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Methoxyketamine

Methoxyketamine molecule structureMethoxyketamine molecule structure
Psychoactive Class
DissociativeHallucinogen
Chemical Class
Arylcyclohexylamine

Methoxyketamine is a dissociative research chemical of the arylcyclohexylamine class and a structural analogue of ketamine. It is reported to produce dissociative and anesthetic effects comparable to those of ketamine, though at a slightly lower potency. The substance is considered extremely rare, with very limited availability and documentation. As with other dissociatives in its class, it may carry habit-forming potential.

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold5-15 mg
Light15-60 mg
Moderate60-130 mg
Strong130-200 mg
Heavy200+ mg

Duration

Onset10-20 minutes
After Effects2-4 hours
Total1-2 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects are described as closely resembling those of ketamine, with dissociation and, at sufficient doses, anesthesia as the defining features. Potency is somewhat lower than ketamine's, so comparable effects require larger amounts. Sedation and hallucinogenic effects are also reported, with anesthesia emerging only at high doses.

Physical

Sedation is a reported physical effect, progressing to anesthesia at high doses.

Sedation

Cognitive

The state is described as dissociative, mirroring the headspace associated with ketamine.

See also: Dissociative Intensity Scale, Subjective Effects of Dissociatives

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow1 → orange1 → red1 → pink1
Mecke(ME)
white → yellow2 → orange2 → red2
Mandelin(MD)
yellow2 → red2 → brown2
Liebermann(LB)
white → brown2
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Pharmacology

Pharmacodynamics

Methoxyketamine is an arylcyclohexylamine and a structural analog of ketamine in which the chlorine atom has been replaced with a methoxy group. Based on its arylcyclohexylamine structure, methoxyketamine most likely acts as an NMDA receptor antagonist, though its precise receptor pharmacology has not been well characterized. It is reported to be less potent than ketamine.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Cross Tolerance

Dissociatives, NMDA receptor antagonists

Harm Potential

Addiction & Dependence

Psychological

Classified as habit-forming, suggesting some potential for psychological dependence, though specific details on addiction liability are not documented.

History & Culture

Methoxyketamine was first documented in the scientific literature in 1963, making it one of the earlier arylcyclohexylamine compounds to be described. The substance represents a structural analog of ketamine in which the chlorine atom has been substituted with a methoxy group. Chemical literature…

Legality

Legality not written up yet

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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Recent changes7 human edits · latest

Times are UTCNewest first

24 January 2026

  1. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  2. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  3. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  4. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  5. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  6. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

  7. Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more

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