MET

N-Ethyl-N-methyltryptamine

Methylethyltryptamine

Psychoactive Class

Chemical Class

MET is a lesser-known synthetic psychedelic of the tryptamine class,¹ structurally related to DMT.² It produces powerful, short-lived psychedelic effects characterized by rapid onset and progressive stages. When smoked or vaporized, its effects have been compared to those of DMT but with a more grounded headspace and reduced subjective intensity. Very little data exists regarding its pharmacology, metabolism, or toxicity, and it has only been available through online research chemical vendors since mid-2016.

Dosage & Duration

Dosage

Threshold~40 mg

Light40-120 mg

Moderate120-150 mg

Strong150-200 mg

Heavy200+ mg

Duration

Onset60-120 minutes

Come Up30-60 minutes

Peak1.5-2.5 hours

Offset1-3 hours

After Effects6-24 hours

Total4-6 hours

Subjective Effects

MET produces a psychedelic tryptamine experience frequently compared to DMT, though gentler and more approachable — it has been described as a 'beginner DMT' and as combining qualities of DMT and Salvia divinorum. When vaporized, the onset is noticeably slower than that of DMT, building over a gradual come-up into a state that blends a slightly LSD-like psychedelic headspace with a warm, MDMA-like emotional core and mild stimulation. A deeply comfortable sense of body warmth is a distinctive feature of the experience.

Physical

The body load centers on a satisfying warmth and comfort accompanied by mild physical stimulation, though muscle tension, cramps, teeth grinding, sweating and chills, and restlessness are also reported. Route-specific discomforts include nasal pain when insufflating the freebase and an unpleasant taste and lung harshness when vaporized.

Cardiovascular

Increased heart rate Increased blood pressure

Stimulation

Uncomfortable

Muscle tension Muscle cramps Teeth grindingAppetite suppression Pupil dilation

Cognitive

The headspace is euphoric and empathogenic, with reports of insight, a softening of the ego, and a general change in perception. Confusion can occur, particularly at stronger doses.

Emotional

The emotional tone is warm and euphoric, with an empathogenic quality compared to MDMA.

Suppressions

Confusion

Visual

Open- and closed-eye visuals are among the most commonly cited effects, with a character often likened to a milder DMT.

Hallucinatory States

Tactile

Touch is noticeably enhanced, contributing to the characteristic sense of bodily warmth and comfort.

Reagent Testing

Loading reagent data

Expected colorimetric results are being prepared.

Pharmacology

Pharmacodynamics

MET acts principally as a partial agonist at serotonin 5-HT2A³ and 5-HT2C receptors. It shows very weak agonist activity at 5-HT1A and 5-HT2B receptors. In addition to its action at serotonin receptors, MET functions as a serotonin releasing agent, though with comparatively lower potency.³

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Tolerance

Full Tolerance

In contrast to most psychedelics, MET is not reported to produce tolerance easily. However, its extended residual effects suggest mild tolerance may occur when doses are taken close together.

Cross Tolerance

Reports indicate minimal, if any, cross-tolerance with other psychedelics, so other psychedelics would be expected to retain their full effects after MET use

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

Early reports characterize MET as non-habit-forming, with interest in taking it potentially declining after regular use. Like most psychedelics, it is generally viewed as self-limiting.

Toxicity

Lethal Dosage

The exact toxic dose is unknown, as the toxicity and long-term health effects of recreational MET use do not appear to have been studied in any scientific context. Anecdotal reports from the community suggest no negative health effects from trying the substance alone at low to moderate doses used sparingly, though nothing can be guaranteed.

History & Culture

MET was first documented in scientific literature in 1981, appearing in Michael Valentine Smith's book "Psychedelic Chemistry." The compound subsequently received a brief entry in Alexander Shulgin's 1997 publication "TiHKAL" (Tryptamines I Have Known and Loved)⁴,…

Legality

By Country

United StatesUnscheduled (Analogue Act may apply)

MET is not specifically scheduled under the Controlled Substances Act. However, it may be considered a controlled substance analogue of DMT or DET, meaning sales for human consumption or possession with intent to ingest could potentially be prosecuted under the Federal Analogue Act.

JapanControlled

Designated as a controlled substance as of March 20, 2023.⁸

SwitzerlandUncontrolled

Not listed under Buchstabe A, B, C, or D of Swiss controlled substances legislation. May be considered legal for possession.

GermanyNpSG (Controlled)

Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) as of July 18, 2019.⁵ Production, import with intent to distribute, administration to others, and trading are punishable offenses.⁶ Possession is prohibited but not subject to criminal penalty.⁷

New ZealandClass C

Controlled as a structural analogue of DMT under New Zealand's drug legislation.

United KingdomClass A

Controlled under the Misuse of Drugs Act 1971 via a generic clause added in 1977 that covers tryptamine derivatives modified by alkyl substitution at the nitrogen atom of the side chain.⁹

References

Source Pages

Citations

Automated synthesis
Information aggregated and synthesized using an autonomous workflow built by Josie Kins.

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MET

N-Ethyl-N-methyltryptamine

Methylethyltryptamine

Psychoactive Class

Psychedelic Hallucinogen

Chemical Class

Tryptamine