Fluclotizolam
Fluclotizolam is a novel thienotriazolodiazepine research chemical structurally derived from etizolam.1 It functions as a depressant and anxiolytic through GABAergic activity.12 Reports suggest it is roughly three times more potent than etizolam with a comparatively shorter duration of action, though dosage information remains inconsistent and poorly established. As with other designer benzodiazepines, it carries significant risks of dependence, and its limited research history means its safety profile is not well characterized.321
Contents
Dosage & Duration
Dosage
These doses are extremely tentative and will vary considerably between individuals based on factors including tolerance, individual sensitivity, and prior exposure to benzodiazepines.
Duration
Subjective Effects
Fluclotizolam produces a classically benzodiazepine-like depressant experience dominated by sedation, anxiety relief, and muscle relaxation, with little to no sensory alteration. As a derivative of etizolam reported to be roughly three times as potent with a shorter half-life, its effects arrive at very small doses and resolve comparatively quickly. At moderate to high doses, memory of the period after ingestion becomes unreliable.
Physical
The body feels heavy, relaxed, and sedated, with pronounced muscle relaxation that scales with dose.
Sedation
Cognitive
The headspace is characterized by a calm, disinhibited mental quiet in which anxious thought loops are suppressed and thinking slows. Gaps in recall are common at higher doses.
Suppressions
Reagent Testing
Loading reagent data
Pharmacology
Pharmacodynamics
Fluclotizolam is a thienotriazolodiazepine, a class of compounds that act as positive allosteric modulators of the GABA-A receptor at the benzodiazepine binding site.4 Detailed pharmacological characterization of fluclotizolam remains limited in publicly available literature, and no specific receptor binding affinities have been reported.
Pharmacokinetics
Reports suggest fluclotizolam has a shorter half-life than etizolam, though details of its metabolism are not described in the available sources.
Tolerance
Benzodiazepines, Thienodiazepines, Other GABAergic depressants
Harm Potential
Addiction & Dependence
Psychological
Classified as habit-forming.2
History & Culture
Fluclotizolam is a thienotriazolodiazepine that was originally synthesized in 197956 but was never developed for medical use or brought to market as a pharmaceutical product.1 The compound remained obscure for nearly four…
Legality
References
Source Pages
Citations
- (n.d.). The blood-to-plasma ratio and predicted GABAA-binding affinity of designer benzodiazepines. https://pmc.ncbi.nlm.nih.gov/articles/PMC9715504/1234
- (n.d.). Novel Designer Benzodiazepines: Comprehensive Review of Evolving Clinical and Adverse Effects. https://pmc.ncbi.nlm.nih.gov/articles/PMC9397074/123
- (n.d.). Challenges of Diagnosing and Managing Designer Benzodiazepine Dependence and Withdrawal: A Case Report. https://pubmed.ncbi.nlm.nih.gov/34001772/1
- (n.d.). The Psychonauts' Benzodiazepines; Quantitative Structure-Activity Relationship (QSAR) Analysis and Docking Prediction of Their Biological Activity. https://pmc.ncbi.nlm.nih.gov/articles/PMC8398354/1
- (n.d.). Thienotriazolodiazepine derivatives (US4155913A). https://patents.google.com/patent/US4155913A/en1
- (n.d.). Fluclotizolam — NPS Discovery Toxicology & Analytical Report (CFSRE, November 2021). https://www.cfsre.org/images/monographs/Fluclotizolam_110521_ToxicologyAnalyticalReport.pdf12
- (n.d.). New benzodiazepines in Europe — a review (EMCDDA, 2021). https://www.euda.europa.eu/system/files/publications/13759/TD0221596ENN_002.pdf1
- (n.d.). An expanding world of new psychoactive substances—designer benzodiazepines (Zawilska & Wojcieszak, Neurotoxicology 2019). https://doi.org/10.1016/j.neuro.2019.02.0151
Further Reading
European Monitoring Centre: New benzodiazepines news release
J Healthcare Initiative: Fluclotizolam effects & dosing
Orsolini et al. (2020) - Designer benzodiazepines review
Orsolini L. et al. 2020 – Review of designer benzodiazepines
Reddit: Active 1.5 mg Fluclotizolam report- Reddit: Fluclotizolam feels mediocre discussion
UK ACMD (2024) - Novel benzodiazepines update
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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