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5-MeO-DPT

5-MeO-DPT molecule structure5-MeO-DPT molecule structure
5-Methoxy-N,N-dipropyltryptamine
O-methyl-N,N-dipropylserotonin, O-Me-DiPS
Psychoactive Class
PsychedelicHallucinogen
Chemical Class
Tryptamine

5-MeO-DPT is a synthetic psychedelic tryptamine1 and an analogue of DPT2, related to 5-MeO-DMT. It is a designer drug2 taken orally. Little is known about its effects, but available descriptions suggest they may resemble those of DPT, DMT, and related compounds.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~3 mg
Light3 mg
Moderate3-5 mg
Strong5-10 mg
Heavy10+ mg

These dosage values are preliminary and should be verified with additional sources before use.

Duration

Onset30-60 minutes
After Effects1-2 hours
Total2-5 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → brown2
Mandelin(MD)
yellow2 → yellow3
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Pharmacology

Pharmacodynamics

5-MeO-DPT is a potent, high-efficacy agonist at serotonin 5-HT2A and 5-HT1A receptors. It also acts as a weak serotonin reuptake inhibitor and as a lower-potency agonist at 5-HT2C receptors.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AMTMAOIsPCP

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

AmphetaminesCocaineDXMTramadol

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

2C-T-x compounds2C-x compoundsCannabisDOx compoundsMDMAMescalineNBOMe compoundsPregabalin
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Tolerance

Tolerance not written up yet

Harm Potential

Toxicity

Lethal Dosage

Dose information is tentative and needs further research; no toxic or lethal dose is provided.

thermoregulatory/autonomic

Sweating and chills are listed among negative effects.

musculoskeletal

Muscle tension is listed among negative effects.

central nervous system

Confusion, insomnia, and unpleasant head-noise effects at 8.4 mg are described.

History & Culture

5-MeO-DPT was first reported to the EMCDDA and Europol on 13 September 2010 by Finland4.

Legality

By Country

Illegal1
United States flagUnited StatesIllegal

References

Source Pages

  1. Bluelight: 5-MeO-DPT First Time Report (6 mg oral)
  2. Bluelight: The Small & Handy 5-MeO-DPT Thread
  3. Erowid: 5-MeO-DPT Experience Vault
  4. PiHKAL-info – Shulgin notes (4–8 mg trials)
  5. Shulgin – TiHKAL Entry #36 (5-MeO-DET, mentioning 5-MeO-DPT)
  6. TiHKAL Info – 5-MeO-DPT Chemical & Pharmacological Data
  7. Wikipedia

Citations

  1. 5-Methoxy-N,N-di-n-propyltryptamine (5-MeO-DPT): freebase and fumarate. Acta Crystallographica Section E (2021). https://doi.org/10.1107/s20569890210037531
  2. The analysis of the chemical drugs among structural isomer. Journal of the Pharmaceutical Society of Japan (2006). https://doi.org/10.1248/yakushi.126.81512
  3. In vitro characterization of new psychoactive substances at the μ-opioid, CB1, 5HT1A, and 5-HT2A receptors—On-target receptor potency and efficacy, and off-target effects. Forensic Science International (2020). https://doi.org/10.1016/j.forsciint.2020.1105531234
  4. EMCDDA–Europol 2010 Annual Report on the implementation of Council Decision 2005/387/JHA. EMCDDA–Europol (2010). https://www.erowid.org/psychoactives/research_chems/research_chems_EMCDDA_2010_report.pdf1
  5. DEA Controlled Substances by CSA Schedule (27-Aug-26). deadiversion.usdoj.gov (n.d.). https://www.deadiversion.usdoj.gov/schedules/orangebook/e_cs_sched.pdf1
  6. 21 CFR Part 1308—Schedules of Controlled Substances (September 1, 2026), § 1308.11(d). ecfr.gov (n.d.). https://www.ecfr.gov/api/versioner/v1/full/2026-09-01/title-21.xml?part=13081
  7. 21 CFR Part 1300—Definitions (September 1, 2026), § 1300.01(b). ecfr.gov (n.d.). https://www.ecfr.gov/api/versioner/v1/full/2026-09-01/title-21.xml?part=13001
  8. Definition of ‘Positional Isomer’ as It Pertains to the Control of Schedule I Controlled Substances, 72 Fed. Reg. 67850. govinfo.gov (n.d.). https://www.govinfo.gov/content/pkg/FR-2007-12-03/html/E7-23413.htm1
  9. Schedules of Controlled Substances: Placement of Alpha-Methyltryptamine and 5-Methoxy-N,N-Diisopropyltryptamine Into Schedule I of the Controlled Substances Act, 69 Fed. Reg. 58050. govinfo.gov (n.d.). https://www.govinfo.gov/content/pkg/FR-2004-09-29/html/04-21755.htm1
  10. 21 U.S.C. § 841—Prohibited acts A. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?req=granuleid%3AUSC-prelim-title21-section841&num=0&edition=prelim1

Further Reading

  1. EMCDDA: Europol Early-Warning list (appearance on NPS market)
  2. IUCr – 5-Methoxy-N,N-di-n-propyltryptamine Crystal Structure (2021)
  3. PubChem: 5-MeO-DPT (Compound 14011047)
  4. Reddit: r/researchchemicals – 5-MeO-DPT thread (5–13 mg vaped reports)
  5. Reddit: r/researchchemicals – Anyone tried 5-MeO-DPT? (qualitative feedback)
  6. ResearchGate: review – 5-MeO tryptamine toxicity (2015)
  7. Wikidoc – 5-MeO-DPT Dosage & Duration

Article Status

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