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3C-P

3C-P molecule structure3C-P molecule structure
3,5-Dimethoxy-4-propoxyamphetamine
3C-Proscaline
Psychoactive Class
Chemical Class
3C-x

3C-P is a psychedelic and stimulant1 and is a substituted amphetamine.2 It is the amphetamine analogue of proscaline3 and produces hallucinogenic effects. Otakar Leminger first described it in the scientific literature by 1972, although its original synthesis date is unknown. Animal studies indicate potency similar to 3C-E,4 but this comparison does not establish equivalent potency in humans4.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold5-10 mg
Light10-20 mg
Moderate20-40 mg
Heavy40+ mg

Duration

Onset1-2 hours
Peak4-8 hours
Offset3-6 hours
After Effects3-6 hours
Total10-16 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → red2
Mecke(ME)
orange2 → brown2
Mandelin(MD)
yellow2 → brown2 → black3
Ehrlich(EH)
No reaction
No reaction
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Pharmacology

Pharmacodynamics

3C-P acts as a serotonin 5-HT2A receptor agonist.5 In rodents, it produces the head-twitch response,6 a behavioral marker used to assess psychedelic activity.7

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Tolerance to the effects of 3C-P develops almost immediately after a dose.
Baseline Reset
Tolerance returns to baseline after about 7 days without further use.
Half Tolerance
Tolerance falls to approximately half its initial level after about 3 days without further use.
Cross Tolerance

All psychedelics

Harm Potential

Toxicity

Lethal Dosage

The toxic dose of 3C-P is unknown.

Psychosis Risk

Paranoia can occur during 3C-P use.

Seizure Risk

Low

Seizures are considered likely to be rare with 3C-P but may occur in predisposed individuals, especially during physically taxing conditions involving dehydration, undernutrition, overheating, or fatigue.

History & Culture

3C-P was first described in the scientific literature by Otakar Leminger by 1972. Alexander Shulgin mentioned it in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved)8, and Daniel Trachsel synthesized it in 2002. Neither Shulgin nor Trachsel reported its effects…

Legality

By Country

Illegal3
United States flagUnited StatesIllegal (analog/blanket ban)
Japan flagJapanIllegal
United Kingdom flagUnited KingdomIllegal

References

Source Pages

  1. Bluelight: 3C-P 40 mg slow-burn trip report
  2. Bluelight: 3C-P 45 mg first-time report
  3. Bluelight: Big & Dandy 3C-P thread
  4. Erowid
  5. Erowid: 3C-P Brief Information
  6. Erowid: Experience - 3C-P 33 mg 'Functional and Addicting'
  7. Erowid: Experience - 3C-P 40 mg 'Euphoric Stimmy Rollercoaster'
  8. Erowid: Experience - 3C-P 40 mg 'Slow Burn'
  9. Erowid: Experience - 3C-P 40 mg 'Smooth, Fun, Therapeutic'
  10. Erowid: Experience - 3C-P 40 mg insufflated + LSD combination
  11. Isomer Design (TiHKAL/PiHKAL)
  12. PiHKAL #140 – 3C-P synthesis note
  13. PsychonautWiki
  14. TripSit Factsheets
  15. Wikipedia

Citations

  1. Protonitazene sold as '3C-P'. Victorian Department of Health (2024). https://www.health.vic.gov.au/drug-alerts/protonitazene-sold-as-3c-p1
  2. Receptor interaction profiles of 4-alkoxy-3,5-dimethoxy-phenethylamines (mescaline derivatives) and related amphetamines. Frontiers in Pharmacology (2022). https://doi.org/10.3389/fphar.2021.7942541
  3. PiHKAL — #140 P (Proscaline). Transform Press; authorized book excerpt hosted by Erowid (1991). https://erowid.org/library/books_online/pihkal/pihkal140.shtml1
  4. Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice. Journal of Psychopharmacology; accepted manuscript hosted by LJMU Research Online (2019). https://doi.org/10.1177/026988111982661012
  5. Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines. Frontiers in Pharmacology (2022). https://doi.org/10.3389/fphar.2021.7942541
  6. Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice. pmc.ncbi.nlm.nih.gov (n.d.). https://pmc.ncbi.nlm.nih.gov/articles/PMC6848748/12
  7. Use of the head-twitch response to investigate the structure–activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines. Psychopharmacology (2022). https://doi.org/10.1007/s00213-022-06279-21
  8. PiHKAL, entry #140: P (Proscaline). Erowid (1991). https://www.erowid.org/library/books_online/pihkal/pihkal140.shtml1
  9. 指定薬物名称・構造式一覧(令和8年8月27日現在). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001743040.pdf1
  10. 医薬品、医療機器等の品質、有効性及び安全性の確保等に関する法律第二条第十五項に規定する指定薬物及び同法第七十六条の四に規定する医療等の用途を定める省令 第一条第百八十二号. laws.e-gov.go.jp (n.d.). https://laws.e-gov.go.jp/api/2/law_data/419M60000100014?elm=MainProvision-Article_1-Paragraph_1-Item_1821

Further Reading

  1. Clinically relevant MAOI drug interactions (review)
  2. Frontiers - Receptor interaction profiles of 4-alkoxy-substituted 2,5-dimethoxyphenethylamines and amphetamines
  3. Frontiers – Cross-tolerance of phenethylamine psychedelics
  4. NCBI: Clinically relevant MAOI drug interactions
  5. Nervewing: blog - 3C-P 40 mg trip report
  6. PMC: Receptor interaction profiles of 4-alkoxy-3,5-dimethoxy-phenethylamines
  7. Reddit: 3C-P 32 mg live trip report
  8. Reddit: 3C-P descriptive information post
  9. Reddit: Summary of 3C-P experiences

Article Status

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    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

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