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6-APDB

This article is a stubmissing:
Subjective Effects
Pharmacology
Tolerance
History & Culture
6-APDB molecule structure6-APDB molecule structure
6-(2-aminopropyl)-2,3-dihydrobenzofuran
4-Desoxy-MDA, EMA-3
Psychoactive Class

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold25-30 mg
Light30-40 mg
Moderate40-75 mg
Strong100-130 mg
Heavy75-100 mg

Duration

Onset30-60 minutes
Come Up30-60 minutes
Peak2-3 hours
Offset2-3 hours
Total6-8 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → purple3
Mecke(ME)
white → green2 → black3
Mandelin(MD)
yellow2 → red2 → black3
Liebermann(LB)
white → orange2 → purple2 → black3
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Pharmacology

Pharmacology not written up yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

5-HTPAlcoholDXMDissociativesMAOIsMDMAMXENBOMe compoundsSNRIsSSRIsSerotonin releasersStimulantsTramadol
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Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Moderate

Chronic 6-APDB use is regarded as moderately addictive, with substantial abuse potential and a possible risk of psychological dependence in some users. If addiction has developed, abruptly stopping use may produce cravings and withdrawal symptoms.

Toxicity

Lethal Dosage

The exact toxic dosage is unknown due to the substance's short history of human use.

Cardiovascular

Long-term heavy use may damage the heart and is suspected of contributing to valvulopathy, similar to concerns documented with MDMA.

Central Nervous System

Repeated or high-dose administration could potentially cause neurotoxic effects, which may appear as problems with cognition, mood-related function, or psychomotor performance.

History & Culture

History & Culture not written up yet

Legality

By Country

Illegal8
United States flagUnited StatesIllegal (analog/blanket ban)
Canada flagCanadaIllegal (analog/blanket ban)
France flagFranceIllegal
Germany flagGermanyIllegal (analog/blanket ban)
Italy flagItalyIllegal
Sweden flagSwedenIllegal
Switzerland flagSwitzerlandIllegal
United Kingdom flagUnited KingdomIllegal

References

Source Pages

  1. Bluelight: The Main 6-APDB Thread
  2. Erowid: 6-APDB Vault
  3. Isomer Design (TiHKAL/PiHKAL)
  4. PsychonautWiki
  5. TripSit Factsheets
  6. TripSit: 6-APDB Factsheet
  7. Wikipedia
  8. Wikipedia: 6-APB

Citations

  1. Controlled Drugs and Substances Act — Schedule I, item 19. laws-lois.justice.gc.ca (n.d.). https://www.laws-lois.justice.gc.ca/eng/acts/C-38.8/section-sched95314.html1
  2. Controlled Drugs and Substances Act — section 2 definition of analogue. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-2.html1
  3. Health Canada’s Controlled Substances Status Determination Process. canada.ca (n.d.). https://www.canada.ca/en/health-canada/corporate/mandate/regulatory-role/what-health-canada-regulates-1/controlled-substances-precursors/overview-substance-control-status-determination-process.html1
  4. PubChem PUG REST — 6-APDB compound properties (CID 192599). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/192599/property/IUPACName,CanonicalSMILES,IsomericSMILES/JSON1
  5. PubChem PUG REST — MDA compound properties (CID 1614). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/3%2C4-methylenedioxyamphetamine/property/IUPACName,CanonicalSMILES/JSON1
  6. Safe Streets and Communities Act — section 44. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/AnnualStatutes/2012_1/section-44.html1
  7. SI/2012-48 — Order Fixing Various Dates as the Day on which Certain Sections of the Safe Streets and Communities Act Come into Force. gazette.gc.ca (n.d.). https://gazette.gc.ca/rp-pr/p2/2012/2012-07-04/html/si-tr48-eng.html1
  8. Controlled Drugs and Substances Act — section 4(1). laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-1.html1
  9. Controlled Drugs and Substances Act — section 6(1). laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-2.html1
  10. Liste consolidée des substances classées comme stupéfiants, mise à jour le 26/06/2026. ansm.sante.fr (n.d.). https://ansm.sante.fr/uploads/2026/06/26/20260626-stupefiants-version-consolidee.pdf1

Further Reading

  1. Iversen et al. (2013) - Neurochemical profiles of novel psychoactive substances
  2. Monte et al. (1993) - Synthesis and pharmacological examination of benzofuran analogues

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed — this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

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24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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