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Isoproscaline
Isoproscaline is a psychedelic phenethylamine and an analogue of mescaline, closely related to proscaline. It replaces mescaline's 4-propoxy group with a branched isopropoxy group while retaining the 3,4,5-substitution pattern on the benzene ring. It was first synthesized by David E. Nichols and colleagues, and appears in PiHKAL. Related compounds include escaline, allylescaline, and methallylescaline.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Wikipedia reports that in PiHKAL, Alexander Shulgin lists a psychedelic dose as being 40-80 mg, with effects lasting 10-16 hours; the route is not specified there. An 80 mg experience report describes a slight descent at 6-7 hours and a slow, pleasant descent until about the 12th hour, with mild irritability the following day.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Isoproscaline produces a psychedelic state described as warm, social, and emotionally genuine, with a long duration and a notably gentle trajectory. Reports describe a lengthy period before the body settles, followed by a sustained plateau of talkative, contented engagement with other people, music, and food. The decline is slow and smooth rather than abrupt, with mild irritability sometimes noted the following day.
Physical
Both mental and physical stimulation are typical, accompanied by restlessness, muscle tension, sweating or chills, decreased appetite, pupil dilation, and difficulty sleeping.
Autonomic
Cognitive
The headspace is characterized by euphoria, empathy, and insight, with emotions felt vividly and without dulling; a softening of ego boundaries and, in some cases, confusion are also reported.
Visual
Visual activity spans brightened color and both closed- and open-eye imagery.
Hallucinatory States
Tactile
Pharmacology
Pharmacodynamics
The hallucinogenic and entheogenic effects of isoproscaline are most likely produced through agonism at the 5-HT2A serotonin receptor in the brain, the mechanism thought to be shared by hallucinogenic tryptamines and phenethylamines. No direct binding or functional data for isoproscaline itself is available.
Pharmacokinetics
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
History & Culture
Isoproscaline, or 4-isopropoxy-3,5-dimethoxyphenethylamine, is an analogue of mescaline closely related to proscaline. It was first synthesized by David E. Nichols and colleagues.…
Legality
Article Status
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Recent changes7 human edits · latest
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24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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