Not yet reviewed — this article is pending editorial review by Lyrea.

PCE

N-Ethyl-1-phenylcyclohexanamine

Eticyclidine, CI-400, Cyclohexamine

Psychoactive Class

Dissociative Hallucinogen

Chemical Class

Arylcyclohexylamine

PCE (eticyclidine) is a dissociative anesthetic of the arylcyclohexylamine class that produces hallucinogenic effects.¹ It is reported to be slightly more potent than its structural relative PCP (phencyclidine).² Like other arylcyclohexylamines, it carries habit-forming potential.³ Limited documentation exists regarding its safety profile, and users should exercise considerable caution given the scarcity of available research on its effects and risks.¹⁴

Dosage & Duration

Dosage

Threshold~1 mg

Light1-3 mg

Moderate3-7 mg

Strong7-15 mg

Heavy15+ mg

Duration

After Effects1-4 hours

Total2-5 hours

Subjective Effects

Reported as a dissociative anesthetic with hallucinogenic effects, described as slightly more potent than PCP. Available material does not detail the character or time course of the experience.

Cognitive

Dissociation

Pharmacology

Pharmacodynamics

PCE (eticyclidine) is a dissociative anesthetic of the arylcyclohexylamine class.⁵ It is structurally related to phencyclidine (PCP) and is reported to be slightly more potent.² Detailed receptor binding data for PCE remains limited in the available literature.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check

TripSit

Tolerance

Cross Tolerance

Dissociatives, NMDA receptor antagonists

Harm Potential

Addiction & Dependence

Psychological

Classified as habit-forming, suggesting some potential for psychological dependence.³

History & Culture

History & Culture not written up yet

Legality

International

PCE (eticyclidine) is internationally controlled in Schedule I of the 1971 Convention on Psychotropic Substances.

By Country

United StatesIllegalSchedule I (DEA code 7455)

21 CFR § 1308.11(d)(32)³⁶³⁷

PCE is expressly listed in federal Schedule I as the ethylamine analog of phencyclidine. The listing identifies it as N-ethyl-1-phenylcyclohexylamine and PCE.

CanadaIllegalSchedule III · Item 13

Controlled Drugs and Substances Act⁸⁹

PCE is expressly named in Schedule III. Under subsection 2(3), a substance expressly named in any of Schedules I to VI is deemed not included in another schedule; therefore the Schedule I phencyclidine analogue provision does not place PCE in Schedule I.

DenmarkIllegalList B · No. 172

Bekendtgørelse om euforiserende stoffer, BEK nr. 405 af 26. marts 2026, effective 29 March 2026¹¹

PCE is covered by the listed INN Eticyclidin. List B substances may only be used for medical and scientific purposes; the order regulates permitted activities through its authorization provisions.

GermanyIllegalPCE

Anlage I zu § 1 Absatz 1 Betäubungsmittelgesetz (BtMG)¹³¹⁴

PCE is listed in Anlage I to the BtMG as Eticyclidin, with PCE given as its other non-proprietary or trivial name. Anlage I is the BtMG's schedule of non-marketable narcotic drugs, so PCE is prohibited rather than prescription-available.

IrelandIllegalSchedule 1

Misuse of Drugs Regulations 2017, Schedule 1 (as amended by S.I. No. 210 of 2022 and S.I. No. 405 of 2025)¹⁶¹⁷

Eticyclidine is expressly listed in Schedule 1 to the Misuse of Drugs Regulations 2017 as substituted by the 2022 amendment. The 2025 amendment adds further Schedule 1 substances and leaves that listing in place; Schedule 1 also covers stereoisomers, esters, ethers, salts and preparations containing a listed substance.

JapanIllegalNarcotic

麻薬、麻薬原料植物、向精神薬、麻薬向精神薬原料等を指定する政令¹⁹²⁰

PCE is individually designated as a narcotic under Japan's designation decree as N-ethyl-1-phenylcyclohexylamine, also named eticyclidine, and its salts. The Ministry of Health, Labour and Welfare's controlled-substances list classifies Eticyclidine as N, meaning narcotic, and states that salts are controlled unless marked otherwise. This entry concerns PCE/Eticyclidine; it does not treat O-PCE as the same substance.

New ZealandIllegalClass A

Misuse of Drugs Act 1975, Schedule 1²²

PCE is listed by its chemical name, N-ethyl-1-phenylcyclohexylamine, in Schedule 1 of the Misuse of Drugs Act 1975. Schedule 1 contains Class A controlled drugs, so PCE is a prohibited controlled drug in New Zealand.

PhilippinesIllegalSchedule I

Updated Lists of Scheduled Controlled Substances as of 06 July 2025²⁵

The Dangerous Drugs Board's current controlled-substances list places Eticyclidine (PCE), chemically N-ethyl-1-phenylcyclohexylamine, in Schedule I of the 1971 Convention list. The Board publishes the list as the Philippines' updated list of scheduled controlled substances. Schedule I includes its stereoisomers where applicable.

RussiaIllegalSchedule I

Government Resolution of the Russian Federation No. 681 of 30 June 1998, as amended 11 June 2025²⁷

Eticyclidine (PCE) is expressly listed as «Этициклидин» among narcotic drugs in Schedule I. Schedule I prohibits circulation in the Russian Federation under Russian law and Russia’s international treaties; the list also covers its possible isomers, esters, salts, and mixtures containing a Schedule I substance.

South AfricaIllegalSchedule 2 Part III

Drugs and Drug Trafficking Act, 1992, Schedule 2 Part III (as substituted by Drugs and Drug Trafficking Amendment Act 14 of 2022)³⁰

PCE is expressly listed as N-ethyl-1-phenylcyclohexylamine among the congeners of phencyclidine in Schedule 2, Part III, headed ‘Undesirable dependence-producing substances’. The 2022 amendment substitutes Schedule 2 to the Drugs and Drug Trafficking Act, 1992, and the official Act page records commencement on 14 December 2022. The listing also covers the specified substances’ isomers, esters, ethers, salts, preparations, mixtures, and certain homologues unless expressly excluded.

ThailandIllegalCategory I

Table of Controlled Psychotropic Substances under Narcotics Code (25 July 2025)³³³⁴

Thailand's FDA lists PCE (eticyclidine) in Category I of its controlled psychotropic-substances table. The FDA describes Category I psychotropic substances as having no medical use and a high likelihood or potential for abuse.

BelgiumIllegalAnnex IIA

Royal Decree of 6 September 2017 regulating narcotic, psychotropic and soporific substances, Annex IIA⁶⁷

Eticyclidine (PCE) is listed in Annex IIA of Belgium's Royal Decree of 6 September 2017. The decree applies to substances in its annexes and requires prior activity authorization for import, export, transport, manufacture, possession, sale, supply, delivery, or acquisition. For Annex IIA products, authorization is granted only for scientific purposes or very limited medical purposes through duly authorized persons in authorized medical or scientific establishments.

ColombiaRestrictedLista Verde I

Ministerio de Salud y Protección Social, Resolución 000116 de 2026, art. 2, Anexo Técnico No. 1¹⁰

PCE is expressly listed under its international name Eticiclidina, with the chemical name N-etil-1-fenilciclohexilamina, in Colombia’s current Anexo Técnico No. 1. Resolution 116 of 2026 replaces the technical annexes adopted by Resolution 315 of 2020 and identifies Annex 1 as the national list of special-control substances subject to fiscalización; this is domestic control, not merely reproduction of the 1971 Convention list.

FinlandIllegal1971 Convention · List I

Valtioneuvoston asetus huumausaineina pidettävistä aineista, valmisteista ja kasveista annetun valtioneuvoston asetuksen muuttamisesta (1119/2025), amending 543/2008¹²

Official amendment 1119/2025 replaces Annex II to Regulation 543/2008. The designation is listed in Annex II, List I of the 1971 Convention; the amendment entered into force on 29 December 2025.

IndiaIllegalSchedule psychotropic substance

The Narcotic Drugs and Psychotropic Substances Act, 1985¹⁵

Eticyclidine is listed at serial number 7 of the Act's Schedule of psychotropic substances, with PCE as its other non-proprietary name and N-Ethyl-1-phenylcyclohexylamine as its chemical name. Section 8 prohibits production, manufacture, possession, sale, purchase, transport, use, consumption, and import or export of psychotropic substances except for medical or scientific purposes and as provided by the Act, rules, or relevant authorisation.

ItalyIllegalTable I

Table I, Decreto del Presidente della Repubblica 9 ottobre 1990, n. 309¹⁸

PCE is present in Table I of Italy's consolidated drug-control law. The Ministry of Health's 2024 Table I update identifies PCE as an arylcyclohexylamine already present in that table. This current official text resolves the earlier 2007 exclusion question without treating the older omission as evidence of present status.

NetherlandsIllegalOpiumwet List I

Opiumwet²¹

Eticyclidine is explicitly listed in List I of the Dutch Opiumwet. Article 2 prohibits importing or exporting, producing, possessing, and supplying or transporting List I drugs, subject to statutory exemptions and ministerial exemptions.

NorwayIllegalP I

Forskrift om narkotika (narkotikaforskriften) § 3, narkotikalisten; § 5²³²⁴

PCE is listed in Norway's Narkotikalisten under its chemical name, N-etyl-1-fenylsykloheksanamin. The listing classifies it as P I. P I substances are prohibited under § 5 of the narcotics regulation.

PortugalIllegalTabela II-A

Tabela II-A, Decreto-Lei n.º 15/93²⁶

Eticiclidina ou PCE (N-etil-1-fenilciclo-hexilamina) is named in Table II-A annexed to Decreto-Lei n.º 15/93. The decree establishes Portugal’s drug-control regime, and unauthorized trafficking or dealing in substances in its tables is criminally prohibited.

SingaporeIllegalClass A drug

Misuse of Drugs Act 1973, First Schedule, Part 1²⁸²⁹

Eticyclidine is expressly listed as a Class A drug in Part 1 of the First Schedule to the Misuse of Drugs Act 1973. The Act defines First Schedule substances as controlled drugs and makes possession or consumption of a controlled drug an offence unless authorised by the Act. The Class A Schedule also extends to stereoisomers, esters or ethers, salts, and preparations containing listed substances, subject to its stated exceptions.

SpainIllegalEticiclidina (PCE)

Orden de 11 de febrero de 1981, que incluye PCE en la Lista I del anexo I del Real Decreto 2829/1977³¹³²

La eticiclidina, también denominada PCE, figura en la Lista I del anexo I del Real Decreto 2829/1977 en su texto consolidado. La Orden de 11 de febrero de 1981 incluye N-etil-1-fenilciclohexilamina (PCE) en esa Lista I. En consecuencia, se prohíben su uso, fabricación, importación, exportación, tránsito, comercio, distribución y tenencia, así como los preparados que la contienen.

United KingdomIllegalClass A Drugs

Misuse of Drugs Act 1971, Schedule 2, Part I³⁵

The current revised official text of Schedule 2, Part I expressly lists Eticyclidine. The 2024 amending Order added Etodesnitazene after the existing Eticyclidine entry and is not the controlling instrument for Eticyclidine.

References

Source Pages

Citations

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