Citation noticeOur citation system is being overhauled
References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.
6-APDB
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
ModerateChronic 6-APDB use is regarded as moderately addictive, with substantial abuse potential and a possible risk of psychological dependence in some users. If addiction has developed, abruptly stopping use may produce cravings and withdrawal symptoms.
Toxicity
The exact toxic dosage is unknown due to the substance's short history of human use.
Long-term heavy use may damage the heart and is suspected of contributing to valvulopathy, similar to concerns documented with MDMA.
Repeated or high-dose administration could potentially cause neurotoxic effects, which may appear as problems with cognition, mood-related function, or psychomotor performance.
History & Culture
Legality
By Country
References
Source Pages
Citations
- Controlled Drugs and Substances Act — Schedule I, item 19. laws-lois.justice.gc.ca (n.d.). https://www.laws-lois.justice.gc.ca/eng/acts/C-38.8/section-sched95314.html1
- Controlled Drugs and Substances Act — section 2 definition of analogue. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-2.html1
- Health Canada’s Controlled Substances Status Determination Process. canada.ca (n.d.). https://www.canada.ca/en/health-canada/corporate/mandate/regulatory-role/what-health-canada-regulates-1/controlled-substances-precursors/overview-substance-control-status-determination-process.html1
- PubChem PUG REST — 6-APDB compound properties (CID 192599). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/192599/property/IUPACName,CanonicalSMILES,IsomericSMILES/JSON1
- PubChem PUG REST — MDA compound properties (CID 1614). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/3%2C4-methylenedioxyamphetamine/property/IUPACName,CanonicalSMILES/JSON1
- Safe Streets and Communities Act — section 44. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/AnnualStatutes/2012_1/section-44.html1
- SI/2012-48 — Order Fixing Various Dates as the Day on which Certain Sections of the Safe Streets and Communities Act Come into Force. gazette.gc.ca (n.d.). https://gazette.gc.ca/rp-pr/p2/2012/2012-07-04/html/si-tr48-eng.html1
- Controlled Drugs and Substances Act — section 4(1). laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-1.html1
- Controlled Drugs and Substances Act — section 6(1). laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-2.html1
- Liste consolidée des substances classées comme stupéfiants, mise à jour le 26/06/2026. ansm.sante.fr (n.d.). https://ansm.sante.fr/uploads/2026/06/26/20260626-stupefiants-version-consolidee.pdf1
Further Reading
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the 6-APDB article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.
Wish to give generalised feedback? You can do so here.