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Ethketamine
Ethketamine is a dissociative research chemical structurally related to ketamine, being an N-ethyl derivative of norketamine. It is reported to produce effects similar to its parent compound, including dissociation, hallucinogenic experiences, sedation, and euphoria. It is considered potentially habit-forming. As a research chemical with very limited formal study, its safety profile, pharmacology, and toxicity remain poorly understood, presenting significant unknown risks to users.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Ethketamine produces a dissociative state broadly comparable to that of ketamine, though its effects remain sparsely documented. Recreational users report euphoria and a characteristic sense of dissociation from the body and surroundings. As with other arylcyclohexylamine dissociatives, hallucinogenic and sedative qualities are presumed to accompany the experience, but detailed phenomenological accounts are lacking.
Physical
The compound is presumed to carry sedative effects consistent with its similarity to ketamine, though specific reports of its body load are limited.
Cognitive
The mental state is marked by euphoria alongside a detached, dissociated quality in which awareness feels separated from the body and immediate environment.
Dissociative
See also: Dissociative Intensity Scale, Subjective Effects of Dissociatives
Pharmacology
Pharmacodynamics
Ethketamine acts as an NMDA receptor antagonist. In mouse models, its antidepressant effects have been shown to depend on activation of both AMPA and 5-HT2 receptors, as pharmacological blockade of either receptor type abolishes this activity.
Pharmacokinetics
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
Categorized as habit-forming, suggesting some potential for psychological dependence, though detailed characterization of addiction potential is lacking due to limited research.
History & Culture
Ethketamine emerged as a designer drug around September 2012, when it first became available for purchase through online vendors. Since its initial appearance on the market, the compound has been identified in seized drug samples by analytical laboratories in the United Kingdom and other European countries, indicating its distribution across multiple jurisdictions within the designer drug market.
Legality
By Country
United StatesIllegal (analog/blanket ban)
AlabamaControlled substance
ChinaIllegal
United KingdomIllegalReferences
Citations
- 我国管制毒品目录（2026年7月更新，540种+三大类）. ga.sz.gov.cn (n.d.). https://ga.sz.gov.cn/SZJDZX/SZBMFW/content/post_12898420.html1
- 麻醉药品和精神药品管理条例 (Regulations on the Administration of Narcotic Drugs and Psychotropic Substances), third revision. xzfg.moj.gov.cn (n.d.). https://xzfg.moj.gov.cn/front/law/detail?LawID=17441
- 非药用类麻醉药品和精神药品列管办法 (Measures for Scheduling Non-Medicinal Narcotic Drugs and Psychotropic Substances). gaj.panjin.gov.cn (n.d.). https://gaj.panjin.gov.cn/2015_10/08_00/content-235605.html1
- 三部门联合发布最新版《非药用类麻醉药品和精神药品目录》. btgaj.xjbt.gov.cn (n.d.). https://btgaj.xjbt.gov.cn/c/2025-07-28/8428464.shtml1
- 中华人民共和国禁毒法 (Anti-Drug Law of the People's Republic of China). sz.gov.cn (n.d.). https://www.sz.gov.cn/cn/xxgk/zfxxgj/zcfg/content/post_8979670.html1
- PubChem PUG REST — CID 57483649 synonyms. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/57483649/synonyms/JSON123
- PubChem PUG REST — CID 57483649 compound properties. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/57483649/property/IUPACName,CanonicalSMILES,MolecularFormula/JSON12
- Misuse of Drugs Act 1971 — current Schedule 2 Part II paragraph 1. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/II/paragraph/11
- Misuse of Drugs Act 1971 — current Schedule 2. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/schedule/21
- Misuse of Drugs Act 1971 — section 2. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/section/21
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed — this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Recent changes7 human edits · latest
Times are UTCNewest first
24 January 2026
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
Josie Kins · Updated the article · also 1,4-Butanediol, 1B-LSD, 1cP-AL-LAD and 573 more
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