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Methylone

Methylone molecule structureMethylone molecule structure
3,4-Methylenedioxy-N-methylcathinone
bk-MDMA, M1, MDMC, beta-keto-MDMA
Psychoactive Class

Methylone is a synthetic stimulant and entactogen of the cathinone class. First synthesized by Peyton Jacob III and Alexander Shulgin in 1996 as a potential antidepressant,citation needed it later gained popularity as a recreational substance.1 Methylone is frequently used as a substitute for MDMA due to overlapping effects,citation needed though Shulgin himself described it as lacking MDMA's "unique magic," noting it is more stimulating and less empathogenic. It has been commonly mis-sold as MDMA.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~60 mg
Light60-150 mg
Moderate150-225 mg
Strong225-270 mg
Heavy270+ mg

Redosing may not reliably intensify or prolong effects. Maintain adequate hydration throughout the experience.

Duration

Onset15-45 minutes
Come Up15-45 minutes
Peak1-1.5 hours
Offset1-1.5 hours
After Effects6-24 hours
Total2.5-4 hours
Half-life
5.8-6.9 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

Cognitive

The general head space of methylone is described by many as one of extreme mental stimulation, feelings of love or empathy and powerful euphoria. It contains a large number of typical psychedelic, entactogenic and stimulant cognitive effects.

Thought accelerationMindfulness

Visual

Forked from Subjective Effect Documentation byJosie Kins October 2014.

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow2
Mecke(ME)
white → yellow2 → orange2
Mandelin(MD)
yellow2 → brown3
Robadope(RB)
orange1 → black2 → brown1
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Pharmacology

Pharmacodynamics

Methylone acts as a mixed releasing agent and reuptake inhibitor of serotonin, norepinephrine, and dopamine.2 Its serotonin transporter affinity (Ki of 242.1 nM) is roughly 3-fold lower than that of MDMA, while its norepinephrine and dopamine transporter affinities are comparable; its VMAT2 affinity is approximately 13-fold lower, contributing to a profile that balances reuptake inhibition with monoamine release rather than acting as a predominant releaser.citation needed Methylone is also a variable-potency partial agonist at 5-HT1A, 5-HT1B, and 5-HT1D receptors and shows no significant activity at 5-HT2A or 5-HT2B receptors. Its activity at 5-HT2C is uncertain, with one study reporting no significant affinity and another finding potent near-full agonism via the Gαq signaling pathway.

Pharmacokinetics

In humans, the mean elimination half-life of methylone following oral doses of 50 to 200 mg ranges from 5.8 to 6.9 hours.citation needed The two major metabolic pathways are N-demethylation to methylenedioxycathinone (MDC) and demethylation followed by O-methylation, producing 4-hydroxy-3-methoxymethcathinone (HMMC) and 3-hydroxy-4-methoxymethcathinone (3-OH-4-MeO-MC). An additional metabolite, 3,4-dihydroxymethcathinone (HHMC), has also been identified. In rats administered 5 mg/kg, approximately 26% was excreted as HMMC within 48 hours, with less than 3% excreted unchanged.

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

5-HTPAlcoholDXMDissociativesMAOIsMDMAMXENBOMe compoundsSNRIsSSRIsSerotonin releasersStimulantsTramadol
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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Many effects can become tolerant rapidly with sustained repeated use, so comparable results may require higher doses.
Baseline Reset
3-6 weeks
Half Tolerance
1-3 weeks
Cross Tolerance

Dopaminergic stimulants

Harm Potential

Addiction & Dependence

Psychological

Moderate

Chronic use of methylone can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users.citation needed Compulsive redosing is commonly reported, likely promoted by the substance's time compression effects which speed up the subjective experience.

Physical

Low

When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. The nature and severity of withdrawal symptoms have not been well characterized.

Toxicity

Cardiovascular

Higher doses and repeated use have been associated with chest pains, heart palpitations, and elevated blood pressure and heart rate; worrying cardiovascular increases have been reported at doses exceeding 180-200 mg.citation needed

Central Nervous System

Animal studies have found methylone to be a monoaminergic neurotoxin producing serotonergic and dopaminergic neurotoxicity in rodents;3 however, one study suggests methylone may be less neurotoxic than MDMA at moderate doses.4

Thermoregulatory

Temperature regulation suppression and increased body temperature occur during use, with hyperthermia risk elevated during physical activity in hot environments such as dance venues.citation needed

Psychosis Risk

Abuse at high dosages for prolonged periods can potentially result in stimulant psychosis presenting with paranoia, hallucinations, or delusions. Based on research into similar stimulants, approximately 5-15% of those who develop stimulant psychosis may not recover completely,citation needed though antipsychotic medications effectively resolve symptoms of acute psychosis. Psychosis very rarely arises from occasional or moderate use.

Seizure Risk

Limited data on seizure risk from methylone use alone.

History & Culture

Discovery and Development

Methylone was first synthesized by chemists Peyton Jacob III and Alexander Shulgin in the mid-1990s, with the compound first described in scientific literature by 1996.citation needed The synthesis occurred after the publication of Shulgin's PiHKAL in 1991, and consequently methylone was not

Legality

International

Methylone is listed in Schedule II of the Convention on Psychotropic Substances of 1971. It is not listed under the 1961 Single Convention on Narcotic Drugs or the 1988 Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.

By Country

Illegal32
United States flagUnited StatesIllegal
Argentina flagArgentinaIllegal
Australia flagAustraliaIllegal
Austria flagAustriaIllegal
Belgium flagBelgiumIllegal
Brazil flagBrazilIllegal
Canada flagCanadaIllegal
Chile flagChileIllegal
Croatia flagCroatiaIllegal (analog/blanket ban)
Czech Republic flagCzech RepublicIllegal
Denmark flagDenmarkIllegal
Estonia flagEstoniaIllegal
Finland flagFinlandIllegal
Germany flagGermanyIllegal
India flagIndiaIllegal
Indonesia flagIndonesiaIllegal
Ireland flagIrelandIllegal
Japan flagJapanIllegal
Netherlands flagNetherlandsIllegal
New Zealand flagNew ZealandIllegal
Norway flagNorwayIllegal
Poland flagPolandIllegal
Russia flagRussiaIllegal
Singapore flagSingaporeIllegal (analog/blanket ban)
Slovak Republic flagSlovak RepublicIllegal
South Korea flagSouth KoreaIllegal (analog/blanket ban)
Sweden flagSwedenIllegal
Switzerland flagSwitzerlandIllegal
Thailand flagThailandIllegal
Ukraine flagUkraineIllegal
United Arab Emirates flagUnited Arab EmiratesIllegal
United Kingdom flagUnited KingdomIllegal (analog/blanket ban)
Controlled / restricted2
Colombia flagColombiaRestricted
Spain flagSpainRestricted
Legal / decriminalized1
Portugal flagPortugalDecriminalized

References

Source Pages

  1. Bluelight: The Big & Dandy bk-MDMA (Methylone) Thread
  2. Disregard Everything I Say
  3. Drug Users Bible by Dominic Milton Trott
  4. Erowid
  5. Erowid Methylone Vault: Dosage
  6. Erowid Methylone Vault: Effects
  7. Isomer Design (TiHKAL/PiHKAL)
  8. PsychonautWiki
  9. TripSit Factsheet: Methylone
  10. TripSit Factsheets
  11. TripSit Wiki: Drug Combinations
  12. Wikipedia

Citations

  1. Poyatos L, Pérez-Mañá C, Hladun O, & et al.. (2023). Pharmacological effects of methylone and MDMA in humans. 14. https://doi.org/10.3389/fphar.2023.11228611
  2. The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue. Neuropsychopharmacology, 37(5), 1192–1203 (2012). https://doi.org/10.1038/npp.2011.3041
  3. Gloria Daziani, Alfredo Fabrizio Lo Faro, Vincenzo Montana, Gaia Goteri, Mauro Pesaresi, Giulia Bambagiotti, Eva Montanari, Raffaele Giorgetti, & Angelo Montana. (March 2023). Synthetic Cathinones and Neurotoxicity Risks: A Systematic Review. Int J Mol Sci, 24(7), 6230. https://doi.org/10.3390/ijms240762301
  4. Raúl López-Arnau, Jordi Camarasa, Marcel·lí Carbó, Núria Nadal-Gratacós, Pol Puigseslloses, María Espinosa-Velasco, Edurne Urquizu, Elena Escubedo, & David Pubill. (2022). 3,4-Methylenedioxy methamphetamine, synthetic cathinones and psychedelics: From recreational to novel psychotherapeutic drugs. Front Psychiatry, 13. https://doi.org/10.3389/fpsyt.2022.9904051
  5. Amanda Jones, Jennifer Warner-Schmidt, Hannah Kwak, Martin Stogniew, Blake Mandell, Terence H.W. Ching, Murray B. Stein, & Benjamin Kelmendi. (February 2026). Efficacy and Safety of the Neuroplastogen TSND-201 for the Treatment of PTSD: A Randomized Clinical Trial. JAMA Psychiatry. https://doi.org/10.1001/jamapsychiatry.2025.462512
  6. Decreto 122/2026, Anexo I del Decreto 560/2019. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/norma-423520/texto1
  7. Decreto 122/2026, Anexo I del Decreto 560/2019. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-560-2019-326675/actualizacion1
  8. Decreto 122/2026, Anexo I del Decreto 560/2019. argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/ley-23737-138/actualizacion1
  9. Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, Schedule 9. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/latest/text1
  10. Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, Schedule 9. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/latest/details1

Article Status

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    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Recent changes7 human edits · latest

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24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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