecule structure
3-HO-2'-Oxo-PCE
Hydroxetamine, O-desmethyl Methoxetamine, 3-hydroxy-2-oxo-PCE
Psychoactive Class
DissociativeHallucinogen
Chemical Class
Arylcyclohexylamine

HXE (3-HO-2'-Oxo-PCE) is a novel dissociative substance of the arylcyclohexylamine class that produces ketamine-like effects. Structurally related to methoxetamine, ketamine, and PCE, it is distinguished by a hydroxy group on the phenyl ring in place of the methoxy group found in MXE.citation needed HXE first became available on the research chemical market in late 2020 after years of synthesis difficulties. Very limited data exists regarding its pharmacology, metabolism, and toxicity in humans.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~30 mg
Light30-60 mg
Moderate60-100 mg
Strong100-130 mg
Heavy130+ mg

Duration

Onset20-60 minutes
Come Up30-60 minutes
Peak2-4 hours
Offset3-6 hours
After Effects1-12 hours
Total3-8 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

HXE is described as producing dissociative effects, consistent with its membership in the arylcyclohexylamine family. and matches more of the sedative arylcyclohexylamines such as MXE than more stimulating derivatives like 3-MeO-PCE.

Physical

Effects

Cognitive

The only attested mental effect is dissociation.

Effects

Visual

Effects

See also: Dissociative Intensity Scale, Subjective Effects of Dissociatives

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow1
Mecke(ME)
white → pink1 → brown1
Mandelin(MD)
yellow2 → green2 → green3
Liebermann(LB)
white → orange2
Powered by PROtestkit.eu

Pharmacology

Pharmacodynamics

HXE was tested as O-desmethyl methoxetamine in an ex vivo mouse brain-slice study. It dose-dependently blocked NMDA-evoked currents in dorsal cochlear nucleus cartwheel cells, with an IC50 of 0.227 mM (95% CI 0.196-0.304 mM), and suppressed NMDA-receptor-mediated excitatory synaptic transmission. This confirms NMDA-receptor antagonism in that experimental preparation; it does not establish human receptor occupancy, clinical potency, or human pharmacokinetics.1

Pharmacokinetics

No formal pharmacokinetic data for HXE appears to have been published. HXE (O-desmethylmethoxetamine) is a known active metabolite of methoxetamine,citation needed produced via demethylation of the methoxy group on the phenyl ring.

Metabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Sustained or repeated HXE use can reduce responsiveness to many effects, leading users to need higher doses for comparable results.
Baseline Reset
1-2 weeks
Half Tolerance
3-7 days
Cross Tolerance

Dissociatives

Harm Potential

Addiction & Dependence

Psychological

Moderate

With chronic use, HXE is regarded as moderately addictive, has a high abuse potential, and may lead to psychological dependence in some users. Compulsive redosing has been reported.citation needed In cases where addiction occurs, stopping use may be accompanied by cravings and withdrawal effects.

Psychosis Risk

Mania can potentially occur in users who are compulsively and regularly consuming large amounts. This effect occurs less often with HXE than with more stimulating dissociatives such as 3-MeO-PCP or 2'-Oxo-PCE.

History & Culture

HXE was first identified as an active metabolite of methoxetamine (MXE), the dissociative arylcyclohexylamine that preceded it on research chemical markets.citation needed Interest in HXE as a standalone substance developed within research chemical communities, with initial…

Legality

By Country

Illegal2
Switzerland flagSwitzerlandIllegal
United Kingdom flagUnited KingdomIllegal
Not scheduled1
United States flagUnited StatesUnscheduled

References

Source Pages

  1. Bluelight: The Small & Handy HXE Thread
  2. Erowid: HXE Experience Index
  3. Isomer Design (TiHKAL/PiHKAL)
  4. PsychonautWiki
  5. Wikipedia

Citations

  1. Irie T, Yanase Y, Demizu Y, Usami M, & Kikura-Hanajiri R. (December 2022). Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors. Journal of Pharmacological Sciences, 150(4), 224–230. https://doi.org/10.1016/j.jphs.2022.09.0051
  2. Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien (Betäubungsmittelverzeichnisverordnung, BetmVV-EDI), SR 812.121.11. Eidgenössisches Departement des Innern (EDI) (2011). https://www.fedlex.admin.ch/eli/cc/2011/363/de1
  3. Psychoactive Substances Act 2016, section 2 – Meaning of 'psychoactive substance'. UK Parliament (2016). https://www.legislation.gov.uk/ukpga/2016/2/section/21
  4. 21 U.S.C. § 813 – Treatment of controlled substance analogues. United States Congress (1986). https://www.law.cornell.edu/uscode/text/21/81312
  5. 21 U.S.C. § 802(32) – Definition of 'controlled substance analogue'. United States Congress (1986). https://www.law.cornell.edu/uscode/text/21/802#321

Further Reading

  1. Cayman Chemical - Hydroxetamine analytical standard
  2. CFSRE: Hydroxetamine Monograph (2022)
  3. CFSRE: Hydroxetamine Toxicology Report (2022)
  4. Morris & Wallach (2014) - Comprehensive review of dissociative drugs
  5. PubChem: Hydroxetamine (CID 163192347)
  6. Reddit: r/dissociatives - DMXE vs HXE comparison
  7. Reddit: r/dissociatives - HXE dosage and effects insight
  8. Reddit: r/dissociatives - HXE is the most sedating disso
  9. Reddit: r/researchchemicals - First trial with HXE
  10. Reddit: r/researchchemicals - HXE 100mg IN experience
  11. Tripsitter: HXE Characteristics and Safety Profile

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Lyrea avatar
    Step 2 · First-pass review

    A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes8 human edits · latest

Times are UTCNewest first

29 August 2026

  1. Lyrea · Reworded 17 words in Subjective Effects › Notes › Overview

  2. Lyrea · Updated the article

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

All changes to this article · Site-wide recent changes

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the HXE article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.