WARNINGMIXING OR WITHDRAWAL CAN BE DANGEROUS
Ordinary doses in combination with other depressants can fatally stop breathing. After prolonged dependency, stopping suddenly can also cause seizures or delirium; seek medical help.
Fluclotizolam
Fluclotizolam is a novel thienotriazolodiazepine research chemical structurally derived from etizolam.citation needed It functions as a depressant and anxiolytic through GABAergic activity. Reports suggest it is roughly three times more potent than etizolam with a comparatively shorter duration of action, though dosage information remains inconsistent and poorly established. As with other designer benzodiazepines, it carries significant risks of dependence, and its limited research history means its safety profile is not well characterized.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
These dosage ranges should be considered provisional estimates. Individual response may vary significantly depending on personal sensitivity, benzodiazepine tolerance, and previous experience with this class of substances.
Duration
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Fluclotizolam produces a classically benzodiazepine-like depressant experience dominated by sedation, anxiety relief, and muscle relaxation, with little to no sensory alteration. As a derivative of etizolam reported to be roughly three times as potent with a shorter half-life, its effects arrive at very small doses and resolve comparatively quickly. At moderate to high doses, memory of the period after ingestion becomes unreliable.
Physical
The body feels heavy, relaxed, and sedated, with pronounced muscle relaxation that scales with dose.
Sedation
Cognitive
The headspace is characterized by a calm, disinhibited mental quiet in which anxious thought loops are suppressed and thinking slows. Gaps in recall are common at higher doses.
Suppressions
Pharmacology
Pharmacodynamics
Fluclotizolam is a thienotriazolodiazepine, a class of compounds that act as positive allosteric modulators of the GABA-A receptor at the benzodiazepine binding site.citation needed Detailed pharmacological characterization of fluclotizolam remains limited in publicly available literature, and no specific receptor binding affinities have been reported.
Pharmacokinetics
Reports suggest fluclotizolam has a shorter half-life than etizolam, though details of its metabolism are not described in the available sources.
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Benzodiazepines, Thienodiazepines, Other GABAergic depressants
Harm Potential
Addiction & Dependence
Psychological
Classified as habit-forming.citation needed
History & Culture
Fluclotizolam is a thienotriazolodiazepine that was originally synthesized in 1979citation needed but was never developed for medical use or brought to market as a pharmaceutical product. The compound remained obscure for nearly four decades until it resurfaced as a designer drug in the mid-2010s. It was first definitively identified through analytical methods in 2017, joining the growing class of novel benzodiazepines appearing on the research chemical market.
Legality
International
As of 23 August 2026, Fluclotizolam is not listed under the international drug-control conventions. INCB's current identity annex identifies Fluclotizolam as CAS 54123-15-8, gives its chemical name as 2-chloro-4-(2-fluorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine and InChIKey ZDYRCUZZLRLMHG-UHFFFAOYSA-N, but assigns no convention or schedule in the international-control column. Exact-name, CAS-number, chemical-name, and InChIKey searches found no corresponding entry in the complete current Yellow, Green, or Red Lists. The only March 2026 addition to the 1971 Convention is MDMB-FUBINACA, effective 25 November 2026; it does not cover Fluclotizolam.
By Country
References
Source Pages
Citations
- Decreto 560/2019, Anexo I (sustituido por Decreto 122/2026). argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-560-2019-326675/actualizacion1
- Decreto 560/2019, Anexo I (sustituido por Decreto 122/2026). argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/nacional/decreto-122-2026-423520/texto1
- Decreto 560/2019, Anexo I (sustituido por Decreto 122/2026). argentina.gob.ar (n.d.). https://www.argentina.gob.ar/normativa/423520_dec122_jpg/archivo1
- Controlled Drugs and Substances Act, Schedule IV, item 18. canada.ca (n.d.). https://www.canada.ca/en/health-canada/services/publications/healthy-living/new-psychoactive-substances-canada-2022.html1
- Nařízení vlády č. 463/2013 Sb., příloha č. 4, ve spojení se zákonem č. 167/1998 Sb.. opendata.eselpoint.gov.cz (n.d.). https://opendata.eselpoint.gov.cz/esel-esb/pr%C3%A1vn%C3%AD-akt-fragment/84246771
- Nařízení vlády č. 463/2013 Sb., příloha č. 4, ve spojení se zákonem č. 167/1998 Sb.. opendata.eselpoint.gov.cz (n.d.). https://opendata.eselpoint.gov.cz/esel-esb/pr%C3%A1vn%C3%AD-akt-fragment/12411532491
- Nařízení vlády č. 463/2013 Sb., příloha č. 4, ve spojení se zákonem č. 167/1998 Sb.. opendata.eselpoint.gov.cz (n.d.). https://opendata.eselpoint.gov.cz/esel-esb/pr%C3%A1vn%C3%AD-akt-fragment/39375671
- Bekendtgørelse om euforiserende stoffer, Order No. 405 of 26 March 2026. retsinformation.dk (n.d.). https://www.retsinformation.dk/eli/lta/2026/405/dan/pdf1
- Government Decree on substances, preparations and plants considered narcotics, as amended effective 5 August 2019. valtioneuvosto.fi (n.d.). https://valtioneuvosto.fi/sv/-/1271139/valtioneuvosto-haluaa-vahentaa-muuntohuumeiden-aiheuttamia-haittoja?languageId=en_US1
- Décision du 10 juillet 2025 portant modification de la liste des substances psychotropes (modifiant l’arrêté du 22 février 1990). ansm.sante.fr (n.d.). https://ansm.sante.fr/actualites/decision-du-10-07-2025-portant-modification-de-la-liste-des-substances-psychotropes1
Further Reading
European Monitoring Centre: New benzodiazepines news release
J Healthcare Initiative: Fluclotizolam effects & dosing
Orsolini et al. (2020) - Designer benzodiazepines review
Orsolini L. et al. 2020 – Review of designer benzodiazepines
Reddit: Active 1.5 mg Fluclotizolam report
Reddit: Fluclotizolam feels mediocre discussion
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass review
A first pass manual review and edit of article prose and copy has been performed by subject-matter expert Lyrea. This does not guarantee factual accuracy. An additional human review for each of this article's citations is yet to be performed.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes8 human edits · latest
Times are UTCNewest first
20 August 2026
Lyrea · Changed a word in Dosage & Duration › Routes 1 › Dose ranges › Light
Lyrea · Changed a word in Dosage & Duration › Routes 1 › Dose ranges › Threshold
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the Fluclotizolam article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.
Wish to give generalised feedback? You can do so here.