PCE
PCE (eticyclidine) is a dissociative anesthetic of the arylcyclohexylamine class that produces hallucinogenic effects.1 It is reported to be slightly more potent than its structural relative PCP (phencyclidine).2 Like other arylcyclohexylamines, it carries habit-forming potential.3 Limited documentation exists regarding its safety profile, and users should exercise considerable caution given the scarcity of available research on its effects and risks.14
Contents
Dosage & Duration
Dosage
Duration
Subjective Effects
Reported as a dissociative anesthetic with hallucinogenic effects, described as slightly more potent than PCP. Available material does not detail the character or time course of the experience.
Cognitive
Reagent Testing
Loading reagent data
Pharmacology
Pharmacodynamics
Pharmacokinetics
Tolerance
Dissociatives, NMDA receptor antagonists
Harm Potential
Addiction & Dependence
Psychological
Classified as habit-forming, suggesting some potential for psychological dependence.3
History & Culture
Legality
International
PCE is treated only as an illegal drug here, with no jurisdiction, schedule, or class specified.
By Country
References
Source Pages
Citations
- (2022). Arylcyclohexylamine Derivatives: Pharmacokinetic, Pharmacodynamic, Clinical and Forensic Aspects. https://doi.org/10.3390/ijms23241557412
- Veasey SC, Fischman MW, & Foltin RW. (1984). Phencyclidine analogs and precursors: rotarod and lethal dose studies in the mouse. https://pubmed.ncbi.nlm.nih.gov/6747825/12
- Chun S. (2020). The Abuse Potential of Novel Synthetic Phencyclidine Derivative 1-(1-(4-Fluorophenyl)Cyclohexyl)Piperidine (4′-F-PCP) in Rodents. https://pmc.ncbi.nlm.nih.gov/articles/PMC7369973/12
- (2025). Qualitative and quantitative in silico toxicity profiling of 'angel dust': phencyclidine (PCP) analogues as new psychoactive substances. https://pmc.ncbi.nlm.nih.gov/articles/PMC12967460/1
- Roth BL, Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, & Iversen L. (2013). The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor. https://pmc.ncbi.nlm.nih.gov/articles/PMC3602154/1
Further Reading
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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