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Cannabis

Cannabis molecule structureCannabis molecule structure
Tetrahydrocannabinol
Marijuana, Weed, Pot, THC, Mary Jane
Cannabis sativa L.

Cannabis is a genus of flowering plant that has been used for thousands of years for medicinal, spiritual, and recreational purposes.1 Its primary psychoactive constituent is delta-9-tetrahydrocannabinol (THC), though dozens of additional cannabinoids and terpenes contribute to its overall effects. It ranks among the most widely consumed recreational substances globally, behind only alcohol, caffeine, and tobacco. Its two principal species, sativa and indica, are recognized for producing distinct effect profiles.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~1 mg
Light1-5 mg
Moderate5-10 mg
Strong10-25 mg
Heavy25+ mg

Doses are expressed as milligrams of THC content. Oral use takes longer to take effect than smoking but lasts longer; effects from large oral doses can persist for an extended period.

Duration

Onset20-60 minutes
Come Up30-60 minutes
Peak1-2 hours
Offset4-6 hours
After Effects6-12 hours
Total4-10 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

When used in combination with psychedelics, cannabis is capable of intensifying and extending the duration of both the visual and cognitive effects with extreme efficiency. This should be used with caution if one is not experienced with psychedelics. When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced. When used in combination with alcohol, cannabis often creates feelings of extreme nausea, dizziness and changes in gravity. It is recommended that people smoke before drinking and not the other way around unless they are extremely cautious.

Physical

Cognitive

Visual

Enhancements

Colour enhancement

Geometry

Cannabis is capable of inconsistently inducing mild psychedelic geometry at extremely high doses within many users. Within many users who also regularly use psychedelics, however, it is capable of inducing these consistently in a visual style which seems to be an averaged out depiction of all the psychedelics one has used within the past. These rarely extend beyond level 4 and are considered to be mild, fine, small and zoomed out (but often well-defined).

Auditory

Multisensory

Forked from Subjective Effect Documentation byJosie Kins September 2015.

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Cann(CA)
white → blue2
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Pharmacology

Pharmacodynamics

The principal psychoactive constituent of cannabis is Δ⁹-tetrahydrocannabinol (THC), one of at least 84 cannabinoids found in the plant alongside other notable compounds such as cannabidiol (CBD), cannabinol (CBN), tetrahydrocannabivarin (THCV), and cannabigerol (CBG). THC acts as an agonist at CB1 cannabinoid receptors,2 inhibiting the adenylate cyclase secondary messenger system in a dose-dependent manner and indirectly increasing dopamine release. THC also potentiates glycine receptor activity, while CBD acts as an allosteric modulator of the mu and delta opioid receptors. Activation of CB1 and CB2 receptors upregulates 5-HT2A receptor activity through the ERK1/ERK2 signaling pathway, though the exact biochemical mechanism underlying this effect is unknown.

Pharmacokinetics

THC undergoes hepatic metabolism, producing the psychoactive metabolite 11-hydroxy-THC.2 CYP2C9 genotype significantly influences THC clearance: individuals with the CYP2C9 *3/*3 genotype exhibit approximately 3-fold higher blood THC concentrations compared to those with *1/*1, while heterozygous *1/*3 carriers show roughly 2-fold higher levels.citation needed

Interactions

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

2C-T-x compounds2C-x compounds5-MeO-xxT tryptaminesAmphetaminesAMTCocaineDMTDOx compoundsLSDMescalineNBOMe compoundsPsilocybin mushrooms
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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Prolonged repeated cannabis use can produce tolerance to many effects, especially with daily consumption. Regular ingestion leads to increased tolerance to stimulating effects more rapidly than to relaxing effects due to the longer half-life of CBD (9 hours) compared to THC's stimulating effects (2-3 hours). Heavy users may require doses several times higher than cannabis-naive individuals to achieve comparable effects.
Baseline Reset
Typically returns to baseline after 2-3 weeks of abstinence, though THC has been detected in heavy users up to 77 days after last use. Withdrawal symptoms in heavy users generally persist for 1-2 weeks.
Half Tolerance
Approximately 1-2 weeks after cessation of use.
Cross Tolerance

All cannabinoids (THC, CBD, synthetic cannabinoids)

Harm Potential

Addiction & Dependence

Psychological

Low

Low to moderate abuse potential with risk of psychological dependence in some individuals with chronic use.citation needed Studies estimate 5-10% of users may become daily users at some point, though most discontinue by age 30. Dependence rates are lower than both alcohol and nicotine.

Physical

Low

Mild physical dependence can develop with regular daily use.citation needed Withdrawal symptoms include irritability, insomnia, sweating, loss of appetite, and restlessness,3 typically lasting 1-2 weeks but occasionally up to 6 weeks in heavy users.citation needed Symptoms are never life-threatening.

Toxicity

Respiratory

Chronic smoking may cause respiratory issues including coughing, bronchitis, increased throat and lung infections, and reduced lung capacity;citation needed however, well-designed epidemiological studies have not found increased risk of lung cancer or COPD from cannabis alone, with pulmonary risks far lower than tobacco smoking.4

Cardiovascular

Acute cardiovascular effects including increased heart rate and blood pressure changes occur during intoxication;citation needed a large study of 65,000 individuals found no increased mortality in users under 50, though those with pre-existing heart conditions may face elevated risk.

Central Nervous System

Regular use may cause cognitive effects including short-term memory impairment, reduced motivation, and difficulty learning;citation needed these effects are typically reversible with abstinence, and well-controlled studies have not found evidence of permanent IQ loss or brain structure changes from cannabis use.

Psychosis Risk

Acute psychotic symptoms including paranoia, delusions, and anxiety can occur, particularly at high doses.7 Prolonged use may increase psychosis risk in predisposed individuals with family history of schizophrenia or other psychotic disorders.citation needed A 2011 FDA report found no clear causal linkage between cannabis use and psychotic disorders in otherwise healthy people, though associations have been documented between adolescent use and later psychotic diagnoses.

History & Culture

Origins and Early History

Cannabis represents one of humanity's oldest cultivated plants, first domesticated approximately 12,000 years ago in East Asia during the early Neolithic period.8 Genetic and archaeological evidence suggests human use may extend even further back, possibly to the

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Legality

International

1961 Single Convention: cannabis and cannabis resin remain in Schedule I.

1971 Convention on Psychotropic Substances: THC-related substances are separately scheduled; this country-level cannabis record makes no additional normalized claim.

1988 Convention: cannabis is not listed in precursor Tables I or II.

By Country

Illegal21
United States flagUnited StatesSchedule I (Federal)
Belgium flagBelgiumIllegal
Bulgaria flagBulgariaIllegal
Estonia flagEstoniaIllegal
Greece flagGreeceIllegal
Hong Kong flagHong KongProhibited
India flagIndiaIllegal
Israel flagIsraelIllegal
Japan flagJapanProhibited
New Zealand flagNew ZealandIllegal
North Korea flagNorth KoreaIllegal
Norway flagNorwayIllegal
Pakistan flagPakistanIllegal
Poland flagPolandIllegal
Romania flagRomaniaIllegal
Russia flagRussiaIllegal
Singapore flagSingaporeClass A
Spain flagSpainIllegal
Sweden flagSwedenIllegal
Taiwan flagTaiwanIllegal
United Kingdom flagUnited KingdomIllegal
Controlled / restricted2
Australia flagAustraliaVaries by state; Schedule 8 (medical)
Netherlands flagNetherlandsRestricted
Prescription1
UruguayLegal (regulated)
Legal / decriminalized12
Argentina flagArgentinaDecriminalized (personal use)
Brazil flagBrazilDecriminalized
Canada flagCanadaLegal (regulated)
Czech Republic flagCzech RepublicLegal (regulated)
Germany flagGermanyLegal (regulated)
Italy flagItalyDecriminalized
JamaicaDecriminalized
Malta flagMaltaDecriminalized
Mexico flagMexicoDecriminalized (small amounts)
Peru flagPeruDecriminalized (personal use)
Portugal flagPortugalDecriminalized (personal use)
Switzerland flagSwitzerlandLegal (<1% THC) / Controlled (>1% THC)

References

Source Pages

  1. Drug Users Bible by Dominic Milton Trott
  2. DrugBank: Δ9-Tetrahydrocannabinol
  3. Erowid
  4. Erowid Cannabis Vault: Dosage
  5. Erowid Cannabis Vault: Effects
  6. Erowid: The LESS Method - Measured Approach to Oral Cannabis
  7. NERVEWING
  8. PsychonautWiki
  9. PsychonautWiki: Cannabis/Summary
  10. The Drug Classroom
  11. TripSit Factsheets
  12. TripSit Wiki
  13. TripSit Wiki: Drug Combinations
  14. Wikipedia
  15. Wikipedia: Cannabis sativa
  16. Wikipedia: Tetrahydrocannabinol

Citations

  1. Zeinab Breijyeh, Buthaina Jubeh, Sabino A Bufo, Rafik Karaman, & Laura Scrano. (2021). Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses. Toxins, 13(2), 117. https://doi.org/10.3390/toxins130201171
  2. Cannabis. Substance Abuse: Clinical Issues in Intensive Outpatient Treatment (2017). https://www.ncbi.nlm.nih.gov/books/NBK425762/12
  3. Allsop DJ, Norberg MM, Copeland J, Fu S, & Budney AJ. (2012). Quantifying the Clinical Significance of Cannabis Withdrawal. https://pmc.ncbi.nlm.nih.gov/articles/PMC3458862/1
  4. Tashkin DP. (2013). Effects of Marijuana Smoking on the Lung. 10(3), 239-247. https://doi.org/10.1513/annalsats.201212-127fr1
  5. Weiland BJ, Thayer RE, Depue BE, Sabbineni A, Bryan AD, & Hutchison KE. (2015). Daily Marijuana Use Is Not Associated with Brain Morphometric Measures in Adolescents or Adults. 35(4), 1505-1512. https://www.jneurosci.org/content/35/4/15051
  6. Jackson NJ, Isen JD, Khoddam R, Irons D, Tuvblad C, Iacono WG, McGue M, Raine A, & Baker LA. (2016). Impact of Adolescent Marijuana Use on Intelligence: Results from Two Longitudinal Twin Studies. https://doi.org/10.1073/pnas.15166481131
  7. Dearness T, & Pantelis C. (2014). Gone to Pot – A Review of the Association between Cannabis and Psychosis. https://pmc.ncbi.nlm.nih.gov/articles/PMC4033190/1
  8. Guangpeng Ren, Xu Zhang, Ying Li, Kate Ridout, Martha L. Serrano-Serrano, Yongzhi Yang, Ai Liu, Gudasalamani Ravikanth, Muhammad Ali Nawaz, Abdul Samad Mumtaz, Nicolas Salamin, & Luca Fumagalli. (July 2021). Large-scale whole-genome resequencing unravels the domestication history of ''Cannabis sativa''. Science Advances, 7(29). https://doi.org/10.1126/sciadv.abg22861
  9. Phytochemical and genetic analyses of ancient cannabis from Central Asia. Journal of Experimental Botany, 59(15), 4171–82 (2008). https://doi.org/10.1093/jxb/ern2601
  10. Cannabis — Etymology, Origin & Meaning. Online Etymology Dictionary (Etymonline) (n.d.). https://www.etymonline.com/word/cannabis1

Further Reading

  1. HempGeneration: THCA Decarboxylation Temperatures
  2. NCBI PMC: Cannabis & Alcohol Impairment Study
  3. NCBI PMC: Cannabis Pharmacokinetics Review
  4. NCBI PMC: Drug Interactions with Cannabinoids
  5. NCBI PMC: Pharmacokinetics of THC & 11-OH-THC
  6. NCBI PMC: Tolerance to High-Dose Oral THC
  7. NIDA: Cannabis Research & Facts
  8. The Psychedelic Society: Cannabis Harm Reduction
  9. WHO ECDD: Cannabinoid Critical Review (2018)

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Lyrea avatar
    Step 2 · First-pass review

    A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes8 human edits · latest

Times are UTCNewest first

26 August 2026

  1. Lyrea · Reworded 9 words in PharmacologyPharmacokinetics

  2. Lyrea · Added a citation in PharmacologyPharmacokinetics

  3. Lyrea · Added a source: CYP2C9, CYP3A and CYP2C19 metabolize Δ9-tetrahydrocannabinol to multiple metabolites but metabolism is affected by human liver fatty acid binding protein (FABP1)

  4. Lyrea · Reworded 2 words in PharmacologyPharmacokinetics

  5. Lyrea · Updated the article

  6. Lyrea · Changed a word in Dosage & DurationRoutes 1 › Dose ranges › Light

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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